Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability

Genes Chromosomes and Cancer

Volumn 33, Issue 1, 2002, Pages 73-81

  Shimizu, Yosuke ^a   Ikeda, Satoshi ^a   Fujimori, Masahiko ^a   Kodama, Shinya ^a   Nakahara, Masahiro ^a   Okajima, Masazumi ^a   Asahara, Toshimasa ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; AXIN; BETA CATENIN; LYMPHOID ENHANCER FACTOR 1; TRANSCRIPTION FACTOR; WNT PROTEIN;

ADULT; ARTICLE; CARCINOGENESIS; COLON POLYPOSIS; COLORECTAL CANCER; CONTROLLED STUDY; FAMILIAL COLON POLYPOSIS; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MICROSATELLITE INSTABILITY; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 0036131933     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.1226     Document Type: Article

References (51)

1. β-catenin is a target for the ubiquitin-proteasome pathway
2. Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β
3. A National Cancer Institute Workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
4. XCtBP is a XTef-3 co-repressor with roles throughout Xenopus development
5. Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas
6. Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability
7. The human T-cell transcription factor-4 gene: Structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines
8. A genetic model for colorectal tumorigenesis
9. Frequent mutation and nuclear localization of β-catenin in anaplastic thyroid carcinoma
10. Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β
11. Identification of cMYC as a target of the APC pathway
12. APC mutations in colorectal tumors with mismatch repair deficiency
13. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3β and β-catenin and promotes GSK3β-dependent phosphorylation of β-catenin
14. GSK3β-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by β-catenin and protein phosphatase 2A complexed with Axin
15. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
16. Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-catenin
17. Roles of Axin in the Wnt signalling pathway
18. Lessons from hereditary colorectal cancer
19. Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of β-catenin
20. DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate β-catenin stability
21. Mutations in β-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumors
22. Genomic instability and alterations in Apc, Mcc and Dcc in Hong Kong patients with colorectal carcinoma
23. Axin directly interacts with plakoglobin and regulates its stability
24. Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer
25. Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling
26. Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24
27. β-Catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway
28. Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients
29. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
30. Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
31. Identification of concurrent germ-line mutations in hMSH2 and/or hMLH1 in Japanese hereditary nonpolyposis colorectal cancer kindreds
32. Wnt genes
33. Alternative genetic pathways in colorectal carcinogenesis
34. Serine phosphorylation-regulated ubiquitination and degradation of β-catenin
35. Frequent somatic mutations of the β-catenin gene in intestinal-type gastric cancer
36. APC mutations occur early during colorectal tumorigenesis
37. TCF transcription factors: Molecular switches in carcinogenesis
38. Loss of β-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene
39. Bridging of β-catenin and glycogen synthase kinase-3β by axin and inhibition of β-catenin-mediated transcription
40. Colorectal cancer with and without microsatellite instability involves different genes
41. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
42. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
43. Structural basis of the Axinadenomatous polyposis coli interaction
44. β-catenin regulates expression of cyclin D1 in colon carcinoma cells
45. Microsatellite instability in cancer of the proximal colon
46. The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)
47. β-catenin mutations in human prostate cancer
48. Sequence variants of the axin gene in breast, colon, and other cancers: An analysis of mutations that interfere with GSK3 binding
49. Analyses of the APC and TGF-β type II receptor genes, and microsatellite instability in mucosal colorectal carcinomas
50. Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3β and β-catenin and inhibits axis formation of Xenopus embryos
51. The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation