Detection of point mutations of the AXIN1 gene in colorectal cancers

International Journal of Cancer

Volumn 107, Issue 5, 2003, Pages 696-699

  Jin, Li Hua ^a   Shao, Qiu Jie ^b   Luo, Wen ^a   Ye, Zhi Yun ^a   Li, Qing ^b   Lin, Sheng Cai ^a,c  

^a XIAMEN UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

AXIN1; Colorectal cancers; PCR SSCP

Indexed keywords

DNA;

ADULT; AGED; ARTICLE; AXIN1 GENE; CARCINOGENESIS; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; GENE AMPLIFICATION; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; GENE STRUCTURE; HUMAN; HUMAN TISSUE; INTRON; LIVER CANCER; MALE; MISSENSE MUTATION; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BASE SEQUENCE; COLONIC NEOPLASMS; COLORECTAL NEOPLASMS; EXONS; HUMANS; MUTATION, MISSENSE; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTEINS; RECTAL NEOPLASMS; REPRESSOR PROTEINS;

EID: 0242268881     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11435     Document Type: Article

References (29)

1. Zeng L, Fagotto F, Zhang T, Hsu W, Vasicek TJ, Perry WL 3rd, Lee JJ, Tilghman SM, Gumbiner BM, Costantini F. The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell 1997;90:181-92.
2. Peifer M, Polakis P. Wnt signaling in oncogenesis and embryogenesis-a look outside the nucleus. Science 2000;287:1606-9.
3. Behrens J, von Kries JP, Kuhl M, Bruhn L, Wedlich D, Grosschedl R, Birchmeier W. Functional interaction of β-catenin with the transcription factor LEF-1. Nature 1996;382:638-42.
4. Shtutman M, Zhurinsky J, Simcha I. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Nat Acad Sci U S A 1999;96:5522-7.
5. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW. Identification of c-MYC as a Target of the APC Pathway. Science 1998;281:1509-12.
6. Neo SY, Zhang Y, Yaw LP, Li P, Lin SC. Axin-induced apoptosis depends on the extent of its JNK activation and its ability to down-regulate beta-catenin levels. Biochem Biophys Res Commun 2000;272:144-50.
7. Rui HL, Fan E, Zhou H, Xu Z, Zhang Y, Lin SC. SUMO-1 modification of the carboxyl-terminal KVEKVD of Axin is required for JNK activation, but has no effect on Wnt signaling. J Biol Chem 2002;277:42981-6.
8. Dahmen RP, Koch A, Denkhaus D, Tonn JC, Sorensen N, Berthold F, Behrens J, Birchmeier W, Wiestler OD, Pietsch T. Deletions of AXIN1, a Component of the WNT/wingless Pathway, in Sporadic Medulloblastomas. Cancer Res 2001;61:7039-43.
9. Baeza N, Masuoka J, Kleihues P, Ohgaki H. AXIN1 mutations but not deletions in cerebellar medulloblastomas. Oncogene 2003:22:632-6.
10. Wu R, Zhai Y, Fearon ER, Cho KR. Diverse mechanisms of beta-catenin deregulation in ovarian endometrioid adenocarcinomas. Cancer Res 2001;61:8247-55.
11. Satoh S, Daigo Y, Furukawa Y, Kato T, Miwa N, Nishiwaki T, Kawasoe T, Ishiguro H, Fujita M, Tokino T, Sasaki Y, Imaoka S, et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet 2000;24:245-50.
12. Taniguchi K, Roberts LR, Aderca IN, Dong X, Qian C, Murphy LM, Nagorney DM, Burgart LJ, Roche PC, Smith DI, Ross JA, Liu W. Mutational spectrum of β-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene 2002;21:4863-71.
13. Koch A, Waha A, Tonn JC, Sorensen N, Berthold F, Wolter M, Reifenberger J, Hartmann W, Friedl W, Reifenberger G, Wiestler OD, Pietsch T. Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors. Int J Cancer 2001;93:445-9.
14. Webster MT, Rozycka M, Sara E, Davis E, Smalley M, Young N, Dale TC, Wooster R. Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding. Genes Chromosomes Cancer 2000;28:443-53.
15. Miyoshi Y, Nagase H, Ando H, Horii A, Ichii S, Nakatsuru S, Aoki T, Miki Y, Mori T, Nakamura Y. Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet 1992;1:229-33.
16. Lu M, Nakamura RM, Dent ED, Zhang JY, Nielsen FC, Christiansen J, Chan EK, Tan EM. Aberrant expression of fetal RNA-binding protein p62 in liver cancer and liver cirrhosis. Am J Pathol. 2001;159:945-53.
17. Sambrook J, Russell DW. Molecular Cloning, 3rd ed. New York: Cold Spring Harbor Laboratory, 2001. 5.61.
18. Budowle B, Chakraborty R, Giusti AM, Eisenberg AJ, Allen RC. Analysis of the VNTR Locus DIS80 by the PCR Followed by High-Resolution PAGE. Am J Hum Genet 1991;48:137-44.
19. Lin YM, Kato T, Satoh S, Nakamura Y, Furukawa Y. Identification of novel polymorphisms in the AXIN1 and CDX-2 genes. J Hum Genet; 2000;45:254-6.
20. Fukui A, Kishida S, Kikuchi A, Asashima M. Effects of rat Axin domain on axis formation in Xenopus embryos. Dev Growth Diff 2000;42:489-98.
21. Julius MA, Schelbert B, Hsu W, Fitzpatrick E, Jho E, Fagotto F, Costantini F, Kitajewski J. Domains of axin and disheveled required for interaction and function in wnt signaling. Biochem Biophys Res Commun 2000;276:1162-9.
22. Sakanaka C, Williams LT. Functional domains of axin-importance of the C terminus as an oligomerization domain. J Biol Chem 1999;274:14090-3.
23. Zhang Y, Neo SY, Wang X, Han J, Lin SC. Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signalling. J Biol Chem 1999;274:35247-54.
24. Zhang Y, Neo SY, Han J, Lin SC. Dimerization choices control the ability of Axin and Dishevelled to activate c-Jun NH2-terminal kinase/stress-activated protein kinase. J Biol Chem 2000;275:25008-14.
25. Powell SM, Zilz N, Beazer-Barclay Y, Bryan TM, Hamilton SR, Thibodeau SN, Vogelstein B, Kinzler KW. APC mutations occur early during colorectal tumorigenesis. Nature 1992;359:235-7.
26. Hart MJ, de los Santos R, Albert IN, Rubinfeld B, Polakis P. Down-regulation of beta-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK-3β. Curr Biol 1998;8:573-81.
27. Kikuchi A. Modulation of Wnt signaling by axin and axil. Cytokine Growth Factor Rev 1999;10:255-265.
28. Spink KE, Polakis P, Weis WI. Structure basis of the Axin-adenomatous polyposis coli interaction. EMBO 2000;19:2270-9.
29. Hinoi T, Yamamoto H, Kishida M, Takada S, Kishida S, Kikuchi A. Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3β-dependent phosphorylation of β-catenin and down-regulates β-catenin. J Biol Chem 2000;275:34399-406.