Inhibition of receptor-localized PI3K preserves cardiac β-adrenergic receptor function and ameliorates pressure overload heart failure

Journal of Clinical Investigation

Volumn 112, Issue 7, 2003, Pages 1067-1079

  Nienaber, Jeffrey J ^a   Tachibana, Hideo ^a   Naga Prasad, Sathyamangla V ^a   Esposito, Giovanni ^b   Wu, Dianqing ^c   Mao, Lan ^a   Rockman, Howard A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; CATECHOLAMINE; COMPLEMENTARY DNA; G PROTEIN COUPLED RECEPTOR; ISOPRENALINE; PHOSPHATIDYLINOSITOL 3 KINASE; BETA ADRENERGIC RECEPTOR KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENZYME INHIBITOR;

ADRENERGIC SYSTEM; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; ENZYME INHIBITION; HEART FAILURE; HEART FUNCTION; HEART VENTRICLE OVERLOAD; IMMUNOBLOTTING; INTERNALIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; ANIMAL; CARDIOMEGALY; CONGESTIVE HEART FAILURE; DRUG ANTAGONISM; MOUSE MUTANT; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN TRANSPORT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BETA-ADRENERGIC RECEPTOR KINASE; CARDIOMEGALY; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; HEART FAILURE, CONGESTIVE; ISOPROTERENOL; MICE; MICE, KNOCKOUT; PROTEIN TRANSPORT; RECEPTORS, ADRENERGIC, BETA;

EID: 85047693926     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI18213     Document Type: Article

References (35)

1. Hunt, S.A., et al. 2001. ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure). Circulation. 104:2996-3007.
2. Cohn, J.N., et al. 1984. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N. Engl. J. Med. 311:819-823.
3. Rockman, H.A., Koch, W.J., and Lefkowitz, R.J. 2002. Seven-transmembrane-spanning receptors and heart function. Nature. 415:206-212.
4. Akhter, S.A., et al. 1999. In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function. Circulation. 100:648-653.
5. Harding, V.B., Jones, L.R., Lefkowitz, R.J., Koch, W.J., and Rockman, H.A. 2001. Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure. Proc. Natl. Acad. Sci. U. S. A. 98:5809-5814.
6. Foody, J.M., Farrell, M.H., and Krumholz, H.M. 2002. β-Blocker therapy in heart failure: scientific review. JAMA 287:883-889.
7. Lefkowitz, R.J. 1998. G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization. J. Biol. Chem. 273:18677-18680.
8. Naga Prasad, S.V., et al. 2002. Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. J. Cell Biol. 158:563-575.
9. Crackower, M.A., et al. 2002. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 110:737-749.
10. Naga Prasad, S.V., Barak, L.S., Rapacciuolo, A., Caron, M.G., and Rockman, H.A. 2001. Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration. J. Biol. Chem. 276:18953-18959.
11. Vanhaesebroeck, B., et al. 2001. Synthesis and function of 3-phosphorylated inositol lipids. Annu. Rev. Biochem. 70:535-602.
12. Jo, S.H., Leblais, V., Wang, P.H., Crow, M.T., and Xiao, R.P. 2002. Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G(s) signaling during beta2-adrenergic stimulation. Circ. Res. 91:46-53.
13. Shioi, T., et al. 2000. The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J. 19:2537-2548.
14. Naga Prasad, S.V., Esposito, G., Mao, L., Koch, W.J., and Rockman, H.A. 2000. Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy. J. Biol. Chem. 275:4693-4698.
15. Gaidarov, I., and Keen, J.H. 1999. Phosphoinositide-AP-2 interactions required for targeting to plasma membrane clathrin-coated pits. J. Cell Biol. 146:755-764.
16. Ma, A.D., Metjian, A., Bagrodia, S., Taylor, S., and Abrams, C.S. 1998. Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase gamma, a Rac guanosine exchange factor, and Rac. Mol. Cell. Biol. 18:4744-4751.
17. Li, Z., et al. 2000. Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science. 287:1046-1049.
18. Esposito, G., et al. 2002. Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. Circulation. 105:85-92.
19. Iaccarino, G., Tomhave, E.D., Lefkowitz, R.J., and Koch, W.J. 1998. Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade. Circulation. 98:1783-1789.
20. Choi, D.J., and Rockman, H.A. 1999. Beta-adrenergic receptor desensitization in cardiac hypertrophy and heart failure. Cell Biochem. Biophys. 31:321-329.
21. Subramaniam, A., et al. 1991. Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice. J. Biol. Chem. 266:24613-24620.
22. Pitcher, J.A., Freedman, N.J., and Lefkowitz, R.J. 1998. G protein-coupled receptor kinases. Annu. Rev. Biochem. 67:653-692.
23. Choi, D.J., Koch, W.J., Hunter, J.J., and Rockman, H.A. 1997. Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase. J. Biol. Chem. 272:17223-17229.
24. Cho, M.C., et al. 1999. Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression. J. Biol. Chem. 274:22251-22256.
25. Rockman, H.A., et al. 1998. Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proc. Natl. Acad. Sci. U. S. A. 95:7000-7005.
26. Bristow, M.R., et al. 1982. Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts. N. Engl. J. Med. 307:205-211.
27. Koch, W.J., et al. 1995. Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science. 268:1350-1353.
28. Krueger, K.M., Daaka, Y., Pitcher, J.A., and Lefkowitz, R.J. 1997. The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification. J. Biol. Chem. 272:5-8.
29. Perry, S.J., and Lefkowitz, R.J. 2002. Arresting developments in heptahelical receptor signaling and regulation. Trends Cell Biol. 12:130-138.
30. Lin, F., Wang, H., and Malbon, C.C. 2000. Gravin-mediated formation of signaling complexes in beta 2-adrenergic receptor desensitization and resensitization. J. Biol. Chem. 275:19025-19034.
31. Shih, M., Lin, F., Scott, J.D., Wang, H.Y., and Malbon, C.C. 1999. Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin. J. Biol. Chem. 274:1588-1595.
32. Clague, M.J., and Urbe, S. 2001. The interface of receptor trafficking and signalling. J. Cell Sci. 114:3075-3081.
33. Zerial, M., and McBride, H. 2001. Rab proteins as membrane organizers. Nat. Rev. Mol. Cell Biol. 2:107-117.
34. Saward, L., and Zahradka, P. 1997. Angiotensin II activates phosphatidylinositol 3-kinase in vascular smooth muscle cells. Circ. Res. 81:249-257.
35. Kim, J., Eckhart, A.D., Eguchi, S., and Koch, W.J. 2002. Beta-adrenergic receptor-mediated DNA synthesis in cardiac fibroblasts is dependent on transactivation of the epidermal growth factor receptor and subsequent activation of extracellular signal-regulated kinases. J. Biol. Chem. 277:32116-32123.