Generation of Aβ38 and Aβ42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and γ-secretase modulation

Journal of Biological Chemistry

Volumn 283, Issue 2, 2008, Pages 677-683

  Page, Richard M ^a   Baumann, Karlheinz ^b   Tomioka, Masanori ^a   Pérez Revuelta, Blanca I ^a   Fukumori, Akio ^a   Jacobsen, Helmut ^b   Flohr, Alexander ^b   Luebbers, Thomas ^b   Ozmen, Laurence ^b   Steiner, Harald ^a   Haass, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASES; AMYLOID PRECURSOR PROTEIN; MUTANTS; PRESENILIN MUTATIONS; PROTEOLYTIC PROCESSING;

AMINO ACIDS; DRUG DOSAGE; MUTAGENESIS; PEPTIDES; PROTEOLYSIS;

DISEASES;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN 38; AMYLOID BETA PROTEIN[1-42]; FENOFIBRATE; GAMMA SECRETASE; PRESENILIN; SULINDAC SULFIDE; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA PROTEIN (25 38); AMYLOID BETA-PROTEIN (1-42); AMYLOID BETA-PROTEIN (25-38); PEPTIDE FRAGMENT; PRESENILIN 1; PRESENILIN 2; SECRETASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; GENE MUTATION; HUMAN; HUMAN CELL; MODULATION; MOUSE; NONHUMAN; ONSET AGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BRAIN; CELL LINE; GENETIC TRANSFECTION; GENETICS; KIDNEY; METABOLISM; MUTATION; PHYSIOLOGY; PRENATAL DEVELOPMENT; TRANSGENIC MOUSE;

MUS MUSCULUS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN; CELL LINE; HUMANS; KIDNEY; MICE; MICE, TRANSGENIC; MUTATION; PEPTIDE FRAGMENTS; PRESENILIN-1; PRESENILIN-2; TRANSFECTION;

EID: 38149013121     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708754200     Document Type: Article

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