Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury

Nature Communications

Volumn 3, Issue , 2012, Pages

  Campbell, Matthew ^a   Hanrahan, Finnian ^a   Gobbo, Oliviero L ^a   Kelly, Michael E ^b   Kiang, Anna Sophia ^a   Humphries, Marian M ^a   Nguyen, Anh T H ^a   Ozaki, Ema ^a   Keaney, James ^a   Blau, Christoph W ^a   Kerskens, Christian M ^a   Cahalan, Stephen D ^c   Callanan, John J ^c   Wallace, Eugene ^d   Grant, Gerald A ^e   Doherty, Colin P ^d   Humphries, Peter ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

^d ST JAMES S HOSPITAL   (Ireland)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLAUDIN 5; RECOMBINANT RNA; SMALL INTERFERING RNA; CLAUDIN; CLDN5 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; COGNITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PATHOLOGY; PROTEIN BLOOD LEVEL; SWELLING; TRAUMATIC BRAIN INJURY; WATER FLOW; ANIMAL; BRAIN INJURY; CHILD; COMPUTER ASSISTED TOMOGRAPHY; GENETICS; INTRACRANIAL PRESSURE; MALE; METABOLISM; PHYSIOLOGY; RADIOGRAPHY; RNA INTERFERENCE;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN EDEMA; BRAIN INJURIES; CHILD; CLAUDINS; COGNITION; HUMANS; INTRACRANIAL PRESSURE; MALE; MICE; RNA INTERFERENCE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84866458070     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms1852     Document Type: Article

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