Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases

Circulation

Volumn 126, Issue 17, 2012, Pages 2073-2083

  Ghigo, Alessandra ^a   Perino, Alessia ^a   Mehel, Hind ^b,c   Zahradníková, Alexandra ^b,c,k   Morello, Fulvio ^d   Leroy, Jérôme ^b,c   Nikolaev, Viacheslav O ^e   Damilano, Federico ^a,j   Cimino, James ^a   De Luca, Elisa ^a   Richter, Wito ^f   Westenbroek, Ruth ^g   Catterall, William A ^g   Zhang, Jin ^h   Yan, Chen ⁱ   Conti, Marco ^f   Gomez, Ana Maria ^b,c   Vandecasteele, Grégoire ^b,c   Hirsch, Emilio ^a   Fischmeister, Rodolphe ^b,c  

^a UNIVERSITY OF TURIN   (Italy)

^b Universite Paris Sud   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d MOLINETTE HOSPITAL   (Italy)

^e UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^h JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^j BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^k INSTITUTE OF MOLECULAR PHYSIOLOGY AND GENETICS   (Slovakia)

more..

Author keywords

3=,5= cyclic AMP phosphodiesterases; arrhythmias, cardiac; class II phosphatidylinositol 3 kinases; cyclic AMP dependent protein kinases; receptors, adrenergic beta 2

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CALCIUM ION; CATECHOLAMINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHODIESTERASE 3A; PHOSPHODIESTERASE 4A; PHOSPHODIESTERASE 4B; PHOSPHODIESTERASE III; PHOSPHODIESTERASE IV; PHOSPHOLAMBAN; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ADRENERGIC STIMULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CALCIUM TRANSPORT; CONTROLLED STUDY; DISEASE PREDISPOSITION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEART MUSCLE CELL; HEART PROTECTION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE EXTRASYSTOLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; SARCOPLASMIC RETICULUM;

ANIMALS; ANIMALS, NEWBORN; BIOFEEDBACK, PSYCHOLOGY; CALCIUM SIGNALING; CATECHOLAMINES; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; GENE KNOCK-IN TECHNIQUES; ISOENZYMES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MYOCYTES, CARDIAC; TACHYCARDIA, VENTRICULAR;

EID: 84867881959     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.112.114074     Document Type: Article

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