메뉴 건너뛰기




Volumn 5, Issue 4, 2013, Pages 479-492

Therapeutic applications of PI3K inhibitors in cardiovascular diseases

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; 2 (6 AMINO 9 PURINYLMETHYL) 5 METHYL 3 (2 METHYLPHENYL) 3H QUINAZOLIN 4 ONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 5 (6 QUINOXALINYLMETHYLENE) 2,4 THIAZOLIDINEDIONE; 5 [(2,2 DIFLUORO 1,3 BENZODIOXOL 5 YL)METHYLIDENE] 2,4 THIAZOLIDINEDIONE; 9 (1 ANILINOETHYL) 7 METHYL 2 MORPHOLINOPYRIDO[1,2 A]PYRIMIDIN 4 ONE; AZD 6482; CZC 24832; GE 21; IC 486068; IDELALISIB; NVF BEZ 235; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PIK 75; TG 100 115; UNCLASSIFIED DRUG; WORTMANNIN; YM 024;

EID: 84875141045     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.13.11     Document Type: Review
Times cited : (29)

References (102)
  • 1
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC. The phosphoinositide 3-kinase pathway. Science 296(5573), 1655-1657 (2002).
    • (2002) Science , vol.296 , Issue.5573 , pp. 1655-1657
    • Cantley, L.C.1
  • 2
    • 46149106818 scopus 로고    scopus 로고
    • T he p110 b isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110g
    • Guillermet-Guibert J, Bjorklof K, Salpekar A et al. T he p110 b isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110g. Proc. Natl Acad. Sci. USA 105(24), 8292-8297 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.24 , pp. 8292-8297
    • Guillermet-Guibert, J.1    Bjorklof, K.2    Salpekar, A.3
  • 4
    • 0027432424 scopus 로고
    • Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3, 4, 5-trisphosphate in neutrophil responses
    • Arcaro A, Wymann MP. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3, 4, 5-trisphosphate in neutrophil responses. Biochem. J. 296 (Pt 2), 297-301 (1993).
    • (1993) Biochem. J. , vol.296 , Issue.PART 2 , pp. 297-301
    • Arcaro, A.1    Wymann, M.P.2
  • 5
    • 0028170210 scopus 로고
    • A specifc inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
    • Vlahos CJ, Matter WF, Hui KY, Brown RF. A specifc inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269(7), 5241-5248 (1994).
    • (1994) J. Biol. Chem. , vol.269 , Issue.7 , pp. 5241-5248
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 6
    • 34250823572 scopus 로고    scopus 로고
    • Pharmacologic characterization of a potent inhibitor of class i phosphatidylinositide 3-kinases
    • Raynaud FI, Eccles S, Clarke Pa et al. Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases. Cancer Res. 67(12), 5840-5850 (2007).
    • (2007) Cancer Res. , vol.67 , Issue.12 , pp. 5840-5850
    • Raynaud, F.I.1    Eccles, S.2    Pa, C.3
  • 7
    • 51049109033 scopus 로고    scopus 로고
    • Identifcation and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo anti-tumor activity
    • Maira SM, Stauffer F, Brueggen J et al. Identifcation and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo anti-tumor activity. Mol. Cancer Ther. 7(7), 1851-1863 (2008).
    • (2008) Mol. Cancer Ther. , vol.7 , Issue.7 , pp. 1851-1863
    • Maira, S.M.1    Stauffer, F.2    Brueggen, J.3
  • 8
    • 0037369696 scopus 로고    scopus 로고
    • Essential role of phosphoinositide 3-kinase d in neutrophil directional movement
    • Sadhu C, Masinovsky B, Dick K, Sowell CG, Staunton DE. Essential role of phosphoinositide 3-kinase d in neutrophil directional movement. J.Immunol. 170(5), 2647-2654 (2003).
    • (2003) J.Immunol. , vol.170 , Issue.5 , pp. 2647-2654
    • Sadhu, C.1    Masinovsky, B.2    Dick, K.3    Sowell, C.G.4    Staunton, D.E.5
  • 9
    • 4344670729 scopus 로고    scopus 로고
    • A specifc antagonist of the p110d catalytic component of phosphatidylinositol 3́-kinase, IC486068, enhances radiation-induced tumor vascular destruction
    • Geng L, Tan J, Himmelfarb E et al. A specifc antagonist of the p110d catalytic component of phosphatidylinositol 3́-kinase, IC486068, enhances radiation-induced tumor vascular destruction. Cancer Res. 64(14), 4893-4899 (2004).
    • (2004) Cancer Res. , vol.64 , Issue.14 , pp. 4893-4899
    • Geng, L.1    Tan, J.2    Himmelfarb, E.3
  • 10
    • 78751553221 scopus 로고    scopus 로고
    • CA L-101, a p110d selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
    • Lannutti BJ, Meadows SA, Herman SE et al. CA L-101, a p110d selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood 117(2), 591-594 (2011).
    • (2011) Blood , vol.117 , Issue.2 , pp. 591-594
    • Lannutti, B.J.1    Meadows, S.A.2    Herman, S.E.3
  • 11
    • 24744449495 scopus 로고    scopus 로고
    • PI3Kg inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
    • Barber DF, Bartolome A, Hernandez C. et al. PI3Kg inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus. Nat. Med. 11(9), 933-935 (2005).
    • (2005) Nat. Med. , vol.11 , Issue.9 , pp. 933-935
    • Barber, D.F.1    Bartolome, A.2    Hernandez, C.3
  • 12
    • 24744435115 scopus 로고    scopus 로고
    • Blockade of PI3Kg suppresses joint infammation and damage in mouse models of rheumatoid arthritis
    • Camps M, Ruckle T, Ji H et al. Blockade of PI3Kg suppresses joint infammation and damage in mouse models of rheumatoid arthritis. Nat. Med. 11(9), 936-943 (2005).
    • (2005) Nat. Med. , vol.11 , Issue.9 , pp. 936-943
    • Camps, M.1    Ruckle, T.2    Ji, H.3
  • 13
    • 84861329091 scopus 로고    scopus 로고
    • A selective inhibitor reveals PI3Kg dependence of T(H)17 cell differentiation
    • Bergamini G, Bell K, Shimamura S et al. A selective inhibitor reveals PI3Kg dependence of T(H)17 cell differentiation. Nat. Chem. Biol. 8(6), 576-582 (2012).
    • (2012) Nat. Chem. Biol. , vol.8 , Issue.6 , pp. 576-582
    • Bergamini, G.1    Bell, K.2    Shimamura, S.3
  • 14
    • 84555177773 scopus 로고    scopus 로고
    • PI3Kg inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism
    • Carnevale D, Vecchione C, Mascio G et al. PI3Kg inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism. Cardiovasc. Res. 93(1), 200-209 (2012).
    • (2012) Cardiovasc. Res. , vol.93 , Issue.1 , pp. 200-209
    • Carnevale, D.1    Vecchione, C.2    Mascio, G.3
  • 15
    • 21044454703 scopus 로고    scopus 로고
    • PI 3-kinase p110b: A new target for antithrombotic therapy
    • Jackson SP, Schoenwaelder SM, Goncalves I et al. PI 3-kinase p110b: a new target for antithrombotic therapy. Nat. Med. 11(5), 507-514 (2005).
    • (2005) Nat. Med. , vol.11 , Issue.5 , pp. 507-514
    • Jackson, S.P.1    Schoenwaelder, S.M.2    Goncalves, I.3
  • 16
    • 84866876711 scopus 로고    scopus 로고
    • Human target validation of phosphoinositide 3-kinase (PI3K)b: Effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kb inhibitor
    • Nylander S, Kull B, Bjorkman JA et al. Human target validation of phosphoinositide 3-kinase (PI3K)b: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kb inhibitor. J. Thromb. Haemost. 10 (10), 2127-2136 (2012).
    • (2012) J. Thromb. Haemost. , vol.10 , Issue.10 , pp. 2127-2136
    • Nylander, S.1    Kull, B.2    Bjorkman, J.A.3
  • 17
    • 71749121027 scopus 로고    scopus 로고
    • Non-redundant roles of phosphoinositide 3-kinase isoforms a and b in glycoprotein VI-induced platelet signaling and thrombus formation
    • Gilio K, Munnix IC, Mangin P et al. Non-redundant roles of phosphoinositide 3-kinase isoforms a and b in glycoprotein VI-induced platelet signaling and thrombus formation. J. Biol. Chem. 284(49), 33750-33762 (2009).
    • (2009) J. Biol. Chem. , vol.284 , Issue.49 , pp. 33750-33762
    • Gilio, K.1    Munnix, I.C.2    Mangin, P.3
  • 18
    • 33646383684 scopus 로고    scopus 로고
    • A pharmacological map of the PI3-K family defnes a role for p110a in insulin signaling
    • Knight ZA, Gonzalez B, Feldman ME et al. A pharmacological map of the PI3-K family defnes a role for p110a in insulin signaling. Cell 125(4), 733-747 (2006).
    • (2006) Cell , vol.125 , Issue.4 , pp. 733-747
    • Knight, Z.A.1    Gonzalez, B.2    Feldman, M.E.3
  • 19
    • 33845919315 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase g/d inhibition limits infarct size after myocardial ischemia/reperfusion injury
    • Doukas J, Wrasidlo W, Noronha G et al. Phosphoinositide 3-kinase g/d inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc. Natl Acad. Sci. USA 103 (52), 19866-19871 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.52 , pp. 19866-19871
    • Doukas, J.1    Wrasidlo, W.2    Noronha, G.3
  • 20
    • 0032515047 scopus 로고    scopus 로고
    • Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3́-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation
    • Gerber HP, Mcmurtrey A, Kowalski J et al. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3́-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J. Biol. Chem. 273(46), 30336-30343 (1998).
    • (1998) J. Biol. Chem. , vol.273 , Issue.46 , pp. 30336-30343
    • Gerber, H.P.1    McMurtrey, A.2    Kowalski, J.3
  • 21
    • 0034254273 scopus 로고    scopus 로고
    • A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3́-kinase activation and endothelial cell migration
    • Gille H, Kowalski J, Yu L et al. A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3́-kinase activation and endothelial cell migration. EMBO J. 19 (15), 4064-4073 (2000).
    • (2000) EMBO J. , vol.19 , Issue.15 , pp. 4064-4073
    • Gille, H.1    Kowalski, J.2    Yu, L.3
  • 22
    • 0028899424 scopus 로고
    • Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain sh2 domains
    • Guo D, Jia Q, Song H-Y, Warren RS, Donner DB. Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain sh2 domains. J. Biol. Chem. 270(12), 6729-6733 (1995).
    • (1995) J. Biol. Chem. , vol.270 , Issue.12 , pp. 6729-6733
    • Guo, D.1    Jia, Q.2    Song, H.-Y.3    Warren, R.S.4    Donner, D.B.5
  • 23
    • 0242624291 scopus 로고    scopus 로고
    • Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
    • Makinen T, Veikkola T, Mustjoki S et al. Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. EMBO J. 20(17), 4762-4773 (2001).
    • (2001) EMBO J. , vol.20 , Issue.17 , pp. 4762-4773
    • Makinen, T.1    Veikkola, T.2    Mustjoki, S.3
  • 24
    • 2642709170 scopus 로고    scopus 로고
    • Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
    • Xia P, Aiello LP, Ishii H et al. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J. Clin. Invest. 98(9), 2018-2026 (1996).
    • (1996) J. Clin. Invest. , vol.98 , Issue.9 , pp. 2018-2026
    • Xia, P.1    Aiello, L.P.2    Ishii, H.3
  • 25
    • 44349119736 scopus 로고    scopus 로고
    • Angiogenesis selectively requires the p110 a isoform of PI3K to control endothelial cell migration
    • Graupera M, Guillermet-Guibert J, Foukas LC et al. Angiogenesis selectively requires the p110 a isoform of PI3K to control endothelial cell migration. Nature 453(7195), 662-666 (2008).
    • (2008) Nature , vol.453 , Issue.7195 , pp. 662-666
    • Graupera, M.1    Guillermet-Guibert, J.2    Foukas, L.C.3
  • 26
    • 51749104480 scopus 로고    scopus 로고
    • Overlapping and distinct roles for PI3K{b} and {g} isoforms in S1P-induced migration of human and mouse endothelial cells
    • Heller R, Chang Q, Ehrlich G et al. Overlapping and distinct roles for PI3K{b} and {g} isoforms in S1P-induced migration of human and mouse endothelial cells. Cardiovasc. Res. 80(1), 96-105 (2008).
    • (2008) Cardiovasc. Res. , vol.80 , Issue.1 , pp. 96-105
    • Heller, R.1    Chang, Q.2    Ehrlich, G.3
  • 27
    • 33749352556 scopus 로고    scopus 로고
    • Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis
    • Ahmad S, Hewett PW, Wang P et al. Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis. Circ. Res. 99(7), 715-722 (2006).
    • (2006) Circ. Res. , vol.99 , Issue.7 , pp. 715-722
    • Ahmad, S.1    Hewett, P.W.2    Wang, P.3
  • 28
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher Am. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399(6736), 601-605 (1999).
    • (1999) Nature , vol.399 , Issue.6736 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, Am.6
  • 29
    • 0033542414 scopus 로고    scopus 로고
    • Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
    • Fulton D, Gratton J-P, Mccabe TJ et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399(6736), 597-601 (1999).
    • (1999) Nature , vol.399 , Issue.6736 , pp. 597-601
    • Fulton, D.1    Gratton, J.-P.2    McCabe, T.J.3
  • 30
    • 0033569924 scopus 로고    scopus 로고
    • Identifcation of fow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002
    • Gallis B, Corthals Gl, Goodlett DR et al. Identifcation of fow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002. J. Biol. Chem. 274 (42), 30101-30108 (1999).
    • (1999) J. Biol. Chem. , vol.274 , Issue.42 , pp. 30101-30108
    • Gallis, B.1    Gl, C.2    Goodlett, D.R.3
  • 31
    • 0033615069 scopus 로고    scopus 로고
    • The Akt kinase signals directly to endothelial nitric oxide synthase
    • Michell BJ, Griffths JE, Mitchelhill KI et al. The Akt kinase signals directly to endothelial nitric oxide synthase. Curr. Biol. 9 (15), 845-848 (1999).
    • (1999) Curr. Biol. , vol.9 , Issue.15 , pp. 845-848
    • Michell, B.J.1    Griffths, J.E.2    Mitchelhill, K.I.3
  • 32
    • 47749118003 scopus 로고    scopus 로고
    • Class 1A PI3K regulates vessel integrity during development and tumorigenesis
    • Yuan Tl, Choi HS, Matsui A et al. Class 1A PI3K regulates vessel integrity during development and tumorigenesis. Proc. Natl Acad. Sci. USA 105(28), 9739-9744 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.28 , pp. 9739-9744
    • Tl, Y.1    Choi, H.S.2    Matsui, A.3
  • 33
    • 79958696667 scopus 로고    scopus 로고
    • Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kg, a single convergent point promoting tumor infammation and progression
    • Schmid MC, Avraamides CJ, Dippold HC et al. Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kg, a single convergent point promoting tumor infammation and progression. Cancer Cell 19(6), 715-727 (2011).
    • (2011) Cancer Cell , vol.19 , Issue.6 , pp. 715-727
    • Schmid, M.C.1    Avraamides, C.J.2    Dippold, H.C.3
  • 34
    • 42549125520 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-kinase-g is integral to homing functions of progenitor cells
    • Chavakis E, Carmona G, Urbich C et al. Phosphatidylinositol-3-kinase-g is integral to homing functions of progenitor cells. Circ. Res. 102(8), 942-949 (2008).
    • (2008) Circ. Res. , vol.102 , Issue.8 , pp. 942-949
    • Chavakis, E.1    Carmona, G.2    Urbich, C.3
  • 35
    • 37549023783 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase g gene knockout impairs postischemic neovascularization and endothelial progenitor cell functions
    • Madeddu P, Kraenkel N, Barcelos Ls et al. Phosphoinositide 3-kinase g gene knockout impairs postischemic neovascularization and endothelial progenitor cell functions. Arterioscler. Thromb. Vasc. Biol. 28(1), 68-76 (2008).
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , Issue.1 , pp. 68-76
    • Madeddu, P.1    Kraenkel, N.2    Ls, B.3
  • 36
    • 70849131663 scopus 로고    scopus 로고
    • Selective inhibition of retinal angiogenesis by targeting PI3 kinase
    • Alvarez Y, Astudillo O, Jensen L et al. Selective inhibition of retinal angiogenesis by targeting PI3 kinase. PLoS ONE 4(11), e7867 (2009).
    • (2009) PLoS ONE , vol.4 , Issue.11
    • Alvarez, Y.1    Astudillo, O.2    Jensen, L.3
  • 37
    • 0038756445 scopus 로고    scopus 로고
    • PTEN and phosphatidylinositol 3́-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: Evidence for an effect on the tumor and endothelial compartment
    • Su JD, Mayo LD, Donner DB, Durden DL. PTEN and phosphatidylinositol 3́-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment. Cancer Res. 63 (13), 3585-3592 (2003).
    • (2003) Cancer Res. , vol.63 , Issue.13 , pp. 3585-3592
    • Su, J.D.1    Mayo, L.D.2    Donner, D.B.3    Durden, D.L.4
  • 38
    • 53049087363 scopus 로고    scopus 로고
    • Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: Implications for clinical imaging
    • Schnell CR, Stauffer FDR, Allegrini PR et al. Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging. Cancer Res. 68(16), 6598-6607 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.16 , pp. 6598-6607
    • Schnell, C.R.1    Fdr, S.2    Allegrini, P.R.3
  • 39
    • 4344670729 scopus 로고    scopus 로고
    • A specifc antagonist of the p110d catalytic component of phosphatidylinositol 3-kinase, IC486068, enhances radiation-induced tumor vascular destruction
    • Geng L, Ta n J, Himmelfarb E et al. A specifc antagonist of the p110d catalytic component of phosphatidylinositol 3-kinase, IC486068, enhances radiation-induced tumor vascular destruction. Cancer Res. 64(14), 4893-4899 (2004).
    • (2004) Cancer Res. , vol.64 , Issue.14 , pp. 4893-4899
    • Geng, L.1    Tan, J.2    Himmelfarb, E.3
  • 40
    • 34249951624 scopus 로고    scopus 로고
    • Deletion of the phosphoinositide 3-kinase p110Î gene attenuates murine atherosclerosis
    • Chang JD, Sukhova GK, Libby P et al. Deletion of the phosphoinositide 3-kinase p110Î gene attenuates murine atherosclerosis. Proc. Natl Acad. Sci. USA 104(19), 8077-8082 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.19 , pp. 8077-8082
    • Chang, J.D.1    Sukhova, G.K.2    Libby, P.3
  • 41
    • 43049176633 scopus 로고    scopus 로고
    • Taming the PI3K team to hold infammation and cancer at bay
    • Hirsch E, Ciraolo E, Ghigo A, Costa C. Taming the PI3K team to hold infammation and cancer at bay. Pharmacol. Ther. 118(2), 192-205 (2008).
    • (2008) Pharmacol. Ther. , vol.118 , Issue.2 , pp. 192-205
    • Hirsch, E.1    Ciraolo, E.2    Ghigo, A.3    Costa, C.4
  • 42
    • 34247203834 scopus 로고    scopus 로고
    • Critical role for casein kinase 2 and phosphoinositide-3-kinase in the interferon-{g}-induced expression of monocyte chemoattractant protein-1 and other key genes implicated in atherosclerosis
    • Harvey EJ, Li N, Ramji DP. Critical role for casein kinase 2 and phosphoinositide-3-kinase in the interferon-{g}-induced expression of monocyte chemoattractant protein-1 and other key genes implicated in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 27(4), 806-812 (2007).
    • (2007) Arterioscler. Thromb. Vasc. Biol. , vol.27 , Issue.4 , pp. 806-812
    • Harvey, E.J.1    Li, N.2    Ramji, D.P.3
  • 43
    • 49049106608 scopus 로고    scopus 로고
    • Type 1 TNF receptor forms a complex with and uses Jak2 and c-Src to selectively engage signaling pathways that regulate transcription factor activity
    • Pincheira R, Castro AF, Ozes ON, Idumalla PS, Donner DB. Type 1 TNF receptor forms a complex with and uses Jak2 and c-Src to selectively engage signaling pathways that regulate transcription factor activity. J. Immunol. 181(2), 1288-1298 (2008).
    • (2008) J. Immunol. , vol.181 , Issue.2 , pp. 1288-1298
    • Pincheira, R.1    Castro, A.F.2    Ozes, O.N.3    Idumalla, P.S.4    Donner, D.B.5
  • 44
    • 51349164414 scopus 로고    scopus 로고
    • Transforming growth factor {b} Engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab
    • Wang SE, Xiang B, Guix M et al. Transforming growth factor {b} Engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab. Mol. Cell. Biol. 28(18), 5605-5620 (2008).
    • (2008) Mol. Cell. Biol. , vol.28 , Issue.18 , pp. 5605-5620
    • Wang, S.E.1    Xiang, B.2    Guix, M.3
  • 45
    • 23744492188 scopus 로고    scopus 로고
    • Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
    • Condliffe AM, Davidson K, Anderson KE et al. Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 106 (4), 1432-1440 (2005).
    • (2005) Blood , vol.106 , Issue.4 , pp. 1432-1440
    • Condliffe, A.M.1    Davidson, K.2    Anderson, K.E.3
  • 46
    • 0034635452 scopus 로고    scopus 로고
    • Central role for G protein-coupled phosphoinositide 3-kinase g in infammation
    • Hirsch E, Katanaev VL, Garlanda C et al. Central role for G protein-coupled phosphoinositide 3-kinase g in infammation. Science 287(5455), 1049-1053 (2000).
    • (2000) Science , vol.287 , Issue.5455 , pp. 1049-1053
    • Hirsch, E.1    Katanaev, V.L.2    Garlanda, C.3
  • 47
    • 0034635221 scopus 로고    scopus 로고
    • Roles of PLC-2 and-3 and PI3K in Chemoattractant-Mediated Signal Transduction
    • Li Z, Jiang H, Xie W, Zhang Z, Smrcka AV, Wu D. Roles of PLC-2 and-3 and PI3K in Chemoattractant-Mediated Signal Transduction. Science 287(5455), 1046-1049 (2000).
    • (2000) Science , vol.287 , Issue.5455 , pp. 1046-1049
    • Li, Z.1    Jiang, H.2    Xie, W.3    Zhang, Z.4    Smrcka, A.V.5    Wu, D.6
  • 48
    • 0034635264 scopus 로고    scopus 로고
    • Function of PI3Kg in thymocyte development, T cell activation, and neutrophil migration
    • Sasaki T, Irie-Sasaki J, Jones RG et al. Function of PI3Kg in thymocyte development, T cell activation, and neutrophil migration. Science 287(5455), 1040-1046 (2000).
    • (2000) Science , vol.287 , Issue.5455 , pp. 1040-1046
    • Sasaki, T.1    Irie-Sasaki, J.2    Jones, R.G.3
  • 49
    • 40549131271 scopus 로고    scopus 로고
    • Genetic and pharmacological targeting of phosphoinositide 3-kinase-g reduces atherosclerosis and favors plaque stability by modulating infammatory processes
    • Fougerat A, Gayral S, Gourdy P et al. Genetic and pharmacological targeting of phosphoinositide 3-kinase-g reduces atherosclerosis and favors plaque stability by modulating infammatory processes. Circulation 117(10), 1310-1317 (2008).
    • (2008) Circulation , vol.117 , Issue.10 , pp. 1310-1317
    • Fougerat, A.1    Gayral, S.2    Gourdy, P.3
  • 50
    • 0035575706 scopus 로고    scopus 로고
    • Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury
    • Yum H-K, Arcaroli J, Kupfner J et al. Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury. J. Immunol. 167(11), 6601-6608 (2001).
    • (2001) J. Immunol. , vol.167 , Issue.11 , pp. 6601-6608
    • Yum, H.-K.1    Arcaroli, J.2    Kupfner, J.3
  • 51
    • 33750525089 scopus 로고    scopus 로고
    • PI3Kg inhibition: Towards an 'aspirin of the 21st century'?
    • Ruckle T, Schwarz MK, Rommel C. PI3Kg inhibition: towards an 'aspirin of the 21st century'? Nat. Rev. Drug Discov. 5(11), 903-918 (2006).
    • (2006) Nat. Rev. Drug Discov. , vol.5 , Issue.11 , pp. 903-918
    • Ruckle, T.1    Schwarz, M.K.2    Rommel, C.3
  • 52
    • 0037629646 scopus 로고    scopus 로고
    • PI3K and negative regulation of TLR signaling
    • Fukao T, Koyasu S. PI3K and negative regulation of TLR signaling. Trends Immunol. 24(7), 358-363 (2003).
    • (2003) Trends Immunol. , vol.24 , Issue.7 , pp. 358-363
    • Fukao, T.1    Koyasu, S.2
  • 53
    • 84455169833 scopus 로고    scopus 로고
    • Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kg-dependent fuid-phase pinocytosis of native LDL
    • Anzinger JJ, Chang J, Xu Q et al. Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kg-dependent fuid-phase pinocytosis of native LDL. J. Lipid Res. 53(1), 34-42 (2012).
    • (2012) J. Lipid Res. , vol.53 , Issue.1 , pp. 34-42
    • Anzinger, J.J.1    Chang, J.2    Xu, Q.3
  • 55
  • 56
    • 0036098158 scopus 로고    scopus 로고
    • Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin a IIbb 3
    • Yap CL, Anderson KE, Hughan SC, Dopheide SM, Salem HH, Jackson SP. Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin a IIbb 3. Blood 99(1), 151-158 (2002).
    • (2002) Blood , vol.99 , Issue.1 , pp. 151-158
    • Yap, C.L.1    Anderson, K.E.2    Hughan, S.C.3    Dopheide, S.M.4    Salem, H.H.5    Jackson, S.P.6
  • 57
    • 70349251723 scopus 로고    scopus 로고
    • Genetic evidence for a predominant role of PI3Kb catalytic activity in ITAM-And integrin-mediated signaling in platelets
    • Canobbio I, Stefanini L, Cipolla L et al. Genetic evidence for a predominant role of PI3Kb catalytic activity in ITAM-And integrin-mediated signaling in platelets. Blood 114(10), 2193-2196 (2009).
    • (2009) Blood , vol.114 , Issue.10 , pp. 2193-2196
    • Canobbio, I.1    Stefanini, L.2    Cipolla, L.3
  • 58
    • 77950423041 scopus 로고    scopus 로고
    • Deletion of the p110b isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo
    • Martin V, Guillermet-Guibert J, Chicanne G et al. Deletion of the p110b isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo. Blood 115(10), 2008-2013 (2010).
    • (2010) Blood , vol.115 , Issue.10 , pp. 2008-2013
    • Martin, V.1    Guillermet-Guibert, J.2    Chicanne, G.3
  • 59
    • 84896060546 scopus 로고    scopus 로고
    • Role and regulation of phosphatidylinositol 3-kinase b in platelet integrin a2b1 signaling
    • Consonni A, Cipolla L, Guidetti G et al. Role and regulation of phosphatidylinositol 3-kinase b in platelet integrin a2b1 signaling. Blood 119(3), 847-856 (2012).
    • (2012) Blood , vol.119 , Issue.3 , pp. 847-856
    • Consonni, A.1    Cipolla, L.2    Guidetti, G.3
  • 60
    • 71749111351 scopus 로고    scopus 로고
    • Role of phosphoinositide 3-kinase b in glycoprotein VI-mediated Akt activation in platelets
    • Kim S, Mangin P, Dangelmaier C et al. Role of phosphoinositide 3-kinase b in glycoprotein VI-mediated Akt activation in platelets. J. Biol. Chem. 284(49), 33763-33772 (2009).
    • (2009) J. Biol. Chem. , vol.284 , Issue.49 , pp. 33763-33772
    • Kim, S.1    Mangin, P.2    Dangelmaier, C.3
  • 61
    • 84856103582 scopus 로고    scopus 로고
    • Vascular remodeling in hypertension: Mechanisms and treatment
    • Schiffrin El. Vascular remodeling in hypertension: mechanisms and treatment. Hypertension 59(2), 367-374 (2012).
    • (2012) Hypertension , vol.59 , Issue.2 , pp. 367-374
    • Schiffrin, El.1
  • 62
    • 19444379631 scopus 로고    scopus 로고
    • Opposing roles of endothelial and smooth muscle phosphatidylinositol 3-kinase in vasoconstriction: Effects of rho-kinase and hypertension
    • Budzyn K, Marley PD, Sobey CG. Opposing roles of endothelial and smooth muscle phosphatidylinositol 3-kinase in vasoconstriction: effects of rho-kinase and hypertension. J. Pharmacol. Exp. Ther. 313 (3), 1248-1253 (2005).
    • (2005) J. Pharmacol. Exp. Ther. , vol.313 , Issue.3 , pp. 1248-1253
    • Budzyn, K.1    Marley, P.D.2    Sobey, C.G.3
  • 63
    • 0032504745 scopus 로고    scopus 로고
    • Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: Involvement in suppression of apoptosis
    • Dimmeler S, Assmus B, Hermann C, Haendeler J, Zeiher AM. Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: involvement in suppression of apoptosis. Circ. Res. 83(3), 334-341 (1998).
    • (1998) Circ. Res. , vol.83 , Issue.3 , pp. 334-341
    • Dimmeler, S.1    Assmus, B.2    Hermann, C.3    Haendeler, J.4    Zeiher, A.M.5
  • 64
    • 0034603858 scopus 로고    scopus 로고
    • Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells
    • Zeng G, Nystrom FH, Ravichandran LV et al. Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation 101(13), 1539-1545 (2000).
    • (2000) Circulation , vol.101 , Issue.13 , pp. 1539-1545
    • Zeng, G.1    Nystrom, F.H.2    Ravichandran, L.V.3
  • 66
    • 0035979994 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase g mediates angiotensin II-induced stimulation of L-type calcium channels in vascular myocytes
    • Quignard JF, Mironneau J, Carricaburu V et al. Phosphoinositide 3-kinase g mediates angiotensin II-induced stimulation of L-type calcium channels in vascular myocytes. J. Biol. Chem. 276(35), 32545-32551 (2001).
    • (2001) J. Biol. Chem. , vol.276 , Issue.35 , pp. 32545-32551
    • Quignard, J.F.1    Mironneau, J.2    Carricaburu, V.3
  • 67
    • 20944433770 scopus 로고    scopus 로고
    • Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kg
    • Vecchione C, Patrucco E, Marino G et al. Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kg. J. Exp. Med. 201(8), 1217-1228 (2005).
    • (2005) J. Exp. Med. , vol.201 , Issue.8 , pp. 1217-1228
    • Vecchione, C.1    Patrucco, E.2    Marino, G.3
  • 68
    • 73849128842 scopus 로고    scopus 로고
    • Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis
    • Fernandez-Hernando C, Jozsef L, Jenkins D, Di Lorenzo A, Sessa WC. Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 29(12), 2033-2040 (2009).
    • (2009) Arterioscler. Thromb. Vasc. Biol. , vol.29 , Issue.12 , pp. 2033-2040
    • Fernandez-Hernando, C.1    Jozsef, L.2    Jenkins, D.3    Di Lorenzo, A.4    Sessa, W.C.5
  • 69
    • 1642501560 scopus 로고    scopus 로고
    • PI3-kinase upregulation and involvement in spontaneous tone in arteries from DOCA-salt rats: Is p110d the culprit?
    • Northcott CA, Hayfick JS, Watts SW. PI3-kinase upregulation and involvement in spontaneous tone in arteries from DOCA-salt rats: is p110d the culprit? Hypertension 43(4), 885-890 (2004).
    • (2004) Hypertension , vol.43 , Issue.4 , pp. 885-890
    • Northcott, C.A.1    Hayfick, J.S.2    Watts, S.W.3
  • 70
    • 0037163065 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase mediates enhanced spontaneous and agonist-induced contraction in aorta of deoxycorticosterone acetate-salt hypertensive rats
    • Northcott CA, Poy MN, Najjar SM, Watts SW. Phosphoinositide 3-kinase mediates enhanced spontaneous and agonist-induced contraction in aorta of deoxycorticosterone acetate-salt hypertensive rats. Circ. Res. 91(4), 360-369 (2002).
    • (2002) Circ. Res. , vol.91 , Issue.4 , pp. 360-369
    • Northcott, C.A.1    Poy, M.N.2    Najjar, S.M.3    Watts, S.W.4
  • 71
    • 77951600823 scopus 로고    scopus 로고
    • Impaired peroxisome proliferator-Activated receptor-g contributes to phenotypic modulation of vascular smooth muscle cells during hypertension
    • Zhang L, Xie P, Wang J et al. Impaired peroxisome proliferator-Activated receptor-g contributes to phenotypic modulation of vascular smooth muscle cells during hypertension. J. Biol. Chem. 285 (18), 13666-13677 (2010).
    • (2010) J. Biol. Chem. , vol.285 , Issue.18 , pp. 13666-13677
    • Zhang, L.1    Xie, P.2    Wang, J.3
  • 72
    • 0348049453 scopus 로고    scopus 로고
    • 2+]e enhances arterial spontaneous tone via phosphatidylinositol 3-kinase in DOCA-salt hypertension
    • 2+]e enhances arterial spontaneous tone via phosphatidylinositol 3-kinase in DOCA-salt hypertension. Hypertension 43(1), 125-129 (2004).
    • (2004) Hypertension , vol.43 , Issue.1 , pp. 125-129
    • Northcott, C.A.1    Watts, S.W.2
  • 73
    • 80053383403 scopus 로고    scopus 로고
    • Genome-wide association study identifes six new loci infuencing pulse pressure and mean arterial pressure
    • Wain LV, Verwoert GC, O'reilly PF et al. Genome-wide association study identifes six new loci infuencing pulse pressure and mean arterial pressure. Nat. Genet. 43 (10), 1005-1011 (2011).
    • (2011) Nat. Genet. , vol.43 , Issue.10 , pp. 1005-1011
    • Wain, L.V.1    Verwoert, G.C.2    O'Reilly, P.F.3
  • 74
    • 78149268896 scopus 로고    scopus 로고
    • 2+-dependent activation of phosphoinositide 3-kinase class IIa isoform-Rho axis in blood vessels of spontaneously hypertensive rats
    • 2+-dependent activation of phosphoinositide 3-kinase class IIa isoform-Rho axis in blood vessels of spontaneously hypertensive rats. Hypertension 56(5), 934-941 (2010).
    • (2010) Hypertension , vol.56 , Issue.5 , pp. 934-941
    • Seok, Y.M.1    Azam, M.A.2    Okamoto, Y.3
  • 75
    • 18644372367 scopus 로고    scopus 로고
    • Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways
    • Crackower MA, Oudit GY, Kozieradzki I et al. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 110(6), 737-749 (2002).
    • (2002) Cell , vol.110 , Issue.6 , pp. 737-749
    • Crackower, M.A.1    Oudit, G.Y.2    Kozieradzki, I.3
  • 76
    • 0142027759 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase(p110a) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy
    • Mcmullen JR, Shioi T, Zhang L et al. Phosphoinositide 3-kinase(p110a) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy. Proc. Natl Acad. Sci. USA 100 (21), 12355-12360 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , Issue.21 , pp. 12355-12360
    • McMullen, J.R.1    Shioi, T.2    Zhang, L.3
  • 77
    • 0034213075 scopus 로고    scopus 로고
    • The conserved phosphoinositide 3-kinase pathway determines heart size in mice
    • Shioi T, Kang PM, Douglas PS et al. The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J. 19(11), 2537-2548 (2000).
    • (2000) EMBO J. , vol.19 , Issue.11 , pp. 2537-2548
    • Shioi, T.1    Kang, P.M.2    Douglas, P.S.3
  • 78
    • 84864621624 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase p110a is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunction
    • Weeks Kl, Gao X, Du X-J et al. Phosphoinositide 3-kinase p110a is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunction. Circ. Heart Fail. 5(4), 523-534 (2012).
    • (2012) Circ. Heart Fail. , vol.5 , Issue.4 , pp. 523-534
    • Kl, W.1    Gao, X.2    Du, X.-J.3
  • 79
    • 77950871530 scopus 로고    scopus 로고
    • PI3K(p110 a) protects against myocardial infarction-induced heart failure: Identifcation of PI3K-regulated miRNA and mRNA
    • Lin RC, Weeks KL, Gao XM et al. PI3K(p110 a) protects against myocardial infarction-induced heart failure: identifcation of PI3K-regulated miRNA and mRNA. Arterioscler. Thromb. Vasc. Biol. 30(4), 724-732 (2010).
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , Issue.4 , pp. 724-732
    • Lin, R.C.1    Weeks, K.L.2    Gao, X.M.3
  • 80
    • 33846318098 scopus 로고    scopus 로고
    • Protective effects of exercise and phosphoinositide 3-kinase(p110a) signaling in dilated and hypertrophic cardiomyopathy
    • Mcmullen JR, Amirahmadi F, Woodcock EA et al. Protective effects of exercise and phosphoinositide 3-kinase(p110a) signaling in dilated and hypertrophic cardiomyopathy. Proc. Natl Acad. Sci. USA 104 (2), 612-617 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.2 , pp. 612-617
    • McMullen, J.R.1    Amirahmadi, F.2    Woodcock, E.A.3
  • 81
    • 70349309772 scopus 로고    scopus 로고
    • Reduced phosphoinositide 3-kinase (p110a) activation increases the susceptibility to atrial fbrillation
    • Pretorius L, Du XJ, Woodcock EA et al. Reduced phosphoinositide 3-kinase (p110a) activation increases the susceptibility to atrial fbrillation. Am. J. Pathol. 175(3), 998-1009 (2009).
    • (2009) Am. J. Pathol. , vol.175 , Issue.3 , pp. 998-1009
    • Pretorius, L.1    Du, X.J.2    Woodcock, E.A.3
  • 82
    • 80052201664 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase (PI3K(p110a)) directly regulates key components of the Z-disc and cardiac structure
    • Waardenberg AJ, Bernardo BC, Ng DC et al. Phosphoinositide 3-kinase (PI3K(p110a)) directly regulates key components of the Z-disc and cardiac structure. J. Biol. Chem. 286(35), 30837-30846 (2011).
    • (2011) J. Biol. Chem. , vol.286 , Issue.35 , pp. 30837-30846
    • Waardenberg, A.J.1    Bernardo, B.C.2    Ng, D.C.3
  • 83
    • 77955979222 scopus 로고    scopus 로고
    • 2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractility
    • 2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractility. Hypertension 56(3), 422-429 (2010).
    • (2010) Hypertension , vol.56 , Issue.3 , pp. 422-429
    • Liang, W.1    Oudit, G.Y.2    Patel, M.M.3
  • 84
    • 68249087374 scopus 로고    scopus 로고
    • Loss of cardiac phosphoinositide 3-kinase p110{a} results in contractile dysfunction
    • Lu Z, Jiang Y-P, Wang W et al. Loss of cardiac phosphoinositide 3-kinase p110{a} results in contractile dysfunction. Circulation 120(4), 318-325 (2009).
    • (2009) Circulation , vol.120 , Issue.4 , pp. 318-325
    • Lu, Z.1    Jiang, Y.-P.2    Wang, W.3
  • 85
    • 33745387361 scopus 로고    scopus 로고
    • 2+ currents via increased PI3Ka/PKB signaling
    • 2+ currents via increased PI3Ka/PKB signaling. Circ. Res. 98(11), 1390-1397 (2006).
    • (2006) Circ. Res. , vol.98 , Issue.11 , pp. 1390-1397
    • Sun, H.1    Kerfant, B.G.2    Zhao, D.3
  • 86
    • 57049126282 scopus 로고    scopus 로고
    • Temporally controlled overexpression of cardiac-specifc PI3Ka induces enhanced myocardial contractility-A new transgenic model
    • Yano N, Tseng A, Zhao TC, Robbins J, Padbury JF, Tseng Y-T. Temporally controlled overexpression of cardiac-specifc PI3Ka induces enhanced myocardial contractility-A new transgenic model. Am. J. Physiol. Heart Circ. Physiol. 295(4), H1690-H1694 (2008).
    • (2008) Am. J. Physiol. Heart Circ. Physiol. , vol.295 , Issue.4
    • Yano, N.1    Tseng, A.2    Zhao, T.C.3    Robbins, J.4    Padbury, J.F.5    Tseng, Y.-T.6
  • 87
    • 80052417831 scopus 로고    scopus 로고
    • PI3Ks maintain the structural integrity of T-tubules in cardiac myocytes
    • Wu CY, Jia Z, Wang W et al. PI3Ks maintain the structural integrity of T-tubules in cardiac myocytes. PLoS ONE 6(9), e24404 (2011).
    • (2011) PLoS ONE , vol.6 , Issue.9
    • Wu, C.Y.1    Jia, Z.2    Wang, W.3
  • 89
    • 4344714889 scopus 로고    scopus 로고
    • PI3Kg modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and-independent effects
    • Patrucco E, Notte A, Barberis L et al. PI3Kg modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and-independent effects. Cell 118(3), 375-387 (2004).
    • (2004) Cell , vol.118 , Issue.3 , pp. 375-387
    • Patrucco, E.1    Notte, A.2    Barberis, L.3
  • 90
    • 79953331935 scopus 로고    scopus 로고
    • Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110g
    • Perino A, Ghigo A, Ferrero E et al. Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110g. Mol. Cell 42(1), 84-95 (2011).
    • (2011) Mol. Cell , vol.42 , Issue.1 , pp. 84-95
    • Perino, A.1    Ghigo, A.2    Ferrero, E.3
  • 91
    • 84864877375 scopus 로고    scopus 로고
    • Anchoring proteins as regulators of signaling pathways
    • Perino A, Ghigo A, Scott JD, Hirsch E. Anchoring proteins as regulators of signaling pathways. Circ. Res. 111(4), 482-492 (2012).
    • (2012) Circ. Res. , vol.111 , Issue.4 , pp. 482-492
    • Perino, A.1    Ghigo, A.2    Scott, J.D.3    Hirsch, E.4
  • 92
    • 84867881959 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase g protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases
    • Ghigo A, Perino A, Mehel H et al. Phosphoinositide 3-kinase g protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases. Circulation 126(17), 2073-2083 (2012).
    • (2012) Circulation , vol.126 , Issue.17 , pp. 2073-2083
    • Ghigo, A.1    Perino, A.2    Mehel, H.3
  • 93
    • 79751524816 scopus 로고    scopus 로고
    • Distinct effects of leukocyte and cardiac phosphoinositide 3-kinase {g} activity in pressure overload-induced cardiac failure
    • Damilano F, Franco I, Perrino C et al. Distinct effects of leukocyte and cardiac phosphoinositide 3-kinase {g} activity in pressure overload-induced cardiac failure. Circulation 123(4), 391-399 (2011).
    • (2011) Circulation , vol.123 , Issue.4 , pp. 391-399
    • Damilano, F.1    Franco, I.2    Perrino, C.3
  • 94
    • 0035375104 scopus 로고    scopus 로고
    • Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by b-Adrenergic receptor kinase 1. A role in receptor sequestration
    • Naga Prasad SV, Barak LS, Rapacciuolo A, Caron MG, Rockman HA. Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by b-Adrenergic receptor kinase 1. A role in receptor sequestration. J. Biol. Chem. 276(22), 18953-18959 (2001).
    • (2001) J. Biol. Chem. , vol.276 , Issue.22 , pp. 18953-18959
    • Naga Prasad, S.V.1    Barak, L.S.2    Rapacciuolo, A.3    Caron, M.G.4    Rockman, H.A.5
  • 95
    • 0036327388 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase regulates b2-Adrenergic receptor endocytosis by AP-2 recruitment to the receptor/b-Arrestin complex
    • Naga Prasad SV, Laporte SA, Chamberlain D, Caron MG, Barak L, Rockman HA. Phosphoinositide 3-kinase regulates b2-Adrenergic receptor endocytosis by AP-2 recruitment to the receptor/b-Arrestin complex. J. Cell Biol. 158(3), 563-575 (2002).
    • (2002) J. Cell Biol. , vol.158 , Issue.3 , pp. 563-575
    • Naga Prasad, S.V.1    Laporte, S.A.2    Chamberlain, D.3    Caron, M.G.4    Barak, L.5    Rockman, H.A.6
  • 96
    • 85047693926 scopus 로고    scopus 로고
    • Inhibition of receptor-localized PI3K preserves cardiac b-Adrenergic receptor function and ameliorates pressure overload heart failure
    • Nienaber JJ, Tachibana H, Naga Prasad SV et al. Inhibition of receptor-localized PI3K preserves cardiac b-Adrenergic receptor function and ameliorates pressure overload heart failure. J. Clin. Invest. 112 (7), 1067-1079 (2003).
    • (2003) J. Clin. Invest. , vol.112 , Issue.7 , pp. 1067-1079
    • Nienaber, J.J.1    Tachibana, H.2    Naga Prasad, S.V.3
  • 97
    • 19644397920 scopus 로고    scopus 로고
    • Restoration of b-Adrenergic receptor signaling and contractile function in heart failure by disruption of the bARK1/phosphoinositide 3-kinase complex
    • Perrino C, Naga Prasad SV, Schroder JN, Hata JA, Milano C, Rockman HA. Restoration of b-Adrenergic receptor signaling and contractile function in heart failure by disruption of the bARK1/phosphoinositide 3-kinase complex. Circulation 111(20), 2579-2587 (2005).
    • (2005) Circulation , vol.111 , Issue.20 , pp. 2579-2587
    • Perrino, C.1    Naga Prasad, S.V.2    Schroder, J.N.3    Hata, J.A.4    Milano, C.5    Rockman, H.A.6
  • 98
    • 70349745617 scopus 로고    scopus 로고
    • Intervention effect of PI3Kgamma inhibitor AS605240 on autoimmune myocarditis in mice
    • 825
    • Jin K, Song LF, He CM, Wang ZL, Hu XH, Wu XH. Intervention effect of PI3Kgamma inhibitor AS605240 on autoimmune myocarditis in mice. Sichuan Da Xue Xue Bao Yi Xue Ban 40(5), 817-820, 825 (2009).
    • (2009) Sichuan da Xue Xue Bao Yi Xue Ban , vol.40 , Issue.5 , pp. 817-820
    • Jin, K.1    Song, L.F.2    He, C.M.3    Wang, Z.L.4    Hu, X.H.5    Wu, X.H.6
  • 99
    • 77949361812 scopus 로고    scopus 로고
    • Involvement of phosphoinositide 3-kinase g in angiogenesis and healing of experimental myocardial infarction in mice
    • Siragusa M, Katare R, Meloni M et al. Involvement of phosphoinositide 3-kinase g in angiogenesis and healing of experimental myocardial infarction in mice. Circ. Res. 106(4), 757-768 (2010).
    • (2010) Circ. Res. , vol.106 , Issue.4 , pp. 757-768
    • Siragusa, M.1    Katare, R.2    Meloni, M.3
  • 100
    • 53249113791 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase g is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning
    • Ban K, Cooper AJ, Samuel S et al. Phosphatidylinositol 3-kinase g is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning. Circ. Res. 103(6), 643-653 (2008).
    • (2008) Circ. Res. , vol.103 , Issue.6 , pp. 643-653
    • Ban, K.1    Cooper, A.J.2    Samuel, S.3
  • 101
    • 77949630188 scopus 로고    scopus 로고
    • PI3Kg protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway
    • Haubner BJ, Neely GG, Voelkl JGJ et al. PI3Kg protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway. PLoS ONE 5(2), e9350 (2010).
    • (2010) PLoS ONE , vol.5 , Issue.2
    • Haubner, B.J.1    Neely, G.G.2    Jgj, V.3
  • 102
    • 33749438378 scopus 로고    scopus 로고
    • Competitive displacement of phosphoinositide 3-kinase from b-Adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling
    • Curcio A, Noma T, Naga Prasad SV et al. Competitive displacement of phosphoinositide 3-kinase from b-Adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling. Am. J. Physiol. Heart Circ. Physiol. 291(4), H1754-H1760 (2006).
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.291 , Issue.4
    • Curcio, A.1    Noma, T.2    Naga Prasad, S.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.