Attenuated Aβ42 responses to low potency γ-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds

Journal of Biological Chemistry

Volumn 286, Issue 17, 2011, Pages 15240-15251

  Kretner, Benedikt ^a   Fukumori, Akio ^a   Gutsmiedl, Amelie ^a   Page, Richard M ^a   Luebbers, Thomas ^b   Galley, Guido ^b   Baumann, Karlheinz ^b   Haass, Christian ^a   Steiner, Harald ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; CATALYTIC SUBUNITS; DIFFERENTIAL RESPONSE; LOW POTENCY; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; PATHOGENIC MUTATION; PRESENILINS; SECOND GENERATION; SECRETASES; SEQUENTIAL PROCESSING; SPATIAL ENVIRONMENTS; STRUCTURAL CLASS; THERAPEUTIC STRATEGY;

AMINO ACIDS;

GLYCOPROTEINS;

AMYLOID BETA PROTEIN[1-42]; GAMMA SECRETASE; GAMMA SECRETASE MODULATOR; NONSTEROID ANTIINFLAMMATORY AGENT; PRESENILIN; PRESENILIN 1; PRESENILIN 2; SULINDAC SULFIDE; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); AMYLOID PRECURSOR PROTEIN; APP PROTEIN, HUMAN; PEPTIDE FRAGMENT; SECRETASE;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVE SITE; GENE MUTATION; GENETIC TRANSFECTION; MUTANT; PRIORITY JOURNAL; CELL LINE; DRUG EFFECT; GENETICS; HUMAN; MUTATION;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; HUMANS; MUTATION; PEPTIDE FRAGMENTS; PRESENILINS;

EID: 79955426777     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.213587     Document Type: Article

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