Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of γ-secretase activity toward amyloid precursor protein and other substrates

Journal of Biological Chemistry

Volumn 285, Issue 49, 2010, Pages 38042-38052

  Gong, Ping ^a   Vetrivel, Kulandaivelu S ^a   Nguyen, Phuong D ^b   Meckler, Xavier ^a   Cheng, Haipeng ^a   Kounnas, Maria Z ^c   Wagner, Steven L ^b   Parent, Angèle T ^a   Thinakaran, Gopal ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Neurogenetics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PEPTIDES; AMYLOID PRECURSOR PROTEINS; BROAD SPECTRUM; C-TERMINAL FRAGMENTS; CATALYTIC ACTIVITY; CATALYTIC CORE; CATALYTIC PROPERTIES; CATALYTIC SITES; CATALYTIC SUBUNITS; COMPLEX FORMATIONS; DOCKING SITES; ENDOPROTEOLYSIS; INTRAMEMBRANE PROTEOLYSIS; LIMITED INFORMATION; MEMBRANE PROTEINS; MUTATION ANALYSIS; N-CADHERIN; N-TERMINAL DOMAINS; N-TERMINALS; NICASTRIN; PRESENILINS; PROTEIN COMPLEXES; SECOND TRANSMEMBRANE DOMAIN; SECRETASE COMPLEX; SECRETASES; TRANS-MEMBRANE PROTEINS; TWO DOMAINS;

ACTIVATION ANALYSIS; BIOLOGICAL MEMBRANES; CATALYST ACTIVITY; COMPLEXATION; GLYCOPROTEINS; PROTEINS;

SUBSTRATES;

AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; GAMMA SECRETASE; MUTANT PROTEIN; NERVE CELL ADHESION MOLECULE; NICASTRIN; PRESENILIN 1;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBSTRATE; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CADHERINS; CATALYTIC DOMAIN; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MUTAGENESIS; MUTATION; PRESENILIN-1; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, NOTCH1; SUBSTRATE SPECIFICITY;

EID: 78649675852     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.132613     Document Type: Article

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