Requirement for small side chain residues within the GxGD-motif of presenilin for γ-secretase substrate cleavage

Journal of Neurochemistry

Volumn 112, Issue 4, 2010, Pages 940-950

  Pérez Revuelta, Blanca Isabel ^a   Fukumori, Akio ^a   Lammich, Sven ^a   Yamasaki, Aya ^a   Haass, Christian ^a   Steiner, Harald ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

secretase; Alzheimer's disease; GxGD type protease; Intramembrane proteolysis; Presenilin

Indexed keywords

GAMMA SECRETASE; GLYCINE; PRESENILIN 1;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF;

ALANINE; AMINO ACID MOTIFS; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTIGENS, CD44; CELLS, CULTURED; EMBRYO, MAMMALIAN; GLYCINE; HUMANS; IMMUNOPRECIPITATION; MICE; MICE, KNOCKOUT; MUTATION; PRESENILIN-1; PRESENILIN-2; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRANSFECTION;

EID: 75149134897     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.06510.x     Document Type: Article

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