Enhanced Ca2++-dependent activation of phosphoinositide 3-kinase class IIα isoform-Rho axis in blood vessels of spontaneously hypertensive rats

Hypertension

Volumn 56, Issue 5, 2010, Pages 934-941

  Seok, Young Mi ^a   Azam, Mohammed Ali ^a   Okamoto, Yasuo ^a   Sato, Atsushi ^a   Yoshioka, Kazuaki ^a   Maeda, Masataka ^a   Kim, Inkyeom ^b   Takuwa, Yoh ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^b Kyungpook National University School of Medicine   (South Korea)

Author keywords

hypertension; L type Ca2+ channel; myosin light chain phosphatase; PI3K C2 , Rho

Indexed keywords

CALCIUM; MYOSIN LIGHT CHAIN PHOSPHATASE; NICARDIPINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE IIALPHA; RHO KINASE; UNCLASSIFIED DRUG; WORTMANNIN; CALCIUM CHANNEL L TYPE; PHOSPHOINOSITIDE 3 KINASE C2ALPHA; PHOSPHOINOSITIDE 3-KINASE C2ALPHA; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL; CONTROLLED STUDY; CORONARY BLOOD VESSEL; HYPERTENSION; MEMBRANE DEPOLARIZATION; MESENTERIC ARTERY; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTION; VASCULAR SMOOTH MUSCLE; ANIMAL; ARTERY; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPONTANEOUSLY HYPERTENSIVE RAT; WISTAR KYOTO RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ARTERIES; CALCIUM; CALCIUM CHANNELS, L-TYPE; HYPERTENSION; MUSCLE, SMOOTH, VASCULAR; MYOSIN-LIGHT-CHAIN PHOSPHATASE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION;

EID: 78149268896     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.110.160853     Document Type: Article

References (29)

1. Cain AE, Khalil RA. Pathophysiology of essential hypertension: role of the pump, the vessel, and the kidney. Semin Nephrol. 2002;22:3-16.
2. Kamm KE, Stull JT. Dedicated myosin light chain kinases with diverse cellular functions. J Biol Chem. 2001;276:4527-4530.
3. Pfitzer G. Regulation of myosin phosphorylation in smooth muscle. J Appl Physiol. 2001;91:497-503.
4. 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev. 2003;83:1325-1358.
5. Hartshorne DJ, Ito M, Erdodi F. Role of protein phosphatase type I in contractile functions: myosin phosphatase. J Biol Chem. 2004;279:37211-37214.
6. Kitazawa T, Masuo M, Somlyo AP. G protein-mediated inhibition of myosin light-chain phosphatase in vascular smooth muscle. Proc Natl Acad Sci USA. 1991;88:9307-9310.
7. Noda M, Yasuda-Fukazawa C, Moriishi K, Kato T, Okuda T, Kurokawa K, Takuwa Y. Involvement of Rho in GTPγS-induced enhancement of phosphorylation of 20 kDa myosin light chain in vascular smooth muscle cells: inhibition of phosphatase activity. FEBS Lett. 1995;67:246-250.
8. Eto M, Kitazawa T, Yazawa M, Mukai H, Ono Y, Brautigan DL. Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein of myosin phosphatase by protein kinase C α and Δ isoforms. J Biol Chem. 2001;276:29072-29078.
9. Loirand G, Guilluy C, Pacaud P. Regulation of Rho proteins by phosphorylation in the cardiovascular system. Trends Cardiovasc Med. 2006;16:199-204.
10. 2+ sensitization in rabbit smooth muscle. J Physiol. 2003;546:879-889.
11. Wang Y, Yoshioka K, Azam MA, Takuwa N, Sakurada S, Kayaba Y, Sugimoto N, Inoki I, Kimura T, Kuwaki T, Takuwa Y. Class II phosphoinositide 3-kinase-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle. Biochem J. 2006;394:581-592.
12. 2+-dependent activation of Rho and Rho kinase in membrane depolarization induced and receptor stimulation-induced vascular smooth muscle contraction. Circ Res. 2003;93:548-556.
13. Mita M, Yanagihara H, Hishinuma S, Saito M, Walsh MP. Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase. Biochem J. 2002;364:431-440.
14. Ratz PH, Berg KM, Urban NH, Miner AS. Regulation of smooth muscle calcium sensitivity: KCl as a calcium-sensitizing stimulus. Am J Physiol Cell Physiol. 2005;288:C769-C683.
15. 2+-induced, Rho-and Rho kinase-dependent regulation of myosin phosphatase and contraction in isolated vascular smooth muscle cells. Mol Pharmacol. 2007;71:912-920.
16. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, Narumiya S. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 1997;389:990-994.
17. Satoh S, Kreutz R, Wilm C, Ganten D, Pfitzer G. Augmented agonistinduced Ca (2 +)-sensitization of coronary artery contraction in genetically hypertensive rats. Evidence for altered signal transduction in the coronary smooth muscle cells. J Clin Invest. 1994;94:1397-1403.
18. Seko T, Ito M, Kureishi Y, Okamoto R, Moriki N, Onishi K, Isaka N, Hartshorne DJ, Nakano T. Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle. Circ Res. 2003;92:411-418.
19. Masumoto A, Hirooka Y, Shimokawa H, Hironaga K, Setoguchi S, Takeshita A. Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans. Hypertension. Circ Res. 2001;38:1307-1310.
20. Sakurada S, Okamoto H, Takuwa N, Sugimoto N, Takuwa Y. Rho activation in excitatory agonist-stimulated vascular smooth muscle. Am J Physiol. 2001;281:C571-C578.
21. Nakanishi S, Kakita S, Takahashi I, Kawahara K, Tsukuda E, Sano T, Yamada K, Yoshida M, Kase H, Matsuda Y. Wortmannin, a microbial product inhibitor of myosin light chain kinase. J Biol Chem. 1992;267:2157-2163.
22. 2+ regulation of phosphoinositide 3-kinase c2α Rho, and myosin phosphatase in vascular smooth muscle. J Pharmacol Exp Ther. 2007;320:907-916. (Pubitemid 46147975)
23. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ, for the National High Blood Pressure Education Program Coordinating Committee. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. Hypertension. 2003;42:1206-1252.
24. Takuwa Y, Yoshioka K, Takuwa N, Wang Y, Azam MA, Sugimoto N. Calcium-dependent regulation of Rho and myosin phosphatase in vascular smooth muscle. Biomed Res. 2005;16:13-21.
25. Domin J, Pages F, Volinia S, Rittenhouse SE, Zvelebil MJ, Stein RC, Waterfield MD. Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. Biochem J. 1997;326:139-147.
26. Godfraind T, Kazda S, Wibo M. Effects of a chronic treatment by nisoldipine, a calcium antagonistic dihydropyridine, on arteries of spontaneously hypertensive rats. Circ Res. 1991;68:674-682.
27. 2+ channels to contractile responses in spontaneously hypertensive rat mesenteric arteries. Am J Hypertens. 1997;10:1231-1239.
28. 2+ channels in mesenteric and skeletal arteries of SHR. Hypertension. 2002;40:214-219.
29. Ellershaw DC, Gurney AM. Mechanisms of hydralazine induced vasodilation in rabbit aorta and pulmonary artery. Br J Pharmacol. 2001;134:621-631.