Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer

Oncogene

Volumn 25, Issue 29, 2006, Pages 4116-4121

  Aguilera, O ^a   Fraga, M F ^b   Ballestar, E ^b   Paz, M F ^b   Herranz, M ^b   Espada, J ^b   Garcia J M ^c   Muoz A ^a   Esteller, M ^b   Gonzalez Sancho J M ^a  

^a INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^b Centro Nacional de Investigaciones Oncológicas   (Spain)

^c HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

Author keywords

Colorectal cancer; DICKKOPF 1; Promoter methylation; Wnt

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; APC PROTEIN; BETA CATENIN; INHIBITOR PROTEIN; PROTEIN DICKKOPF 1; REGULATOR PROTEIN; SECRETED FRIZZLED RELATED PROTEIN; T CELL FACTOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; WNT INHIBITOR FACTOR 1; WNT PROTEIN;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CARCINOGENESIS; COLONY FORMATION; COLORECTAL CANCER; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EPIGENETICS; GENE; GENE EXPRESSION; GENE INACTIVATION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; METHYLATION; NUDE MOUSE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; CARRIER PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; COLON; COLORECTAL NEOPLASMS; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; EPITHELIUM; GENES, TUMOR SUPPRESSOR; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANSPLANTATION, HETEROLOGOUS; WNT PROTEINS;

MUS MUSCULUS;

EID: 33745765883     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209439     Document Type: Article

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