Transforming growth factor β engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab

Molecular and Cellular Biology

Volumn 28, Issue 18, 2008, Pages 5605-5620

  Wang, Shizhen Emily ^a,d   Xiang, Bin ^a   Guix, Marta ^a   Olivares, Maria Graciela ^a   Parker, Joel ^b   Chung, Christine H ^a   Pandiella, Atanasio ^c   Arteaga, Carlos L ^a,d  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b Expression Analysis   (United States)

^c UNIVERSITY OF SALAMANCA   (Spain)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIREGULIN; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; NEU DIFFERENTIATION FACTOR; PERTUZUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRASTUZUMAB; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

ARTICLE; BREAST CANCER; CONTROLLED STUDY; DESENSITIZATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RNA INTERFERENCE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAM PROTEINS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELLS, CULTURED; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION PROFILING; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, ERBB-2; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TREATMENT OUTCOME;

EID: 51349164414     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00787-08     Document Type: Article

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