VE-cadherin-cre-recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells

Developmental Dynamics

Volumn 235, Issue 3, 2006, Pages 759-767

  Alva, Jackelyn A ^a   Zovein, Ann C ^a   Monvoisin, Arnaud ^a   Murphy, Thomas ^a   Salazar, Anthony ^a   Harvey, Natasha L ^b   Carmeliet, Peter ^c   Iruela Arispe, M Luisa ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Blood vessel; Cadherin; Cardiovascular system; Hematopoietic progenitors; Vasculature

Indexed keywords

BETA GALACTOSIDASE; CRE RECOMBINASE; VASCULAR ENDOTHELIAL CADHERIN;

ANIMAL CELL; ARTICLE; CARDIOVASCULAR SYSTEM; CELL COMPARTMENTALIZATION; CELL LINEAGE; ENDOTHELIUM CELL; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE DELETION; GENE TARGETING; GENETIC ANALYSIS; GENETIC MANIPULATION; HISTOLOGY; MORPHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD; CADHERINS; ENDOTHELIUM, VASCULAR; GENE DELETION; GENE EXPRESSION REGULATION; INTEGRASES; MICE; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); RECOMBINATION, GENETIC; VIRAL PROTEINS;

ANIMALIA; MUS MUSCULUS;

EID: 33644925814     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.20643     Document Type: Article

References (34)

1. Baumann CI, Bailey AS, Li W, Ferkowicz MJ, Yoder MC, Fleming WH. 2004. PECAM-1 is expressed on hematopoietic stem cells throughout ontogeny and identifies a population of erythroid progenitors. Blood 104:1010-1016
2. Calera MR, Venkatakrishnan A, Kazlauskas A. 2004. VE-cadherin increases the half-life of VEGF receptor 2. Exp Cell Res 300:248-256.
3. Carmeliet P, Lampugnani MG, Moons L, Breviario F, Compernolle V, Bono F, Balconi G, Spagnuolo R, Oostuyse B, Dewerchin M, Zanetti A, Angellilo A, Mattot V, Nuyens D, Lutgens E, Clotman F, de Ruiter MC, Gittenberger-de Groot A, Poelmann R, Lupu F, Herbert JM, Collen D, Dejana E. 1999. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell 98:147-157.
4. Chang CC, Chang TY, Yu CH, Tsai ML. 2005. Induction of VE-cadherin in rat placental trophoblasts by VEGF through a NO-dependent pathway. Placenta 26: 234-241.
5. Condorelli G, Borello U, De Angelis L, Latronico M, Sirabella D, Coletta M, Galli R, Balconi G, Follenzi A, Frati G, Cusella De Angelis MG, Gioglio L, Amuchastegui S, Adorini L, Naldini L, Vescovi A, Dejana E, Cossu G. 2001. Cardiomyocytes induce endothelial cells to trans-differentiate into cardiac muscle; implications for myocardium regeneration. Proc Natl Acad Sci USA 98:10733-10738.
6. Corada M, Liao F, Lindgren M, Lampugnani MG, Breviario F, Frank R, Muller WA, Hicklin DJ, Bohlen P, Dejana E. 2001. Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability. Blood 97:1679-1684.
7. Dejana E. 1996. Endothelial adherens junctions: implications in the control of vascular permeability and angiogenesis. J Clin Invest 98:1949-1953.
8. Ferkowicz MJ, Starr M, Xie X, Li W, Johnson SA, Shelley WC, Morrison PR, Yoder MC. 2003. CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Development 130:4393-4403.
9. Gory S, Vernet M, Laurent M, Dejana E, Dalmon J, Huber P. 1999. The vascular endothelial-cadherin promoter directs endothelial-specific expression in transgenic mice. Blood 93:184-192.
10. Gory-Faure S, Prandini MH, Pointu H, Roullot V, Pignot-Paintrand I, Vernet M, Huber P. 1999. Role of vascular endothelial-cadherin in vascular morphogenesis. Development 126:2093-2102.
11. Gothert JR, Gustin SE, Hall MA, Green AR, Gottgens B, Izon DJ, Begley CG. 2005. In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis. Blood 105:2724-2732.
12. Gustafsson E, Brakebusch C, Hietanen K, Fassler R. 2001. Tie-1-directed expression of Cre recombinase in endothelial cells of embryoid bodies and transgenic mice. J Cell Sci 114:671-676.
13. Hirashima M, Kataoka H, Nishikawa S, Matsuyoshi N. 1999. Maturation of embryonic stem cells into endothelial cells in an in vitro model of vasculogenesis. Blood 93:1253-1263.
14. Hisatsune H, Matsumura K, Ogawa M, Uemura A, Kondo N, Yamashita JK, Katsuta H, Nishikawa S, Chiba T. 2005. High level of endothelial cell-specific gene expression by a combination of the 5′ flanking region and the 5′ half of the first intron of the VE-cadherin gene. Blood 105:4657-4663.
15. Iida M, Heike T, Yoshimoto M, Baba S, Doi H, Nakahata T. 2005. Identification of cardiac stem cells with FLK1, CD31, and VE-cadherin expression during embryonic stem cell differentiation. Faseb J 19:371-378.
16. Kim I, Yilmaz OH, Morrison SJ. 2005. CD144 (VE-cadherin) is transiently expressed by fetal liver hematopoietic stem cells. Blood 106:903-905.
17. Kisanuki YY, Hammer RE, Miyazaki J, Williams SC, Richardson JA, Yanagisawa M. 2001. Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Dev Biol 230:230-242.
18. Lambeng N, Wallez Y, Rampon C, Cand F, Christe G, Gulino-Debrac D, Vilgrain I, Huber P. 2005. Vascular endothelial-cadherin tyrosine phosphorylation in angiogenic and quiescent adult tissues. Circ Res 96:384-391.
19. Lampugnani MG, Corada M, Caveda L, Breviario F, Ayalon O, Geiger B, Dejana E. 1995. The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin). J Cell Biol 129:203-217.
20. Li W, Ferkowicz MJ, Johnson SA, Shelley WC, Yoder MC. 2005. Endothelial cells in the early murine yolk sac give rise to CD41-expressing hematopoietic cells. Stem Cells Dev 14:44-54.
21. Licht AH, Raab S, Hofmann U, Breier G. 2004. Endothelium-specific Cre recombinase activity in flk-1-Cre transgenic mice. Dev Dyn 229:312-318.
22. Mao X, Fujiwara Y, Chapdelaine A, Yang H, Orkin SH. 2001. Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain. Blood 97:324-326.
23. May C, Doody JF, Abdullah R, Balderes P, Xu X, Chen CP, Zhu Z, Shapiro L, Kussie P, Hicklin DJ, Liao F, Bohlen P. 2005. Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature. Blood 105:4337-4344.
24. Mikkola HK, Fujiwara Y, Schlaeger TM, Traver D, Orkin SH. 2003. Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood 101:508-516.
25. Motoike T, Markham DW, Rossant J, Sato TN. 2003. Evidence for novel fate of Flk1+ progenitor: contribution to muscle lineage. Genesis 35:153-159.
26. Nagy A. 2000. Cre recombinase: the universal reagent for genome tailoring. Genesis 26:99-109.
27. Nishikawa SI, Nishikawa S, Kawamoto H, Yoshida H, Kizumoto M, Kataoka H, Katsura Y. 1998. In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos. Immunity 8:761-769.
28. Prandini MH, Dreher I, Bouillot S, Benkerri S, Moll T, Huber P. 2005. The human VE-cadherin promoter is subjected to organ-specific regulation and is activated in tumour angiogenesis. Oncogene 24:2992-3001.
29. Soriano P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21:70-71.
30. Terry RW, Kwee L, Baldwin HS, Labow MA. 1997. Cre-mediated generation of a VCAM-1 null allele in transgenic mice. Transgenic Res 6:349-356.
31. Venkiteswaran K, Xiao K, Summers S, Calkins CC, Vincent PA, Pumiglia K, Kowalczyk AP. 2002. Regulation of endothelial barrier function and growth by VE-cadherin, plakoglobin, and beta-catenin. Am J Physiol Cell Physiol 283:C811-821.
32. Wigle JT, Oliver G. 1999. Prox1 function is required for the development of the murine lymphatic system. Cell 98:769-778.
33. Wigle JT, Harvey N, Detmar M, Lagutina I, Grosveld G, Gunn MD, Jackson DG, Oliver G. 2002. An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. Embo J 21: 1505-1513.
34. Yamashita J, Itoh H, Hirashima M, Ogawa M, Nishikawa S, Yurugi T, Naito M, Nakao K. 2000. Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature 408:92-96.