Mutations in nicastrin protein differentially affect amyloid β-peptide production and notch protein processing

Journal of Biological Chemistry

Volumn 286, Issue 36, 2011, Pages 31153-31158

  Pamrén, Annelie ^a   Wanngren, Johanna ^a   Tjernberg, Lars O ^a   Winblad, Bengt ^a   Bhat, Ratan ^b   Näslund, Jan ^b   Karlström, Helena ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; CLINICAL TRIAL; COMPLEX ASSEMBLY; CYSTEINE RESIDUES; ECTODOMAIN; INTRACELLULAR DOMAIN; NICASTRIN; NOTCH SIGNALING; PEPTIDE PRODUCTION; PRESENILINS; PROTEIN PROCESSING; SECRETASE COMPLEX; SECRETASES; SIDE EFFECT; SIGNALING PATHWAYS; SINGLE RESIDUE; SUBSTRATE RECOGNITION;

AMINO ACIDS; GLYCOPROTEINS; NEURODEGENERATIVE DISEASES; PEPTIDES; SIGNALING;

SUBSTRATES;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CYSTEINE; GAMMA SECRETASE; MUTANT PROTEIN; NICASTRIN; NOTCH RECEPTOR; SERINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN SYNTHESIS;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELLS, CULTURED; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MUTATION; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 80052405149     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C111.235267     Document Type: Article

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