-
1
-
-
0043172396
-
Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis
-
Grunert, S., Jechlinger, M. & Beug, H. Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nature Rev. Mol. Cell Biol. 4, 657-665 (2003).
-
(2003)
Nature Rev. Mol. Cell Biol.
, vol.4
, pp. 657-665
-
-
Grunert, S.1
Jechlinger, M.2
Beug, H.3
-
2
-
-
0036595629
-
Epithelial-mesenchymal transitions in tumour progression
-
Thiery, J. P. Epithelial-mesenchymal transitions in tumour progression. Nature Rev. Cancer 2, 442-454 (2002).
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 442-454
-
-
Thiery, J.P.1
-
3
-
-
24644480749
-
Molecular requirements for epithelial-mesenchymal transition during tumor progression
-
Huber, M. A., Kraut, N. & Beug, H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell Biol. 17, 548-558 (2005).
-
(2005)
Curr. Opin. Cell Biol.
, vol.17
, pp. 548-558
-
-
Huber, M.A.1
Kraut, N.2
Beug, H.3
-
4
-
-
0242499448
-
Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer
-
Siegel, P. M. & Massague, J. Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer. Nature Rev. Cancer 3, 807-821 (2003).
-
(2003)
Nature Rev. Cancer
, vol.3
, pp. 807-821
-
-
Siegel, P.M.1
Massague, J.2
-
5
-
-
0036551486
-
Scatter-factor and semaphorin receptors: Cell signalling for invasive growth
-
Trusolino, L. & Comoglio, P. M. Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nature Rev. Cancer 2, 289-300 (2002).
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 289-300
-
-
Trusolino, L.1
Comoglio, P.M.2
-
6
-
-
20444404630
-
Cancer therapy: Can the challenge be MET?
-
Corso, S., Comoglio, P. M. & Giordano, S. Cancer therapy: can the challenge be MET? Trends Mol. Med. 11, 284-292 (2005).
-
(2005)
Trends Mol. Med.
, vol.11
, pp. 284-292
-
-
Corso, S.1
Comoglio, P.M.2
Giordano, S.3
-
7
-
-
0345601083
-
Met, metastasis, motility and more
-
Birchmeier, C., Birchmeier, W., Gherardi, E. & Vande Woude, G. F. Met, metastasis, motility and more. Nature Rev. Mol. Cell Biol. 4, 915-925 (2003).
-
(2003)
Nature Rev. Mol. Cell Biol.
, vol.4
, pp. 915-925
-
-
Birchmeier, C.1
Birchmeier, W.2
Gherardi, E.3
Vande Woude, G.F.4
-
8
-
-
15244345941
-
The MET oncogene drives a genetic programme linking cancer to haemostasis
-
Boccaccio, C. et al. The MET oncogene drives a genetic programme linking cancer to haemostasis. Nature 434, 396-400 (2005).
-
(2005)
Nature
, vol.434
, pp. 396-400
-
-
Boccaccio, C.1
-
9
-
-
0035977147
-
A signaling adapter function for α6β4 integrin in the control of HGF-dependent invasive growth
-
Trusolino, L., Bertotti, A. & Comoglio, P. M. A signaling adapter function for α6β4 integrin in the control of HGF-dependent invasive growth. Cell 107, 643-654 (2001).
-
(2001)
Cell
, vol.107
, pp. 643-654
-
-
Trusolino, L.1
Bertotti, A.2
Comoglio, P.M.3
-
10
-
-
2442520826
-
Interplay between scatter factor receptors and B plexins controls invasive growth
-
Conrotto, P., Corso, S., Gamberini, S., Comoglio, P. M. & Giordano, S. Interplay between scatter factor receptors and B plexins controls invasive growth. Oncogene 23, 5131-5137 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 5131-5137
-
-
Conrotto, P.1
Corso, S.2
Gamberini, S.3
Comoglio, P.M.4
Giordano, S.5
-
11
-
-
0036711644
-
The semaphorin 4D receptor controls invasive growth by coupling with Met
-
Giordano, S. et al. The semaphorin 4D receptor controls invasive growth by coupling with Met. Nature Cell Biol. 4, 720-724 (2002).
-
(2002)
Nature Cell Biol.
, vol.4
, pp. 720-724
-
-
Giordano, S.1
-
12
-
-
18144423532
-
Negative feedback regulation of Met-dependent invasive growth by Notch
-
Stella, M. C., Trusolino, L., Pennacchietti, S. & Comoglio, P. M. Negative feedback regulation of Met-dependent invasive growth by Notch. Mol. Cell Biol. 25, 3982-3996 (2005).
-
(2005)
Mol. Cell Biol.
, vol.25
, pp. 3982-3996
-
-
Stella, M.C.1
Trusolino, L.2
Pennacchietti, S.3
Comoglio, P.M.4
-
13
-
-
3142512610
-
Targeting the tumor and its microenvironment by a dual-function decoy Met receptor
-
Michieli, P. et al. Targeting the tumor and its microenvironment by a dual-function decoy Met receptor. Cancer Cell 6, 61-73 (2004).
-
(2004)
Cancer Cell
, vol.6
, pp. 61-73
-
-
Michieli, P.1
-
14
-
-
0036087521
-
Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects
-
Yang, Y. A. et al. Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects. J. Clin. Invest. 109, 1607-1615 (2002).
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1607-1615
-
-
Yang, Y.A.1
-
15
-
-
4344627055
-
Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB
-
Douma, S. et al. Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature 430, 1034-1039 (2004).
-
(2004)
Nature
, vol.430
, pp. 1034-1039
-
-
Douma, S.1
-
16
-
-
0036559535
-
Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis
-
Lopez, T. & Hanahan, D. Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 1, 339-353 (2002).
-
(2002)
Cancer Cell
, vol.1
, pp. 339-353
-
-
Lopez, T.1
Hanahan, D.2
-
17
-
-
12144290914
-
Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors
-
Mitsiades, C. S. et al. Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer Cell 5, 221-230 (2004).
-
(2004)
Cancer Cell
, vol.5
, pp. 221-230
-
-
Mitsiades, C.S.1
-
18
-
-
12144285705
-
In vivo antitumor activity of NVP-AEW541 - A novel, potent, and selective inhibitor of the IGF-IR kinase
-
Garcia-Echeverria, C. et al. In vivo antitumor activity of NVP-AEW541 - A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell 5, 231-239 (2004).
-
(2004)
Cancer Cell
, vol.5
, pp. 231-239
-
-
Garcia-Echeverria, C.1
-
19
-
-
2942707615
-
Memo mediates ErbB2-driven cell motility
-
Marone, R. et al. Memo mediates ErbB2-driven cell motility. Nature Cell Biol. 6, 515-522 (2004).
-
(2004)
Nature Cell Biol.
, vol.6
, pp. 515-522
-
-
Marone, R.1
-
20
-
-
6044243650
-
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
-
Karhadkar, S. S. et al. Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 431, 707-712 (2004).
-
(2004)
Nature
, vol.431
, pp. 707-712
-
-
Karhadkar, S.S.1
-
21
-
-
0037478437
-
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
-
Pennacchietti, S. et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 3, 347-361 (2003).
-
(2003)
Cancer Cell
, vol.3
, pp. 347-361
-
-
Pennacchietti, S.1
-
22
-
-
25844441598
-
Hepatocyte growth factor enhances CXCR4 expression favoring breast cancer cell invasiveness
-
Matteucci, E., Locati, M. & Desiderio, M. A. Hepatocyte growth factor enhances CXCR4 expression favoring breast cancer cell invasiveness. Exp. Cell Res. 310, 176-185 (2005).
-
(2005)
Exp. Cell Res.
, vol.310
, pp. 176-185
-
-
Matteucci, E.1
Locati, M.2
Desiderio, M.A.3
-
23
-
-
20444445920
-
Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1α
-
Phillips, R. J. et al. Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1α. J. Biol. Chem. 280, 22473-22481 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 22473-22481
-
-
Phillips, R.J.1
-
24
-
-
1042267263
-
Cell adhesion and signalling by cadherins and Ig-CAMs in cancer
-
Cavallaro, U. & Christofori, G. Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nature Rev. Cancer 4, 118-132 (2004).
-
(2004)
Nature Rev. Cancer
, vol.4
, pp. 118-132
-
-
Cavallaro, U.1
Christofori, G.2
-
25
-
-
0032510494
-
A causal role for E-cadherin in the transition from adenoma to carcinoma
-
Perl, A. K., Wilgenbus, P., Dahl, U., Semb, H. & Christofori, G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 392, 190-193 (1998).
-
(1998)
Nature
, vol.392
, pp. 190-193
-
-
Perl, A.K.1
Wilgenbus, P.2
Dahl, U.3
Semb, H.4
Christofori, G.5
-
26
-
-
15944363787
-
Unraveling signalling cascades for the Snail family of transcription factors
-
De Craene, B., van Roy, F. & Berx, G. Unraveling signalling cascades for the Snail family of transcription factors. Cell Signal. 17, 535-547 (2005).
-
(2005)
Cell Signal.
, vol.17
, pp. 535-547
-
-
De Craene, B.1
Van Roy, F.2
Berx, G.3
-
27
-
-
4043052971
-
Epithelial-mesenchymal transitions: Twist in development and metastasis
-
Kang, Y. & Massague, J. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 118, 277-279 (2004).
-
(2004)
Cell
, vol.118
, pp. 277-279
-
-
Kang, Y.1
Massague, J.2
-
28
-
-
0346363757
-
Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex
-
Peinado, H., Ballestar, E., Esteller, M. & Cano, A. Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol. Cell. Biol. 24, 306-319 (2004).
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 306-319
-
-
Peinado, H.1
Ballestar, E.2
Esteller, M.3
Cano, A.4
-
29
-
-
0036392129
-
Epigenetic versus genetic alterations in the inactivation of E-cadherin
-
Strathdee, G. Epigenetic versus genetic alterations in the inactivation of E-cadherin. Semin. Cancer Biol. 12, 373-379 (2002).
-
(2002)
Semin. Cancer Biol.
, vol.12
, pp. 373-379
-
-
Strathdee, G.1
-
30
-
-
15744374449
-
Wnt-dependent regulation of the E-cadherin repressor snail
-
Yook, J. I., Li, X. Y., Ota, I., Fearon, E. R. & Weiss, S. J. Wnt-dependent regulation of the E-cadherin repressor snail. J. Biol. Chem. 280, 11740-11748 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 11740-11748
-
-
Yook, J.I.1
Li, X.Y.2
Ota, I.3
Fearon, E.R.4
Weiss, S.J.5
-
31
-
-
0345736990
-
Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion
-
Lu, Z., Ghosh, S., Wang, Z. & Hunter, T. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion. Cancer Cell 4, 499-515 (2003).
-
(2003)
Cancer Cell
, vol.4
, pp. 499-515
-
-
Lu, Z.1
Ghosh, S.2
Wang, Z.3
Hunter, T.4
-
32
-
-
5444269904
-
Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition
-
Zhou, B. P. et al. Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition. Nature Cell Biol. 6, 931-940 (2004).
-
(2004)
Nature Cell Biol.
, vol.6
, pp. 931-940
-
-
Zhou, B.P.1
-
33
-
-
12144266241
-
Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: Implications for the epithelial-mesenchymal transition
-
Bachelder, R. E., Yoon, S. O., Franci, C., de Herreros, A. G. & Mercurio, A. M. Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. J. Cell Biol. 168, 29-33 (2005).
-
(2005)
J. Cell Biol.
, vol.168
, pp. 29-33
-
-
Bachelder, R.E.1
Yoon, S.O.2
Franci, C.3
De Herreros, A.G.4
Mercurio, A.M.5
-
34
-
-
27144518237
-
A molecular role for lysyl oxidase-like 2 enzyme in Snail regulation and tumor progression
-
Peinado, H. et al. A molecular role for lysyl oxidase-like 2 enzyme in Snail regulation and tumor progression. EMBO J. 24, 3446-3458 (2005).
-
(2005)
EMBO J.
, vol.24
, pp. 3446-3458
-
-
Peinado, H.1
-
35
-
-
0036121308
-
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
-
Fujita, Y. et al. Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nature Cell Biol. 4, 222-231 (2002).
-
(2002)
Nature Cell Biol.
, vol.4
, pp. 222-231
-
-
Fujita, Y.1
-
36
-
-
13944268218
-
L1, a novel target of β-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers
-
Gavert, N. et al. L1, a novel target of β-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers. J. Cell Biol. 168, 633-642 (2005).
-
(2005)
J. Cell Biol.
, vol.168
, pp. 633-642
-
-
Gavert, N.1
-
37
-
-
0037102578
-
Nr-CAM is a target gene of the β-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis
-
Conacci-Sorrell, M. E. et al. Nr-CAM is a target gene of the β-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis. Genes Dev. 16, 2058-2072 (2002).
-
(2002)
Genes Dev.
, vol.16
, pp. 2058-2072
-
-
Conacci-Sorrell, M.E.1
-
38
-
-
0032978138
-
Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic β tumor cells
-
Perl, A. K. et al. Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic β tumor cells. Nature Med. 5, 286-291 (1999).
-
(1999)
Nature Med.
, vol.5
, pp. 286-291
-
-
Perl, A.K.1
-
39
-
-
0034945537
-
N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling
-
Cavallaro, U., Niedermeyer, J., Fuxa, M. & Christofori, G. N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling. Nature Cell Biol. 3, 650-657 (2001).
-
(2001)
Nature Cell Biol.
, vol.3
, pp. 650-657
-
-
Cavallaro, U.1
Niedermeyer, J.2
Fuxa, M.3
Christofori, G.4
-
40
-
-
0036488589
-
Role of integrins in cell invasion and migration
-
Hood, J. D. & Cheresh, D. A. Role of integrins in cell invasion and migration. Nature Rev. Cancer 2, 91-100 (2002).
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 91-100
-
-
Hood, J.D.1
Cheresh, D.A.2
-
41
-
-
0037145037
-
Integrins: Bidirectional, allosteric signaling machines
-
Hynes, R. O. Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687 (2002).
-
(2002)
Cell
, vol.110
, pp. 673-687
-
-
Hynes, R.O.1
-
42
-
-
5044238876
-
Integrin signalling during tumour progression
-
Guo, W. & Giancotti, F. G. Integrin signalling during tumour progression. Nature Rev. Mol. Cell Biol. 5, 816-826 (2004).
-
(2004)
Nature Rev. Mol. Cell Biol.
, vol.5
, pp. 816-826
-
-
Guo, W.1
Giancotti, F.G.2
-
43
-
-
11144357346
-
Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway
-
Bao, S. et al. Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell 5, 329-339 (2004).
-
(2004)
Cancer Cell
, vol.5
, pp. 329-339
-
-
Bao, S.1
-
44
-
-
12344318372
-
Context, tissue plasticity, and cancer: Are tumor stem cells also regulated by the microenvironment?
-
Bissell, M. J. & Labarge, M. A. Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment? Cancer Cell 7, 17-23 (2005).
-
(2005)
Cancer Cell
, vol.7
, pp. 17-23
-
-
Bissell, M.J.1
Labarge, M.A.2
-
45
-
-
0035890799
-
Malignant transformation in a nontumorigenic human prostatic epithelial cell line
-
Hayward, S. W. et al. Malignant transformation in a nontumorigenic human prostatic epithelial cell line. Cancer Res. 61, 8135-8142 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 8135-8142
-
-
Hayward, S.W.1
-
46
-
-
18844428327
-
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
-
Orimo, A. et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121, 335-348 (2005).
-
(2005)
Cell
, vol.121
, pp. 335-348
-
-
Orimo, A.1
-
47
-
-
0842288323
-
TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
-
Bhowmick, N. A. et al. TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 303, 848-851 (2004).
-
(2004)
Science
, vol.303
, pp. 848-851
-
-
Bhowmick, N.A.1
-
48
-
-
19344365408
-
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
-
de Visser, K. E., Korets, L. V. & Coussens, L. M. De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell 7, 411-423 (2005).
-
(2005)
Cancer Cell
, vol.7
, pp. 411-423
-
-
De Visser, K.E.1
Korets, L.V.2
Coussens, L.M.3
-
49
-
-
0347123433
-
Tumour-educated macrophages promote tumour progression and metastasis
-
Pollard, J. W. Tumour-educated macrophages promote tumour progression and metastasis. Nature Rev. Cancer 4, 71-78 (2004).
-
(2004)
Nature Rev. Cancer
, vol.4
, pp. 71-78
-
-
Pollard, J.W.1
-
50
-
-
20444412646
-
Therapeutic targeting of the tumor microenvironment
-
Joyce, J. A. Therapeutic targeting of the tumor microenvironment. Cancer Cell 7, 513-520 (2005).
-
(2005)
Cancer Cell
, vol.7
, pp. 513-520
-
-
Joyce, J.A.1
-
51
-
-
0347302952
-
Cytokines in cancer pathogenesis and cancer therapy
-
Dranoff, G. Cytokines in cancer pathogenesis and cancer therapy. Nature Rev. Cancer 4, 11-22 (2004).
-
(2004)
Nature Rev. Cancer
, vol.4
, pp. 11-22
-
-
Dranoff, G.1
-
52
-
-
0034721666
-
MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis
-
Coussens, L. M., Tinkle, C. L., Hanahan, D. & Werb, Z. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103, 481-490 (2000).
-
(2000)
Cell
, vol.103
, pp. 481-490
-
-
Coussens, L.M.1
Tinkle, C.L.2
Hanahan, D.3
Werb, Z.4
-
53
-
-
0035911221
-
Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
-
Lin, E. Y., Nguyen, A. V., Russell, R. G. & Pollard, J. W. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J. Exp. Med. 193, 727-740 (2001).
-
(2001)
J. Exp. Med.
, vol.193
, pp. 727-740
-
-
Lin, E.Y.1
Nguyen, A.V.2
Russell, R.G.3
Pollard, J.W.4
-
54
-
-
0037105725
-
Colony-stimulating factor-1 antisense treatment suppresses growth of human tumor xenografts in mice
-
Aharinejad, S. et al. Colony-stimulating factor-1 antisense treatment suppresses growth of human tumor xenografts in mice. Cancer Res. 62, 5317-5324 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 5317-5324
-
-
Aharinejad, S.1
-
55
-
-
24944587964
-
Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
-
De Palma, M. et al. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 8, 211-226 (2005).
-
(2005)
Cancer Cell
, vol.8
, pp. 211-226
-
-
De Palma, M.1
-
56
-
-
21844432918
-
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
-
Radisky, D. C. et al. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 436, 123-127 (2005).
-
(2005)
Nature
, vol.436
, pp. 123-127
-
-
Radisky, D.C.1
-
57
-
-
13544255506
-
PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells
-
Boire, A. et al. PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell 120, 303-313 (2005).
-
(2005)
Cell
, vol.120
, pp. 303-313
-
-
Boire, A.1
-
58
-
-
0037967272
-
Tumorigenesis and the angiogenic switch
-
Bergers, G. & Benjamin, L. E. Tumorigenesis and the angiogenic switch. Nature Rev. Cancer 3, 401-410 (2003).
-
(2003)
Nature Rev. Cancer
, vol.3
, pp. 401-410
-
-
Bergers, G.1
Benjamin, L.E.2
-
59
-
-
0036984640
-
Role of angiogenesis in tumor growth and metastasis
-
Folkman, J. Role of angiogenesis in tumor growth and metastasis. Semin. Oncol. 29, 15-18 (2002).
-
(2002)
Semin. Oncol.
, vol.29
, pp. 15-18
-
-
Folkman, J.1
-
60
-
-
13844265843
-
Focus on lymphangiogenesis in tumor metastasis
-
Achen, M. G., McColl, B. K. & Stacker, S. A. Focus on lymphangiogenesis in tumor metastasis. Cancer Cell 7, 121-127 (2005).
-
(2005)
Cancer Cell
, vol.7
, pp. 121-127
-
-
Achen, M.G.1
McColl, B.K.2
Stacker, S.A.3
-
61
-
-
2942668041
-
Lymphatic vasculature: Development, molecular regulation and role in tumor metastasis and inflammation
-
Saharinen, P., Tammela, T., Karkkainen, M. J. & Alitalo, K. Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation. Trends Immunol. 25, 387-395 (2004).
-
(2004)
Trends Immunol.
, vol.25
, pp. 387-395
-
-
Saharinen, P.1
Tammela, T.2
Karkkainen, M.J.3
Alitalo, K.4
-
62
-
-
0035282432
-
Involvement of chemokine receptors in breast cancer metastasis
-
Muller, A. et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 410, 50-56 (2001).
-
(2001)
Nature
, vol.410
, pp. 50-56
-
-
Muller, A.1
-
63
-
-
0038079014
-
The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases
-
Zeelenberg, I. S., Ruuls-Van Stalle, L. & Roos, E. The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases. Cancer Res. 63, 3833-3839 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 3833-3839
-
-
Zeelenberg, I.S.1
Ruuls-Van Stalle, L.2
Roos, E.3
-
64
-
-
0038488950
-
A multigenic program mediating breast cancer metastasis to bone
-
Kang, Y. et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3, 537-549 (2003).
-
(2003)
Cancer Cell
, vol.3
, pp. 537-549
-
-
Kang, Y.1
-
65
-
-
23144461051
-
Genes that mediate breast cancer metastasis to lung
-
Minn, A. J. et al. Genes that mediate breast cancer metastasis to lung. Nature 436, 518-524 (2005).
-
(2005)
Nature
, vol.436
, pp. 518-524
-
-
Minn, A.J.1
-
66
-
-
21144438505
-
MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL
-
Lynch, C. C. et al. MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Cancer Cell 7, 485-496 (2005).
-
(2005)
Cancer Cell
, vol.7
, pp. 485-496
-
-
Lynch, C.C.1
-
67
-
-
1842634484
-
Metadherin, a cell surface protein in breast tumors that mediates lung metastasis
-
Brown, D. M. & Ruoslahti, E. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 5, 365-374 (2004).
-
(2004)
Cancer Cell
, vol.5
, pp. 365-374
-
-
Brown, D.M.1
Ruoslahti, E.2
-
68
-
-
28644432204
-
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
-
Kaplan, R. N. et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438, 820-827 (2005).
-
(2005)
Nature
, vol.438
, pp. 820-827
-
-
Kaplan, R.N.1
-
69
-
-
0036674501
-
Dissemination and growth of cancer cells in metastatic sites
-
Chambers, A. F., Groom, A. C. & MacDonald, I. C. Dissemination and growth of cancer cells in metastatic sites. Nature Rev. Cancer 2, 563-572 (2002).
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 563-572
-
-
Chambers, A.F.1
Groom, A.C.2
MacDonald, I.C.3
-
70
-
-
0036781973
-
A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor
-
Suyama, K., Shapiro, I., Guttman, M. & Hazan, R. B. A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor. Cancer Cell 2, 301-314 (2002).
-
(2002)
Cancer Cell
, vol.2
, pp. 301-314
-
-
Suyama, K.1
Shapiro, I.2
Guttman, M.3
Hazan, R.B.4
-
71
-
-
0141429160
-
A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations
-
Marambaud, P. et al. A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell 114, 635-645 (2003).
-
(2003)
Cell
, vol.114
, pp. 635-645
-
-
Marambaud, P.1
-
72
-
-
4344612243
-
NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
-
Huber, M. A. et al. NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J. Clin. Invest. 114, 569-581 (2004).
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 569-581
-
-
Huber, M.A.1
-
73
-
-
14844364701
-
Regulation of the polarity protein Par6 by TGFβ receptors controls epithelial cell plasticity
-
Ozdamar, B. et al. Regulation of the polarity protein Par6 by TGFβ receptors controls epithelial cell plasticity. Science 307, 1603-1609 (2005).
-
(2005)
Science
, vol.307
, pp. 1603-1609
-
-
Ozdamar, B.1
-
74
-
-
0036896923
-
CD44 is required for two consecutive steps in HGF/c-Met signaling
-
Orian-Rousseau, V., Chen, L., Sleeman, J. P., Herrlich, P. & Ponta, H. CD44 is required for two consecutive steps in HGF/c-Met signaling. Genes Dev. 16, 3074-3086 (2002).
-
(2002)
Genes Dev.
, vol.16
, pp. 3074-3086
-
-
Orian-Rousseau, V.1
Chen, L.2
Sleeman, J.P.3
Herrlich, P.4
Ponta, H.5
-
75
-
-
0033525829
-
Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met
-
van der Voort, R. et al. Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met. J. Biol. Chem. 274, 6499-6506 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 6499-6506
-
-
Van Der Voort, R.1
|