Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Lu, Wenyan ^a   Lin, Cuihong ^a   Roberts, Michael J ^a   Waud, William R ^a   Piazza, Gary A ^b   Li, Yonghe ^a  

^a SOUTHERN RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF SOUTH ALABAMA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; DISHEVELLED 2; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; NICLOSAMIDE; WNT PROTEIN; DISHEVELLED PROTEINS; LRP6 PROTEIN, HUMAN; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TUMOR PROTEIN; WNT3A PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL PROLIFERATION; CELL STRAIN HEK293; CELL SURFACE; CONTROLLED STUDY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; PROSTATE CANCER; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; BREAST TUMOR; DRUG EFFECT; DRUG SCREENING; FEMALE; MALE; METABOLISM; NEOPLASM; PATHOLOGY; PHOSPHORYLATION; PROSTATE TUMOR; TUMOR CELL LINE; WNT SIGNALING PATHWAY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; BETA CATENIN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HEK293 CELLS; HUMANS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-6; MALE; NEOPLASM PROTEINS; NEOPLASMS; NICLOSAMIDE; PHOSPHOPROTEINS; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEOLYSIS; WNT PROTEINS; WNT SIGNALING PATHWAY; WNT3A PROTEIN;

EID: 83455182133     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029290     Document Type: Article

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