A role for leukocyte-endothelial adhesion mechanisms in epilepsy

Nature Medicine

Volumn 14, Issue 12, 2008, Pages 1377-1383

  Fabene, Paolo F ^a   Mora, Graciela Navarro ^a   Martinello, Marianna ^a   Rossi, Barbara ^a   Merigo, Flavia ^a   Ottoboni, Linda ^a   Bach, Simona ^a   Angiari, Stefano ^a   Benati, Donatella ^a   Chakir, Asmaa ^a   Zanetti, Lara ^a   Schio, Federica ^a   Osculati, Antonio ^b   Marzola, Pasquina ^c   Nicolato, Elena ^a   Homeister, Jonathon W ^d   Xia, Lijun ^e   Lowe, John B ^f   McEver, Rodger P ^e   Osculati, Francesco ^a,g   Sbarbati, Andrea ^a   Butcher, Eugene C ^h,i   Constantin, Gabriela ^a   more..

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY OF INSUBRIA   (Italy)

^c UNIVERSITY OF VERONA   (Italy)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^f CASE WESTERN RESERVE UNIVERSITY   (United States)

^g IRCCS CENTRO NEUROLESI BONINO PULEJO   (Italy)

^h STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUCIN; P SELECTIN GLYCOPROTEIN LIGAND 1; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 1; VERY LATE ACTIVATION ANTIGEN 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; CONTROLLED STUDY; DEPLETION; DISEASE COURSE; DISEASE SEVERITY; ENDOTHELIUM; EPILEPSY; GENE INTERACTION; LEUKOCYTE ADHERENCE; LEUKOCYTE ROLLING; MOUSE; NERVE CELL; NERVE CELL EXCITABILITY; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEIZURE;

ANIMALS; CELL ADHESION; CELL ADHESION MOLECULES; ELECTROENCEPHALOGRAPHY; ENDOTHELIAL CELLS; EPILEPSY; LEUKOCYTES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT;

MUS;

EID: 57349141812     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.1878     Document Type: Article

References (30)

1. Strzelczyk, A., Reese, J.P., Dodel, R. & Hamer, H.M. Cost of epilepsy: a systematic review. Pharmacoeconomics 26, 463-476 (2008).
2. Holmes, G.L. Seizure-induced neuronal injury: animal data. Neurology 59, S3-S6 (2002).
3. Duncan, J.S. Seizure-induced neuronal injury: human data. Neurology 59, S15-S20 (2002).
4. Vezzani, A. Inflammation and epilepsy. Epilepsy Curr. 5, 1-6 (2005).
5. Vezzani, A. & Granata, T. Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia 46, 1724-1743 (2005).
6. Seiffert, E. et al. Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex. J. Neurosci. 24, 7829-7836 (2004).
7. Ivens, S. et al. TGF-β receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis. Brain 130, 535-547 (2007).
8. Van Vliet, E.A. et al. Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy. Brain 130, 521-534 (2007).
9. Marchi, N. et al. In vivo and in vitro effects of pilocarpine: relevance to ictogenesis. Epilepsia 48, 1934-1946 (2007).
10. Luster, A.D., Alon, R. & von Andrian, U.H. Immune cell migration in inflammation: present and future therapeutic targets. Nat. Immunol. 6, 1182-1190 (2005).
11. Ransohoff, R.M., Kivisakk, P. & Kidd, G. Three or more routes for leukocyte migration into the central nervous system. Nat. Rev. Immunol. 3, 569-581 (2003).
12. Shibley, H. & Smith, B.N. Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL/6 and CD-1 mice. Epilepsy Res. 49, 109-120 (2002).
13. Gröticke, I., Hoffmann, K. & Löscher, W. Behavioral alterations in the pilocarpine model of temporal lobe epilepsy in mice. Exp. Neurol. 207, 329-349 (2007).
14. Fabene, P.F., Marzola, P., Sbarbati, A. & Bentivoglio, M. Magnetic resonance imaging of changes elicited by status epilepticus in the rat brain: diffusion-weighted and T2-weighted images, regional blood volume maps and direct correlation with tissue and cell damage. Neuroimage 18, 375-389 (2003).
15. Piccio, L. et al. Molecular mechanisms involved in lymphocyte recruitment in brain microcirculation: critical roles for PSGL-1 and trimeric Gαi linked receptors. J. Immunol. 168, 1940-1949 (2002).
16. Glien, M. et al. Repeated low-dose treatment of rats with pilocarpine: low mortality but high proportion of rats developing epilepsy. Epilepsy Res. 46, 111-119 (2001).
17. Klitgaard, H., Matagne, A., Veneste-Goemaere, J. & Margineanu, D.G. Pilocarpine-induced epileptogenesis in the rat: impact of initial duration of status epilepticus on electrophysiological and neuropathological alterations. Epilepsy Res. 51, 93-107 (2002).
18. Racine, R.J. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 32, 281-294 (1972).
19. Ley, K. & Kansas, G.S. Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation. Nat. Rev. Immunol. 4, 325-335 (2004).
20. Ley, K., Laudanna, C., Cybulsky, M.I. & Nourshargh, S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat. Rev. Immunol. 7, 678-689 (2007).
21. Oby, E. & Janigro, D. The blood-brain barrier and epilepsy. Epilepsia 47, 1761-1774 (2006).
22. Lebwohl, M. et al. A novel targeted T-cell modulator, efalizumab, for plaque psoriasis. N. Engl. J. Med. 349, 2004-2013 (2003).
23. Polman, C.H. et al. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. 354, 899-910 (2006).
24. Maly, P. et al. The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E- and P-selectin ligand biosynthesis. Cell 86, 643-653 (1996).
25. Homeister, J.W. et al. The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing. Immunity 15, 115-126 (2001).
26. Xia, L. et al. P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow. J. Clin. Invest. 109, 939-950 (2002).
27. Runge, V.M. et al. The use of Gd DTPA as a perfusion agent and marker of blood-brain barrier disruption. Magn. Reson. Imaging 3, 43-55 (1985).
28. Lowell, C.A., Fumagalli, L. & Berton, G. Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J. Cell Biol. 133, 895-910 (1996).
29. + T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1. Blood 101, 4775-4782 (2003).
30. 2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow. Immunity 13, 759-769 (2000).