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Volumn 243, Issue 6, 2006, Pages 833-842

Targeted molecular therapy of the PI3K pathway: Therapeutic significance of PI3K subunit targeting in colorectal carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN KINASE B BETA; PROTEIN P110; PROTEIN P85; SMALL INTERFERING RNA; RNA;

EID: 33745325973     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.sla.0000220040.66012.a9     Document Type: Article
Times cited : (98)

References (62)
  • 2
    • 0033604577 scopus 로고    scopus 로고
    • Signaling by distinct classes of phosphoinositide 3-kinases
    • Vanhaesebroeck B, Waterfield MD. Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res. 1999;253:239-254.
    • (1999) Exp Cell Res , vol.253 , pp. 239-254
    • Vanhaesebroeck, B.1    Waterfield, M.D.2
  • 3
    • 0036829983 scopus 로고    scopus 로고
    • The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras
    • Jimenez C, Hernandez C, Pimentel B, et al. The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras. J Biol Chem. 2002;277:41556-41562.
    • (2002) J Biol Chem , vol.277 , pp. 41556-41562
    • Jimenez, C.1    Hernandez, C.2    Pimentel, B.3
  • 4
    • 0035886016 scopus 로고    scopus 로고
    • The phosphatidylinositol 3′-kinase p85{alpha} gene is an oncogene in human ovarian and colon tumors
    • Philp AJ, Campbell IG, Leet C, et al. The phosphatidylinositol 3′-kinase p85{alpha} gene is an oncogene in human ovarian and colon tumors. Cancer Res. 2001;61:7426-7429.
    • (2001) Cancer Res , vol.61 , pp. 7426-7429
    • Philp, A.J.1    Campbell, I.G.2    Leet, C.3
  • 5
    • 1242307944 scopus 로고    scopus 로고
    • Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma
    • Khaleghpour K, Li Y, Banville D, et al. Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma. Carcinogenesis. 2004;25:241-248.
    • (2004) Carcinogenesis , vol.25 , pp. 241-248
    • Khaleghpour, K.1    Li, Y.2    Banville, D.3
  • 6
    • 1642535579 scopus 로고    scopus 로고
    • Roles of phosphatidylinositol 3′-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial cells
    • Shao J, Evers BM, Sheng H. Roles of phosphatidylinositol 3′-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial cells. Cancer Res. 2004;64:229-235.
    • (2004) Cancer Res , vol.64 , pp. 229-235
    • Shao, J.1    Evers, B.M.2    Sheng, H.3
  • 7
    • 7444250290 scopus 로고    scopus 로고
    • Mutation of the PIK3CA gene in ovarian and breast cancer
    • Campbell IG, Russell SE, Choong DY, et al. Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res. 2004;64:7678-7681.
    • (2004) Cancer Res , vol.64 , pp. 7678-7681
    • Campbell, I.G.1    Russell, S.E.2    Choong, D.Y.3
  • 8
    • 0032472913 scopus 로고    scopus 로고
    • Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase
    • Jimenez C, Jones DR, Rodriguez-Viciana P, et al. Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase. EMBO J. 1998;17:743-753.
    • (1998) EMBO J , vol.17 , pp. 743-753
    • Jimenez, C.1    Jones, D.R.2    Rodriguez-Viciana, P.3
  • 9
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature. 2001;411:355-365.
    • (2001) Nature , vol.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 10
    • 0036898614 scopus 로고    scopus 로고
    • Down-regulation of PIK3CG, a catalytic subunit of phosphatidylinositol 3-OH kinase, by CpG hypermethylation in human colorectal carcinoma
    • Semba S, Itoh N, Ito M, et al. Down-regulation of PIK3CG, a catalytic subunit of phosphatidylinositol 3-OH kinase, by CpG hypermethylation in human colorectal carcinoma. Clin Cancer Res. 2002;8:3824-3831.
    • (2002) Clin Cancer Res , vol.8 , pp. 3824-3831
    • Semba, S.1    Itoh, N.2    Ito, M.3
  • 12
    • 0026095665 scopus 로고
    • A retroviral oncogene, Akt, encoding a serine-threonine kinase containing an Sh2-like region
    • Bellacosa A, Testa JR, Staal SP, et al. A retroviral oncogene, Akt, encoding a serine-threonine kinase containing an Sh2-like region. Science. 1991;254:274-277.
    • (1991) Science , vol.254 , pp. 274-277
    • Bellacosa, A.1    Testa, J.R.2    Staal, S.P.3
  • 13
    • 0036195196 scopus 로고    scopus 로고
    • AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis
    • Roy HK, Olusola BF, Clemens DL, et al. AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Carcinogenesis. 2002;23:201-205.
    • (2002) Carcinogenesis , vol.23 , pp. 201-205
    • Roy, H.K.1    Olusola, B.F.2    Clemens, D.L.3
  • 14
    • 9644253003 scopus 로고    scopus 로고
    • The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells
    • Asano T, Yao Y, Zhu J, et al. The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells. Oncogene. 2004;23:8571-8580.
    • (2004) Oncogene , vol.23 , pp. 8571-8580
    • Asano, T.1    Yao, Y.2    Zhu, J.3
  • 15
    • 0037096804 scopus 로고    scopus 로고
    • Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma
    • Itoh N, Semba S, Ito M, et al. Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma. Cancer. 2002;94:3127-3134.
    • (2002) Cancer , vol.94 , pp. 3127-3134
    • Itoh, N.1    Semba, S.2    Ito, M.3
  • 16
    • 6444220198 scopus 로고    scopus 로고
    • Rapamycin inhibits Akt-mediated oncogenic transformation and tumor growth
    • Liu X, Powlas J, Shi Y, et al. Rapamycin inhibits Akt-mediated oncogenic transformation and tumor growth. Anticancer Res. 2004;24:2697-2704.
    • (2004) Anticancer Res , vol.24 , pp. 2697-2704
    • Liu, X.1    Powlas, J.2    Shi, Y.3
  • 17
    • 0036278686 scopus 로고    scopus 로고
    • Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3′-kinase inhibition in the KM20 human colon cancer cell cine
    • Wang Q, Li N, Wang X, et al. Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3′-kinase inhibition in the KM20 human colon cancer cell cine. Clin Cancer Res. 2002;8:1940-1947.
    • (2002) Clin Cancer Res , vol.8 , pp. 1940-1947
    • Wang, Q.1    Li, N.2    Wang, X.3
  • 18
    • 0034659774 scopus 로고    scopus 로고
    • Developments in chemotherapy of breast cancer
    • Hortobagyi GN. Developments in chemotherapy of breast cancer. Cancer. 2000;88(suppl 12):3073-3079.
    • (2000) Cancer , vol.88 , Issue.12 SUPPL. , pp. 3073-3079
    • Hortobagyi, G.N.1
  • 19
    • 0024315482 scopus 로고
    • Acute pathological effects on rats of orally administered wortmannin-containing preparations and purified wortmannin from Fusarium oxysporum
    • Gunther R, Abbas HK, Mirocha CJ. Acute pathological effects on rats of orally administered wortmannin-containing preparations and purified wortmannin from Fusarium oxysporum. Food Chem Toxicol. 1989;27:173-179.
    • (1989) Food Chem Toxicol , vol.27 , pp. 173-179
    • Gunther, R.1    Abbas, H.K.2    Mirocha, C.J.3
  • 20
    • 10644237968 scopus 로고    scopus 로고
    • RNAi-mediated pathways in the nucleus
    • Matzke MA, Birchler JA. RNAi-mediated pathways in the nucleus. Nat Rev Genet. 2005;6:24-35.
    • (2005) Nat Rev Genet , vol.6 , pp. 24-35
    • Matzke, M.A.1    Birchler, J.A.2
  • 21
    • 0141706705 scopus 로고    scopus 로고
    • siRNA agents inhibit oncogene expression and attenuate human tumor cell growth
    • Yin JQ, Gao J, Shao R, et al. siRNA agents inhibit oncogene expression and attenuate human tumor cell growth. J Exp Ther. 2003;3:194-204.
    • (2003) J Exp Ther , vol.3 , pp. 194-204
    • Yin, J.Q.1    Gao, J.2    Shao, R.3
  • 22
    • 24744464786 scopus 로고    scopus 로고
    • Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo
    • Takeshita F, Minakuchi Y, Nagahara S, et al. Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. Proc Natl Acad Sci USA. 2005;102:12177-12782.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 12177-12782
    • Takeshita, F.1    Minakuchi, Y.2    Nagahara, S.3
  • 23
    • 0023032871 scopus 로고
    • A molecular gradient in early Drosophila embryos and its role in specifying the body pattern
    • Macdonald PM, Struhl G. A molecular gradient in early Drosophila embryos and its role in specifying the body pattern. Nature. 1986;324:537-545.
    • (1986) Nature , vol.324 , pp. 537-545
    • Macdonald, P.M.1    Struhl, G.2
  • 24
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 25
    • 0030988580 scopus 로고    scopus 로고
    • Inhibition of neurotensin-induced pancreatic carcinoma growth by a nonpeptide neurotensin receptor antagonist, SR48692
    • Iwase K, Evers BM, Hellmich MR, et al. Inhibition of neurotensin-induced pancreatic carcinoma growth by a nonpeptide neurotensin receptor antagonist, SR48692. Cancer. 1997;79:1787-1793.
    • (1997) Cancer , vol.79 , pp. 1787-1793
    • Iwase, K.1    Evers, B.M.2    Hellmich, M.R.3
  • 26
    • 0033107768 scopus 로고    scopus 로고
    • In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice
    • Bruns CJ, Harbison MT, Kuniyasu H, et al. In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice. Neoplasia. 1999;1:50-62.
    • (1999) Neoplasia , vol.1 , pp. 50-62
    • Bruns, C.J.1    Harbison, M.T.2    Kuniyasu, H.3
  • 27
    • 19044373371 scopus 로고    scopus 로고
    • Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation
    • Watanabe H, Saito H, Rychahou PG, et al. Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation. Gastroenterology. 2005;128:1391-1404.
    • (2005) Gastroenterology , vol.128 , pp. 1391-1404
    • Watanabe, H.1    Saito, H.2    Rychahou, P.G.3
  • 28
    • 0023359384 scopus 로고
    • TNM classification of malignant tumors: The new 1987 edition
    • Hermanek P, Scheibe O, Spiessl B, et al. TNM classification of malignant tumors: the new 1987 edition. Rontgenblatter. 1987;40:200.
    • (1987) Rontgenblatter , vol.40 , pp. 200
    • Hermanek, P.1    Scheibe, O.2    Spiessl, B.3
  • 29
    • 0036449793 scopus 로고    scopus 로고
    • Current status of the molecular mechanisms of anticancer drug-induced apoptosis: The contribution of molecular-level analysis to cancer chemotherapy
    • Kim R, Tanabe K, Uchida Y, et al. Current status of the molecular mechanisms of anticancer drug-induced apoptosis: the contribution of molecular-level analysis to cancer chemotherapy. Cancer Chemother Pharmacol. 2002;50:343-352.
    • (2002) Cancer Chemother Pharmacol , vol.50 , pp. 343-352
    • Kim, R.1    Tanabe, K.2    Uchida, Y.3
  • 30
    • 0031870959 scopus 로고    scopus 로고
    • Pten is essential for embryonic development and tumour suppression
    • Di Cristofano A, Pesce B, Cordon-Cardo C, et al. Pten is essential for embryonic development and tumour suppression. Nat Genet. 1998;19:348-355.
    • (1998) Nat Genet , vol.19 , pp. 348-355
    • Di Cristofano, A.1    Pesce, B.2    Cordon-Cardo, C.3
  • 31
    • 0036789215 scopus 로고    scopus 로고
    • PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway
    • Kim S, Domon-Dell C, Wang Q, et al. PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway. Gastroenterology. 2002;123:1163-1178.
    • (2002) Gastroenterology , vol.123 , pp. 1163-1178
    • Kim, S.1    Domon-Dell, C.2    Wang, Q.3
  • 32
    • 13844273087 scopus 로고    scopus 로고
    • PI3K-Akt pathway: Its functions and alterations in human cancer
    • Osaki M, Oshimura M, Ito H. PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis. 2004;9:667-676.
    • (2004) Apoptosis , vol.9 , pp. 667-676
    • Osaki, M.1    Oshimura, M.2    Ito, H.3
  • 33
    • 0036729867 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy
    • Krystal GW, Sulanke G, Litz J. Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy. Mol Cancer Ther. 2002;1:913-922.
    • (2002) Mol Cancer Ther , vol.1 , pp. 913-922
    • Krystal, G.W.1    Sulanke, G.2    Litz, J.3
  • 35
    • 20444374445 scopus 로고    scopus 로고
    • Mutant PIK3CA promotes cell growth and invasion of human cancer cells
    • Samuels Y, Diaz LA Jr, Schmidt-Kittler O, et al. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell. 2005;7:561-573.
    • (2005) Cancer Cell , vol.7 , pp. 561-573
    • Samuels, Y.1    Diaz Jr., L.A.2    Schmidt-Kittler, O.3
  • 36
    • 0037348329 scopus 로고    scopus 로고
    • RNA interference targeting Fas protects mice from fulminant hepatitis
    • Song E, Lee SK, Wang J, et al. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med. 2003;9:347-351.
    • (2003) Nat Med , vol.9 , pp. 347-351
    • Song, E.1    Lee, S.K.2    Wang, J.3
  • 37
    • 0033166561 scopus 로고    scopus 로고
    • High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA
    • Zhang G, Budker V, Wolff JA. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther. 1999;10:1735-1737.
    • (1999) Hum Gene Ther , vol.10 , pp. 1735-1737
    • Zhang, G.1    Budker, V.2    Wolff, J.A.3
  • 38
    • 24344482476 scopus 로고    scopus 로고
    • Targeted RNA interference of PI3K pathway components sensitizes colon cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)
    • Rychahou PG, Murillo CA, Evers BM. Targeted RNA interference of PI3K pathway components sensitizes colon cancer cells to TNF-related apoptosis-inducing ligand (TRAIL). Surgery. 2005;138:391-397.
    • (2005) Surgery , vol.138 , pp. 391-397
    • Rychahou, P.G.1    Murillo, C.A.2    Evers, B.M.3
  • 39
    • 0031887249 scopus 로고    scopus 로고
    • Regulation of the p85/p110 phosphatidylinositol 3′-kinase: Stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit
    • Yu J, Zhang Y, McIlroy J, et al. Regulation of the p85/p110 phosphatidylinositol 3′-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit. Mol Cell Biol. 1998;18:1379-1387.
    • (1998) Mol Cell Biol , vol.18 , pp. 1379-1387
    • Yu, J.1    Zhang, Y.2    McIlroy, J.3
  • 40
    • 21144457217 scopus 로고    scopus 로고
    • Functional analysis of PIK3CA gene mutations in human colorectal cancer
    • Ikenoue T, Kanai F, Hikiba Y, et al. Functional analysis of PIK3CA gene mutations in human colorectal cancer. Cancer Res. 2005;65:4562-4567.
    • (2005) Cancer Res , vol.65 , pp. 4562-4567
    • Ikenoue, T.1    Kanai, F.2    Hikiba, Y.3
  • 41
    • 28844444157 scopus 로고    scopus 로고
    • Exploring the tumour environment: Cancer-associated fibroblasts as targets in cancer therapy
    • Micke P, Ostman A. Exploring the tumour environment: cancer-associated fibroblasts as targets in cancer therapy. Exp Opin Ther Targets. 2005;9:1217-1233.
    • (2005) Exp Opin Ther Targets , vol.9 , pp. 1217-1233
    • Micke, P.1    Ostman, A.2
  • 42
    • 0032853715 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase expression in human breast cancer
    • Gershtein ES, Shatskaya VA, Ermilova VD, et al. Phosphatidylinositol 3-kinase expression in human breast cancer. Clin Chim Acta. 1999;287:59-67.
    • (1999) Clin Chim Acta , vol.287 , pp. 59-67
    • Gershtein, E.S.1    Shatskaya, V.A.2    Ermilova, V.D.3
  • 43
    • 0032125580 scopus 로고    scopus 로고
    • Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors
    • Phillips WA, St. Clair F, Munday AD, et al. Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors. Cancer. 1998;83:41-47.
    • (1998) Cancer , vol.83 , pp. 41-47
    • Phillips, W.A.1    St. Clair, F.2    Munday, A.D.3
  • 44
    • 2342527930 scopus 로고    scopus 로고
    • Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion
    • Hutchinson JN, Jin J, Cardiff RD, et al. Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion. Cancer Res. 2004;64:3171-3178.
    • (2004) Cancer Res , vol.64 , pp. 3171-3178
    • Hutchinson, J.N.1    Jin, J.2    Cardiff, R.D.3
  • 45
    • 0037229714 scopus 로고    scopus 로고
    • Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells
    • Arboleda MJ, Lyons JF, Kabbinavar FF, et al. Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res. 2003;63:196-206.
    • (2003) Cancer Res , vol.63 , pp. 196-206
    • Arboleda, M.J.1    Lyons, J.F.2    Kabbinavar, F.F.3
  • 46
    • 0033984095 scopus 로고    scopus 로고
    • Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis
    • Guanti G, Resta N, Simone C, et al. Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis. Hum Mol Genet. 2000;9:283-7.
    • (2000) Hum Mol Genet , vol.9 , pp. 283-287
    • Guanti, G.1    Resta, N.2    Simone, C.3
  • 47
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • Cantley LC, Neel BG. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA. 1999;96:4240-4245.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 48
    • 2342504508 scopus 로고    scopus 로고
    • Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers
    • Goel A, Arnold CN, Niedzwiecki D, et al. Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers. Cancer Res. 2004;64:3014-3021.
    • (2004) Cancer Res , vol.64 , pp. 3014-3021
    • Goel, A.1    Arnold, C.N.2    Niedzwiecki, D.3
  • 49
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science. 1997;275:1943-1947.
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3
  • 50
    • 23944439945 scopus 로고    scopus 로고
    • Phase II Study of Temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer
    • Chan S, Scheulen ME, Johnston S, et al. Phase II Study of Temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer. J Clin Oncol. 2005;23:5314-5322.
    • (2005) J Clin Oncol , vol.23 , pp. 5314-5322
    • Chan, S.1    Scheulen, M.E.2    Johnston, S.3
  • 51
    • 2942735384 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
    • Raymond E, Alexandre J, Faivre S, et al. Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J Clin Oncol. 2004;22:2336-2347.
    • (2004) J Clin Oncol , vol.22 , pp. 2336-2347
    • Raymond, E.1    Alexandre, J.2    Faivre, S.3
  • 52
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies SP, Reddy H, Caivano M, et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000;351(Pt 1):95-105.
    • (2000) Biochem J , vol.351 , Issue.1 PART , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3
  • 53
    • 0036278927 scopus 로고    scopus 로고
    • The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3′-kinase, in human colon cancer cells
    • Semba S, Itoh N, Ito M, et al. The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3′-kinase, in human colon cancer cells. Clin Cancer Res. 2002;8:1957-1963.
    • (2002) Clin Cancer Res , vol.8 , pp. 1957-1963
    • Semba, S.1    Itoh, N.2    Ito, M.3
  • 54
    • 0034792844 scopus 로고    scopus 로고
    • Wortmannin inhibits PKB/Akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice
    • Ng SSW, Tsao M-S, Nicklee T, et al. Wortmannin inhibits PKB/Akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice. Clin Cancer Res. 2001;7:3269-3275.
    • (2001) Clin Cancer Res , vol.7 , pp. 3269-3275
    • Ng, S.S.W.1    Tsao, M.-S.2    Nicklee, T.3
  • 55
    • 0028217223 scopus 로고
    • Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3- kinase
    • Powis G, Bonjouklian R, Berggren MM, et al. Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Cancer Res. 1994;54:2419-2423.
    • (1994) Cancer Res , vol.54 , pp. 2419-2423
    • Powis, G.1    Bonjouklian, R.2    Berggren, M.M.3
  • 56
    • 24344452505 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: Molecular mechanisms and biological consequences
    • Ren S-y, Bolton E, Mohi MG, et al. Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences. Mol Cell Biol. 2005;25:8001-8008.
    • (2005) Mol Cell Biol , vol.25 , pp. 8001-8008
    • Ren, S.-Y.1    Bolton, E.2    Mohi, M.G.3
  • 57
    • 26244431767 scopus 로고    scopus 로고
    • Inhibiting the growth of malignant melanoma by blocking the expression of vascular endothelial growth factor using an RNA interference approach
    • Tao J, Tu YT, Huang CZ, et al. Inhibiting the growth of malignant melanoma by blocking the expression of vascular endothelial growth factor using an RNA interference approach. Br J Dermatol. 2005;153:715-724.
    • (2005) Br J Dermatol , vol.153 , pp. 715-724
    • Tao, J.1    Tu, Y.T.2    Huang, C.Z.3
  • 58
    • 24344499042 scopus 로고    scopus 로고
    • Tumor growth inhibition by simultaneously blocking epidermal growth factor receptor and cyclooxygenase-2 in a xenograft model
    • Zhang X, Chen Z, Choe MS, et al. Tumor growth inhibition by simultaneously blocking epidermal growth factor receptor and cyclooxygenase-2 in a xenograft model. Clin Cancer Res. 2005;11:6261-6269.
    • (2005) Clin Cancer Res , vol.11 , pp. 6261-6269
    • Zhang, X.1    Chen, Z.2    Choe, M.S.3
  • 59
    • 3042853830 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo
    • Uchida H, Tanaka T, Sasaki K, et al. Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo. Molecular Therapy. 2004;10:162.
    • (2004) Molecular Therapy , vol.10 , pp. 162
    • Uchida, H.1    Tanaka, T.2    Sasaki, K.3
  • 60
    • 0242298666 scopus 로고    scopus 로고
    • Viral and non-viral vectors in gene therapy: Technology development and clinical trials
    • Lundstrom K, Boulikas T. Viral and non-viral vectors in gene therapy: technology development and clinical trials. Technol Cancer Res Treat. 2003;2:471-486.
    • (2003) Technol Cancer Res Treat , vol.2 , pp. 471-486
    • Lundstrom, K.1    Boulikas, T.2
  • 61
    • 0344926320 scopus 로고    scopus 로고
    • Cationic liposome-mediated delivery of siRNAs in adult mice
    • Sioud M, Sorensen DR. Cationic liposome-mediated delivery of siRNAs in adult mice. Biochem Biophys Res Commun. 2003;312:1220-1225.
    • (2003) Biochem Biophys Res Commun , vol.312 , pp. 1220-1225
    • Sioud, M.1    Sorensen, D.R.2
  • 62
    • 0041331496 scopus 로고    scopus 로고
    • siRNA function in RNAi: A chemical modification analysis
    • Chiu Y-L, Rana TM. siRNA function in RNAi: a chemical modification analysis. RNA. 2003;9:1034-1048.
    • (2003) RNA , vol.9 , pp. 1034-1048
    • Chiu, Y.-L.1    Rana, T.M.2


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