Non-redundant roles of phosphoinositide 3-kinase isoforms α and β in glycoprotein VI-induced platelet signaling and thrombus formation

Journal of Biological Chemistry

Volumn 284, Issue 49, 2009, Pages 33750-33762

  Gilio, Karen ^a   Munnix, Imke C A ^a   Mangin, Pierre ^b   Cosemans, Judith M E M ^a   Feijge, Marion A H ^a   van der Meijden, Paola E J ^a   Olieslagers, Servé ^a   Chrzanowska Wodnicka, Magdalena B ^c   Lillian, Rivka ^b   Schoenwaelder, Simone ^b   Koyasu, Shigeo ^d   Sage, Stewart O ^e   Jackson, Shaun P ^b   Heemskerk, Johan W M ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MONASH UNIVERSITY   (Australia)

^c BLOOD RESEARCH INSTITUTE   (United States)

^d KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BLOOD VESSELS; CELL MEMBRANES; CELL SIGNALING; CHEMICAL ACTIVATION; COLLAGEN; GLYCOPROTEINS; SIGNALING;

ANTI-THROMBOTIC EFFECT; IMMUNOGLOBULIN RECEPTORS; INOSITOL 1 ,4 ,5-TRIPHOSPHATE; PHOSPHOINOSITIDE 3-KINASE; PLATELET ACTIVATION; SERINE PHOSPHORYLATION; SURFACE EXPRESSION; THROMBUS FORMATION;

PLATELETS;

CALCIUM; GLYCOPROTEIN VI; INOSITOL 1,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE BETA; PHOSPHATIDYLINOSITOL 3 KINASE DELTA; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHATIDYLSERINE; PROTEIN KINASE B; RAP1 PROTEIN; SERINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CONTROLLED STUDY; DOWNSTREAM PROCESSING; ENZYME INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SECRETORY GRANULE; THROMBOCYTE ACTIVATION; THROMBOGENESIS;

EID: 71749121027     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.048439     Document Type: Article

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