β-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas

Cancer Research

Volumn 59, Issue 7, 1999, Pages 1442-1444

  Samowitz, Wade S ^a   Powers, Michael D ^b   Spirio, Lisa N ^c   Nollet, Friedel ^d   Van Roy, Frans ^d   Slattery, Martha L ^b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^d GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN;

ADENOMA; AMINO ACID SUBSTITUTION; ARTICLE; CANCER INVASION; COLORECTAL CANCER; DNA SEQUENCE; GENE MUTATION; HUMAN; HUMAN TISSUE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

ADENOMA; AGED; BETA CATENIN; COLORECTAL NEOPLASMS; CYTOSKELETAL PROTEINS; GENES, APC; HUMANS; MIDDLE AGED; MUTATION; TRANS-ACTIVATORS;

EID: 0033119582     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Korinek, V., Barker, N., Morin, P. J., van Wichen, D., de Weger, R., Kinzler, K. W., Vogelstein, B., and Clevers, H. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC -/- colon carcinoma. Science (Washington DC), 275: 1784-1787, 1997.
2. Kinzler, W., and Vogelstein, B. Lessons from hereditary colorectal cancer. Cell, 87: 159-170, 1996.
3. Munemitsu, S., Albert, I., Souza, B., Rubinfeld, B., and Polakis, P. Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc. Natl. Acad. Sci. USA, 92: 3046-3050, 1995.
4. Morin, P. J., Sparks, A. B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., and Kinzler, K. W. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science (Washington DC), 275: 1787-1790, 1997.
5. Sparks, A. B., Morin, P. J., Vogelstein, B., Kinzler, and K. W. Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer. Cancer Res., 58: 1130-1134, 1998.
6. Kitaeva, M. N., Grogan, L., Williams, J. P., Dimond, E., Nakahara, K., Hausner, P., DeNobile, J. W., Soballe, P. W., and Kirsch, I. R. Mutations in β-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumors. Cancer Res., 57: 4478-4481, 1997.
7. Samowitz, W. S., Slattery, M. L., and Kerber, R. A. Microsatellite instability in human colonic cancer is not a useful clinical indicator of familial colorectal cancer. Gastroenterology, 109: 1765-1771, 1995.
8. Samowitz, W. S., and Slattery, M. L. Microsatellite instability in colorectal adenomas. Gastroenterology, 112: 1515-1519, 1997.
9. Samowitz, W. S., and Slattery, M. L. Transforming growth factor β receptor type 2 mutations and microsatellite instability in sporadic colorectal adenomas and carcinomas. Am. J. Pathol., 151: 33-35, 1997.
10. Spirio, L. N., Samowitz, W. S., Robertson, J., Robertson, M., Burt, R. W., Leppert, M. L., and White, R. Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps. Nat. Genet., 20: 385-388, 1998.
11. Takahashi, M., Fukuda, K., Sugimura, T., and Wakabayashi, K. β-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors. Cancer Res., 58: 42-46, 1998.
12. Miyoshi, Y., Iwao, K., Nagasawa, Y., Aihara, T., Sasaki, Y., Imaoka, S., Murata, M., Shimano, T., and Nakamura, Y. Activation of the β-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Res., 58: 2524-2527, 1998.
13. Iwao, K., Nakamori, S., Kameyama, M., Imaoka, S., Kinoshita, M., Fukui, T., Ishiguro, S., Nakamura, Y., and Miyoshi, Y. Activation of the β-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations. Cancer Res., 58: 1021-1026, 1998.
14. Powell, S. M., Zilz, N., Beazer-Barclay, Y., Bryan, T. M., Hamilton, S. R., Thibodeau, S. N., Vogelstein, B., and Kinzler, K. APC mutations occur early during colorectal tumorigenesis. Nature (Lond.), 359: 235-237, 1992.
15. Konishi, M., Kikuchi-Yanoshita, R., Tanaka, K., Muraoka, M., Onda, A., Okumura, Y., Kishi, N., Iwama, T., Mori, T., Koike, M., Ushio, K., Chiba, M., Nomizu, S., Konishi, F., Utsunomiya, J., and Miyaki M. Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. Gastroenterology. 111: 307-317, 1996.
16. Aaltonen, L. A., Peltomaki, P., Mecklin, J. P., Jarvinen, H., Jass, J. R., Green, J. S., Lynch, H. T., Watson, P., Tallqvist, G., Juhola, M., Sistonen, P., Hamilton, S. R., Kinzler, K. W., Vogelstein, B., and de la Chapelle, A. Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients. Cancer Res., 54: 1645-1648, 1994.
17. Young, J., Leggett, B., Gustafson, C., Ward, M., Searle, J., Thomas, L., Buttenshaw, R., Chenevix-Trench G. Genomic instability occurs in colorectal carcinomas but not in adenomas. Hum. Mutat., 2: 351-354, 1993.
18. Lothe, R. A., Andersen, S. N., Hofstad, B., Meling, G. I., Peltomaki, P., Heim, S., Brogger, A., Vatn, M., Rognum, T. O., and Borresen, A-L. Deletion of 1p loci and microsatellile instability in colorectal polyps. Genes Chromosomes Cancer, 14: 182-188, 1995.
19. Huang, J., Papadopoulos, N., McKinley, A. J., Farrington, S. M., Curtis, L. J., Wyllie, A. H., Zheng, S., Willson, J. K. V., Markowitz, S. D., Morin, P., Kinzler, K. W., Vogelstein, B., and Dunlop, M. G. APC mutations in colorectal tumors with mismatch repair deficiency. Proc. Natl. Acad. Sci. USA. 93: 9049-9054, 1996.
20. Olschwang, S., Hamelin, R., Laurent-Puig, P. Thuille, B., De Rycke, Y., Li, Y., Muzeau, F., Girodet, J., Salmon, R., and Thomas, G. Alternative genetic pathways in colorectal carcinogenesis. Proc. Natl. Acad. Sci. USA. 94: 12122-12127, 1997.