Deletion of the p110β isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

Blood

Volumn 115, Issue 10, 2010, Pages 2008-2013

  Martin, Valérie ^a   Guillermet Guibert, Julie ^b   Chicanne, Gaétan ^a   Cabou, Cendrine ^c   Jandrot Perrus, Martine ^d   Plantavid, Monique ^a   Vanhaesebroeck, Bart ^b   Payrastre, Bernard ^a   Gratacap, Marie Pierre ^a  

^a France   (France)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c INSERM   (France)

^d BICHAT HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; FERROUS CHLORIDE; FIBRINOGEN; G PROTEIN COUPLED RECEPTOR; GLYCOPROTEIN VI; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN KINASE B; PROTEIN P110; PROTEIN P110 BETA; TYROSINE; UNCLASSIFIED DRUG; 1 PHOSPHATIDYLINOSITOL 3 KINASE P110 SUBUNIT, MOUSE; 1-PHOSPHATIDYLINOSITOL 3-KINASE P110 SUBUNIT, MOUSE; CHLORIDE; FERRIC CHLORIDE; FERRIC ION; ISOENZYME; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3,4,5-TRIPHOSPHATE; POLYPHOSPHOINOSITIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING TIME; CONTROLLED STUDY; FIBRIN CLOT; GENE DELETION; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; LUNG EMBOLISM; MEGAKARYOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOGENESIS; ANIMAL; CELL CULTURE; CELL LINEAGE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; ENZYME ACTIVATION; ENZYMOLOGY; GENETIC PREDISPOSITION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; THROMBOCYTE AGGREGATION; THROMBOSIS; TRANSGENIC MOUSE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLEEDING TIME; BLOOD PLATELETS; CELL LINEAGE; CELLS, CULTURED; CHLORIDES; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; FERRIC COMPOUNDS; GENE DELETION; GENETIC PREDISPOSITION TO DISEASE; ISOENZYMES; MEGAKARYOCYTES; MICE; MICE, TRANSGENIC; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL PHOSPHATES; PLATELET AGGREGATION; THROMBOSIS;

EID: 77950423041     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-04-217224     Document Type: Article

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