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Volumn 19, Issue 5, 2013, Pages 841-863

Anti-metastatic treatment in colorectal cancer: Targeting signaling pathways

Author keywords

Colorectal cancer; HGF Met pathway; Metastasis; Molecular therapeutics; Wnt catenin pathway

Indexed keywords

ANTIMETASTATIC AGENT; APC PROTEIN; B RAF KINASE; BC 21; BETA CATENIN; BEVACIZUMAB; CALVASCULIN; CAPECITABINE PLUS OXALIPLATIN; CETUXIMAB; CYCLOOXYGENASE 2 INHIBITOR; EFLORNITHINE; EPIDERMAL GROWTH FACTOR RECEPTOR; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; GLYCOGEN SYNTHASE KINASE 3BETA; IRINOTECAN; K RAS PROTEIN; NICLOSAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; OXALIPLATIN; PANITUMUMAB; PROTEIN P53; SCATTER FACTOR RECEPTOR; SMAD4 PROTEIN; SMALL INTERFERING RNA; SULINDAC; UNCLASSIFIED DRUG; UNINDEXED DRUG; UVOMORULIN; WNT PROTEIN;

EID: 84875092951     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161213804547277     Document Type: Review
Times cited : (18)

References (291)
  • 1
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: Globocan 2008
    • Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: Globocan 2008. Int J Cancer 2010; 127(12): 2893-917.
    • (2010) Int J Cancer , vol.127 , Issue.12 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3
  • 2
    • 76049128595 scopus 로고    scopus 로고
    • Estimates of cancer incidence and mortality in europe in 2008
    • Ferlay J, Parkin DM, Steliarova-Foucher E. Estimates of cancer incidence and mortality in europe in 2008. Eur J Cancer 2010; 46(4): 765-81.
    • (2010) Eur J Cancer , vol.46 , Issue.4 , pp. 765-781
    • Ferlay, J.1    Parkin, D.M.2    Steliarova-Foucher, E.3
  • 3
    • 16244403039 scopus 로고    scopus 로고
    • Cancer incidence and mortality in europe, 2004
    • Boyle P, Ferlay J. Cancer incidence and mortality in europe, 2004. Ann Oncol 2005; 16(3): 481-8.
    • (2005) Ann Oncol , vol.16 , Issue.3 , pp. 481-488
    • Boyle, P.1    Ferlay, J.2
  • 4
    • 34547141354 scopus 로고    scopus 로고
    • Clinical, biological, and molecular aspects of metastasis in colorectal cancer
    • Stein U, Schlag PM. Clinical, biological, and molecular aspects of metastasis in colorectal cancer. Recent Results Cancer Res 2007; 176: 61-80.
    • (2007) Recent Results Cancer Res , vol.176 , pp. 61-80
    • Stein, U.1    Schlag, P.M.2
  • 5
    • 6944230093 scopus 로고    scopus 로고
    • Colon cancer survival rates with the new american joint committee on cancer sixth edition staging
    • O'connell JB, Maggard MA, Ko CY. Colon cancer survival rates with the new american joint committee on cancer sixth edition staging. J Natl Cancer Inst 2004; 96(19): 1420-5.
    • (2004) J Natl Cancer Inst , vol.96 , Issue.19 , pp. 1420-1425
    • O'connell, J.B.1    Maggard, M.A.2    Ko, C.Y.3
  • 6
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61(5): 759-67.
    • (1990) Cell , vol.61 , Issue.5 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 7
    • 0035496104 scopus 로고    scopus 로고
    • Apc, signal transduction and genetic instability in colorectal cancer
    • Fodde R, Smits R, Clevers H. Apc, signal transduction and genetic instability in colorectal cancer. Nat Rev Cancer 2001; 1(1): 55-67.
    • (2001) Nat Rev Cancer , vol.1 , Issue.1 , pp. 55-67
    • Fodde, R.1    Smits, R.2    Clevers, H.3
  • 8
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996; 87(2): 159-70.
    • (1996) Cell , vol.87 , Issue.2 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 9
    • 0027973077 scopus 로고
    • Molecular determinants of dysplasia in colorectal lesions
    • Jen J, Powell SM, Papadopoulos N, et al. Molecular determinants of dysplasia in colorectal lesions. Cancer Res 1994; 54(21): 5523-6.
    • (1994) Cancer Res , vol.54 , Issue.21 , pp. 5523-5526
    • Jen, J.1    Powell, S.M.2    Papadopoulos, N.3
  • 10
    • 0026630266 scopus 로고
    • Apc mutations occur early during colorectal tumorigenesis
    • Powell SM, Zilz N, Beazer-Barclay Y, et al. Apc mutations occur early during colorectal tumorigenesis. Nature 1992; 359(6392): 235-7.
    • (1992) Nature , vol.359 , Issue.6392 , pp. 235-237
    • Powell, S.M.1    Zilz, N.2    Beazer-Barclay, Y.3
  • 11
    • 0027146559 scopus 로고
    • Mutations of the apc (adenomatous polyposis coli) gene
    • Nagase H, Nakamura Y. Mutations of the apc (adenomatous polyposis coli) gene. Hum Mutat 1993; 2(6): 425-34.
    • (1993) Hum Mutat , vol.2 , Issue.6 , pp. 425-434
    • Nagase, H.1    Nakamura, Y.2
  • 12
    • 0034098691 scopus 로고    scopus 로고
    • Biology of the adenomatous polyposis coli tumor suppressor
    • Goss KH, Groden J. Biology of the adenomatous polyposis coli tumor suppressor. J Clin Oncol 2000; 18(9): 1967-79.
    • (2000) J Clin Oncol , vol.18 , Issue.9 , pp. 1967-1979
    • Goss, K.H.1    Groden, J.2
  • 13
    • 72449176846 scopus 로고    scopus 로고
    • Molecular origins of cancer: Molecular basis of colorectal cancer
    • Markowitz SD, Bertagnolli MM. Molecular origins of cancer: Molecular basis of colorectal cancer. N Engl J Med 2009; 361(25): 2449-60.
    • (2009) N Engl J Med , vol.361 , Issue.25 , pp. 2449-2460
    • Markowitz, S.D.1    Bertagnolli, M.M.2
  • 14
    • 57049114832 scopus 로고    scopus 로고
    • The genetics of the p53 pathway, apoptosis and cancer therapy
    • Vazquez A, Bond EE, Levine AJ, Bond GL. The genetics of the p53 pathway, apoptosis and cancer therapy. Nat Rev Drug Discov 2008; 7(12): 979-87.
    • (2008) Nat Rev Drug Discov , vol.7 , Issue.12 , pp. 979-987
    • Vazquez, A.1    Bond, E.E.2    Levine, A.J.3    Bond, G.L.4
  • 15
    • 0025634118 scopus 로고
    • P53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis
    • Baker SJ, Preisinger AC, Jessup JM, et al. P53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res 1990; 50(23): 7717-22.
    • (1990) Cancer Res , vol.50 , Issue.23 , pp. 7717-7722
    • Baker, S.J.1    Preisinger, A.C.2    Jessup, J.M.3
  • 16
    • 0030593038 scopus 로고    scopus 로고
    • Dpc4, a candidate tumor suppressor gene at human chromosome 18q21.1
    • Hahn SA, Schutte M, Hoque AT, et al. Dpc4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 1996; 271(5247): 350-3.
    • (1996) Science , vol.271 , Issue.5247 , pp. 350-353
    • Hahn, S.A.1    Schutte, M.2    Hoque, A.T.3
  • 17
    • 0037757793 scopus 로고    scopus 로고
    • Role of smad4 (dpc4) inactivation in human cancer
    • Miyaki M, Kuroki T. Role of smad4 (dpc4) inactivation in human cancer. Biochem Biophys Res Commun 2003; 306(4): 799-804.
    • (2003) Biochem Biophys Res Commun , vol.306 , Issue.4 , pp. 799-804
    • Miyaki, M.1    Kuroki, T.2
  • 18
    • 0034604110 scopus 로고    scopus 로고
    • Role of transforming growth factor beta in human disease
    • Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor beta in human disease. N Engl J Med 2000; 342(18): 1350-8.
    • (2000) N Engl J Med , vol.342 , Issue.18 , pp. 1350-1358
    • Blobe, G.C.1    Schiemann, W.P.2    Lodish, H.F.3
  • 19
    • 70349939382 scopus 로고    scopus 로고
    • Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer
    • Siena S, Sartore-Bianchi A, Di Nicolantonio F, Balfour J, Bardelli A. Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer. J Natl Cancer Inst 2009; 101(19): 1308-24.
    • (2009) J Natl Cancer Inst , vol.101 , Issue.19 , pp. 1308-1324
    • Siena, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3    Balfour, J.4    Bardelli, A.5
  • 20
    • 33745297408 scopus 로고    scopus 로고
    • New signals from the invasive front
    • Christofori G. New signals from the invasive front. Nature 2006; 441(7092): 444-50.
    • (2006) Nature , vol.441 , Issue.7092 , pp. 444-450
    • Christofori, G.1
  • 21
    • 0038481970 scopus 로고    scopus 로고
    • The pathogenesis of cancer metastasis: The 'seed and soil' hypothesis revisited
    • Fidler IJ. The pathogenesis of cancer metastasis: The 'seed and soil' hypothesis revisited. Nat Rev Cancer 2003; 3(6): 453-8.
    • (2003) Nat Rev Cancer , vol.3 , Issue.6 , pp. 453-458
    • Fidler, I.J.1
  • 22
    • 2942538264 scopus 로고    scopus 로고
    • Dissecting the metastatic cascade
    • Pantel K, Brakenhoff RH. Dissecting the metastatic cascade. Nat Rev Cancer 2004; 4(6): 448-56.
    • (2004) Nat Rev Cancer , vol.4 , Issue.6 , pp. 448-456
    • Pantel, K.1    Brakenhoff, R.H.2
  • 23
    • 0037158692 scopus 로고    scopus 로고
    • A progression puzzle
    • Bernards R, Weinberg RA. A progression puzzle. Nature 2002; 418(6900): 823.
    • (2002) Nature , vol.418 , Issue.6900 , pp. 823
    • Bernards, R.1    Weinberg, R.A.2
  • 24
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • Chaffer CL, Weinberg RA. A perspective on cancer cell metastasis. Science 2011; 331(6024): 1559-64.
    • (2011) Science , vol.331 , Issue.6024 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 25
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119(6): 1420-8.
    • (2009) J Clin Invest , vol.119 , Issue.6 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 26
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
    • Yang J, Weinberg RA. Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis. Dev Cell 2008; 14(6): 818-29.
    • (2008) Dev Cell , vol.14 , Issue.6 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 27
    • 70450198396 scopus 로고    scopus 로고
    • Epithelialmesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelialmesenchymal transitions in development and disease. Cell 2009; 139(5): 871-90.
    • (2009) Cell , vol.139 , Issue.5 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 28
    • 84857375987 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal and mesenchymalto-epithelial transitions in the colon
    • Sipos F, Galamb O. Epithelial-to-mesenchymal and mesenchymalto-epithelial transitions in the colon. World J Gastroenterol 2012; 18(7): 601-8.
    • (2012) World J Gastroenterol , vol.18 , Issue.7 , pp. 601-608
    • Sipos, F.1    Galamb, O.2
  • 29
    • 77953725220 scopus 로고    scopus 로고
    • Targeted treatments in colorectal cancer: State of the art and future perspectives
    • Arnold D, Seufferlein T. Targeted treatments in colorectal cancer: State of the art and future perspectives. Gut 2010; 59(6): 838-58.
    • (2010) Gut , vol.59 , Issue.6 , pp. 838-858
    • Arnold, D.1    Seufferlein, T.2
  • 30
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin Oncol 2002; 29(6 Suppl 16): 15-8.
    • (2002) Semin Oncol , vol.29 , Issue.6 SUPPL. 16 , pp. 15-18
    • Folkman, J.1
  • 31
    • 0031969264 scopus 로고    scopus 로고
    • Angiogenesis and tumor metastasis
    • Zetter BR. Angiogenesis and tumor metastasis. Annu Rev Med 1998; 49: 407-24.
    • (1998) Annu Rev Med , vol.49 , pp. 407-424
    • Zetter, B.R.1
  • 32
    • 47949089077 scopus 로고    scopus 로고
    • Vegf-targeted therapy: Mechanisms of antitumour activity
    • Ellis LM, Hicklin DJ. Vegf-targeted therapy: Mechanisms of antitumour activity. Nat Rev Cancer 2008; 8(8): 579-91.
    • (2008) Nat Rev Cancer , vol.8 , Issue.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 33
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350(23): 2335-42.
    • (2004) N Engl J Med , vol.350 , Issue.23 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 34
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase iii study
    • Saltz LB, Clarke S, Diaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase iii study. J Clin Oncol 2008; 26(12): 2013-9.
    • (2008) J Clin Oncol , vol.26 , Issue.12 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Diaz-Rubio, E.3
  • 35
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (folfox4) for previously treated metastatic colorectal cancer: Results from the eastern cooperative oncology group study e3200
    • Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (folfox4) for previously treated metastatic colorectal cancer: Results from the eastern cooperative oncology group study e3200. J Clin Oncol 2007; 25(12): 1539-44.
    • (2007) J Clin Oncol , vol.25 , Issue.12 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 36
    • 34748831698 scopus 로고    scopus 로고
    • Biology of interactions: Antiepidermal growth factor receptor agents
    • Harari PM, Allen GW, Bonner JA. Biology of interactions: Antiepidermal growth factor receptor agents. J Clin Oncol 2007; 25(26): 4057-65.
    • (2007) J Clin Oncol , vol.25 , Issue.26 , pp. 4057-4065
    • Harari, P.M.1    Allen, G.W.2    Bonner, J.A.3
  • 38
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004; 351(4): 337-45.
    • (2004) N Engl J Med , vol.351 , Issue.4 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 39
    • 36148941301 scopus 로고    scopus 로고
    • Cetuximab for the treatment of colorectal cancer
    • Jonker DJ, O'callaghan CJ, Karapetis CS, et al. Cetuximab for the treatment of colorectal cancer. N Engl J Med 2007; 357(20): 2040-8.
    • (2007) N Engl J Med , vol.357 , Issue.20 , pp. 2040-2048
    • Jonker, D.J.1    O'callaghan, C.J.2    Karapetis, C.S.3
  • 40
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E, Kohne CH, Hitre E, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009; 360(14): 1408-17.
    • (2009) N Engl J Med , vol.360 , Issue.14 , pp. 1408-1417
    • van Cutsem, E.1    Kohne, C.H.2    Hitre, E.3
  • 41
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008; 359(17): 1757-65.
    • (2008) N Engl J Med , vol.359 , Issue.17 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 42
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the firstline treatment of metastatic colorectal cancer
    • Bokemeyer C, Bondarenko I, Makhson A, et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the firstline treatment of metastatic colorectal cancer. J Clin Oncol 2009; 27(5): 663-71.
    • (2009) J Clin Oncol , vol.27 , Issue.5 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3
  • 43
    • 77949435827 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer
    • Bardelli A, Siena S. Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. J Clin Oncol 2010; 28(7): 1254-61.
    • (2010) J Clin Oncol , vol.28 , Issue.7 , pp. 1254-1261
    • Bardelli, A.1    Siena, S.2
  • 44
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase iii trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
    • Van Cutsem E, Peeters M, Siena S, et al. Open-label phase iii trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 2007; 25(13): 1658-64.
    • (2007) J Clin Oncol , vol.25 , Issue.13 , pp. 1658-1664
    • van Cutsem, E.1    Peeters, M.2    Siena, S.3
  • 45
    • 78149250536 scopus 로고    scopus 로고
    • Randomized, phase iii trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (folfox4) versus folfox4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: The prime study
    • Douillard JY, Siena S, Cassidy J, et al. Randomized, phase iii trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (folfox4) versus folfox4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: The prime study. J Clin Oncol 2010; 28(31): 4697-705.
    • (2010) J Clin Oncol , vol.28 , Issue.31 , pp. 4697-4705
    • Douillard, J.Y.1    Siena, S.2    Cassidy, J.3
  • 46
    • 78149239651 scopus 로고    scopus 로고
    • Randomized phase iii study of panitumumab with fluorouracil, leucovorin, and irinotecan (folfiri) compared with folfiri alone as second-line treatment in patients with metastatic colorectal cancer
    • Peeters M, Price TJ, Cervantes A, et al. Randomized phase iii study of panitumumab with fluorouracil, leucovorin, and irinotecan (folfiri) compared with folfiri alone as second-line treatment in patients with metastatic colorectal cancer. J Clin Oncol 2010; 28(31): 4706-13.
    • (2010) J Clin Oncol , vol.28 , Issue.31 , pp. 4706-4713
    • Peeters, M.1    Price, T.J.2    Cervantes, A.3
  • 47
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type kras is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado RG, Wolf M, Peeters M, et al. Wild-type kras is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008; 26(10): 1626-34.
    • (2008) J Clin Oncol , vol.26 , Issue.10 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 48
    • 79551647059 scopus 로고    scopus 로고
    • Dasatinib sensitizes kras mutant colorectal tumors to cetuximab
    • Dunn EF, Iida M, Myers RA, et al. Dasatinib sensitizes kras mutant colorectal tumors to cetuximab. Oncogene 2011; 30(5): 561-74.
    • (2011) Oncogene , vol.30 , Issue.5 , pp. 561-574
    • Dunn, E.F.1    Iida, M.2    Myers, R.A.3
  • 50
    • 84863000299 scopus 로고    scopus 로고
    • The molecular evolution of acquired resistance to targeted egfr blockade in colorectal cancers
    • Diaz Jr. LA, Williams RT, Wu J, et al. The molecular evolution of acquired resistance to targeted egfr blockade in colorectal cancers. Nature 2012; 486: 537-40.
    • (2012) Nature , vol.486 , pp. 537-540
    • Diaz Jr., L.A.1    Williams, R.T.2    Wu, J.3
  • 51
    • 84862999938 scopus 로고    scopus 로고
    • Emergence of kras mutations and acquired resistance to anti-egfr therapy in colorectal cancer
    • Misale S, Yaeger R, Hobor S, et al. Emergence of kras mutations and acquired resistance to anti-egfr therapy in colorectal cancer. Nature 2012; 486: 532-6.
    • (2012) Nature , vol.486 , pp. 532-536
    • Misale, S.1    Yaeger, R.2    Hobor, S.3
  • 52
    • 35648969554 scopus 로고    scopus 로고
    • Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells
    • Fevr T, Robine S, Louvard D, Huelsken J. Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells. Mol Cell Biol 2007; 27(21): 7551-9.
    • (2007) Mol Cell Biol , vol.27 , Issue.21 , pp. 7551-7559
    • Fevr, T.1    Robine, S.2    Louvard, D.3    Huelsken, J.4
  • 53
    • 0031848068 scopus 로고    scopus 로고
    • Depletion of epithelial stemcell compartments in the small intestine of mice lacking tcf-4
    • Korinek V, Barker N, Moerer P, et al. Depletion of epithelial stemcell compartments in the small intestine of mice lacking tcf-4. Nat Genet 1998; 19(4): 379-83.
    • (1998) Nat Genet , vol.19 , Issue.4 , pp. 379-383
    • Korinek, V.1    Barker, N.2    Moerer, P.3
  • 54
    • 0346458662 scopus 로고    scopus 로고
    • Essential requirement for wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of dickkopf-1
    • Kuhnert F, Davis CR, Wang HT, et al. Essential requirement for wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of dickkopf-1. Proc Natl Acad Sci USA 2004; 101(1): 266-71.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.1 , pp. 266-271
    • Kuhnert, F.1    Davis, C.R.2    Wang, H.T.3
  • 55
    • 79959951346 scopus 로고    scopus 로고
    • The evolutionary history of the catenin gene family during metazoan evolution
    • Zhao ZM, Reynolds AB, Gaucher EA. The evolutionary history of the catenin gene family during metazoan evolution. BMC Evol Biol 2011; 11: 198.
    • (2011) BMC Evol Biol , vol.11 , pp. 198
    • Zhao, Z.M.1    Reynolds, A.B.2    Gaucher, E.A.3
  • 56
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006; 127(3): 469-80.
    • (2006) Cell , vol.127 , Issue.3 , pp. 469-480
    • Clevers, H.1
  • 57
    • 0036571011 scopus 로고    scopus 로고
    • Axin-mediated cki phosphorylation of beta-catenin at ser 45: A molecular switch for the wnt pathway
    • Amit S, Hatzubai A, Birman Y, et al. Axin-mediated cki phosphorylation of beta-catenin at ser 45: A molecular switch for the wnt pathway. Genes Dev 2002; 16(9): 1066-76.
    • (2002) Genes Dev , vol.16 , Issue.9 , pp. 1066-1076
    • Amit, S.1    Hatzubai, A.2    Birman, Y.3
  • 58
    • 0141593670 scopus 로고    scopus 로고
    • Phosphorylation of betacatenin at s33, s37, or t41 can occur in the absence of phosphorylation at t45 in colon cancer cells
    • Wang Z, Vogelstein B, Kinzler KW. Phosphorylation of betacatenin at s33, s37, or t41 can occur in the absence of phosphorylation at t45 in colon cancer cells. Cancer Res 2003; 63(17): 5234-5.
    • (2003) Cancer Res , vol.63 , Issue.17 , pp. 5234-5235
    • Wang, Z.1    Vogelstein, B.2    Kinzler, K.W.3
  • 59
    • 56849086074 scopus 로고    scopus 로고
    • Apc is essential for targeting phosphorylated beta-catenin to the scfbeta-trcp ubiquitin ligase
    • Su Y, Fu C, Ishikawa S, et al. Apc is essential for targeting phosphorylated beta-catenin to the scfbeta-trcp ubiquitin ligase. Mol Cell 2008; 32(5): 652-61.
    • (2008) Mol Cell , vol.32 , Issue.5 , pp. 652-661
    • Su, Y.1    Fu, C.2    Ishikawa, S.3
  • 60
    • 0032497485 scopus 로고    scopus 로고
    • The xenopus wnt effector xtcf-3 interacts with groucho-related transcriptional repressors
    • Roose J, Molenaar M, Peterson J, et al. The xenopus wnt effector xtcf-3 interacts with groucho-related transcriptional repressors. Nature 1998; 395(6702): 608-12.
    • (1998) Nature , vol.395 , Issue.6702 , pp. 608-612
    • Roose, J.1    Molenaar, M.2    Peterson, J.3
  • 61
    • 0033616573 scopus 로고    scopus 로고
    • Biochemical characterization of wnt-frizzled interactions using a soluble, biologically active vertebrate wnt protein
    • Hsieh JC, Rattner A, Smallwood PM, Nathans J. Biochemical characterization of wnt-frizzled interactions using a soluble, biologically active vertebrate wnt protein. Proc Natl Acad Sci USA 1999; 96(7): 3546-51.
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.7 , pp. 3546-3551
    • Hsieh, J.C.1    Rattner, A.2    Smallwood, P.M.3    Nathans, J.4
  • 62
    • 0034727078 scopus 로고    scopus 로고
    • An ldlreceptor-related protein mediates wnt signalling in mice
    • Pinson KI, Brennan J, Monkley S, Avery BJ, Skarnes WC. An ldlreceptor-related protein mediates wnt signalling in mice. Nature 2000; 407(6803): 535-8.
    • (2000) Nature , vol.407 , Issue.6803 , pp. 535-538
    • Pinson, K.I.1    Brennan, J.2    Monkley, S.3    Avery, B.J.4    Skarnes, W.C.5
  • 63
    • 0034727104 scopus 로고    scopus 로고
    • Ldl-receptor-related proteins in wnt signal transduction
    • Tamai K, Semenov M, Kato Y, et al. Ldl-receptor-related proteins in wnt signal transduction. Nature 2000; 407(6803): 530-5.
    • (2000) Nature , vol.407 , Issue.6803 , pp. 530-535
    • Tamai, K.1    Semenov, M.2    Kato, Y.3
  • 64
    • 28644439005 scopus 로고    scopus 로고
    • A dual-kinase mechanism for wnt co-receptor phosphorylation and activation
    • Zeng X, Tamai K, Doble B, et al. A dual-kinase mechanism for wnt co-receptor phosphorylation and activation. Nature 2005; 438(7069): 873-7.
    • (2005) Nature , vol.438 , Issue.7069 , pp. 873-877
    • Zeng, X.1    Tamai, K.2    Doble, B.3
  • 65
    • 28644444440 scopus 로고    scopus 로고
    • Casein kinase 1 gamma couples wnt receptor activation to cytoplasmic signal transduction
    • Davidson G, Wu W, Shen J, et al. Casein kinase 1 gamma couples wnt receptor activation to cytoplasmic signal transduction. Nature 2005; 438(7069): 867-72.
    • (2005) Nature , vol.438 , Issue.7069 , pp. 867-872
    • Davidson, G.1    Wu, W.2    Shen, J.3
  • 66
    • 4243067196 scopus 로고    scopus 로고
    • The roles of apc and axin derived from experimental and theoretical analysis of the wnt pathway
    • Lee E, Salic A, Kruger R, Heinrich R, Kirschner MW. The roles of apc and axin derived from experimental and theoretical analysis of the wnt pathway. PLoS Biol 2003; 1(1): E10.
    • (2003) PLoS Biol , vol.1 , Issue.1
    • Lee, E.1    Salic, A.2    Kruger, R.3    Heinrich, R.4    Kirschner, M.W.5
  • 67
    • 34547750005 scopus 로고    scopus 로고
    • Dynamic recruitment of axin by dishevelled protein assemblies
    • Schwarz-Romond T, Metcalfe C, Bienz M. Dynamic recruitment of axin by dishevelled protein assemblies. J Cell Sci 2007; 120(Pt 14): 2402-12.
    • (2007) J Cell Sci , vol.120 , Issue.PART 14 , pp. 2402-2412
    • Schwarz-Romond, T.1    Metcalfe, C.2    Bienz, M.3
  • 68
    • 18744400798 scopus 로고    scopus 로고
    • Beta-catenin directly displaces groucho/tle repressors from tcf/lef in wnt-mediated transcription activation
    • Daniels DL, Weis WI. Beta-catenin directly displaces groucho/tle repressors from tcf/lef in wnt-mediated transcription activation. Nat Struct Mol Biol 2005; 12(4): 364-71.
    • (2005) Nat Struct Mol Biol , vol.12 , Issue.4 , pp. 364-371
    • Daniels, D.L.1    Weis, W.I.2
  • 69
    • 0001003110 scopus 로고    scopus 로고
    • Xtcf-3 transcription factor mediates beta-catenin-induced axis formation in xenopus embryos
    • Molenaar M, Van De Wetering M, Oosterwegel M, et al. Xtcf-3 transcription factor mediates beta-catenin-induced axis formation in xenopus embryos. Cell 1996; 86(3): 391-9.
    • (1996) Cell , vol.86 , Issue.3 , pp. 391-399
    • Molenaar, M.1    van de Wetering, M.2    Oosterwegel, M.3
  • 70
    • 0029781509 scopus 로고    scopus 로고
    • Functional interaction of beta-catenin with the transcription factor lef-1
    • Behrens J, Von Kries JP, Kuhl M, et al. Functional interaction of beta-catenin with the transcription factor lef-1. Nature 1996; 382(6592): 638-42.
    • (1996) Nature , vol.382 , Issue.6592 , pp. 638-642
    • Behrens, J.1    von Kries, J.P.2    Kuhl, M.3
  • 71
    • 33646555522 scopus 로고    scopus 로고
    • Parafibromin/hyrax activates wnt/wg target gene transcription by direct association with betacatenin/ armadillo
    • Mosimann C, Hausmann G, Basler K. Parafibromin/hyrax activates wnt/wg target gene transcription by direct association with betacatenin/ armadillo. Cell 2006; 125(2): 327-41.
    • (2006) Cell , vol.125 , Issue.2 , pp. 327-341
    • Mosimann, C.1    Hausmann, G.2    Basler, K.3
  • 72
    • 34548708035 scopus 로고    scopus 로고
    • Mastermind-like 1 is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival
    • Alves-Guerra MC, Ronchini C, Capobianco AJ. Mastermind-like 1 is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival. Cancer Res 2007; 67(18): 8690-8.
    • (2007) Cancer Res , vol.67 , Issue.18 , pp. 8690-8698
    • Alves-Guerra, M.C.1    Ronchini, C.2    Capobianco, A.J.3
  • 73
    • 0037023584 scopus 로고    scopus 로고
    • Wnt/wingless signaling requires bcl9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-tcf complex
    • Kramps T, Peter O, Brunner E, et al. Wnt/wingless signaling requires bcl9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-tcf complex. Cell 2002; 109(1): 47-60.
    • (2002) Cell , vol.109 , Issue.1 , pp. 47-60
    • Kramps, T.1    Peter, O.2    Brunner, E.3
  • 74
    • 0038783316 scopus 로고    scopus 로고
    • Secreted antagonists of the wnt signalling pathway
    • Kawano Y, Kypta R. Secreted antagonists of the wnt signalling pathway. J Cell Sci 2003; 116(Pt 13): 2627-34.
    • (2003) J Cell Sci , vol.116 , Issue.PART 13 , pp. 2627-2634
    • Kawano, Y.1    Kypta, R.2
  • 75
    • 33845359084 scopus 로고    scopus 로고
    • Function and biological roles of the dickkopf family of wnt modulators
    • Niehrs C. Function and biological roles of the dickkopf family of wnt modulators. Oncogene 2006; 25(57): 7469-81.
    • (2006) Oncogene , vol.25 , Issue.57 , pp. 7469-7481
    • Niehrs, C.1
  • 76
    • 0034933057 scopus 로고    scopus 로고
    • Novel mechanism of wnt signalling inhibition mediated by dickkopf-1 interaction with lrp6/arrow
    • Bafico A, Liu G, Yaniv A, Gazit A, Aaronson SA. Novel mechanism of wnt signalling inhibition mediated by dickkopf-1 interaction with lrp6/arrow. Nat Cell Biol 2001; 3(7): 683-6.
    • (2001) Nat Cell Biol , vol.3 , Issue.7 , pp. 683-686
    • Bafico, A.1    Liu, G.2    Yaniv, A.3    Gazit, A.4    Aaronson, S.A.5
  • 77
    • 0035902050 scopus 로고    scopus 로고
    • Ldl-receptor-related protein 6 is a receptor for dickkopf proteins
    • Mao B, Wu W, Li Y, et al. Ldl-receptor-related protein 6 is a receptor for dickkopf proteins. Nature 2001; 411(6835): 321-5.
    • (2001) Nature , vol.411 , Issue.6835 , pp. 321-325
    • Mao, B.1    Wu, W.2    Li, Y.3
  • 78
    • 0035954281 scopus 로고    scopus 로고
    • Head inducer dickkopf-1 is a ligand for wnt coreceptor lrp6
    • Semenov MV, Tamai K, Brott BK, et al. Head inducer dickkopf-1 is a ligand for wnt coreceptor lrp6. Curr Biol 2001; 11(12): 951-61.
    • (2001) Curr Biol , vol.11 , Issue.12 , pp. 951-961
    • Semenov, M.V.1    Tamai, K.2    Brott, B.K.3
  • 79
    • 0037030681 scopus 로고    scopus 로고
    • Kremen proteins are dickkopf receptors that regulate wnt/beta-catenin signalling
    • Mao B, Wu W, Davidson G, et al. Kremen proteins are dickkopf receptors that regulate wnt/beta-catenin signalling. Nature 2002; 417(6889): 664-7.
    • (2002) Nature , vol.417 , Issue.6889 , pp. 664-667
    • Mao, B.1    Wu, W.2    Davidson, G.3
  • 80
    • 13944282066 scopus 로고    scopus 로고
    • The wnt antagonist dickkopf-1 gene is a downstream target of betacatenin/ tcf and is downregulated in human colon cancer
    • Gonzalez-Sancho JM, Aguilera O, Garcia JM, et al. The wnt antagonist dickkopf-1 gene is a downstream target of betacatenin/ tcf and is downregulated in human colon cancer. Oncogene 2005; 24(6): 1098-103.
    • (2005) Oncogene , vol.24 , Issue.6 , pp. 1098-1103
    • Gonzalez-Sancho, J.M.1    Aguilera, O.2    Garcia, J.M.3
  • 81
    • 0037155185 scopus 로고    scopus 로고
    • Second cysteine-rich domain of dickkopf-2 activates canonical wnt signaling pathway via lrp-6 independently of dishevelled
    • Li L, Mao J, Sun L, Liu W, Wu D. Second cysteine-rich domain of dickkopf-2 activates canonical wnt signaling pathway via lrp-6 independently of dishevelled. J Biol Chem 2002; 277(8): 5977-81.
    • (2002) J Biol Chem , vol.277 , Issue.8 , pp. 5977-5981
    • Li, L.1    Mao, J.2    Sun, L.3    Liu, W.4    Wu, D.5
  • 82
    • 0039174251 scopus 로고    scopus 로고
    • Secreted frizzled-related protein-1 binds directly to wingless and is a biphasic modulator of wnt signaling
    • Uren A, Reichsman F, Anest V, et al. Secreted frizzled-related protein-1 binds directly to wingless and is a biphasic modulator of wnt signaling. J Biol Chem 2000; 275(6): 4374-82.
    • (2000) J Biol Chem , vol.275 , Issue.6 , pp. 4374-4382
    • Uren, A.1    Reichsman, F.2    Anest, V.3
  • 83
    • 33846941247 scopus 로고    scopus 로고
    • Wnt pathway may not be implicated in all routes to colorectal cancer
    • author reply-10
    • Jass JR. Wnt pathway may not be implicated in all routes to colorectal cancer. Gut 2007; 56(2): 309; author reply-10.
    • (2007) Gut , vol.56 , Issue.2 , pp. 309
    • Jass, J.R.1
  • 84
    • 0242268881 scopus 로고    scopus 로고
    • Detection of point mutations of the axin1 gene in colorectal cancers
    • Jin LH, Shao QJ, Luo W, et al. Detection of point mutations of the axin1 gene in colorectal cancers. Int J Cancer 2003; 107(5): 696-9.
    • (2003) Int J Cancer , vol.107 , Issue.5 , pp. 696-699
    • Jin, L.H.1    Shao, Q.J.2    Luo, W.3
  • 85
    • 0033780630 scopus 로고    scopus 로고
    • Mutations in axin2 cause colorectal cancer with defective mismatch repair by activating betacatenin/ tcf signalling
    • Liu W, Dong X, Mai M, et al. Mutations in axin2 cause colorectal cancer with defective mismatch repair by activating betacatenin/ tcf signalling. Nat Genet 2000; 26(2): 146-7.
    • (2000) Nat Genet , vol.26 , Issue.2 , pp. 146-147
    • Liu, W.1    Dong, X.2    Mai, M.3
  • 86
    • 11944252481 scopus 로고
    • Germ-line mutations of the apc gene in 53 familial adenomatous polyposis patients
    • Miyoshi Y, Ando H, Nagase H, et al. Germ-line mutations of the apc gene in 53 familial adenomatous polyposis patients. Proc Natl Acad Sci USA 1992; 89(10): 4452-6.
    • (1992) Proc Natl Acad Sci USA , vol.89 , Issue.10 , pp. 4452-4456
    • Miyoshi, Y.1    Ando, H.2    Nagase, H.3
  • 87
    • 12244308400 scopus 로고
    • Screening for germ-line mutations in familial adenomatous polyposis patients: 61 new patients and a summary of 150 unrelated patients
    • Nagase H, Miyoshi Y, Horii A, et al. Screening for germ-line mutations in familial adenomatous polyposis patients: 61 new patients and a summary of 150 unrelated patients. Hum Mutat 1992; 1(6): 467-73.
    • (1992) Hum Mutat , vol.1 , Issue.6 , pp. 467-473
    • Nagase, H.1    Miyoshi, Y.2    Horii, A.3
  • 89
    • 0034102422 scopus 로고    scopus 로고
    • Apc mutations are sufficient for the growth of early colorectal adenomas
    • Lamlum H, Papadopoulou A, Ilyas M, et al. Apc mutations are sufficient for the growth of early colorectal adenomas. Proc Natl Acad Sci USA 2000; 97(5): 2225-8.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.5 , pp. 2225-2228
    • Lamlum, H.1    Papadopoulou, A.2    Ilyas, M.3
  • 90
    • 77953489241 scopus 로고    scopus 로고
    • Colorectal cancers show distinct mutation spectra in members of the canonical wnt signaling pathway according to their anatomical location and type of genetic instability
    • Albuquerque C, Baltazar C, Filipe B, et al. Colorectal cancers show distinct mutation spectra in members of the canonical wnt signaling pathway according to their anatomical location and type of genetic instability. Genes Chromosomes Cancer 2010; 49(8): 746-59.
    • (2010) Genes Chromosomes Cancer , vol.49 , Issue.8 , pp. 746-759
    • Albuquerque, C.1    Baltazar, C.2    Filipe, B.3
  • 91
    • 19944432960 scopus 로고    scopus 로고
    • Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome
    • Johnson V, Volikos E, Halford SE, et al. Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome. Gut 2005; 54(2): 264-7.
    • (2005) Gut , vol.54 , Issue.2 , pp. 264-267
    • Johnson, V.1    Volikos, E.2    Halford, S.E.3
  • 92
    • 0033119582 scopus 로고    scopus 로고
    • Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas
    • Samowitz WS, Powers MD, Spirio LN, et al. Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas. Cancer Res 1999; 59(7): 1442-4.
    • (1999) Cancer Res , vol.59 , Issue.7 , pp. 1442-1444
    • Samowitz, W.S.1    Powers, M.D.2    Spirio, L.N.3
  • 93
    • 0033565255 scopus 로고    scopus 로고
    • Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway
    • Mirabelli-Primdahl L, Gryfe R, Kim H, et al. Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway. Cancer Res 1999; 59(14): 3346-51.
    • (1999) Cancer Res , vol.59 , Issue.14 , pp. 3346-3351
    • Mirabelli-Primdahl, L.1    Gryfe, R.2    Kim, H.3
  • 94
    • 0036131933 scopus 로고    scopus 로고
    • Frequent alterations in the wnt signaling pathway in colorectal cancer with microsatellite instability
    • Shimizu Y, Ikeda S, Fujimori M, et al. Frequent alterations in the wnt signaling pathway in colorectal cancer with microsatellite instability. Genes Chromosomes Cancer 2002; 33(1): 73-81.
    • (2002) Genes Chromosomes Cancer , vol.33 , Issue.1 , pp. 73-81
    • Shimizu, Y.1    Ikeda, S.2    Fujimori, M.3
  • 95
    • 0033948526 scopus 로고    scopus 로고
    • Sequence variants of the axin gene in breast, colon, and other cancers: An analysis of mutations that interfere with gsk3 binding
    • Webster MT, Rozycka M, Sara E, et al. Sequence variants of the axin gene in breast, colon, and other cancers: An analysis of mutations that interfere with gsk3 binding. Genes Chromosomes Cancer 2000; 28(4): 443-53.
    • (2000) Genes Chromosomes Cancer , vol.28 , Issue.4 , pp. 443-453
    • Webster, M.T.1    Rozycka, M.2    Sara, E.3
  • 96
    • 80455173856 scopus 로고    scopus 로고
    • Wnt signaling and colon tumorigenesis--a view from the periphery
    • Burgess AW, Faux MC, Layton MJ, Ramsay RG. Wnt signaling and colon tumorigenesis--a view from the periphery. Exp Cell Res 2011; 317(19): 2748-58.
    • (2011) Exp Cell Res , vol.317 , Issue.19 , pp. 2748-2758
    • Burgess, A.W.1    Faux, M.C.2    Layton, M.J.3    Ramsay, R.G.4
  • 97
    • 33845234807 scopus 로고    scopus 로고
    • Cytoskeleton out of the cupboard: Colon cancer and cytoskeletal changes induced by loss of apc
    • Nathke I. Cytoskeleton out of the cupboard: Colon cancer and cytoskeletal changes induced by loss of apc. Nat Rev Cancer 2006; 6(12): 967-74.
    • (2006) Nat Rev Cancer , vol.6 , Issue.12 , pp. 967-974
    • Nathke, I.1
  • 98
    • 0035176077 scopus 로고    scopus 로고
    • Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by gsk3 beta phosphorylation
    • Zumbrunn J, Kinoshita K, Hyman AA, Nathke IS. Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by gsk3 beta phosphorylation. Curr Biol 2001; 11(1): 44-9.
    • (2001) Curr Biol , vol.11 , Issue.1 , pp. 44-49
    • Zumbrunn, J.1    Kinoshita, K.2    Hyman, A.A.3    Nathke, I.S.4
  • 99
    • 2942668475 scopus 로고    scopus 로고
    • Loss of apc in vivo immediately perturbs wnt signaling, differentiation, and migration
    • Sansom OJ, Reed KR, Hayes AJ, et al. Loss of apc in vivo immediately perturbs wnt signaling, differentiation, and migration. Genes Dev 2004; 18(12): 1385-90.
    • (2004) Genes Dev , vol.18 , Issue.12 , pp. 1385-1390
    • Sansom, O.J.1    Reed, K.R.2    Hayes, A.J.3
  • 100
    • 0031727409 scopus 로고    scopus 로고
    • Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front
    • Brabletz T, Jung A, Hermann K, et al. Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front. Pathol Res Pract 1998; 194(10): 701-4.
    • (1998) Pathol Res Pract , vol.194 , Issue.10 , pp. 701-704
    • Brabletz, T.1    Jung, A.2    Hermann, K.3
  • 101
    • 56749176437 scopus 로고    scopus 로고
    • Cadherins and cancer: How does cadherin dysfunction promote tumor progression?
    • Jeanes A, Gottardi CJ, Yap AS. Cadherins and cancer: How does cadherin dysfunction promote tumor progression? Oncogene 2008; 27(55): 6920-9.
    • (2008) Oncogene , vol.27 , Issue.55 , pp. 6920-6929
    • Jeanes, A.1    Gottardi, C.J.2    Yap, A.S.3
  • 102
    • 0028923175 scopus 로고
    • Level of expression of e-cadherin mrna in colorectal cancer correlates with clinical outcome
    • Dorudi S, Hanby AM, Poulsom R, Northover J, Hart IR. Level of expression of e-cadherin mrna in colorectal cancer correlates with clinical outcome. Br J Cancer 1995; 71(3): 614-6.
    • (1995) Br J Cancer , vol.71 , Issue.3 , pp. 614-616
    • Dorudi, S.1    Hanby, A.M.2    Poulsom, R.3    Northover, J.4    Hart, I.R.5
  • 103
    • 0033067504 scopus 로고    scopus 로고
    • E-cadherin expression correlates with tumor differentiation in colorectal cancer
    • Karatzas G, Karayiannakis AJ, Syrigos KN, et al. E-cadherin expression correlates with tumor differentiation in colorectal cancer. Hepatogastroenterology 1999; 46(25): 232-5.
    • (1999) Hepatogastroenterology , vol.46 , Issue.25 , pp. 232-235
    • Karatzas, G.1    Karayiannakis, A.J.2    Syrigos, K.N.3
  • 104
    • 0030726150 scopus 로고    scopus 로고
    • Prognostic significance of e-cadherin expression in human colorectal cancer tissue
    • Mohri Y. Prognostic significance of e-cadherin expression in human colorectal cancer tissue. Surg Today 1997; 27(7): 606-12.
    • (1997) Surg Today , vol.27 , Issue.7 , pp. 606-612
    • Mohri, Y.1
  • 105
    • 56449127312 scopus 로고    scopus 로고
    • E-cadherin and betacatenin mrna levels throughout colon cancer progression
    • Truant SC, Gouyer VP, Leteurtre EA, et al. E-cadherin and betacatenin mrna levels throughout colon cancer progression. J Surg Res 2008; 150(2): 212-8.
    • (2008) J Surg Res , vol.150 , Issue.2 , pp. 212-218
    • Truant, S.C.1    Gouyer, V.P.2    Leteurtre, E.A.3
  • 106
    • 29144536745 scopus 로고    scopus 로고
    • E-cadherin modulates wnt-dependent transcription in colorectal cancer cells but does not alter wntindependent gene expression in fibroblasts
    • Kuphal F, Behrens J. E-cadherin modulates wnt-dependent transcription in colorectal cancer cells but does not alter wntindependent gene expression in fibroblasts. Exp Cell Res 2006; 312(4): 457-67.
    • (2006) Exp Cell Res , vol.312 , Issue.4 , pp. 457-467
    • Kuphal, F.1    Behrens, J.2
  • 107
    • 33745765883 scopus 로고    scopus 로고
    • Epigenetic inactivation of the wnt antagonist dickkopf-1 (dkk-1) gene in human colorectal cancer
    • Aguilera O, Fraga MF, Ballestar E, et al. Epigenetic inactivation of the wnt antagonist dickkopf-1 (dkk-1) gene in human colorectal cancer. Oncogene 2006; 25(29): 4116-21.
    • (2006) Oncogene , vol.25 , Issue.29 , pp. 4116-4121
    • Aguilera, O.1    Fraga, M.F.2    Ballestar, E.3
  • 108
    • 0036613250 scopus 로고    scopus 로고
    • A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer
    • Suzuki H, Gabrielson E, Chen W, et al. A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet 2002; 31(2): 141-9.
    • (2002) Nat Genet , vol.31 , Issue.2 , pp. 141-149
    • Suzuki, H.1    Gabrielson, E.2    Chen, W.3
  • 109
    • 10744229341 scopus 로고    scopus 로고
    • The wnt antagonist sfrp1 in colorectal tumorigenesis
    • Caldwell GM, Jones C, Gensberg K, et al. The wnt antagonist sfrp1 in colorectal tumorigenesis. Cancer Res 2004; 64(3): 883-8.
    • (2004) Cancer Res , vol.64 , Issue.3 , pp. 883-888
    • Caldwell, G.M.1    Jones, C.2    Gensberg, K.3
  • 110
    • 12144291274 scopus 로고    scopus 로고
    • Epigenetic inactivation of sfrp genes allows constitutive wnt signaling in colorectal cancer
    • Suzuki H, Watkins DN, Jair KW, et al. Epigenetic inactivation of sfrp genes allows constitutive wnt signaling in colorectal cancer. Nat Genet 2004; 36(4): 417-22.
    • (2004) Nat Genet , vol.36 , Issue.4 , pp. 417-422
    • Suzuki, H.1    Watkins, D.N.2    Jair, K.W.3
  • 111
    • 33750717864 scopus 로고    scopus 로고
    • The metastasis-associated gene s100a4 is a novel target of beta-catenin/t-cell factor signaling in colon cancer
    • Stein U, Arlt F, Walther W, et al. The metastasis-associated gene s100a4 is a novel target of beta-catenin/t-cell factor signaling in colon cancer. Gastroenterology 2006; 131(5): 1486-500.
    • (2006) Gastroenterology , vol.131 , Issue.5 , pp. 1486-1500
    • Stein, U.1    Arlt, F.2    Walther, W.3
  • 113
    • 77149165061 scopus 로고    scopus 로고
    • Wnt up your mind-intervention strategies for s100a4-induced metastasis in colon cancer
    • Sack U, Stein U. Wnt up your mind-intervention strategies for s100a4-induced metastasis in colon cancer. Gen Physiol Biophys 2009; 28(Focus Issue): F55-F64.
    • (2009) Gen Physiol Biophys , vol.28 , Issue.FOCUS ISSUE
    • Sack, U.1    Stein, U.2
  • 114
    • 33646853875 scopus 로고    scopus 로고
    • Metastasis-associated protein s100a4--a potential prognostic marker for colorectal cancer
    • Hemandas AK, Salto-Tellez M, Maricar SH, Leong AF, Leow CK. Metastasis-associated protein s100a4--a potential prognostic marker for colorectal cancer. J Surg Oncol 2006; 93(6): 498-503.
    • (2006) J Surg Oncol , vol.93 , Issue.6 , pp. 498-503
    • Hemandas, A.K.1    Salto-Tellez, M.2    Maricar, S.H.3    Leong, A.F.4    Leow, C.K.5
  • 115
    • 0036829087 scopus 로고    scopus 로고
    • Prognostic significance of calcium-binding protein s100a4 in colorectal cancer
    • Gongoll S, Peters G, Mengel M, et al. Prognostic significance of calcium-binding protein s100a4 in colorectal cancer. Gastroenterology 2002; 123(5): 1478-84.
    • (2002) Gastroenterology , vol.123 , Issue.5 , pp. 1478-1484
    • Gongoll, S.1    Peters, G.2    Mengel, M.3
  • 116
    • 80054775320 scopus 로고    scopus 로고
    • Maintenance of adenomatous polyposis coli (apc)-mutant colorectal cancer is dependent on wnt/beta-catenin signaling
    • Scholer-Dahirel A, Schlabach MR, Loo A, et al. Maintenance of adenomatous polyposis coli (apc)-mutant colorectal cancer is dependent on wnt/beta-catenin signaling. Proc Natl Acad Sci USA 2011; 108(41): 17135-40.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.41 , pp. 17135-17140
    • Scholer-Dahirel, A.1    Schlabach, M.R.2    Loo, A.3
  • 117
    • 33751530490 scopus 로고    scopus 로고
    • Mining the wnt pathway for cancer therapeutics
    • Barker N, Clevers H. Mining the wnt pathway for cancer therapeutics. Nat Rev Drug Discov 2006; 5(12): 997-1014.
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.12 , pp. 997-1014
    • Barker, N.1    Clevers, H.2
  • 119
    • 58249122326 scopus 로고    scopus 로고
    • Small molecule-mediated disruption of wnt-dependent signaling in tissue regeneration and cancer
    • Chen B, Dodge ME, Tang W, et al. Small molecule-mediated disruption of wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 2009; 5(2): 100-7.
    • (2009) Nat Chem Biol , vol.5 , Issue.2 , pp. 100-107
    • Chen, B.1    Dodge, M.E.2    Tang, W.3
  • 120
    • 70349695861 scopus 로고    scopus 로고
    • Tankyrase inhibition stabilizes axin and antagonizes wnt signalling
    • Huang SM, Mishina YM, Liu S, et al. Tankyrase inhibition stabilizes axin and antagonizes wnt signalling. Nature 2009; 461(7264): 614-20.
    • (2009) Nature , vol.461 , Issue.7264 , pp. 614-620
    • Huang, S.M.1    Mishina, Y.M.2    Liu, S.3
  • 121
    • 21644446778 scopus 로고    scopus 로고
    • Arming antibodies for cancer therapy
    • Polakis P. Arming antibodies for cancer therapy. Curr Opin Pharmacol 2005; 5(4): 382-7.
    • (2005) Curr Opin Pharmacol , vol.5 , Issue.4 , pp. 382-387
    • Polakis, P.1
  • 122
    • 1642341682 scopus 로고    scopus 로고
    • A monoclonal antibody against wnt-1 induces apoptosis in human cancer cells
    • He B, You L, Uematsu K, et al. A monoclonal antibody against wnt-1 induces apoptosis in human cancer cells. Neoplasia 2004; 6(1): 7-14.
    • (2004) Neoplasia , vol.6 , Issue.1 , pp. 7-14
    • He, B.1    You, L.2    Uematsu, K.3
  • 123
    • 0037388638 scopus 로고    scopus 로고
    • Small interfering rnas directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells
    • Verma UN, Surabhi RM, Schmaltieg A, Becerra C, Gaynor RB. Small interfering rnas directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells. Clin Cancer Res 2003; 9(4): 1291-300.
    • (2003) Clin Cancer Res , vol.9 , Issue.4 , pp. 1291-1300
    • Verma, U.N.1    Surabhi, R.M.2    Schmaltieg, A.3    Becerra, C.4    Gaynor, R.B.5
  • 124
    • 77953431049 scopus 로고    scopus 로고
    • Oligodeoxyribozymes that cleave beta-catenin messenger rna inhibit growth of colon cancer cells via reduction of beta-catenin response transcription
    • Choi BR, Gwak J, Kwon HM, et al. Oligodeoxyribozymes that cleave beta-catenin messenger rna inhibit growth of colon cancer cells via reduction of beta-catenin response transcription. Mol Cancer Ther 2010; 9(6): 1894-902.
    • (2010) Mol Cancer Ther , vol.9 , Issue.6 , pp. 1894-1902
    • Choi, B.R.1    Gwak, J.2    Kwon, H.M.3
  • 125
    • 80054773989 scopus 로고    scopus 로고
    • A systematic screen for micro-rnas regulating the canonical wnt pathway
    • Anton R, Chatterjee SS, Simundza J, Cowin P, Dasgupta R. A systematic screen for micro-rnas regulating the canonical wnt pathway. PLoS One 2011; 6(10): e26257.
    • (2011) PLoS One , vol.6 , Issue.10
    • Anton, R.1    Chatterjee, S.S.2    Simundza, J.3    Cowin, P.4    Dasgupta, R.5
  • 126
    • 80455137130 scopus 로고    scopus 로고
    • P53 and microrna-34 are suppressors of canonical wnt signaling
    • Kim NH, Kim HS, Kim NG, et al. P53 and microrna-34 are suppressors of canonical wnt signaling. Sci Signal 2011; 4(197): ra71.
    • (2011) Sci Signal , vol.4 , Issue.197
    • Kim, N.H.1    Kim, H.S.2    Kim, N.G.3
  • 127
    • 84860319933 scopus 로고    scopus 로고
    • Mirna-34 intrinsically links p53 tumor suppressor and wnt signaling
    • Cha YH, Kim NH, Park C, et al. Mirna-34 intrinsically links p53 tumor suppressor and wnt signaling. Cell Cycle 2012; 11(7): 1273-81.
    • (2012) Cell Cycle , vol.11 , Issue.7 , pp. 1273-1281
    • Cha, Y.H.1    Kim, N.H.2    Park, C.3
  • 128
    • 84863372530 scopus 로고    scopus 로고
    • Microrna-200a suppresses the wnt/beta-catenin signaling pathway by interacting with betacatenin
    • Su J, Zhang A, Shi Z, et al. Microrna-200a suppresses the wnt/beta-catenin signaling pathway by interacting with betacatenin. Int J Oncol 2012; 40(4): 1162-70.
    • (2012) Int J Oncol , vol.40 , Issue.4 , pp. 1162-1170
    • Su, J.1    Zhang, A.2    Shi, Z.3
  • 129
    • 84859812754 scopus 로고    scopus 로고
    • Microrna-320a suppresses human colon cancer cell proliferation by directly targeting beta-catenin
    • Sun JY, Huang Y, Li JP, et al. Microrna-320a suppresses human colon cancer cell proliferation by directly targeting beta-catenin. Biochem Biophys Res Commun 2012; 420(4): 787-92.
    • (2012) Biochem Biophys Res Commun , vol.420 , Issue.4 , pp. 787-792
    • Sun, J.Y.1    Huang, Y.2    Li, J.P.3
  • 130
    • 84856510440 scopus 로고    scopus 로고
    • Mir-1 downregulation cooperates with macc1 in promoting met overexpression in human colon cancer
    • Migliore C, Martin V, Leoni VP, et al. Mir-1 downregulation cooperates with macc1 in promoting met overexpression in human colon cancer. Clin Cancer Res 2012; 18(3): 737-47.
    • (2012) Clin Cancer Res , vol.18 , Issue.3 , pp. 737-747
    • Migliore, C.1    Martin, V.2    Leoni, V.P.3
  • 131
    • 32644470964 scopus 로고    scopus 로고
    • Colon cancer--understanding how nsaids work
    • Clevers H. Colon cancer--understanding how nsaids work. N Engl J Med 2006; 354(7): 761-3.
    • (2006) N Engl J Med , vol.354 , Issue.7 , pp. 761-763
    • Clevers, H.1
  • 132
    • 0037138743 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs as anticancer agents: Mechanistic, pharmacologic, and clinical issues
    • Thun MJ, Henley SJ, Patrono C. Nonsteroidal anti-inflammatory drugs as anticancer agents: Mechanistic, pharmacologic, and clinical issues. J Natl Cancer Inst 2002; 94(4): 252-66.
    • (2002) J Natl Cancer Inst , vol.94 , Issue.4 , pp. 252-266
    • Thun, M.J.1    Henley, S.J.2    Patrono, C.3
  • 133
    • 11144344179 scopus 로고    scopus 로고
    • Wnt/beta-catenin-pathway as a molecular target for future anti-cancer therapeutics
    • Dihlmann S, Von Knebel Doeberitz M. Wnt/beta-catenin-pathway as a molecular target for future anti-cancer therapeutics. Int J Cancer 2005; 113(4): 515-24.
    • (2005) Int J Cancer , vol.113 , Issue.4 , pp. 515-524
    • Dihlmann, S.1    von Knebel Doeberitz, M.2
  • 134
    • 82055161852 scopus 로고    scopus 로고
    • Cyclooxygenase as a target for colorectal cancer chemoprevention
    • Moreira L, Castells A. Cyclooxygenase as a target for colorectal cancer chemoprevention. Curr Drug Targets 2011; 12(13): 1888-94.
    • (2011) Curr Drug Targets , vol.12 , Issue.13 , pp. 1888-1894
    • Moreira, L.1    Castells, A.2
  • 135
    • 0036130051 scopus 로고    scopus 로고
    • Nsaid inhibition of gi cancer growth: Clinical implications and molecular mechanisms of action
    • Husain SS, Szabo IL, Tamawski AS. Nsaid inhibition of gi cancer growth: Clinical implications and molecular mechanisms of action. Am J Gastroenterol 2002; 97(3): 542-53.
    • (2002) Am J Gastroenterol , vol.97 , Issue.3 , pp. 542-553
    • Husain, S.S.1    Szabo, I.L.2    Tamawski, A.S.3
  • 136
    • 0346881625 scopus 로고    scopus 로고
    • Cyclooxygenase inhibition and mechanisms of colorectal cancer prevention
    • Chan TA. Cyclooxygenase inhibition and mechanisms of colorectal cancer prevention. Curr Cancer Drug Targets 2003; 3(6): 455-63.
    • (2003) Curr Cancer Drug Targets , vol.3 , Issue.6 , pp. 455-463
    • Chan, T.A.1
  • 137
    • 65349152488 scopus 로고    scopus 로고
    • Aspirin and non-steroidal antiinflammatory drugs for cancer prevention: An international consensus statement
    • Cuzick J, Otto F, Baron JA, et al. Aspirin and non-steroidal antiinflammatory drugs for cancer prevention: An international consensus statement. Lancet Oncol 2009; 10(5): 501-7.
    • (2009) Lancet Oncol , vol.10 , Issue.5 , pp. 501-507
    • Cuzick, J.1    Otto, F.2    Baron, J.A.3
  • 138
    • 39449084394 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition inhibits c-met kinase activity and wnt activity in colon cancer
    • Tuynman JB, Vermeulen L, Boon EM, et al. Cyclooxygenase-2 inhibition inhibits c-met kinase activity and wnt activity in colon cancer. Cancer Res 2008; 68(4): 1213-20.
    • (2008) Cancer Res , vol.68 , Issue.4 , pp. 1213-1220
    • Tuynman, J.B.1    Vermeulen, L.2    Boon, E.M.3
  • 139
    • 33750344255 scopus 로고    scopus 로고
    • Selecting targets for cancer prevention: Where do we go from here?
    • Szabo E. Selecting targets for cancer prevention: Where do we go from here? Nat Rev Cancer 2006; 6(11): 867-74.
    • (2006) Nat Rev Cancer , vol.6 , Issue.11 , pp. 867-874
    • Szabo, E.1
  • 140
    • 55549132996 scopus 로고    scopus 로고
    • Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: A randomized placebo-controlled, double-blind trial
    • Meyskens FL, Jr., Mclaren CE, Pelot D, et al. Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: A randomized placebo-controlled, double-blind trial. Cancer Prev Res (Phila) 2008; 1(1): 32-8.
    • (2008) Cancer Prev Res (Phila) , vol.1 , Issue.1 , pp. 32-38
    • Meyskens Jr., F.L.1    Mclaren, C.E.2    Pelot, D.3
  • 141
    • 55549143635 scopus 로고    scopus 로고
    • Concomitant dfmo and sulindac chemoprevention of colorectal adenomas: A major clinical advance
    • Sporn MB, Hong WK. Concomitant dfmo and sulindac chemoprevention of colorectal adenomas: A major clinical advance. Nat Clin Pract Oncol 2008; 5(11): 628-9.
    • (2008) Nat Clin Pract Oncol , vol.5 , Issue.11 , pp. 628-629
    • Sporn, M.B.1    Hong, W.K.2
  • 142
    • 79951502992 scopus 로고    scopus 로고
    • Intervening in beta-catenin signaling by sulindac inhibits s100a4-dependent colon cancer metastasis
    • Stein U, Arlt F, Smith J, et al. Intervening in beta-catenin signaling by sulindac inhibits s100a4-dependent colon cancer metastasis. Neoplasia 2011; 13(2): 131-44.
    • (2011) Neoplasia , vol.13 , Issue.2 , pp. 131-144
    • Stein, U.1    Arlt, F.2    Smith, J.3
  • 143
    • 80052823397 scopus 로고    scopus 로고
    • S100a4-induced cell motility and metastasis is restricted by the wnt/beta-catenin pathway inhibitor calcimycin in colon cancer cells
    • Sack U, Walther W, Scudiero D, et al. S100a4-induced cell motility and metastasis is restricted by the wnt/beta-catenin pathway inhibitor calcimycin in colon cancer cells. Mol Biol Cell 2011; 22(18): 3344-54.
    • (2011) Mol Biol Cell , vol.22 , Issue.18 , pp. 3344-3354
    • Sack, U.1    Walther, W.2    Scudiero, D.3
  • 144
    • 1842585925 scopus 로고    scopus 로고
    • Quantification of plasma beta-catenin mrna in colorectal cancer and adenoma patients
    • Wong SC, Lo SF, Cheung MT, et al. Quantification of plasma beta-catenin mrna in colorectal cancer and adenoma patients. Clin Cancer Res 2004; 10(5): 1613-7.
    • (2004) Clin Cancer Res , vol.10 , Issue.5 , pp. 1613-1617
    • Wong, S.C.1    Lo, S.F.2    Cheung, M.T.3
  • 145
    • 1642512639 scopus 로고    scopus 로고
    • Small-molecule antagonists of the oncogenic tcf/beta-catenin protein complex
    • Lepourcelet M, Chen YN, France DS, et al. Small-molecule antagonists of the oncogenic tcf/beta-catenin protein complex. Cancer Cell 2004; 5(1): 91-102.
    • (2004) Cancer Cell , vol.5 , Issue.1 , pp. 91-102
    • Lepourcelet, M.1    Chen, Y.N.2    France, D.S.3
  • 146
    • 4344587136 scopus 로고    scopus 로고
    • A small molecule inhibitor of beta-catenin/creb-binding protein transcription [corrected]
    • Emami KH, Nguyen C, Ma H, et al. A small molecule inhibitor of beta-catenin/creb-binding protein transcription [corrected]. Proc Natl Acad Sci USA 2004; 101(34): 12682-7.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.34 , pp. 12682-12687
    • Emami, K.H.1    Nguyen, C.2    Ma, H.3
  • 147
    • 79960263940 scopus 로고    scopus 로고
    • Novel effect of antihelminthic niclosamide on s100a4-mediated metastatic progression in colon cancer
    • Sack U, Walther W, Scudiero D, et al. Novel effect of antihelminthic niclosamide on s100a4-mediated metastatic progression in colon cancer. J Natl Cancer Inst 2011; 103(13): 1018-36.
    • (2011) J Natl Cancer Inst , vol.103 , Issue.13 , pp. 1018-1036
    • Sack, U.1    Walther, W.2    Scudiero, D.3
  • 148
    • 83455182133 scopus 로고    scopus 로고
    • Niclosamide suppresses cancer cell growth by inducing wnt co-receptor lrp6 degradation and inhibiting the wnt/beta-catenin pathway
    • Lu W, Lin C, Roberts MJ, et al. Niclosamide suppresses cancer cell growth by inducing wnt co-receptor lrp6 degradation and inhibiting the wnt/beta-catenin pathway. PLoS One 2011; 6(12): e29290.
    • (2011) PLoS One , vol.6 , Issue.12
    • Lu, W.1    Lin, C.2    Roberts, M.J.3
  • 149
    • 70350489312 scopus 로고    scopus 로고
    • The anti-helminthic niclosamide inhibits wnt/frizzled1 signaling
    • Chen M, Wang J, Lu J, et al. The anti-helminthic niclosamide inhibits wnt/frizzled1 signaling. Biochemistry 2009; 48(43): 10267-74.
    • (2009) Biochemistry , vol.48 , Issue.43 , pp. 10267-10274
    • Chen, M.1    Wang, J.2    Lu, J.3
  • 150
    • 79958812414 scopus 로고    scopus 로고
    • Antihelminth compound niclosamide downregulates wnt signaling and elicits antitumor responses in tumors with activating apc mutations
    • Osada T, Chen M, Yang XY, et al. Antihelminth compound niclosamide downregulates wnt signaling and elicits antitumor responses in tumors with activating apc mutations. Cancer Res 2011; 71(12): 4172-82.
    • (2011) Cancer Res , vol.71 , Issue.12 , pp. 4172-4182
    • Osada, T.1    Chen, M.2    Yang, X.Y.3
  • 151
    • 84876710119 scopus 로고    scopus 로고
    • Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells
    • Pan JX, Ding K, Wang CY. Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells. Chin J Cancer 2012.
    • (2012) Chin J Cancer
    • Pan, J.X.1    Ding, K.2    Wang, C.Y.3
  • 152
    • 84862916465 scopus 로고    scopus 로고
    • Structure-based discovery of a novel inhibitor targeting the beta-catenin/tcf4 interaction
    • Tian W, Han X, Yan M, et al. Structure-based discovery of a novel inhibitor targeting the beta-catenin/tcf4 interaction. Biochemistry 2012; 51(2): 724-31.
    • (2012) Biochemistry , vol.51 , Issue.2 , pp. 724-731
    • Tian, W.1    Han, X.2    Yan, M.3
  • 153
    • 0028798286 scopus 로고
    • Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros
    • Woolf AS, Kolatsi-Joannou M, Hardman P, et al. Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros. J Cell Biol 1995; 128(1-2): 171-84.
    • (1995) J Cell Biol , vol.128 , Issue.1-2 , pp. 171-184
    • Woolf, A.S.1    Kolatsi-Joannou, M.2    Hardman, P.3
  • 154
    • 3242663197 scopus 로고    scopus 로고
    • Met provides essential signals for liver regeneration
    • Borowiak M, Garratt AN, Wustefeld T, et al. Met provides essential signals for liver regeneration. Proc Natl Acad Sci USA 2004; 101(29): 10608-13.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.29 , pp. 10608-10613
    • Borowiak, M.1    Garratt, A.N.2    Wustefeld, T.3
  • 155
    • 1842428601 scopus 로고    scopus 로고
    • Hepatocyte growth factor/cmet signaling pathway is required for efficient liver regeneration and repair
    • Huh CG, Factor VM, Sanchez A, et al. Hepatocyte growth factor/cmet signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci USA 2004; 101(13): 4477-82.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.13 , pp. 4477-4482
    • Huh, C.G.1    Factor, V.M.2    Sanchez, A.3
  • 156
    • 34247142787 scopus 로고    scopus 로고
    • C-met is essential for wound healing in the skin
    • Chmielowiec J, Borowiak M, Morkel M, et al. C-met is essential for wound healing in the skin. J Cell Biol 2007; 177(1): 151-62.
    • (2007) J Cell Biol , vol.177 , Issue.1 , pp. 151-162
    • Chmielowiec, J.1    Borowiak, M.2    Morkel, M.3
  • 157
    • 0028899952 scopus 로고
    • Scatter factor/hepatocyte growth factor is essential for liver development
    • Schmidt C, Bladt F, Goedecke S, et al. Scatter factor/hepatocyte growth factor is essential for liver development. Nature 1995; 373(6516): 699-702.
    • (1995) Nature , vol.373 , Issue.6516 , pp. 699-702
    • Schmidt, C.1    Bladt, F.2    Goedecke, S.3
  • 158
    • 0028911690 scopus 로고
    • Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor
    • Uehara Y, Minowa O, Mori C, et al. Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature 1995; 373(6516): 702-5.
    • (1995) Nature , vol.373 , Issue.6516 , pp. 702-705
    • Uehara, Y.1    Minowa, O.2    Mori, C.3
  • 159
    • 0029134104 scopus 로고
    • Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
    • Bladt F, Riethmacher D, Isenmann S, Aguzzi A, Birchmeier C. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 1995; 376(6543): 768-71.
    • (1995) Nature , vol.376 , Issue.6543 , pp. 768-771
    • Bladt, F.1    Riethmacher, D.2    Isenmann, S.3    Aguzzi, A.4    Birchmeier, C.5
  • 160
    • 0031440947 scopus 로고    scopus 로고
    • Met receptor signaling is required for sensory nerve development and hgf promotes axonal growth and survival of sensory neurons
    • Maina F, Hilton MC, Ponzetto C, Davies AM, Klein R. Met receptor signaling is required for sensory nerve development and hgf promotes axonal growth and survival of sensory neurons. Genes Dev 1997; 11(24): 3341-50.
    • (1997) Genes Dev , vol.11 , Issue.24 , pp. 3341-3350
    • Maina, F.1    Hilton, M.C.2    Ponzetto, C.3    Davies, A.M.4    Klein, R.5
  • 161
    • 0029816082 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor-met signaling in tumorigenicity and invasion/metastasis
    • Jeffers M, Rong S, Woude GF. Hepatocyte growth factor/scatter factor-met signaling in tumorigenicity and invasion/metastasis. J Mol Med (Berl) 1996; 74(9): 505-13.
    • (1996) J Mol Med (Berl) , vol.74 , Issue.9 , pp. 505-513
    • Jeffers, M.1    Rong, S.2    Woude, G.F.3
  • 162
    • 0028564863 scopus 로고
    • Scatter factor and the c-met receptor: A paradigm for mesenchymal/epithelial interaction
    • Rosen EM, Nigam SK, Goldberg ID. Scatter factor and the c-met receptor: A paradigm for mesenchymal/epithelial interaction. J Cell Biol 1994; 127(6 Pt 2): 1783-7.
    • (1994) J Cell Biol , vol.127 , Issue.6 PART 2 , pp. 1783-1787
    • Rosen, E.M.1    Nigam, S.K.2    Goldberg, I.D.3
  • 163
    • 0029564113 scopus 로고
    • Hepatocyte growth factor/scatter factor induces a variety of tissuespecific morphogenic programs in epithelial cells
    • Brinkmann V, Foroutan H, Sachs M, Weidner KM, Birchmeier W. Hepatocyte growth factor/scatter factor induces a variety of tissuespecific morphogenic programs in epithelial cells. J Cell Biol 1995; 131(6 Pt 1): 1573-86.
    • (1995) J Cell Biol , vol.131 , Issue.6 PART 1 , pp. 1573-1586
    • Brinkmann, V.1    Foroutan, H.2    Sachs, M.3    Weidner, K.M.4    Birchmeier, W.5
  • 164
    • 77957011173 scopus 로고    scopus 로고
    • Oncogenic engagement of the met receptor is sufficient to evoke angiogenic, tumorigenic, and metastatic activities in rat intestinal epithelial cells
    • Bernier J, Chababi W, Pomerleau V, Saucier C. Oncogenic engagement of the met receptor is sufficient to evoke angiogenic, tumorigenic, and metastatic activities in rat intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 2010; 299(3): G677-86.
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.299 , Issue.3
    • Bernier, J.1    Chababi, W.2    Pomerleau, V.3    Saucier, C.4
  • 165
    • 0028276786 scopus 로고
    • Invasiveness and metastasis of nih 3t3 cells induced by methepatocyte growth factor/scatter factor autocrine stimulation
    • Rong S, Segal S, Anver M, Resau JH, Vande Woude GF. Invasiveness and metastasis of nih 3t3 cells induced by methepatocyte growth factor/scatter factor autocrine stimulation. Proc Natl Acad Sci USA 1994; 91(11): 4731-5.
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.11 , pp. 4731-4735
    • Rong, S.1    Segal, S.2    Anver, M.3    Resau, J.H.4    Vande Woude, G.F.5
  • 166
    • 0032564341 scopus 로고    scopus 로고
    • The mutationally activated met receptor mediates motility and metastasis
    • Jeffers M, Fiscella M, Webb CP, et al. The mutationally activated met receptor mediates motility and metastasis. Proc Natl Acad Sci USA 1998; 95(24): 14417-22.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.24 , pp. 14417-14422
    • Jeffers, M.1    Fiscella, M.2    Webb, C.P.3
  • 167
    • 0025734655 scopus 로고
    • Hepatocyte growth factor (hgf) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-met
    • Naldini L, Vigna E, Narsimhan RP, et al. Hepatocyte growth factor (hgf) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-met. Oncogene 1991; 6(4): 501-4.
    • (1991) Oncogene , vol.6 , Issue.4 , pp. 501-504
    • Naldini, L.1    Vigna, E.2    Narsimhan, R.P.3
  • 168
    • 0025805633 scopus 로고
    • Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
    • Bottaro DP, Rubin JS, Faletto DL, et al. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 1991; 251(4995): 802-4.
    • (1991) Science , vol.251 , Issue.4995 , pp. 802-804
    • Bottaro, D.P.1    Rubin, J.S.2    Faletto, D.L.3
  • 169
    • 0026699904 scopus 로고
    • Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer
    • Naka D, Ishii T, Yoshiyama Y, et al. Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer. J Biol Chem 1992; 267(28): 20114-9.
    • (1992) J Biol Chem , vol.267 , Issue.28 , pp. 20114-20119
    • Naka, D.1    Ishii, T.2    Yoshiyama, Y.3
  • 170
    • 0032730169 scopus 로고    scopus 로고
    • Hgf: A multifunctional growth factor controlling cell scattering
    • Stella MC, Comoglio PM. Hgf: A multifunctional growth factor controlling cell scattering. Int J Biochem Cell Biol 1999; 31(12): 1357-62.
    • (1999) Int J Biochem Cell Biol , vol.31 , Issue.12 , pp. 1357-1362
    • Stella, M.C.1    Comoglio, P.M.2
  • 171
    • 0025771101 scopus 로고
    • Scatter factor and hepatocyte growth factor are indistinguishable ligands for the met receptor
    • Naldini L, Weidner KM, Vigna E, et al. Scatter factor and hepatocyte growth factor are indistinguishable ligands for the met receptor. EMBO J 1991; 10(10): 2867-78.
    • (1991) EMBO J , vol.10 , Issue.10 , pp. 2867-2878
    • Naldini, L.1    Weidner, K.M.2    Vigna, E.3
  • 172
    • 0142091400 scopus 로고    scopus 로고
    • Functional map and domain structure of met, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor
    • Gherardi E, Youles ME, Miguel RN, et al. Functional map and domain structure of met, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor. Proc Natl Acad Sci USA 2003; 100(21): 12039-44.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.21 , pp. 12039-12044
    • Gherardi, E.1    Youles, M.E.2    Miguel, R.N.3
  • 173
    • 0028351702 scopus 로고
    • A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
    • Ponzetto C, Bardelli A, Zhen Z, et al. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell 1994; 77(2): 261-71.
    • (1994) Cell , vol.77 , Issue.2 , pp. 261-271
    • Ponzetto, C.1    Bardelli, A.2    Zhen, Z.3
  • 174
    • 0030297898 scopus 로고    scopus 로고
    • Uncoupling of grb2 from the met receptor in vivo reveals complex roles in muscle development
    • Maina F, Casagranda F, Audero E, et al. Uncoupling of grb2 from the met receptor in vivo reveals complex roles in muscle development. Cell 1996; 87(3): 531-42.
    • (1996) Cell , vol.87 , Issue.3 , pp. 531-542
    • Maina, F.1    Casagranda, F.2    Audero, E.3
  • 175
    • 0029855280 scopus 로고    scopus 로고
    • Interaction between gab1 and the c-met receptor tyrosine kinase is responsible for epithelial morphogenesis
    • Weidner KM, Di Cesare S, Sachs M, et al. Interaction between gab1 and the c-met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature 1996; 384(6605): 173-6.
    • (1996) Nature , vol.384 , Issue.6605 , pp. 173-176
    • Weidner, K.M.1    Di Cesare, S.2    Sachs, M.3
  • 176
    • 0034613198 scopus 로고    scopus 로고
    • Identification of an atypical grb2 carboxyl-terminal sh3 domain binding site in gab docking proteins reveals grb2-dependent and-independent recruitment of gab1 to receptor tyrosine kinases
    • Lock LS, Royal I, Naujokas MA, Park M. Identification of an atypical grb2 carboxyl-terminal sh3 domain binding site in gab docking proteins reveals grb2-dependent and-independent recruitment of gab1 to receptor tyrosine kinases. J Biol Chem 2000; 275(40): 31536-45.
    • (2000) J Biol Chem , vol.275 , Issue.40 , pp. 31536-31545
    • Lock, L.S.1    Royal, I.2    Naujokas, M.A.3    Park, M.4
  • 177
    • 0029007694 scopus 로고
    • The motogenic and mitogenic responses to hgf are amplified by the shc adaptor protein
    • Pelicci G, Giordano S, Zhen Z, et al. The motogenic and mitogenic responses to hgf are amplified by the shc adaptor protein. Oncogene 1995; 10(8): 1631-8.
    • (1995) Oncogene , vol.10 , Issue.8 , pp. 1631-1638
    • Pelicci, G.1    Giordano, S.2    Zhen, Z.3
  • 178
    • 0032518375 scopus 로고    scopus 로고
    • Induction of epithelial tubules by growth factor hgf depends on the stat pathway
    • Boccaccio C, Ando M, Tamagnone L, et al. Induction of epithelial tubules by growth factor hgf depends on the stat pathway. Nature 1998; 391(6664): 285-8.
    • (1998) Nature , vol.391 , Issue.6664 , pp. 285-288
    • Boccaccio, C.1    Ando, M.2    Tamagnone, L.3
  • 179
    • 15844411673 scopus 로고    scopus 로고
    • Motogenic and morphogenic activity of epithelial receptor tyrosine kinases
    • Sachs M, Weidner KM, Brinkmann V, et al. Motogenic and morphogenic activity of epithelial receptor tyrosine kinases. J Cell Biol 1996; 133(5): 1095-107.
    • (1996) J Cell Biol , vol.133 , Issue.5 , pp. 1095-1107
    • Sachs, M.1    Weidner, K.M.2    Brinkmann, V.3
  • 180
    • 0029999150 scopus 로고    scopus 로고
    • Specific uncoupling of grb2 from the met receptor. Differential effects on transformation and motility
    • Ponzetto C, Zhen Z, Audero E, et al. Specific uncoupling of grb2 from the met receptor. Differential effects on transformation and motility. J Biol Chem 1996; 271(24): 14119-23.
    • (1996) J Biol Chem , vol.271 , Issue.24 , pp. 14119-14123
    • Ponzetto, C.1    Zhen, Z.2    Audero, E.3
  • 181
    • 0033050405 scopus 로고    scopus 로고
    • Mitogenactivated protein kinase (mapk) regulates the expression of progelatinase b (mmp-9) in breast epithelial cells
    • Reddy KB, Krueger JS, Kondapaka SB, Diglio CA. Mitogenactivated protein kinase (mapk) regulates the expression of progelatinase b (mmp-9) in breast epithelial cells. Int J Cancer 1999; 82(2): 268-73.
    • (1999) Int J Cancer , vol.82 , Issue.2 , pp. 268-273
    • Reddy, K.B.1    Krueger, J.S.2    Kondapaka, S.B.3    Diglio, C.A.4
  • 182
    • 0035849787 scopus 로고    scopus 로고
    • Temporal and quantitative regulation of mitogen-activated protein kinase (mapk) modulates cell motility and invasion
    • Krueger JS, Keshamouni VG, Atanaskova N, Reddy KB. Temporal and quantitative regulation of mitogen-activated protein kinase (mapk) modulates cell motility and invasion. Oncogene 2001; 20(31): 4209-18.
    • (2001) Oncogene , vol.20 , Issue.31 , pp. 4209-4218
    • Krueger, J.S.1    Keshamouni, V.G.2    Atanaskova, N.3    Reddy, K.B.4
  • 183
    • 0032990608 scopus 로고    scopus 로고
    • Role of erk and jnk pathways in regulating cell motility and matrix metalloproteinase 9 production in growth factor-stimulated human epidermal keratinocytes
    • Zeigler ME, Chi Y, Schmidt T, Varani J. Role of erk and jnk pathways in regulating cell motility and matrix metalloproteinase 9 production in growth factor-stimulated human epidermal keratinocytes. J Cell Physiol 1999; 180(2): 271-84.
    • (1999) J Cell Physiol , vol.180 , Issue.2 , pp. 271-284
    • Zeigler, M.E.1    Chi, Y.2    Schmidt, T.3    Varani, J.4
  • 184
    • 0035844129 scopus 로고    scopus 로고
    • Mapk/erk overrides the apoptotic signaling from fas, tnf, and trail receptors
    • Tran SE, Holmstrom TH, Ahonen M, Kahari VM, Eriksson JE. Mapk/erk overrides the apoptotic signaling from fas, tnf, and trail receptors. J Biol Chem 2001; 276(19): 16484-90.
    • (2001) J Biol Chem , vol.276 , Issue.19 , pp. 16484-16490
    • Tran, S.E.1    Holmstrom, T.H.2    Ahonen, M.3    Kahari, V.M.4    Eriksson, J.E.5
  • 185
    • 0030927326 scopus 로고    scopus 로고
    • Activation of the jnk pathway is essential for transformation by the met oncogene
    • Rodrigues GA, Park M, Schlessinger J. Activation of the jnk pathway is essential for transformation by the met oncogene. EMBO J 1997; 16(10): 2634-45.
    • (1997) EMBO J , vol.16 , Issue.10 , pp. 2634-2645
    • Rodrigues, G.A.1    Park, M.2    Schlessinger, J.3
  • 186
    • 0032475843 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of focal adhesion kinase stimulated by hepatocyte growth factor leads to mitogen-activated protein kinase activation
    • Chen HC, Chan PC, Tang MJ, Cheng CH, Chang TJ. Tyrosine phosphorylation of focal adhesion kinase stimulated by hepatocyte growth factor leads to mitogen-activated protein kinase activation. J Biol Chem 1998; 273(40): 25777-82.
    • (1998) J Biol Chem , vol.273 , Issue.40 , pp. 25777-25782
    • Chen, H.C.1    Chan, P.C.2    Tang, M.J.3    Cheng, C.H.4    Chang, T.J.5
  • 187
    • 0032735443 scopus 로고    scopus 로고
    • Hgf induces fak activation and integrinmediated adhesion in mtln3 breast carcinoma cells
    • Beviglia L, Kramer RH. Hgf induces fak activation and integrinmediated adhesion in mtln3 breast carcinoma cells. Int J Cancer 1999; 83(5): 640-9.
    • (1999) Int J Cancer , vol.83 , Issue.5 , pp. 640-649
    • Beviglia, L.1    Kramer, R.H.2
  • 188
    • 0031046551 scopus 로고    scopus 로고
    • Expression of scatter factor and cmet receptor in benign and malignant breast tissue
    • Jin L, Fuchs A, Schnitt SJ, et al. Expression of scatter factor and cmet receptor in benign and malignant breast tissue. Cancer 1997; 79(4): 749-60.
    • (1997) Cancer , vol.79 , Issue.4 , pp. 749-760
    • Jin, L.1    Fuchs, A.2    Schnitt, S.J.3
  • 189
    • 8044219670 scopus 로고    scopus 로고
    • Overexpression and activation of hepatocyte growth factor/scatter factor in human nonsmall-cell lung carcinomas
    • Olivero M, Rizzo M, Madeddu R, et al. Overexpression and activation of hepatocyte growth factor/scatter factor in human nonsmall-cell lung carcinomas. Br J Cancer 1996; 74(12): 1862-8.
    • (1996) Br J Cancer , vol.74 , Issue.12 , pp. 1862-1868
    • Olivero, M.1    Rizzo, M.2    Madeddu, R.3
  • 190
    • 0035136177 scopus 로고    scopus 로고
    • Expression of hepatocyte growth factor in human hepatocellular carcinoma
    • Guirouilh J, Le Bail B, Boussarie L, et al. Expression of hepatocyte growth factor in human hepatocellular carcinoma. J Hepatol 2001; 34(1): 78-83.
    • (2001) J Hepatol , vol.34 , Issue.1 , pp. 78-83
    • Guirouilh, J.1    Le Bail, B.2    Boussarie, L.3
  • 191
    • 0037255048 scopus 로고    scopus 로고
    • Hgf, met, and matrix-related proteases in hepatocellular carcinoma, fibrolamellar variant, cirrhotic and normal liver
    • Schoedel KE, Tyner VZ, Kim TH, Michalopoulos GK, Mars WM. Hgf, met, and matrix-related proteases in hepatocellular carcinoma, fibrolamellar variant, cirrhotic and normal liver. Mod Pathol 2003; 16(1): 14-21.
    • (2003) Mod Pathol , vol.16 , Issue.1 , pp. 14-21
    • Schoedel, K.E.1    Tyner, V.Z.2    Kim, T.H.3    Michalopoulos, G.K.4    Mars, W.M.5
  • 192
    • 0036242160 scopus 로고    scopus 로고
    • Expression of hgf/sf and met protein is associated with genetic alterations of vhl gene in primary renal cell carcinomas
    • Oh RR, Park JY, Lee JH, et al. Expression of hgf/sf and met protein is associated with genetic alterations of vhl gene in primary renal cell carcinomas. APMIS 2002; 110(3): 229-38.
    • (2002) APMIS , vol.110 , Issue.3 , pp. 229-238
    • Oh, R.R.1    Park, J.Y.2    Lee, J.H.3
  • 193
    • 0034131506 scopus 로고    scopus 로고
    • Functional expression of hgf and its receptor in human colorectal cancer
    • Otte JM, Schmitz F, Kiehne K, et al. Functional expression of hgf and its receptor in human colorectal cancer. Digestion 2000; 61(4): 237-46.
    • (2000) Digestion , vol.61 , Issue.4 , pp. 237-246
    • Otte, J.M.1    Schmitz, F.2    Kiehne, K.3
  • 194
    • 0028946604 scopus 로고
    • Overexpression and amplification of the met/hgf receptor gene during the progression of colorectal cancer
    • Di Renzo MF, Olivero M, Giacomini A, et al. Overexpression and amplification of the met/hgf receptor gene during the progression of colorectal cancer. Clin Cancer Res 1995; 1(2): 147-54.
    • (1995) Clin Cancer Res , vol.1 , Issue.2 , pp. 147-154
    • Di Renzo, M.F.1    Olivero, M.2    Giacomini, A.3
  • 195
    • 17344381429 scopus 로고    scopus 로고
    • Germline and somatic mutations in the tyrosine kinase domain of the met proto-oncogene in papillary renal carcinomas
    • Schmidt L, Duh FM, Chen F, et al. Germline and somatic mutations in the tyrosine kinase domain of the met proto-oncogene in papillary renal carcinomas. Nat Genet 1997; 16(1): 68-73.
    • (1997) Nat Genet , vol.16 , Issue.1 , pp. 68-73
    • Schmidt, L.1    Duh, F.M.2    Chen, F.3
  • 196
    • 0028940362 scopus 로고
    • Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-offunction mutations of the met receptor in epithelial cells
    • Weidner KM, Sachs M, Riethmacher D, Birchmeier W. Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-offunction mutations of the met receptor in epithelial cells. Proc Natl Acad Sci USA 1995; 92(7): 2597-601.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.7 , pp. 2597-2601
    • Weidner, K.M.1    Sachs, M.2    Riethmacher, D.3    Birchmeier, W.4
  • 197
    • 80053559947 scopus 로고    scopus 로고
    • Activating mutation in met oncogene in familial colorectal cancer
    • Neklason DW, Done MW, Sargent NR, et al. Activating mutation in met oncogene in familial colorectal cancer. BMC Cancer 2011; 11: 424.
    • (2011) BMC Cancer , vol.11 , pp. 424
    • Neklason, D.W.1    Done, M.W.2    Sargent, N.R.3
  • 198
    • 77955353614 scopus 로고    scopus 로고
    • Met receptor sequence variants r970c and t992i lack transforming capacity
    • Tyner JW, Fletcher LB, Wang EQ, et al. Met receptor sequence variants r970c and t992i lack transforming capacity. Cancer Res 2010; 70(15): 6233-7.
    • (2010) Cancer Res , vol.70 , Issue.15 , pp. 6233-6237
    • Tyner, J.W.1    Fletcher, L.B.2    Wang, E.Q.3
  • 199
    • 0033045355 scopus 로고    scopus 로고
    • Clinical significance of c-met oncogene alterations in human colorectal cancer
    • Umeki K, Shiota G, Kawasaki H. Clinical significance of c-met oncogene alterations in human colorectal cancer. Oncology 1999; 56(4): 314-21.
    • (1999) Oncology , vol.56 , Issue.4 , pp. 314-321
    • Umeki, K.1    Shiota, G.2    Kawasaki, H.3
  • 200
    • 0037478437 scopus 로고    scopus 로고
    • Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
    • Pennacchietti S, Michieli P, Galluzzo M, et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 2003; 3(4): 347-61.
    • (2003) Cancer Cell , vol.3 , Issue.4 , pp. 347-361
    • Pennacchietti, S.1    Michieli, P.2    Galluzzo, M.3
  • 201
    • 0027528783 scopus 로고
    • Scatter factor induces blood vessel formation in vivo
    • Grant DS, Kleinman HK, Goldberg ID, et al. Scatter factor induces blood vessel formation in vivo. Proc Natl Acad Sci USA 1993; 90(5): 1937-41.
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.5 , pp. 1937-1941
    • Grant, D.S.1    Kleinman, H.K.2    Goldberg, I.D.3
  • 202
    • 0036531819 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces wnt-independent nuclear translocation of betacatenin after met-beta-catenin dissociation in hepatocytes
    • Monga SP, Mars WM, Pediaditakis P, et al. Hepatocyte growth factor induces wnt-independent nuclear translocation of betacatenin after met-beta-catenin dissociation in hepatocytes. Cancer Res 2002; 62(7): 2064-71.
    • (2002) Cancer Res , vol.62 , Issue.7 , pp. 2064-2071
    • Monga, S.P.1    Mars, W.M.2    Pediaditakis, P.3
  • 203
    • 0034908762 scopus 로고    scopus 로고
    • Oncogenic mutants of ron and met receptor tyrosine kinases cause activation of the beta-catenin pathway
    • Danilkovitch-Miagkova A, Miagkov A, Skeel A, et al. Oncogenic mutants of ron and met receptor tyrosine kinases cause activation of the beta-catenin pathway. Mol Cell Biol 2001; 21(17): 5857-68.
    • (2001) Mol Cell Biol , vol.21 , Issue.17 , pp. 5857-5868
    • Danilkovitch-Miagkova, A.1    Miagkov, A.2    Skeel, A.3
  • 204
    • 0037386758 scopus 로고    scopus 로고
    • C-met expression level in primary colon cancer: A predictor of tumor invasion and lymph node metastases
    • Takeuchi H, Bilchik A, Saha S, et al. C-met expression level in primary colon cancer: A predictor of tumor invasion and lymph node metastases. Clin Cancer Res 2003; 9(4): 1480-8.
    • (2003) Clin Cancer Res , vol.9 , Issue.4 , pp. 1480-1488
    • Takeuchi, H.1    Bilchik, A.2    Saha, S.3
  • 205
    • 33847326735 scopus 로고    scopus 로고
    • Molecular coexpression of the c-met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome
    • Kammula US, Kuntz EJ, Francone TD, et al. Molecular coexpression of the c-met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome. Cancer Lett 2007; 248(2): 219-28.
    • (2007) Cancer Lett , vol.248 , Issue.2 , pp. 219-228
    • Kammula, U.S.1    Kuntz, E.J.2    Francone, T.D.3
  • 207
    • 58149352266 scopus 로고    scopus 로고
    • Macc1, a newly identified key regulator of hgf-met signaling, predicts colon cancer metastasis
    • Stein U, Walther W, Arlt F, et al. Macc1, a newly identified key regulator of hgf-met signaling, predicts colon cancer metastasis. Nat Med 2009; 15(1): 59-67.
    • (2009) Nat Med , vol.15 , Issue.1 , pp. 59-67
    • Stein, U.1    Walther, W.2    Arlt, F.3
  • 208
    • 57749110627 scopus 로고    scopus 로고
    • Micrornas impair metmediated invasive growth
    • Migliore C, Petrelli A, Ghiso E, et al. Micrornas impair metmediated invasive growth. Cancer Res 2008; 68(24): 10128-36.
    • (2008) Cancer Res , vol.68 , Issue.24 , pp. 10128-10136
    • Migliore, C.1    Petrelli, A.2    Ghiso, E.3
  • 209
    • 48849095238 scopus 로고    scopus 로고
    • Microrna mir-199a* regulates the met proto-oncogene and the downstream extracellular signalregulated kinase 2 (erk2)
    • Kim S, Lee UJ, Kim MN, et al. Microrna mir-199a* regulates the met proto-oncogene and the downstream extracellular signalregulated kinase 2 (erk2). J Biol Chem 2008; 283(26): 18158-66.
    • (2008) J Biol Chem , vol.283 , Issue.26 , pp. 18158-18166
    • Kim, S.1    Lee, U.J.2    Kim, M.N.3
  • 210
    • 84859809988 scopus 로고    scopus 로고
    • Mirna profiling in colorectal cancer highlights mir-1 involvement in met-dependent proliferation
    • Reid JF, Sokolova V, Zoni E, et al. Mirna profiling in colorectal cancer highlights mir-1 involvement in met-dependent proliferation. Mol Cancer Res 2012; 10(4): 504-15.
    • (2012) Mol Cancer Res , vol.10 , Issue.4 , pp. 504-515
    • Reid, J.F.1    Sokolova, V.2    Zoni, E.3
  • 211
    • 33746355289 scopus 로고    scopus 로고
    • Hepatocyte growth factor activation inhibitors (hai-1 and hai-2) regulate hgf-induced invasion of human breast cancer cells
    • Parr C, Jiang WG. Hepatocyte growth factor activation inhibitors (hai-1 and hai-2) regulate hgf-induced invasion of human breast cancer cells. Int J Cancer 2006; 119(5): 1176-83.
    • (2006) Int J Cancer , vol.119 , Issue.5 , pp. 1176-1183
    • Parr, C.1    Jiang, W.G.2
  • 212
    • 38049174343 scopus 로고    scopus 로고
    • Structural insight into distinct mechanisms of protease inhibition by antibodies
    • Wu Y, Eigenbrot C, Liang WC, et al. Structural insight into distinct mechanisms of protease inhibition by antibodies. Proc Natl Acad Sci USA 2007; 104(50): 19784-9.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.50 , pp. 19784-19789
    • Wu, Y.1    Eigenbrot, C.2    Liang, W.C.3
  • 213
    • 70350228630 scopus 로고    scopus 로고
    • Therapeutic potential of hepatocyte growth factor/scatter factor neutralizing antibodies: Inhibition of tumor growth in both autocrine and paracrine hepatocyte growth factor/scatter factor: C-met-driven models of leiomyosarcoma
    • Gao CF, Xie Q, Zhang YW, et al. Therapeutic potential of hepatocyte growth factor/scatter factor neutralizing antibodies: Inhibition of tumor growth in both autocrine and paracrine hepatocyte growth factor/scatter factor: C-met-driven models of leiomyosarcoma. Mol Cancer Ther 2009; 8(10): 2803-10.
    • (2009) Mol Cancer Ther , vol.8 , Issue.10 , pp. 2803-2810
    • Gao, C.F.1    Xie, Q.2    Zhang, Y.W.3
  • 214
    • 68649091709 scopus 로고    scopus 로고
    • Rilotumumab, a mab against human hepatocyte growth factor for the treatment of cancer
    • Giordano S. Rilotumumab, a mab against human hepatocyte growth factor for the treatment of cancer. Curr Opin Mol Ther 2009; 11(4): 448-55.
    • (2009) Curr Opin Mol Ther , vol.11 , Issue.4 , pp. 448-455
    • Giordano, S.1
  • 215
    • 76649131263 scopus 로고    scopus 로고
    • Biochemical characterization of amg 102: A neutralizing, fully human monoclonal antibody to human and nonhuman primate hepatocyte growth factor
    • Burgess TL, Sun J, Meyer S, et al. Biochemical characterization of amg 102: A neutralizing, fully human monoclonal antibody to human and nonhuman primate hepatocyte growth factor. Mol Cancer Ther 2010; 9(2): 400-9.
    • (2010) Mol Cancer Ther , vol.9 , Issue.2 , pp. 400-409
    • Burgess, T.L.1    Sun, J.2    Meyer, S.3
  • 216
    • 79955766450 scopus 로고    scopus 로고
    • A phase ii study evaluating the efficacy and safety of amg 102 (rilotumumab) in patients with recurrent glioblastoma
    • Wen PY, Schiff D, Cloughesy TF, et al. A phase ii study evaluating the efficacy and safety of amg 102 (rilotumumab) in patients with recurrent glioblastoma. Neuro Oncol 2011; 13(4): 437-46.
    • (2011) Neuro Oncol , vol.13 , Issue.4 , pp. 437-446
    • Wen, P.Y.1    Schiff, D.2    Cloughesy, T.F.3
  • 217
    • 80051991655 scopus 로고    scopus 로고
    • A phase ii study of the efficacy and safety of amg 102 in patients with metastatic renal cell carcinoma
    • Schoffski P, Garcia JA, Stadler WM, et al. A phase ii study of the efficacy and safety of amg 102 in patients with metastatic renal cell carcinoma. BJU Int 2011; 108(5): 679-86.
    • (2011) BJU Int , vol.108 , Issue.5 , pp. 679-686
    • Schoffski, P.1    Garcia, J.A.2    Stadler, W.M.3
  • 218
    • 77950797736 scopus 로고    scopus 로고
    • Discovery of small molecule c-met inhibitors: Evolution and profiles of clinical candidates
    • Underiner TL, Herbertz T, Miknyoczki SJ. Discovery of small molecule c-met inhibitors: Evolution and profiles of clinical candidates. Anticancer Agents Med Chem 2010; 10(1): 7-27.
    • (2010) Anticancer Agents Med Chem , vol.10 , Issue.1 , pp. 7-27
    • Underiner, T.L.1    Herbertz, T.2    Miknyoczki, S.J.3
  • 219
    • 33644769210 scopus 로고    scopus 로고
    • Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts
    • Kim KJ, Wang L, Su YC, et al. Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts. Clin Cancer Res 2006; 12(4): 1292-8.
    • (2006) Clin Cancer Res , vol.12 , Issue.4 , pp. 1292-1298
    • Kim, K.J.1    Wang, L.2    Su, Y.C.3
  • 220
    • 0031583998 scopus 로고    scopus 로고
    • Hgf/nk4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor
    • Date K, Matsumoto K, Shimura H, Tanaka M, Nakamura T. Hgf/nk4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor. FEBS Lett 1997; 420(1): 1-6.
    • (1997) FEBS Lett , vol.420 , Issue.1 , pp. 1-6
    • Date, K.1    Matsumoto, K.2    Shimura, H.3    Tanaka, M.4    Nakamura, T.5
  • 221
    • 2942555478 scopus 로고    scopus 로고
    • Hepatic gene expression of nk4, an hgf-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice
    • Wen J, Matsumoto K, Taniura N, Tomioka D, Nakamura T. Hepatic gene expression of nk4, an hgf-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice. Cancer Gene Ther 2004; 11(6): 419-30.
    • (2004) Cancer Gene Ther , vol.11 , Issue.6 , pp. 419-430
    • Wen, J.1    Matsumoto, K.2    Taniura, N.3    Tomioka, D.4    Nakamura, T.5
  • 222
    • 33750683969 scopus 로고    scopus 로고
    • A novel one-armed anti-c-met antibody inhibits glioblastoma growth in vivo
    • Martens T, Schmidt NO, Eckerich C, et al. A novel one-armed anti-c-met antibody inhibits glioblastoma growth in vivo. Clin Cancer Res 2006; 12(20 Pt 1): 6144-52.
    • (2006) Clin Cancer Res , vol.12 , Issue.20 PART 1 , pp. 6144-6152
    • Martens, T.1    Schmidt, N.O.2    Eckerich, C.3
  • 223
    • 49249100382 scopus 로고    scopus 로고
    • Metmab, the one-armed 5d5 anti-cmet antibody, inhibits orthotopic pancreatic tumor growth and improves survival
    • Jin H, Yang R, Zheng Z, et al. Metmab, the one-armed 5d5 anti-cmet antibody, inhibits orthotopic pancreatic tumor growth and improves survival. Cancer Res 2008; 68(11): 4360-8.
    • (2008) Cancer Res , vol.68 , Issue.11 , pp. 4360-4368
    • Jin, H.1    Yang, R.2    Zheng, Z.3
  • 224
    • 80555135913 scopus 로고    scopus 로고
    • Role of metmab (oa-5d5) in c-met active lung malignancies
    • Surati M, Patel P, Peterson A, Salgia R. Role of metmab (oa-5d5) in c-met active lung malignancies. Expert Opin Biol Ther 2011; 11(12): 1655-62.
    • (2011) Expert Opin Biol Ther , vol.11 , Issue.12 , pp. 1655-1662
    • Surati, M.1    Patel, P.2    Peterson, A.3    Salgia, R.4
  • 225
    • 37649014199 scopus 로고    scopus 로고
    • Preclinical efficacy of the c-met inhibitor ce-355621 in a u87 mg mouse xenograft model evaluated by 18f-fdg small-animal pet
    • Tseng JR, Kang KW, Dandekar M, et al. Preclinical efficacy of the c-met inhibitor ce-355621 in a u87 mg mouse xenograft model evaluated by 18f-fdg small-animal pet. J Nucl Med 2008; 49(1): 129-34.
    • (2008) J Nucl Med , vol.49 , Issue.1 , pp. 129-134
    • Tseng, J.R.1    Kang, K.W.2    Dandekar, M.3
  • 226
    • 33645518840 scopus 로고    scopus 로고
    • Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor downregulation and hampers biological activity
    • Petrelli A, Circosta P, Granziero L, et al. Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor downregulation and hampers biological activity. Proc Natl Acad Sci USA 2006; 103(13): 5090-5.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.13 , pp. 5090-5095
    • Petrelli, A.1    Circosta, P.2    Granziero, L.3
  • 227
    • 0034650543 scopus 로고    scopus 로고
    • The geldanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-meturokinase plasminogen activator-plasmin proteolytic network
    • Webb CP, Hose CD, Koochekpour S, et al. The geldanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-meturokinase plasminogen activator-plasmin proteolytic network. Cancer Res 2000; 60(2): 342-9.
    • (2000) Cancer Res , vol.60 , Issue.2 , pp. 342-349
    • Webb, C.P.1    Hose, C.D.2    Koochekpour, S.3
  • 228
    • 19844368824 scopus 로고    scopus 로고
    • Geldanamycins exquisitely inhibit hgf/sf-mediated tumor cell invasion
    • Xie Q, Gao CF, Shinomiya N, et al. Geldanamycins exquisitely inhibit hgf/sf-mediated tumor cell invasion. Oncogene 2005; 24(23): 3697-707.
    • (2005) Oncogene , vol.24 , Issue.23 , pp. 3697-3707
    • Xie, Q.1    Gao, C.F.2    Shinomiya, N.3
  • 229
    • 77953196233 scopus 로고    scopus 로고
    • Arq-197, an oral small-molecule inhibitor of c-met for the treatment of solid tumors
    • Bagai R, Fan W, Ma PC. Arq-197, an oral small-molecule inhibitor of c-met for the treatment of solid tumors. IDrugs 2010; 13(6): 404-14.
    • (2010) IDrugs , vol.13 , Issue.6 , pp. 404-414
    • Bagai, R.1    Fan, W.2    Ma, P.C.3
  • 230
    • 77953458271 scopus 로고    scopus 로고
    • Arq 197, a novel and selective inhibitor of the human c-met receptor tyrosine kinase with antitumor activity
    • Munshi N, Jeay S, Li Y, et al. Arq 197, a novel and selective inhibitor of the human c-met receptor tyrosine kinase with antitumor activity. Mol Cancer Ther 2010; 9(6): 1544-53.
    • (2010) Mol Cancer Ther , vol.9 , Issue.6 , pp. 1544-1553
    • Munshi, N.1    Jeay, S.2    Li, Y.3
  • 232
    • 66749185251 scopus 로고    scopus 로고
    • Mp470, a novel receptor tyrosine kinase inhibitor, in combination with erlotinib inhibits the her family/pi3k/akt pathway and tumor growth in prostate cancer
    • Qi W, Cooke LS, Stejskal A, et al. Mp470, a novel receptor tyrosine kinase inhibitor, in combination with erlotinib inhibits the her family/pi3k/akt pathway and tumor growth in prostate cancer. BMC Cancer 2009; 9: 142.
    • (2009) BMC Cancer , vol.9 , pp. 142
    • Qi, W.1    Cooke, L.S.2    Stejskal, A.3
  • 233
    • 33144462553 scopus 로고    scopus 로고
    • Amplification of met may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor pha-665752
    • Smolen GA, Sordella R, Muir B, et al. Amplification of met may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor pha-665752. Proc Natl Acad Sci USA 2006; 103(7): 2316-21.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.7 , pp. 2316-2321
    • Smolen, G.A.1    Sordella, R.2    Muir, B.3
  • 234
    • 10744228765 scopus 로고    scopus 로고
    • A selective small molecule inhibitor of c-met kinase inhibits c-met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo
    • Christensen JG, Schreck R, Burrows J, et al. A selective small molecule inhibitor of c-met kinase inhibits c-met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo. Cancer Res 2003; 63(21): 7345-55.
    • (2003) Cancer Res , vol.63 , Issue.21 , pp. 7345-7355
    • Christensen, J.G.1    Schreck, R.2    Burrows, J.3
  • 235
    • 34249324494 scopus 로고    scopus 로고
    • An orally available small-molecule inhibitor of c-met, pf-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms
    • Zou HY, Li Q, Lee JH, et al. An orally available small-molecule inhibitor of c-met, pf-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res 2007; 67(9): 4408-17.
    • (2007) Cancer Res , vol.67 , Issue.9 , pp. 4408-4417
    • Zou, H.Y.1    Li, Q.2    Lee, J.H.3
  • 236
    • 84055193418 scopus 로고    scopus 로고
    • Crizotinib: In locally advanced or metastatic non-small cell lung cancer
    • Curran MP. Crizotinib: In locally advanced or metastatic non-small cell lung cancer. Drugs 2012; 72(1): 99-107.
    • (2012) Drugs , vol.72 , Issue.1 , pp. 99-107
    • Curran, M.P.1
  • 237
    • 80052840444 scopus 로고    scopus 로고
    • Proteolytic activation of pro-macrophage-stimulating protein by hepsin
    • Ganesan R, Kolumam GA, Lin SJ, et al. Proteolytic activation of pro-macrophage-stimulating protein by hepsin. Mol Cancer Res 2011; 9(9): 1175-86.
    • (2011) Mol Cancer Res , vol.9 , Issue.9 , pp. 1175-1186
    • Ganesan, R.1    Kolumam, G.A.2    Lin, S.J.3
  • 238
    • 17144462419 scopus 로고    scopus 로고
    • Potent and selective inhibitors of the met [hepatocyte growth factor/scatter factor (hgf/sf) receptor] tyrosine kinase block hgf/sf-induced tumor cell growth and invasion
    • Wang X, Le P, Liang C, et al. Potent and selective inhibitors of the met [hepatocyte growth factor/scatter factor (hgf/sf) receptor] tyrosine kinase block hgf/sf-induced tumor cell growth and invasion. Mol Cancer Ther 2003; 2(11): 1085-92.
    • (2003) Mol Cancer Ther , vol.2 , Issue.11 , pp. 1085-1092
    • Wang, X.1    Le, P.2    Liang, C.3
  • 239
    • 33745552897 scopus 로고    scopus 로고
    • Dysregulation of growth factor signaling in human hepatocellular carcinoma
    • Breuhahn K, Longerich T, Schirmacher P. Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene 2006; 25(27): 3787-800.
    • (2006) Oncogene , vol.25 , Issue.27 , pp. 3787-3800
    • Breuhahn, K.1    Longerich, T.2    Schirmacher, P.3
  • 240
    • 83355166909 scopus 로고    scopus 로고
    • Cabozantinib (xl184), a novel met and vegfr2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth
    • Yakes FM, Chen J, Tan J, et al. Cabozantinib (xl184), a novel met and vegfr2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther 2011; 10(12): 2298-308.
    • (2011) Mol Cancer Ther , vol.10 , Issue.12 , pp. 2298-2308
    • Yakes, F.M.1    Chen, J.2    Tan, J.3
  • 241
    • 83255186301 scopus 로고    scopus 로고
    • Multi-targeted tyrosine kinase inhibitors in clinical development: Focus on xl-184 (cabozantinib)
    • Bowles DW, Kessler ER, Jimeno A. Multi-targeted tyrosine kinase inhibitors in clinical development: Focus on xl-184 (cabozantinib). Drugs Today (Barc) 2011; 47(11): 857-68.
    • (2011) Drugs Today (Barc) , vol.47 , Issue.11 , pp. 857-868
    • Bowles, D.W.1    Kessler, E.R.2    Jimeno, A.3
  • 242
    • 79959215032 scopus 로고    scopus 로고
    • Foretinib (gsk1363089), an orally available multikinase inhibitor of c-met and vegfr-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis
    • Zillhardt M, Park SM, Romero IL, et al. Foretinib (gsk1363089), an orally available multikinase inhibitor of c-met and vegfr-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis. Clin Cancer Res 2011; 17(12): 4042-51.
    • (2011) Clin Cancer Res , vol.17 , Issue.12 , pp. 4042-4051
    • Zillhardt, M.1    Park, S.M.2    Romero, I.L.3
  • 243
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the braf gene in human cancer
    • Davies H, Bignell GR, Cox C, et al. Mutations of the braf gene in human cancer. Nature 2002; 417(6892): 949-54.
    • (2002) Nature , vol.417 , Issue.6892 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 244
    • 33745298429 scopus 로고    scopus 로고
    • Rational design of inhibitors that bind to inactive kinase conformations
    • Liu Y, Gray NS. Rational design of inhibitors that bind to inactive kinase conformations. Nat Chem Biol 2006; 2(7): 358-64.
    • (2006) Nat Chem Biol , vol.2 , Issue.7 , pp. 358-364
    • Liu, Y.1    Gray, N.S.2
  • 245
    • 77955602211 scopus 로고    scopus 로고
    • Gatekeeper mutations mediate resistance to braf-targeted therapies
    • Whittaker S, Kirk R, Hayward R, et al. Gatekeeper mutations mediate resistance to braf-targeted therapies. Sci Transl Med 2010; 2(35): 35ra41.
    • (2010) Sci Transl Med , vol.2 , Issue.35
    • Whittaker, S.1    Kirk, R.2    Hayward, R.3
  • 246
    • 4944249117 scopus 로고    scopus 로고
    • Bay 43-9006 exhibits broad spectrum oral antitumor activity and targets the raf/mek/erk pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, et al. Bay 43-9006 exhibits broad spectrum oral antitumor activity and targets the raf/mek/erk pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004; 64(19): 7099-109.
    • (2004) Cancer Res , vol.64 , Issue.19 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 247
    • 84860531989 scopus 로고    scopus 로고
    • A phase i dose-escalation study of regorafenib (bay 73-4506), an inhibitor of oncogenic, angiogenic and stromal kinases, in patients with advanced solid tumors
    • Mross K, Frost A, Steinbild S, et al. A phase i dose-escalation study of regorafenib (bay 73-4506), an inhibitor of oncogenic, angiogenic and stromal kinases, in patients with advanced solid tumors. Clin Cancer Res 2012; 18(9): 2658-67.
    • (2012) Clin Cancer Res , vol.18 , Issue.9 , pp. 2658-2667
    • Mross, K.1    Frost, A.2    Steinbild, S.3
  • 248
    • 79952393631 scopus 로고    scopus 로고
    • Use of DNA microarray and small animal positron emission tomography in preclinical drug evaluation of raf265, a novel b-raf/vegfr-2 inhibitor
    • Tseng JR, Stuart D, Aardalen K, et al. Use of DNA microarray and small animal positron emission tomography in preclinical drug evaluation of raf265, a novel b-raf/vegfr-2 inhibitor. Neoplasia 2011; 13(3): 266-75.
    • (2011) Neoplasia , vol.13 , Issue.3 , pp. 266-275
    • Tseng, J.R.1    Stuart, D.2    Aardalen, K.3
  • 249
    • 77954376912 scopus 로고    scopus 로고
    • Rg7204 (plx4032), a selective brafv600e inhibitor, displays potent antitumor activity in preclinical melanoma models
    • Yang H, Higgins B, Kolinsky K, et al. Rg7204 (plx4032), a selective brafv600e inhibitor, displays potent antitumor activity in preclinical melanoma models. Cancer Res 2010; 70(13): 5518-27.
    • (2010) Cancer Res , vol.70 , Issue.13 , pp. 5518-5527
    • Yang, H.1    Higgins, B.2    Kolinsky, K.3
  • 250
    • 79960233861 scopus 로고    scopus 로고
    • Overcoming metastatic melanoma with braf inhibitors
    • Hong S, Han SB. Overcoming metastatic melanoma with braf inhibitors. Arch Pharm Res 2011; 34(5): 699-701.
    • (2011) Arch Pharm Res , vol.34 , Issue.5 , pp. 699-701
    • Hong, S.1    Han, S.B.2
  • 251
    • 84863230465 scopus 로고    scopus 로고
    • Unresponsiveness of colon cancer to braf(v600e) inhibition through feedback activation of egfr
    • Prahallad A, Sun C, Huang S, et al. Unresponsiveness of colon cancer to braf(v600e) inhibition through feedback activation of egfr. Nature 2012; 483(7387): 100-3.
    • (2012) Nature , vol.483 , Issue.7387 , pp. 100-103
    • Prahallad, A.1    Sun, C.2    Huang, S.3
  • 252
    • 0026690922 scopus 로고
    • Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated a431 cells
    • Seger R, Ahn NG, Posada J, et al. Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated a431 cells. J Biol Chem 1992; 267(20): 14373-81.
    • (1992) J Biol Chem , vol.267 , Issue.20 , pp. 14373-14381
    • Seger, R.1    Ahn, N.G.2    Posada, J.3
  • 253
    • 1242290740 scopus 로고    scopus 로고
    • Mek2 is dispensable for mouse growth and development
    • Belanger LF, Roy S, Tremblay M, et al. Mek2 is dispensable for mouse growth and development. Mol Cell Biol 2003; 23(14): 4778-87.
    • (2003) Mol Cell Biol , vol.23 , Issue.14 , pp. 4778-4787
    • Belanger, L.F.1    Roy, S.2    Tremblay, M.3
  • 254
    • 15744380263 scopus 로고    scopus 로고
    • Structures of human map kinase kinase 1 (mek1) and mek2 describe novel noncompetitive kinase inhibition
    • Ohren JF, Chen H, Pavlovsky A, et al. Structures of human map kinase kinase 1 (mek1) and mek2 describe novel noncompetitive kinase inhibition. Nat Struct Mol Biol 2004; 11(12): 1192-7.
    • (2004) Nat Struct Mol Biol , vol.11 , Issue.12 , pp. 1192-1197
    • Ohren, J.F.1    Chen, H.2    Pavlovsky, A.3
  • 256
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 2000; 351(Pt 1): 95-105.
    • (2000) Biochem J , vol.351 , Issue.PART 1 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 257
    • 0032984348 scopus 로고    scopus 로고
    • Blockade of the map kinase pathway suppresses growth of colon tumors in vivo
    • Sebolt-Leopold JS, Dudley DT, Herrera R, et al. Blockade of the map kinase pathway suppresses growth of colon tumors in vivo. Nat Med 1999; 5(7): 810-6.
    • (1999) Nat Med , vol.5 , Issue.7 , pp. 810-816
    • Sebolt-Leopold, J.S.1    Dudley, D.T.2    Herrera, R.3
  • 258
    • 23944439944 scopus 로고    scopus 로고
    • Phase i and pharmacodynamic study of the oral mek inhibitor ci-1040 in patients with advanced malignancies
    • Lorusso PM, Adjei AA, Varterasian M, et al. Phase i and pharmacodynamic study of the oral mek inhibitor ci-1040 in patients with advanced malignancies. J Clin Oncol 2005; 23(23): 5281-93.
    • (2005) J Clin Oncol , vol.23 , Issue.23 , pp. 5281-5293
    • Lorusso, P.M.1    Adjei, A.A.2    Varterasian, M.3
  • 259
    • 14844285975 scopus 로고    scopus 로고
    • Multicenter phase ii study of the oral mek inhibitor, ci-1040, in patients with advanced nonsmall-cell lung, breast, colon, and pancreatic cancer
    • Rinehart J, Adjei AA, Lorusso PM, et al. Multicenter phase ii study of the oral mek inhibitor, ci-1040, in patients with advanced nonsmall-cell lung, breast, colon, and pancreatic cancer. J Clin Oncol 2004; 22(22): 4456-62.
    • (2004) J Clin Oncol , vol.22 , Issue.22 , pp. 4456-4462
    • Rinehart, J.1    Adjei, A.A.2    Lorusso, P.M.3
  • 260
    • 10344258041 scopus 로고    scopus 로고
    • Targeting the mitogen-activated protein kinase cascade to treat cancer
    • Sebolt-Leopold JS, Herrera R. Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer 2004; 4(12): 937-47.
    • (2004) Nat Rev Cancer , vol.4 , Issue.12 , pp. 937-947
    • Sebolt-Leopold, J.S.1    Herrera, R.2
  • 261
    • 77949766280 scopus 로고    scopus 로고
    • Phase i pharmacokinetic and pharmacodynamic study of the oral mapk/erk kinase inhibitor pd-0325901 in patients with advanced cancers
    • Lorusso PM, Krishnamurthi SS, Rinehart JJ, et al. Phase i pharmacokinetic and pharmacodynamic study of the oral mapk/erk kinase inhibitor pd-0325901 in patients with advanced cancers. Clin Cancer Res 2010; 16(6): 1924-37.
    • (2010) Clin Cancer Res , vol.16 , Issue.6 , pp. 1924-1937
    • Lorusso, P.M.1    Krishnamurthi, S.S.2    Rinehart, J.J.3
  • 262
    • 77951016969 scopus 로고    scopus 로고
    • A phase ii study of pd-0325901, an oral mek inhibitor, in previously treated patients with advanced non-small cell lung cancer
    • Haura EB, Ricart AD, Larson TG, et al. A phase ii study of pd-0325901, an oral mek inhibitor, in previously treated patients with advanced non-small cell lung cancer. Clin Cancer Res 2010; 16(8): 2450-7.
    • (2010) Clin Cancer Res , vol.16 , Issue.8 , pp. 2450-2457
    • Haura, E.B.1    Ricart, A.D.2    Larson, T.G.3
  • 263
    • 34548097240 scopus 로고    scopus 로고
    • Azd6244 (arry-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: Mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models
    • Davies BR, Logie A, Mckay JS, et al. Azd6244 (arry-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: Mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models. Mol Cancer Ther 2007; 6(8): 2209-19.
    • (2007) Mol Cancer Ther , vol.6 , Issue.8 , pp. 2209-2219
    • Davies, B.R.1    Logie, A.2    Mckay, J.S.3
  • 264
    • 40749124035 scopus 로고    scopus 로고
    • The mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor azd6244 (arry-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxel
    • Haass NK, Sproesser K, Nguyen TK, et al. The mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor azd6244 (arry-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxel. Clin Cancer Res 2008; 14(1): 230-9.
    • (2008) Clin Cancer Res , vol.14 , Issue.1 , pp. 230-239
    • Haass, N.K.1    Sproesser, K.2    Nguyen, T.K.3
  • 265
    • 43749103335 scopus 로고    scopus 로고
    • Phase i pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogenactivated protein kinase kinase 1/2 inhibitor azd6244 (arry-142886) in patients with advanced cancers
    • Adjei AA, Cohen RB, Franklin W, et al. Phase i pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogenactivated protein kinase kinase 1/2 inhibitor azd6244 (arry-142886) in patients with advanced cancers. J Clin Oncol 2008; 26(13): 2139-46.
    • (2008) J Clin Oncol , vol.26 , Issue.13 , pp. 2139-2146
    • Adjei, A.A.1    Cohen, R.B.2    Franklin, W.3
  • 266
    • 84859410770 scopus 로고    scopus 로고
    • Phase ii efficacy and pharmacogenomic study of selumetinib (azd6244; arry-142886) in iodine-131 refractory papillary thyroid carcinoma with or without follicular elements
    • Hayes DN, Lucas AS, Tanvetyanon T, et al. Phase ii efficacy and pharmacogenomic study of selumetinib (azd6244; arry-142886) in iodine-131 refractory papillary thyroid carcinoma with or without follicular elements. Clin Cancer Res 2012; 18(7): 2056-65.
    • (2012) Clin Cancer Res , vol.18 , Issue.7 , pp. 2056-2065
    • Hayes, D.N.1    Lucas, A.S.2    Tanvetyanon, T.3
  • 267
    • 84859926095 scopus 로고    scopus 로고
    • Preclinical disposition of gdc-0973 and prospective and retrospective analysis of human dose and efficacy predictions
    • Choo EF, Belvin M, Boggs J, et al. Preclinical disposition of gdc-0973 and prospective and retrospective analysis of human dose and efficacy predictions. Drug Metab Dispos 2012; 40(5): 919-27.
    • (2012) Drug Metab Dispos , vol.40 , Issue.5 , pp. 919-927
    • Choo, E.F.1    Belvin, M.2    Boggs, J.3
  • 268
    • 23844445836 scopus 로고    scopus 로고
    • Colorectal cancer: Mutations in a signalling pathway
    • Parsons DW, Wang TL, Samuels Y, et al. Colorectal cancer: Mutations in a signalling pathway. Nature 2005; 436(7052): 792.
    • (2005) Nature , vol.436 , Issue.7052 , pp. 792
    • Parsons, D.W.1    Wang, T.L.2    Samuels, Y.3
  • 269
    • 58149503692 scopus 로고    scopus 로고
    • Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis
    • Rychahou PG, Kang J, Gulhati P, et al. Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis. Proc Natl Acad Sci USA 2008; 105(51): 20315-20.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.51 , pp. 20315-20320
    • Rychahou, P.G.1    Kang, J.2    Gulhati, P.3
  • 270
    • 33745325973 scopus 로고    scopus 로고
    • Targeted molecular therapy of the pi3k pathway: Therapeutic significance of pi3k subunit targeting in colorectal carcinoma
    • discussion 43-4
    • Rychahou PG, Jackson LN, Silva SR, Rajaraman S, Evers BM. Targeted molecular therapy of the pi3k pathway: Therapeutic significance of pi3k subunit targeting in colorectal carcinoma. Ann Surg 2006; 243(6): 833-42; discussion 43-4.
    • (2006) Ann Surg , vol.243 , Issue.6 , pp. 833-842
    • Rychahou, P.G.1    Jackson, L.N.2    Silva, S.R.3    Rajaraman, S.4    Evers, B.M.5
  • 271
    • 77952311165 scopus 로고    scopus 로고
    • Novel expression patterns of pi3k/akt/mtor signaling pathway components in colorectal cancer
    • Johnson SM, Gulhati P, Rampy BA, et al. Novel expression patterns of pi3k/akt/mtor signaling pathway components in colorectal cancer. J Am Coll Surg 2010; 210(5): 767-76, 76-8.
    • (2010) J Am Coll Surg , vol.210 , Issue.5
    • Johnson, S.M.1    Gulhati, P.2    Rampy, B.A.3
  • 272
    • 80051590039 scopus 로고    scopus 로고
    • Preclinical characterization of osi-027, a potent and selective inhibitor of mtorc1 and mtorc2: Distinct from rapamycin
    • Bhagwat SV, Gokhale PC, Crew AP, et al. Preclinical characterization of osi-027, a potent and selective inhibitor of mtorc1 and mtorc2: Distinct from rapamycin. Mol Cancer Ther 2011; 10(8): 1394-406.
    • (2011) Mol Cancer Ther , vol.10 , Issue.8 , pp. 1394-1406
    • Bhagwat, S.V.1    Gokhale, P.C.2    Crew, A.P.3
  • 273
    • 75149112670 scopus 로고    scopus 로고
    • Azd8055 is a potent, selective, and orally bioavailable atp-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity
    • Chresta CM, Davies BR, Hickson I, et al. Azd8055 is a potent, selective, and orally bioavailable atp-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. Cancer Res 2010; 70(1): 288-98.
    • (2010) Cancer Res , vol.70 , Issue.1 , pp. 288-298
    • Chresta, C.M.1    Davies, B.R.2    Hickson, I.3
  • 274
    • 80053169195 scopus 로고    scopus 로고
    • The dual pi3k/mtor inhibitor nvp-bez235 induces tumor regression in a genetically engineered mouse model of pik3ca wild-type colorectal cancer
    • Roper J, Richardson MP, Wang WV, et al. The dual pi3k/mtor inhibitor nvp-bez235 induces tumor regression in a genetically engineered mouse model of pik3ca wild-type colorectal cancer. PLoS One 2011; 6(9): e25132.
    • (2011) PLoS One , vol.6 , Issue.9
    • Roper, J.1    Richardson, M.P.2    Wang, W.V.3
  • 275
    • 84857961934 scopus 로고    scopus 로고
    • Antitumor activities of atp-competitive inhibitors of mtor in colon cancer cells
    • Blaser B, Waselle L, Dormond-Meuwly A, et al. Antitumor activities of atp-competitive inhibitors of mtor in colon cancer cells. BMC Cancer 2012; 12: 86.
    • (2012) BMC Cancer , vol.12 , pp. 86
    • Blaser, B.1    Waselle, L.2    Dormond-Meuwly, A.3
  • 276
    • 84861539889 scopus 로고    scopus 로고
    • An update on the current and emerging targeted agents in metastatic colorectal cancer
    • Chu E. An update on the current and emerging targeted agents in metastatic colorectal cancer. Clin Colorectal Cancer 2012; 11(1): 1-13.
    • (2012) Clin Colorectal Cancer , vol.11 , Issue.1 , pp. 1-13
    • Chu, E.1
  • 277
    • 84859948881 scopus 로고    scopus 로고
    • Perifosine, an oral, anti-cancer agent and inhibitor of the akt pathway: Mechanistic actions, pharmacodynamics, pharmacokinetics, and clinical activity
    • Richardson PG, Eng C, Kolesar J, Hideshima T, Anderson KC. Perifosine, an oral, anti-cancer agent and inhibitor of the akt pathway: Mechanistic actions, pharmacodynamics, pharmacokinetics, and clinical activity. Expert Opin Drug Metab Toxicol 2012; 8(5): 623-33.
    • (2012) Expert Opin Drug Metab Toxicol , vol.8 , Issue.5 , pp. 623-633
    • Richardson, P.G.1    Eng, C.2    Kolesar, J.3    Hideshima, T.4    Anderson, K.C.5
  • 278
    • 81755172138 scopus 로고    scopus 로고
    • Randomized placebocontrolled phase ii trial of perifosine plus capecitabine as secondor third-line therapy in patients with metastatic colorectal cancer
    • Bendell JC, Nemunaitis J, Vukelja SJ, et al. Randomized placebocontrolled phase ii trial of perifosine plus capecitabine as secondor third-line therapy in patients with metastatic colorectal cancer. J Clin Oncol 2011; 29(33): 4394-400.
    • (2011) J Clin Oncol , vol.29 , Issue.33 , pp. 4394-4400
    • Bendell, J.C.1    Nemunaitis, J.2    Vukelja, S.J.3
  • 279
    • 48649092117 scopus 로고    scopus 로고
    • High-resolution melting analysis for rapid detection of kras, braf, and pik3ca gene mutations in colorectal cancer
    • Simi L, Pratesi N, Vignoli M, et al. High-resolution melting analysis for rapid detection of kras, braf, and pik3ca gene mutations in colorectal cancer. Am J Clin Pathol 2008; 130(2): 247-53.
    • (2008) Am J Clin Pathol , vol.130 , Issue.2 , pp. 247-253
    • Simi, L.1    Pratesi, N.2    Vignoli, M.3
  • 280
    • 79955420135 scopus 로고    scopus 로고
    • Induction of met by ionizing radiation and its role in radioresistance and invasive growth of cancer
    • De Bacco F, Luraghi P, Medico E, et al. Induction of met by ionizing radiation and its role in radioresistance and invasive growth of cancer. J Natl Cancer Inst 2011; 103(8): 645-61.
    • (2011) J Natl Cancer Inst , vol.103 , Issue.8 , pp. 645-661
    • de Bacco, F.1    Luraghi, P.2    Medico, E.3
  • 281
    • 76749097199 scopus 로고    scopus 로고
    • Mk-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-met receptor
    • Pan BS, Chan GK, Chenard M, et al. Mk-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-met receptor. Cancer Res 2010; 70(4): 1524-33.
    • (2010) Cancer Res , vol.70 , Issue.4 , pp. 1524-1533
    • Pan, B.S.1    Chan, G.K.2    Chenard, M.3
  • 282
    • 84862738310 scopus 로고    scopus 로고
    • Sensitivity of selected human tumor models to pf-04217903, a novel selective c-met kinase inhibitor
    • Zou HY, Li Q, Lee JH, et al. Sensitivity of selected human tumor models to pf-04217903, a novel selective c-met kinase inhibitor. Mol Cancer Ther 2012; 11(4): 1036-47.
    • (2012) Mol Cancer Ther , vol.11 , Issue.4 , pp. 1036-1047
    • Zou, H.Y.1    Li, Q.2    Lee, J.H.3
  • 283
    • 80051564889 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of sorafenib combined with capecitabine in patients with advanced solid tumors: Results of a phase 1 trial
    • Awada A, Gil T, Whenham N, et al. Safety and pharmacokinetics of sorafenib combined with capecitabine in patients with advanced solid tumors: Results of a phase 1 trial. J Clin Pharmacol 2011; 51(12): 1674-84.
    • (2011) J Clin Pharmacol , vol.51 , Issue.12 , pp. 1674-1684
    • Awada, A.1    Gil, T.2    Whenham, N.3
  • 284
    • 79952001479 scopus 로고    scopus 로고
    • Role of cetuximab and sorafenib in treatment of metastatic colorectal cancer
    • Galal KM, Khaled Z, Mourad AM. Role of cetuximab and sorafenib in treatment of metastatic colorectal cancer. Indian J Cancer 2011; 48(1): 47-54.
    • (2011) Indian J Cancer , vol.48 , Issue.1 , pp. 47-54
    • Galal, K.M.1    Khaled, Z.2    Mourad, A.M.3
  • 285
    • 84863012433 scopus 로고    scopus 로고
    • Antitumor activity of braf inhibitor vemurafenib in preclinical models of braf-mutant colorectal cancer
    • Yang H, Higgins B, Kolinsky K, et al. Antitumor activity of braf inhibitor vemurafenib in preclinical models of braf-mutant colorectal cancer. Cancer Res 2012; 72(3): 779-89.
    • (2012) Cancer Res , vol.72 , Issue.3 , pp. 779-789
    • Yang, H.1    Higgins, B.2    Kolinsky, K.3
  • 286
    • 84855415767 scopus 로고    scopus 로고
    • Intermittent administration of mek inhibitor gdc-0973 plus pi3k inhibitor gdc-0941 triggers robust apoptosis and tumor growth inhibition
    • Hoeflich KP, Merchant M, Orr C, et al. Intermittent administration of mek inhibitor gdc-0973 plus pi3k inhibitor gdc-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res 2012; 72(1): 210-9.
    • (2012) Cancer Res , vol.72 , Issue.1 , pp. 210-219
    • Hoeflich, K.P.1    Merchant, M.2    Orr, C.3
  • 287
    • 84859412782 scopus 로고    scopus 로고
    • Enhanced apoptosis and tumor growth suppression elicited by combination of mek (selumetinib) and mtor kinase inhibitors (azd8055)
    • Holt SV, Logie A, Davies BR, et al. Enhanced apoptosis and tumor growth suppression elicited by combination of mek (selumetinib) and mtor kinase inhibitors (azd8055). Cancer Res 2012; 72(7): 1804-13.
    • (2012) Cancer Res , vol.72 , Issue.7 , pp. 1804-1813
    • Holt, S.V.1    Logie, A.2    Davies, B.R.3
  • 288
    • 80052197143 scopus 로고    scopus 로고
    • A phase ii trial of bevacizumab plus everolimus for patients with refractory metastatic colorectal cancer
    • Altomare I, Bendell JC, Bullock KE, et al. A phase ii trial of bevacizumab plus everolimus for patients with refractory metastatic colorectal cancer. Oncologist 2011; 16(8): 1131-7.
    • (2011) Oncologist , vol.16 , Issue.8 , pp. 1131-1137
    • Altomare, I.1    Bendell, J.C.2    Bullock, K.E.3
  • 289
    • 84865562515 scopus 로고    scopus 로고
    • Phase i safety, pharmacokinetic, and pharmacodynamic study of the oral phosphatidylinositol-3-kinase and mtor inhibitor bgt226 in patients with advanced solid tumors
    • Markman B, Tabernero J, Krop I, et al. Phase i safety, pharmacokinetic, and pharmacodynamic study of the oral phosphatidylinositol-3-kinase and mtor inhibitor bgt226 in patients with advanced solid tumors. Ann Oncol 2012.
    • (2012) Ann Oncol
    • Markman, B.1    Tabernero, J.2    Krop, I.3
  • 290
    • 84856071447 scopus 로고    scopus 로고
    • Phase i, dose-escalation study of bkm120, an oral pan-class i pi3k inhibitor, in patients with advanced solid tumors
    • Bendell JC, Rodon J, Burris HA, et al. Phase i, dose-escalation study of bkm120, an oral pan-class i pi3k inhibitor, in patients with advanced solid tumors. J Clin Oncol 2012; 30(3): 282-90.
    • (2012) J Clin Oncol , vol.30 , Issue.3 , pp. 282-290
    • Bendell, J.C.1    Rodon, J.2    Burris, H.A.3
  • 291
    • 83255162603 scopus 로고    scopus 로고
    • First-in-man clinical trial of the oral pan-akt inhibitor mk-2206 in patients with advanced solid tumors
    • Yap TA, Yan L, Patnaik A, et al. First-in-man clinical trial of the oral pan-akt inhibitor mk-2206 in patients with advanced solid tumors. J Clin Oncol 2011; 29(35): 4688-95.
    • (2011) J Clin Oncol , vol.29 , Issue.35 , pp. 4688-4695
    • Yap, T.A.1    Yan, L.2    Patnaik, A.3


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