The Wnt Antagonist sFRP1 in Colorectal Tumorigenesis

Cancer Research

Volumn 64, Issue 3, 2004, Pages 883-888

  Caldwell, Germaine M ^a   Jones, Carolyn ^a   Gensberg, Karl ^a   Jan, Shamem ^a   Hardy, Robert G ^a   Byrd, Philip ^a   Chughtai, Shaheen ^a   Wallis, Yvonne ^b   Matthews, Glenn M ^a,c   Morton, Dion G ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b BIRMINGHAM WOMEN S HOSPITAL   (United Kingdom)

^c QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; MESSENGER RNA; PROTEIN; SECRETED FRIZZLED RELATED PROTEIN; SIGNAL PEPTIDE; UNCLASSIFIED DRUG; WNT PROTEIN;

ALLELE; ALTERNATIVE RNA SPLICING; ARTICLE; BASE MISPAIRING; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CHROMOSOME 8P; CHROMOSOME ARM; CHROMOSOME DELETION; COHORT ANALYSIS; COLORECTAL TUMOR; CONTROLLED STUDY; CPG ISLAND; CYSTEINE RICH DOMAIN; DOWN REGULATION; EPIGENETICS; EXON; GENE AMPLIFICATION; GENE INACTIVATION; GENE INSERTION; GENE MUTATION; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; INTESTINE MUCOSA; LARGE INTESTINE; METHYLATION; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; QUANTITATIVE ANALYSIS; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; BASE SEQUENCE; COLORECTAL NEOPLASMS; DNA METHYLATION; DOWN-REGULATION; EXONS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LOSS OF HETEROZYGOSITY; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; WNT PROTEINS; ZEBRAFISH PROTEINS;

EID: 10744229341     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-1346     Document Type: Article

References (41)

1. Takanishi, D. M., Jr., Kim, S. Y., Kelemen, P. R., Yaremko, M. L., Kim, A. H., Ramesar, J. E., Horrigan, S. K., Montag, A., Michelassi, F., and Westbrook, C. A. Chromosome 8 losses in colorectal carcinoma: localization and correlation with invasive disease. Mol. Diagn., 2: 3-10, 1997.
2. Adelaide, J., Chaffanet, M., Imbert, A., Allione, F., Geneix, J., Popovici, C., van Alewijk, D., Trapman, J., Zeillinger, R., Borresen-Dale, A. L., Lidereau, R., Birnbaum, D., and Pebusque, M. J. Chromosome region 8p11-p21: refined mapping and molecular alterations in breast cancer. Genes Chromosomes Cancer, 22: 186-199, 1998.
3. El-Naggar, A. K., Coombes, M. M., Batsakis, J. G., Hong, W. K., Goepfert, H., and Kagan, J. Localization of chromosome 8p regions involved in early tumorigenesis of oral and laryngeal squamous carcinoma. Oncogene, 16: 2983-2987, 1998.
4. Wright, K., Wilson, P. J., Kerr, J., Do, K., Hurst, T., Khoo, S. K., Ward, B., and Chenevix-Trench, G. Frequent loss of heterozygosity and three critical regions on the short arm of chromosome 8 in ovarian adenocarcinomas. Oncogene, 17: 1185-1188, 1998.
5. Qin, L. X., Tang, Z. Y., Sham, J. S., Ma, Z. C., Ye, S. L., Zhou, X. D., Wu, Z. Q., Trent, J. M., and Guan, X. Y. The association of chromosome 8p deletion and tumor metastasis in human hepatocellular carcinoma. Cancer Res., 59: 5662-5665, 1999.
6. Piao, Z., Kim, N. G., Kim, H., and Park, C. Deletion mapping on the short arm of chromosome 8 in hepatocellular carcinoma. Cancer Lett., 138: 227-232, 1999.
7. Lerebours, F., Olschwang, S., Thuille, B., Schmitz, A., Fouchet, P., Buecher, B., Martinet, N., Galateau, F., and Thomas, G. Fine deletion mapping of chromosome 8p in non-small-cell lung carcinoma. Int. J. Cancer, 81: 854-858, 1999.
8. Seitz, S., Rohde, K., Bender, E., Nothnagel, A., Kolble, K., Schlag, P. M., and Scherneck, S. Strong indication for a breast cancer susceptibility gene on chromosome 8p12-p22: linkage analysis in German breast cancer families. Oncogene, 14: 741-743, 1997.
9. Charafe-Jauffret, E., Moulin, J. F., Ginestier, C., Bechlian, D., Conte, N., Geneix, J., Adelaide, J., Noguchi, T., Hassoun, J., Jacquemier, J., and Birnbaum, D. Loss of heterozygosity at microsatellite markers from region p11-21 of chromosome 8 in microdissected breast tumor but not in peritumoral cells. Int. J. Oncol., 21: 989-996, 2002.
10. Crundwell, M., Chughtai, S., James, N., Lee, S., Wallace, D., Neoptolemos, J., Morton, D., and Phillips, S. Allelic loss of DCC, chromosome 22 and chromosome 8 in human prostate cancer. Int. J. Cancer, 69: 295-300, 1996.
11. Kuo, M. J., Crundwell, M. C., Knowles, M., Oates, J., Watkinson, J. C., Warfield, A. T., Morton, D. G., and Neoptolemos, J. P. Allelic deletion at 8p11.2 is a frequent event in head and neck cancer and identifiable using FISH on tumour imprints. Br. J. Surg., 85: 1563, 1998.
12. Chughtai, S. A., Crundwell, M. C., Cruickshank, N. R. J., Affie, E., Armstrong, S., Knowles, M., Takle, L., Kuo, M., Khan, N., Phillips, S. M. A., Neoptolemos, J. P., and Morton, D. G. Two novel regions of interstitial deletion on chromosome 8p in colorectal cancer. Oncogene, 18: 657-665, 1999.
13. Finch, P. W., He, X., Kelley, M. J., Üren, A., Schaudies, R. S., Popescu, N. C., Rudikoff, S., Aaronson, S. A., Varmus, H. E., and Rubin, J. S. Purification and molecular cloning of a secreted, frizzled-related antagonist of Wnt action. Proc. Natl. Acad. Sci. USA, 94: 6770-6775, 1997.
14. Nusse, R., van Ooyen, A., Cox, D., Fung, Y. K., and Varmus, H. Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15. Nature (Lond.), 307: 131-136, 1984.
15. Wodarz, A., and Nusse, R. Mechanisms of Wnt signaling in development. Annu. Rev. Cell. Dev. Biol., 14: 59-88, 1998.
16. Morin, P. J., Sparks, A. B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., and Kinzler, K. W. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science (Wash. DC), 275: 1787-1790, 1997.
17. Boutros, M., Paricio, N., Strutt, D. I., and Mlodzik, M. Disheveled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell, 94: 109-118, 1998.
18. + pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet., 16: 279-283, 2000.
19. Haertel-Wiesmann, M., Liang, Y., Fantl, W. J., and Williams, L. T. Regulation of cyclooxygenase-2 and periostin by Wnt-3 in mouse mammary epithelial cells. J. Biol. Chem., 275: 32046-32051, 2000.
20. Yan, D., Wiesmann, M., Rohan, M., Chan, V., Jefferson, A. B., Guo, L., Sakamoto, D., Caothien, R. H., Fuller, J. H., Reinhard, C., Garcia, P. D., Randazzo, F. M., Escobedo, J., Fantl, W. J., and Williams, L. T. Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/β-catenin signaling is activated in human colon tumors. Proc. Natl. Acad. Sci. USA, 98: 14973-14978, 2001.
21. Yan, D., Wallingford, J. B., Sun, T. Q., Nelson, A. M., Sakanaka, C., Reinhard, C., Harland, R. M., Fantl, W. J., and Williams, L. T. Cell autonomous regulation of multiple disheveled-dependent pathways by mammalian Nkd. Proc. Natl. Acad. Sci. USA, 98: 3802-3807, 2001.
22. Hsieh J-C., Rattner, A., Smallwood, P. M., and Nathans, J. Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein. Proc. Natl. Acad. Sci. USA, 96: 3546-3551, 1999.
23. Krupnik, V. E., Sharp, J. D., Jiang, C., Robison, K., Chickering, T. W., Amaravadi, L., Brown, D. E., Guyot, D., Mays, G., Leiby, K., Chang, B., Duong, T., Goodearl, A. D., Gearing, D. P., Sokol, S. Y., and McCarthy, S. A. Functional and structural diversity of the human Dickkopf gene family. Gene, 238: 301-313, 1999.
24. Melkonyan, H. S., Chang, W. C., Shapiro, J. P., Mahadevappa, M., Fitzpatrick, P. A., Kiefer, M. C., Tomei, L. D., and Umansky S. R. SARPs: a family of secreted apoptosis-related proteins. Proc. Natl. Acad. Sci. USA, 94: 13636-13641, 1997.
25. Mao, B., Wu, W., Li, Y., Hoppe, D., Stannek, P., Glinka, A., and Niehrs, C. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature (Lond.), 411: 321-325, 2001.
26. Bafico, A., Gazit, A., Pramila, T., Finch, P. W., Yaniv, A., and Aaronson, S. A. Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling. J. Biol. Chem., 274: 16180-16187, 1999.
27. Wong, S. C., Lo, S. F., Lee, K. C., Yam, J. W., Chan, J. K., and Hsiao, W. L. Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours. J. Pathol., 196: 145-153, 2002.
28. Hardy, R. G., Tselepsis, C., Hoylands, J., Wallis, Y., Pretlow, T. P., Talbot, I., Sanders, S. A. Matthews, G. Morton, D., and Jankowski, J. A. Z., Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon. Gut, 50: 513-519, 2002.
29. Grunau, C., Clark, S. J., and Rosenthal, A. Bisulfite genomic sequencing: systemic investigation of critical experimental parameters. Nucleic Acids Res., 29: E65, 2001.
30. Xiong, Z., and Laird, P. W. COBRA: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res., 25: 2532-2534, 1997.
31. Leyns, L., Bouwmeester, T., Kim, S. H., Piccolo, S., and De Robertis, E. M. Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell, 88: 747-756, 1997.
32. Lin K., Wang S., Julius M. A., Kitajewski J., Moos M., Jr., and Luyten, F. P. The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling. Proc. Natl. Acad. Sci. USA, 94: 11196-11200, 1997.
33. Zhou, Z., Wang, J., Han, X., Zhou, J., and Linder, S. Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors. Int. J. Cancer, 78: 95-99, 1998.
34. Ugolini, F., Charafe-Jauffret, E., Bardou, V. J., Geneix, J., Adelaida, J., Labat-Moleur, F., Penault-Llorca, F., Longy, M., Jacquemier, J., Birnbaum, D., and Pebusque, M. J. WNT pathway and mammary carcinogenesis: loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type. Oncogene, 20: 5810-5817, 2001.
35. To, K. F., Chan, M. W., Leung, W. K., Yu, J., Tong, J. H., Lee, T. L., Chan, F. K., and Sung, J. J. Alterations of frizzled (FzE3) and secreted frizzled related protein (hsFRP) expression in gastric cancer. Life Sci., 70: 483-489, 2001.
36. Uren, A., Reichsman, F., Anest, V., Taylor, W. G., Muraiso, K., Bottaro, D. P., Cumberledge, S., and Rubin, J. S. Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling. J. Biol. Chem., 275: 4374-4382, 2000.
37. Suzuki, H., Gabrielson, E., Chen, W., Anbazhagan, R., van Engeland, M., Weijenberg, M. P., Herman, J. G., and Baylin, S. B. A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat. Genet., 31: 141-149, 2002.
38. Mehlen, P., Rabizadeh, S., Snipas, S. J., Assa-Munt, N., Salvesen, G. S., and Bredesen, D. E. The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature (Lond.), 395: 801-804, 1998.
39. Banyai, L., and Patthy, L. The NTR module: domains of netrins, secreted frizzled related proteins, and type 1 procollagen C-proteinase enhancer protein are homologous with tissue inhibitors of metalloproteases. Protein Sci., 8, 1636-1642, 1999.
40. Li, L., Yuan, H., Xie, W., Mao, J., Caruso, A. M., McMahon, A., Sussman, D. J., and Wu, D. Dishevelled proteins lead to two signaling pathways. Regulation of lef-1 and c-jun N-terminal kinase in mammalian cells. J. Biol. Chem., 274: 129-134, 1999.
41. Sheldahl, L. C., Park, M., Malbon, C. C., and Moon, R. T. Protein kinase C is differentially stimulated by Wnt and frizzled homologs in a G-protein-dependent manner. Curr. Biol., 9: 695-698, 1999.