Minimally invasive molecular delivery into the brain using optical modulation of vascular permeability

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 22, 2011, Pages 9256-9261

  Choi, Myunghwan ^a   Ku, Taeyun ^a   Chong, Kyuha ^a   Yoon, Jonghee ^a   Choi, Chulhee ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Femtosecond pulsed laser; Laser tissue interaction; Molecular delivery; Permeability

Indexed keywords

NANOPARTICLE; VIRUS VECTOR;

ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; BLOOD VESSEL PERMEABILITY; BLOOD VESSEL WALL; BRAIN; BRAIN CORTEX; CONTROLLED STUDY; FEMTOSECOND LASER; GENE DELIVERY SYSTEM; IRRADIATION; MALE; MINIMALLY INVASIVE PROCEDURE; MOLECULAR DELIVERY; MOLECULAR PROBE; MOUSE; NONHUMAN; OPTICS; PHOTOACTIVATION; PLASMA; PRIORITY JOURNAL; SKULL; VASODILATATION;

ANIMALS; ASTROCYTES; BRAIN; CALCIUM; CAPILLARY PERMEABILITY; FLUORESCENT DYES; LASERS; LIGHT; MALE; MICE; MICE, INBRED ICR; MICROSCOPY, FLUORESCENCE; PERMEABILITY; PHOTOCHEMISTRY; PHOTONS;

EID: 79959349811     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1018790108     Document Type: Article

References (29)

1. Brightman MW (1977) Morphology of blood-brain interfaces. Exp Eye Res 25(Suppl):1-25.
2. Pardridge WM (2007) Blood-brain barrier delivery. Drug Discov Today 12:54-61.
3. Holtmaat A, et al. (2009) Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window. Nat Protoc 4:1128-1144.
4. Xu HT, Pan F, Yang G, Gan WB (2007) Choice of cranial window type for in vivo imaging affects dendritic spine turnover in the cortex. Nat Neurosci 10:549-551. (Pubitemid 46652440)
5. Hanson LR, Frey WH, 2nd (2008) Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease. BMC Neurosci 9(Suppl 3):S5.
6. McDannold N, Vykhodtseva N, Hynynen K (2008) Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index. Ultrasound Med Biol 34:834-840. (Pubitemid 351608039)
7. Baker M (2010) Laser tricks without labels. Nat Methods 7:261-266.
8. Smith NI, et al. (2001) Generation of calcium waves in living cells by pulsed-laser-induced photodisruption. Appl Phys Lett 79:1208-1210. (Pubitemid 33596884)
9. Watanabe W, et al. (2004) Femtosecond laser disruption of subcellular organelles in a living cell. Opt Express 12:4203-4213.
10. Tirlapur UK, König K (2002) Targeted transfection by femtosecond laser. Nature 418:290-291.
11. Nishimura N, et al. (2006) Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: Three models of stroke. Nat Methods 3:99-108. (Pubitemid 43173308)
12. Choi CJ, Belobraydich AR, Chan LL, Mathias PC, Cunningham BT (2010) Comparison of label-free biosensing in microplate, microfluidic, and spot-based affinity capture assays. Anal Biochem 405:1-10.
13. Stosiek C, Garaschuk O, Holthoff K, Konnerth A (2003) In vivo two-photon calcium imaging of neuronal networks. Proc Natl Acad Sci USA 100:7319-7324.
14. DiNapoli VA, Huber JD, Houser K, Li X, Rosen CL (2008) Early disruptions of the blood-brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats. Neurobiol Aging 29:753-764. (Pubitemid 351400829)
15. Lyubimova NV, Coultas PG, Yuen K, Martin RF (2001) In vivo radioprotection of mouse brain endothelial cells by Hoechst 33342. Br J Radiol 74:77-82.
16. Zuluaga MF, et al. (2007) Synergies of VEGF inhibition and photodynamic therapy in the treatment of age-related macular degeneration. Invest Ophthalmol Vis Sci 48:1767-1772.
17. Ay I, Francis JW, Brown RH, Jr. (2008) VEGF increases blood-brain barrier permeability to Evans blue dye and tetanus toxin fragment C but not adeno-associated virus in ALS mice. Brain Res 1234:198-205.
18. Takata N, Hirase H (2008) Cortical layer 1 and layer 2/3 astrocytes exhibit distinct calcium dynamics in vivo. PLoS ONE 3:e2525.
19. Jobsis PD, Rothstein EC, Balaban RS (2007) Limited utility of acetoxymethyl (AM)-based intracellular delivery systems, in vivo: Interference by extracellular esterases. J Microsc 226:74-81. (Pubitemid 46457359)
20. Kerr JN, Greenberg D, Helmchen F (2005) Imaging input and output of neocortical networks in vivo. Proc Natl Acad Sci USA 102:14063-14068. (Pubitemid 41377703)
21. Takano T, et al. (2006) Astrocyte-mediated control of cerebral blood flow. Nat Neurosci 9:260-267. (Pubitemid 43164550)
22. Drew PJ, et al. (2010) Chronic optical access through a polished and reinforced thinned skull. Nat Methods 7:981-984.
23. Andresen V, et al. (2009) Infrared multiphoton microscopy: Subcellular-resolved deep tissue imaging. Curr Opin Biotechnol 20:54-62.
24. Nadal A, Fuentes E, Pastor J, McNaughton PA (1995) Plasma albumin is a potent trigger of calcium signals and DNA synthesis in astrocytes. Proc Natl Acad Sci USA 92:1426-1430.
25. Vogel A, Venugopalan V (2003) Mechanisms of pulsed laser ablation of biological tissues. Chem Rev 103:577-644.
26. Ando J, Smith NI, Fujita K, Kawata S (2009) Photogeneration of membrane potential hyperpolarization and depolarization in non-excitable cells. Eur Biophys J 38:255-262.
27. Kreppel F, Kochanek S (2008) Modification of adenovirus gene transfer vectors with synthetic polymers: A scientific review and technical guide. Mol Ther 16:16-29.
28. Paques M, et al. (2007) High-resolution imaging of retinal cells in the living eye. Eye (Lond) 21(Suppl 1):S18-S20.
29. Isaka N, Padera TP, Hagendoorn J, Fukumura D, Jain RK (2004) Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function. Cancer Res 64:4400-4404. (Pubitemid 38856908)