메뉴 건너뛰기




Volumn 2, Issue 2, 2012, Pages

Antigen-specific therapeutic approaches in type 1 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

ALTERED PEPTIDE LIGAND; ALUMINUM POTASSIUM SULFATE; CHAPERONIN 60; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DENDRITIC CELL TARGETED PEPTIDE; DENDRITIC CELL VACCINE; DIMER; DNA VACCINE; ETHYLENE CARBODIIMIDE; ETHYLENE DERIVATIVE; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 65; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; INSULIN; INTERLEUKIN 10; INTERLEUKIN 4; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NANOPARTICLE; RECOMBINANT ENZYME; RECOMBINANT GLUTAMATE DECARBOXYLASE; SILVER; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; ANTIGEN; ENZYME INHIBITOR;

EID: 84873135697     PISSN: None     EISSN: 21571422     Source Type: Journal    
DOI: 10.1101/cshperspect.a007773     Document Type: Article
Times cited : (42)

References (194)
  • 1
    • 0029100015 scopus 로고
    • Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness
    • Abastado JP, Lone YC, Casrouge A, Boulot G, Kourilsky P. 1995. Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness. J Exp Med 182: 439-447.
    • (1995) J Exp Med , vol.182 , pp. 439-447
    • Abastado, J.P.1    Lone, Y.C.2    Casrouge, A.3    Boulot, G.4    Kourilsky, P.5
  • 2
    • 0031913650 scopus 로고    scopus 로고
    • Islet T cells secreting IFN-γ in NOD mouse diabetes: Arrest by p277 peptide treatment
    • Ablamunits V, Elias D, Reshef T, Cohen IR. 1998. Islet T cells secreting IFN-γ in NOD mouse diabetes: Arrest by p277 peptide treatment. J Autoimmun 11: 73-81.
    • (1998) J Autoimmun , vol.11 , pp. 73-81
    • Ablamunits, V.1    Elias, D.2    Reshef, T.3    Cohen, I.R.4
  • 3
    • 0033106415 scopus 로고    scopus 로고
    • T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides
    • Abulafia-Lapid R, Elias D, Raz I, Keren-Zur Y, Atlan H, Cohen IR. 1999. T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides. J Autoimmun 12: 121-129.
    • (1999) J Autoimmun , vol.12 , pp. 121-129
    • Abulafia-Lapid, R.1    Elias, D.2    Raz, I.3    Keren-Zur, Y.4    Atlan, H.5    Cohen, I.R.6
  • 4
    • 0038617504 scopus 로고    scopus 로고
    • T cells and autoantibodies to human HSP70 in type 1 diabetes in children
    • Abulafia-Lapid R, Gillis D, Yosef O, Atlan H, Cohen IR. 2003. T cells and autoantibodies to human HSP70 in type 1 diabetes in children. J Autoimmun 20: 313-321.
    • (2003) J Autoimmun , vol.20 , pp. 313-321
    • Abulafia-Lapid, R.1    Gillis, D.2    Yosef, O.3    Atlan, H.4    Cohen, I.R.5
  • 6
    • 0036300542 scopus 로고    scopus 로고
    • Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide
    • Alleva DG, Gaur A, Jin L, Wegmann D, Gottlieb PA, Pahuja A, Johnson EB, Motheral T, Putnam A, Crowe PD, et al. 2002. Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide. Diabetes 51: 2126-2134.
    • (2002) Diabetes , vol.51 , pp. 2126-2134
    • Alleva, D.G.1    Gaur, A.2    Jin, L.3    Wegmann, D.4    Gottlieb, P.A.5    Pahuja, A.6    Johnson, E.B.7    Motheral, T.8    Putnam, A.9    Crowe, P.D.10
  • 8
    • 0034680105 scopus 로고    scopus 로고
    • Progression of autoimmune diabetes driven by avidity maturation of a T-cell population
    • Amrani A, Verdaguer J, Serra P, Tafuro S, Tan R, Santamaria P. 2000. Progression of autoimmune diabetes driven by avidity maturation of a T-cell population. Nature 406: 739-742.
    • (2000) Nature , vol.406 , pp. 739-742
    • Amrani, A.1    Verdaguer, J.2    Serra, P.3    Tafuro, S.4    Tan, R.5    Santamaria, P.6
  • 10
    • 0036408394 scopus 로고    scopus 로고
    • Nasal administration of CTB-insulin induces active tolerance against autoimmune diabetes in non-obese diabetic (NOD) mice
    • Aspord C, Thivolet C. 2002. Nasal administration of CTB-insulin induces active tolerance against autoimmune diabetes in non-obese diabetic (NOD) mice. Clin Exp Immunol 130: 204-211.
    • (2002) Clin Exp Immunol , vol.130 , pp. 204-211
    • Aspord, C.1    Thivolet, C.2
  • 11
    • 0025472820 scopus 로고
    • Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy
    • Atkinson MA, Maclaren NK, Luchetta R. 1990. Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy. Diabetes 39: 933-937.
    • (1990) Diabetes , vol.39 , pp. 933-937
    • Atkinson, M.A.1    McLaren, N.K.2    Luchetta, R.3
  • 12
    • 0027529913 scopus 로고
    • Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes
    • Atkinson MA, Kaufman DL, Newman D, Tobin AJ, Maclaren NK. 1993. Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes. J Clin Invest 91: 350-356.
    • (1993) J Clin Invest , vol.91 , pp. 350-356
    • Atkinson, M.A.1    Kaufman, D.L.2    Newman, D.3    Tobin, A.J.4    McLaren, N.K.5
  • 13
    • 78651376427 scopus 로고    scopus 로고
    • Early induction of GAD(65)-reactive Th2 response in type 1 diabetic children treated with alum-formulated GAD(65)
    • Axelsson S, Hjorth M, Akerman L, Ludvigsson J, Casas R. 2010. Early induction of GAD(65)-reactive Th2 response in type 1 diabetic children treated with alum-formulated GAD(65). Diabetes Metab Res Rev 26: 559-568.
    • (2010) Diabetes Metab Res Rev , vol.26 , pp. 559-568
    • Axelsson, S.1    Hjorth, M.2    Akerman, L.3    Ludvigsson, J.4    Casas, R.5
  • 15
    • 0019959221 scopus 로고
    • Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins
    • Baekkeskov S, Nielsen JH, Marner B, Bilde T, Ludvigsson J, Lernmark A. 1982. Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins. Nature 298: 167-169.
    • (1982) Nature , vol.298 , pp. 167-169
    • Baekkeskov, S.1    Nielsen, J.H.2    Marner, B.3    Bilde, T.4    Ludvigsson, J.5    Lernmark, A.6
  • 17
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
    • Bielekova B, Goodwin B, Richert N, Cortese I, Kondo T, Afshar G, Gran B, EatonJ, Antel J, Frank JA, et al. 2000. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand. Nat Med 6: 1167-1175.
    • (2000) Nat Med , vol.6 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3    Cortese, I.4    Kondo, T.5    Afshar, G.6    Gran, B.7    Eaton, J.8    Antel, J.9    Frank, J.A.10
  • 20
    • 0035451681 scopus 로고    scopus 로고
    • Plasmid vaccination with insulin B chain prevents autoimmune diabetes in nonobese diabetic mice
    • Bot A, Smith D, Bot S, Hughes A, Wolfe T, Wang L, Woods C, von Herrath M. 2001. Plasmid vaccination with insulin B chain prevents autoimmune diabetes in nonobese diabetic mice. J Immunol 167: 2950-2955.
    • (2001) J Immunol , vol.167 , pp. 2950-2955
    • Bot, A.1    Smith, D.2    Bot, S.3    Hughes, A.4    Wolfe, T.5    Wang, L.6    Woods, C.7    von Herrath, M.8
  • 21
    • 33646392755 scopus 로고    scopus 로고
    • Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs
    • Bresson D, Togher L, Rodrigo E, Chen Y, Bluestone JA, Herold KC, von HerrathM. 2006. Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J Clin Invest 116: 1371-1381.
    • (2006) J Clin Invest , vol.116 , pp. 1371-1381
    • Bresson, D.1    Togher, L.2    Rodrigo, E.3    Chen, Y.4    Bluestone, J.A.5    Herold, K.C.6    von Herrath, M.7
  • 22
    • 76349093141 scopus 로고    scopus 로고
    • Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes
    • Bresson D, Fradkin M, Manenkova Y, Rottembourg D, von Herrath M. 2010. Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes. Mol Ther 18: 307-316.
    • (2010) Mol Ther , vol.18 , pp. 307-316
    • Bresson, D.1    Fradkin, M.2    Manenkova, Y.3    Rottembourg, D.4    von Herrath, M.5
  • 25
    • 0027451440 scopus 로고
    • Efficient loading of identical viral peptide onto class II molecules by antigenized immunoglobulin and influenza virus
    • Brumeanu TD, Swiggard WJ, Steinman RM, Bona CA, Zaghouani H. 1993. Efficient loading of identical viral peptide onto class II molecules by antigenized immunoglobulin and influenza virus. J Exp Med 178: 1795-1799.
    • (1993) J Exp Med , vol.178 , pp. 1795-1799
    • Brumeanu, T.D.1    Swiggard, W.J.2    Steinman, R.M.3    Bona, C.A.4    Zaghouani, H.5
  • 29
    • 0030731920 scopus 로고    scopus 로고
    • Retardation or acceleration of diabetes in NOD/Lt mice mediated by intrathymic administration of candidate β-cell antigens
    • Cetkovic-Cvrlje M, Gerling IC, Muir A, Atkinson MA, Elliott JF, Leiter EH. 1997. Retardation or acceleration of diabetes in NOD/Lt mice mediated by intrathymic administration of candidate β-cell antigens. Diabetes 46: 1975-1982.
    • (1997) Diabetes , vol.46 , pp. 1975-1982
    • Cetkovic-Cvrlje, M.1    Gerling, I.C.2    Muir, A.3    Atkinson, M.A.4    Elliott, J.F.5    Leiter, E.H.6
  • 30
    • 17444437590 scopus 로고    scopus 로고
    • Oral insulin administration and residual β-cell function in recent-onset type 1 diabetes: A multicentre randomised controlled trial. Diabete Insuline Orale group
    • Chaillous L, Lefevre H, Thivolet C, Boitard C, Lahlou N, Atlan-Gepner C, Bouhanick B, Mogenet A, Nicolino M, Carel JC, et al. 2000. Oral insulin administration and residual β-cell function in recent-onset type 1 diabetes: A multicentre randomised controlled trial. Diabete Insuline Orale group. Lancet 356: 545-549.
    • (2000) Lancet , vol.356 , pp. 545-549
    • Chaillous, L.1    Lefevre, H.2    Thivolet, C.3    Boitard, C.4    Lahlou, N.5    Atlan-Gepner, C.6    Bouhanick, B.7    Mogenet, A.8    Nicolino, M.9    Carel, J.C.10
  • 31
    • 27944486723 scopus 로고    scopus 로고
    • DNA vaccination with an insulin construct and a chimeric protein binding to both CTLA4 and CD40 ameliorates type 1 diabetes in NOD mice
    • Chang Y, Yap S, Ge X, Piganelli J, Bertera S, Giannokakis N, Mathews C, Prud'homme G, Trucco M. 2005. DNA vaccination with an insulin construct and a chimeric protein binding to both CTLA4 and CD40 ameliorates type 1 diabetes in NOD mice. Gene Ther 12: 1679-1685.
    • (2005) Gene Ther , vol.12 , pp. 1679-1685
    • Chang, Y.1    Yap, S.2    Ge, X.3    Piganelli, J.4    Bertera, S.5    Giannokakis, N.6    Mathews, C.7    Prud'homme, G.8    Trucco, M.9
  • 32
    • 0035500757 scopus 로고    scopus 로고
    • Evidence that a peptide spanning the B-C junction of proinsulin is an early autoantigen epitope in the pathogenesis of type 1 diabetes
    • Chen W, Bergerot I, Elliott JF, Harrison LC, Abiru N, Eisenbarth GS, DelovitchTL. 2001. Evidence that a peptide spanning the B-C junction of proinsulin is an early autoantigen epitope in the pathogenesis of type 1 diabetes. J Immunol 167: 4926-4935.
    • (2001) J Immunol , vol.167 , pp. 4926-4935
    • Chen, W.1    Bergerot, I.2    Elliott, J.F.3    Harrison, L.C.4    Abiru, N.5    Eisenbarth, G.S.6    Delovitch, T.L.7
  • 33
  • 34
    • 0038783708 scopus 로고    scopus 로고
    • Induction of autoantigen-specific Th2 and Tr1 regulatory T cells and modulation of autoimmune diabetes
    • Chen C, Lee WH, Yun P, Snow P, Liu CP. 2003. Induction of autoantigen-specific Th2 and Tr1 regulatory T cells and modulation of autoimmune diabetes. J Immunol 171: 733-744.
    • (2003) J Immunol , vol.171 , pp. 733-744
    • Chen, C.1    Lee, W.H.2    Yun, P.3    Snow, P.4    Liu, C.P.5
  • 35
    • 77956614531 scopus 로고    scopus 로고
    • GAD-alum treatment in patients with type 1 diabetes and the subsequent effect on GADA IgG subclass distribution, GAD65 enzyme activity and humoral response
    • Cheramy M, Skoglund C, Johansson I, Ludvigsson J, Hampe CS, Casas R. 2010. GAD-alum treatment in patients with type 1 diabetes and the subsequent effect on GADA IgG subclass distribution, GAD65 enzyme activity and humoral response. Clin Immunol 137: 31-40.
    • (2010) Clin Immunol , vol.137 , pp. 31-40
    • Cheramy, M.1    Skoglund, C.2    Johansson, I.3    Ludvigsson, J.4    Hampe, C.S.5    Casas, R.6
  • 36
    • 0025718751 scopus 로고
    • Pancreatic β cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble
    • Christgau S, Schierbeck H, Aanstoot HJ, Aagaard L, Begley K, Kofod H, HejnaesK, Baekkeskov S. 1991. Pancreatic β cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble. J Biol Chem 266: 23516.
    • (1991) J Biol Chem , vol.266 , pp. 23516
    • Christgau, S.1    Schierbeck, H.2    Aanstoot, H.J.3    Aagaard, L.4    Begley, K.5    Kofod, H.6    Hejnaes, K.7    Baekkeskov, S.8
  • 37
    • 0026684592 scopus 로고
    • Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM. Studies with identical twins
    • Christie MR, Tun RY, Lo SS, Cassidy D, Brown TJ, Hollands J, Shattock M, Bottazzo GF, Leslie RD. 1992. Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM. Studies with identical twins. Diabetes 41: 782-787.
    • (1992) Diabetes , vol.41 , pp. 782-787
    • Christie, M.R.1    Tun, R.Y.2    Lo, S.S.3    Cassidy, D.4    Brown, T.J.5    Hollands, J.6    Shattock, M.7    Bottazzo, G.F.8    Leslie, R.D.9
  • 39
    • 80052479923 scopus 로고    scopus 로고
    • Peptide-MHC-based nanovaccines for the treatment of autoimmunity: A "one size fits all" approach?
    • Clemente-Casares X, Tsai S, Yang Y, Santamaria P. 2011. Peptide-MHC-based nanovaccines for the treatment of autoimmunity: A "one size fits all" approach? J Mol Med 89: 733-742.
    • (2011) J Mol Med , vol.89 , pp. 733-742
    • Clemente-Casares, X.1    Tsai, S.2    Yang, Y.3    Santamaria, P.4
  • 42
    • 0029872093 scopus 로고    scopus 로고
    • Intranasal administration of insulin peptide B: 9-23 protects NOD mice from diabetes
    • Daniel D, Wegmann DR. 1996a. Intranasal administration of insulin peptide B: 9-23 protects NOD mice from diabetes. Ann NY Acad Sci 778: 371-372.
    • (1996) Ann NY Acad Sci , vol.778 , pp. 371-372
    • Daniel, D.1    Wegmann, D.R.2
  • 43
    • 0030069688 scopus 로고    scopus 로고
    • Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)
    • Daniel D, Wegmann DR. 1996b. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc Natl Acad Sci 93: 956-960.
    • (1996) Proc Natl Acad Sci , vol.93 , pp. 956-960
    • Daniel, D.1    Wegmann, D.R.2
  • 45
    • 0026667626 scopus 로고
    • Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes
    • De Aizpurua HJ, Wilson YM, Harrison LC. 1992. Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes. Proc Natl Acad Sci 89: 9841-9845.
    • (1992) Proc Natl Acad Sci , vol.89 , pp. 9841-9845
    • De Aizpurua, H.J.1    Wilson, Y.M.2    Harrison, L.C.3
  • 46
    • 3242665039 scopus 로고    scopus 로고
    • Differential immune response to B: 9-23 insulin 1 and insulin 2 peptides in animal models of type 1 diabetes
    • Devendra D, Paronen J, Moriyama H, Miao D, Eisenbarth GS, Liu E. 2004. Differential immune response to B: 9-23 insulin 1 and insulin 2 peptides in animal models of type 1 diabetes. J Autoimmun 23: 17-26.
    • (2004) J Autoimmun , vol.23 , pp. 17-26
    • Devendra, D.1    Paronen, J.2    Moriyama, H.3    Miao, D.4    Eisenbarth, G.S.5    Liu, E.6
  • 47
    • 0037198427 scopus 로고    scopus 로고
    • Effects of insulin in relatives of patients with type 1 diabetes mellitus
    • Diabetes Prevention Trial-Type 1 Diabetes Study Group
    • Diabetes Prevention Trial-Type 1 Diabetes Study Group. 2002. Effects of insulin in relatives of patients with type 1 diabetes mellitus. N Engl J Med 346: 1685-1691.
    • (2002) N Engl J Med , vol.346 , pp. 1685-1691
  • 48
    • 0028215907 scopus 로고
    • Peptide therapy for diabetes in NOD mice
    • Elias D, Cohen IR. 1994. Peptide therapy for diabetes in NOD mice. Lancet 343: 704-706.
    • (1994) Lancet , vol.343 , pp. 704-706
    • Elias, D.1    Cohen, I.R.2
  • 49
    • 0028787305 scopus 로고
    • Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock protein 60 peptide 277
    • Elias D, Cohen IR. 1995. Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock protein 60 peptide 277. Diabetes 44: 1132-1138.
    • (1995) Diabetes , vol.44 , pp. 1132-1138
    • Elias, D.1    Cohen, I.R.2
  • 50
    • 0025058568 scopus 로고
    • Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein
    • Elias D, Markovits D, Reshef T, van der Zee R, Cohen IR. 1990. Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. Proc Natl Acad Sci 87: 1576-1580.
    • (1990) Proc Natl Acad Sci , vol.87 , pp. 1576-1580
    • Elias, D.1    Markovits, D.2    Reshef, T.3    van der Zee, R.4    Cohen, I.R.5
  • 51
    • 0026322837 scopus 로고
    • Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein
    • Elias D, Reshef T, Birk OS, van der Zee R, Walker MD, Cohen IR. 1991. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc Natl Acad Sci 88: 3088-3091.
    • (1991) Proc Natl Acad Sci , vol.88 , pp. 3088-3091
    • Elias, D.1    Reshef, T.2    Birk, O.S.3    van der Zee, R.4    Walker, M.D.5    Cohen, I.R.6
  • 52
    • 0028787628 scopus 로고
    • Induction of diabetes in standard mice by immunization with the p277 peptide of a 60-kDa heat shock protein
    • Elias D, Marcus H, Reshef T, Ablamunits V, Cohen IR. 1995. Induction of diabetes in standard mice by immunization with the p277 peptide of a 60-kDa heat shock protein. Eur J Immunol 25: 2851-2857.
    • (1995) Eur J Immunol , vol.25 , pp. 2851-2857
    • Elias, D.1    Marcus, H.2    Reshef, T.3    Ablamunits, V.4    Cohen, I.R.5
  • 53
    • 0030960632 scopus 로고    scopus 로고
    • Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various β-cell antigens
    • Elias D, Meilin A, Ablamunits V, Birk OS, Carmi P, Konen-Waisman S, Cohen IR. 1997. Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various β-cell antigens. Diabetes 46: 758-764.
    • (1997) Diabetes , vol.46 , pp. 758-764
    • Elias, D.1    Meilin, A.2    Ablamunits, V.3    Birk, O.S.4    Carmi, P.5    Konen-Waisman, S.6    Cohen, I.R.7
  • 54
    • 0028586035 scopus 로고
    • Immunization with the larger isoform of mouse glutamic acid decarboxylase (GAD67) prevents autoimmune diabetes in NOD mice
    • Elliott JF, Qin HY, Bhatti S, Smith DK, Singh RK, Dillon T, Lauzon J, Singh B. 1994. Immunization with the larger isoform of mouse glutamic acid decarboxylase (GAD67) prevents autoimmune diabetes in NOD mice. Diabetes 43: 1494-1499.
    • (1994) Diabetes , vol.43 , pp. 1494-1499
    • Elliott, J.F.1    Qin, H.Y.2    Bhatti, S.3    Smith, D.K.4    Singh, R.K.5    Dillon, T.6    Lauzon, J.7    Singh, B.8
  • 55
    • 0007102288 scopus 로고    scopus 로고
    • Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients
    • Endl J, Otto H, Jung G, Dreisbusch B, Donie F, Stahl P, Elbracht R, Schmitz G, Meinl E, Hummel M, et al. 1997. Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients. J Clin Invest 99: 2405-2415.
    • (1997) J Clin Invest , vol.99 , pp. 2405-2415
    • Endl, J.1    Otto, H.2    Jung, G.3    Dreisbusch, B.4    Donie, F.5    Stahl, P.6    Elbracht, R.7    Schmitz, G.8    Meinl, E.9    Hummel, M.10
  • 57
    • 0026434554 scopus 로고
    • Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand
    • Evavold BD, Allen PM. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252: 1308-1310.
    • (1991) Science , vol.252 , pp. 1308-1310
    • Evavold, B.D.1    Allen, P.M.2
  • 58
    • 0027333348 scopus 로고
    • Tickling the TCR: Selective T-cell functions stimulated by altered peptide ligands
    • Evavold BD, Sloan-Lancaster J, Allen PM. 1993. Tickling the TCR: Selective T-cell functions stimulated by altered peptide ligands. Immunol Today 14: 602-609.
    • (1993) Immunol Today , vol.14 , pp. 602-609
    • Evavold, B.D.1    Sloan-Lancaster, J.2    Allen, P.M.3
  • 60
    • 0027134795 scopus 로고
    • Localization and quantitation of expression of two glutamate decarboxylase genes in pancreatic β-cells and other peripheral tissues of mouse and rat
    • Faulkner-Jones BE, Cram DS, Kun J, Harrison LC. 1993. Localization and quantitation of expression of two glutamate decarboxylase genes in pancreatic β-cells and other peripheral tissues of mouse and rat. Endocrinology 133: 2962-2972.
    • (1993) Endocrinology , vol.133 , pp. 2962-2972
    • Faulkner-Jones, B.E.1    Cram, D.S.2    Kun, J.3    Harrison, L.C.4
  • 63
    • 0036318881 scopus 로고    scopus 로고
    • Regulatory Th2 response induced following adoptive transfer of dendritic cells in prediabetic NOD mice
    • Feili-Hariri M, Falkner DH, Morel PA. 2002. Regulatory Th2 response induced following adoptive transfer of dendritic cells in prediabetic NOD mice. Eur J Immunol 32: 2021-2030.
    • (2002) Eur J Immunol , vol.32 , pp. 2021-2030
    • Feili-Hariri, M.1    Falkner, D.H.2    Morel, P.A.3
  • 66
    • 0035573750 scopus 로고    scopus 로고
    • Effects of plasmid DNA injection on cyclophosphamide-accelerated diabetes in NOD mice
    • Filippova M, Liu J, Escher A. 2001. Effects of plasmid DNA injection on cyclophosphamide-accelerated diabetes in NOD mice. DNA Cell Biol 20: 175-181.
    • (2001) DNA Cell Biol , vol.20 , pp. 175-181
    • Filippova, M.1    Liu, J.2    Escher, A.3
  • 67
    • 76149134396 scopus 로고    scopus 로고
    • Immunomodulation with heat shock protein DiaPep277 to preserve β cell function in type 1 diabetes-an update
    • Fischer B, Elias D, Bretzel RG, Linn T. 2010. Immunomodulation with heat shock protein DiaPep277 to preserve β cell function in type 1 diabetes-an update. Expert Opin Biol Ther 10: 265-272.
    • (2010) Expert Opin Biol Ther , vol.10 , pp. 265-272
    • Fischer, B.1    Elias, D.2    Bretzel, R.G.3    Linn, T.4
  • 69
    • 77955549725 scopus 로고    scopus 로고
    • Subcutaneous insulin B: 9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNγ
    • Fousteri G, Dave A, Bot A, Juntti T, Omid S, von Herrath M. 2010. Subcutaneous insulin B: 9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNγ. Diabetologia 53: 1958-1970.
    • (2010) Diabetologia , vol.53 , pp. 1958-1970
    • Fousteri, G.1    Dave, A.2    Bot, A.3    Juntti, T.4    Omid, S.5    von Herrath, M.6
  • 71
    • 3543046812 scopus 로고    scopus 로고
    • DNA vaccination encoding glutamic acid decarboxylase can enhance insulitis and diabetes in correlation with a specific Th2/3 CD4 T cell response in non-obese diabetic mice
    • Gauvrit A, Debailleul M, Vu AT, Sai P, Bach JM. 2004. DNA vaccination encoding glutamic acid decarboxylase can enhance insulitis and diabetes in correlation with a specific Th2/3 CD4 T cell response in non-obese diabetic mice. Clin Exp Immunol 137: 253-262.
    • (2004) Clin Exp Immunol , vol.137 , pp. 253-262
    • Gauvrit, A.1    Debailleul, M.2    Vu, A.T.3    Sai, P.4    Bach, J.M.5
  • 72
    • 0031754261 scopus 로고    scopus 로고
    • Altered peptide ligands of islet autoantigen Imogen 38 inhibit antigen specific T cell reactivity in human type-1 diabetes
    • Geluk A, van Meijgaarden KE, Roep BO, Ottenhoff TH. 1998. Altered peptide ligands of islet autoantigen Imogen 38 inhibit antigen specific T cell reactivity in human type-1 diabetes. J Autoimmun 11: 353-361.
    • (1998) J Autoimmun , vol.11 , pp. 353-361
    • Geluk, A.1    van Meijgaarden, K.E.2    Roep, B.O.3    Ottenhoff, T.H.4
  • 73
    • 0032543998 scopus 로고    scopus 로고
    • Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease
    • Geng L, Solimena M, Flavell RA, Sherwin RS, Hayday AC. 1998. Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease. Proc Natl Acad Sci 95: 10055-10060.
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 10055-10060
    • Geng, L.1    Solimena, M.2    Flavell, R.A.3    Sherwin, R.S.4    Hayday, A.C.5
  • 74
    • 33748168720 scopus 로고    scopus 로고
    • Protective regulatory T cell generation in autoimmune diabetes by DNA covaccination with islet antigens and a selective CTLA-4 ligand
    • Glinka Y, Chang Y, Prud'homme GJ. 2006. Protective regulatory T cell generation in autoimmune diabetes by DNA covaccination with islet antigens and a selective CTLA-4 ligand. Mol Ther 14: 578-587.
    • (2006) Mol Ther , vol.14 , pp. 578-587
    • Glinka, Y.1    Chang, Y.2    Prud'homme, G.J.3
  • 76
    • 51449104527 scopus 로고    scopus 로고
    • Gene gun-mediated DNA vaccination enhances antigen-specific immunotherapy at a late preclinical stage of type 1 diabetes in nonobese diabetic mice
    • Goudy KS, Wang B, Tisch R. 2008. Gene gun-mediated DNA vaccination enhances antigen-specific immunotherapy at a late preclinical stage of type 1 diabetes in nonobese diabetic mice. Clin Immunol 129: 49-57.
    • (2008) Clin Immunol , vol.129 , pp. 49-57
    • Goudy, K.S.1    Wang, B.2    Tisch, R.3
  • 77
    • 10344245538 scopus 로고    scopus 로고
    • A sudden decline in active membrane-bound TGF-β impairs both T regulatory cell function and protection against autoimmune diabetes
    • Gregg RK, Jain R, Schoenleber SJ, Divekar R, Bell JJ, Lee HH, Yu P, Zaghouani H. 2004. A sudden decline in active membrane-bound TGF-β impairs both T regulatory cell function and protection against autoimmune diabetes. J Immunol 173: 7308-7316.
    • (2004) J Immunol , vol.173 , pp. 7308-7316
    • Gregg, R.K.1    Jain, R.2    Schoenleber, S.J.3    Divekar, R.4    Bell, J.J.5    Lee, H.H.6    Yu, P.7    Zaghouani, H.8
  • 78
    • 20944441042 scopus 로고    scopus 로고
    • Prevention of diabetes by manipulation of anti-IGRP autoimmunity: High efficiency of a low-affinity peptide
    • Han B, Serra P, Amrani A, Yamanouchi J, Maree AF, Edelstein-Keshet L, Santamaria P. 2005. Prevention of diabetes by manipulation of anti-IGRP autoimmunity: High efficiency of a low-affinity peptide. Nat Med 11: 645-652.
    • (2005) Nat Med , vol.11 , pp. 645-652
    • Han, B.1    Serra, P.2    Amrani, A.3    Yamanouchi, J.4    Maree, A.F.5    Edelstein-Keshet, L.6    Santamaria, P.7
  • 79
    • 0030456670 scopus 로고    scopus 로고
    • Aerosol insulin induces regulatory CD8 γ δ T cells that prevent murine insulin-dependent diabetes
    • Harrison LC, Dempsey-Collier M, Kramer DR, Takahashi K. 1996. Aerosol insulin induces regulatory CD8 γ δ T cells that prevent murine insulin-dependent diabetes. J Exp Med 184: 2167-2174.
    • (1996) J Exp Med , vol.184 , pp. 2167-2174
    • Harrison, L.C.1    Dempsey-Collier, M.2    Kramer, D.R.3    Takahashi, K.4
  • 80
    • 4644230843 scopus 로고    scopus 로고
    • Pancreatic β-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes
    • Harrison LC, Honeyman MC, Steele CE, Stone NL, Sarugeri E, Bonifacio E, Couper JJ, Colman PG. 2004. Pancreatic β-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes. Diabetes Care 27: 2348-2355.
    • (2004) Diabetes Care , vol.27 , pp. 2348-2355
    • Harrison, L.C.1    Honeyman, M.C.2    Steele, C.E.3    Stone, N.L.4    Sarugeri, E.5    Bonifacio, E.6    Couper, J.J.7    Colman, P.G.8
  • 81
    • 36849017514 scopus 로고    scopus 로고
    • Programmed death-1 ligands-transfected dendritic cells loaded with glutamic acid decarboxylase 65 (GAD65) inhibit both the alloresponse and the GAD65-reactive lymphocyte response
    • He FR, Zhu HF, Huang H, Dai YD, Shen X, Wang M, Li L, Xing W, Shen GX. 2008. Programmed death-1 ligands-transfected dendritic cells loaded with glutamic acid decarboxylase 65 (GAD65) inhibit both the alloresponse and the GAD65-reactive lymphocyte response. Clin Exp Immunol 151: 86-93.
    • (2008) Clin Exp Immunol , vol.151 , pp. 86-93
    • He, F.R.1    Zhu, H.F.2    Huang, H.3    Dai, Y.D.4    Shen, X.5    Wang, M.6    Li, L.7    Xing, W.8    Shen, G.X.9
  • 82
    • 0022637719 scopus 로고
    • The requirements for antigen multivalency in class I antigen recognition and triggering of primed precursor cytolytic T lymphocytes
    • Herrmann SH, Mescher MF. 1986. The requirements for antigen multivalency in class I antigen recognition and triggering of primed precursor cytolytic T lymphocytes. J Immunol 136: 2816-2825.
    • (1986) J Immunol , vol.136 , pp. 2816-2825
    • Herrmann, S.H.1    Mescher, M.F.2
  • 84
    • 0027534912 scopus 로고
    • Glutamic acid decarboxylase 67-reactive T cells: A marker of insulin-dependent diabetes
    • Honeyman MC, Cram DS, Harrison LC. 1993. Glutamic acid decarboxylase 67-reactive T cells: A marker of insulin-dependent diabetes. J Exp Med 177: 535-540.
    • (1993) J Exp Med , vol.177 , pp. 535-540
    • Honeyman, M.C.1    Cram, D.S.2    Harrison, L.C.3
  • 85
    • 0029135158 scopus 로고
    • Comparative study of the protective effect afforded by intravenous administration of bovine or ovine insulin to young NOD mice
    • Hutchings PR, Cooke A. 1995. Comparative study of the protective effect afforded by intravenous administration of bovine or ovine insulin to young NOD mice. Diabetes 44: 906-910.
    • (1995) Diabetes , vol.44 , pp. 906-910
    • Hutchings, P.R.1    Cooke, A.2
  • 86
    • 0031777665 scopus 로고    scopus 로고
    • Protection from insulin dependent diabetes mellitus afforded by insulin antigens in incomplete Freund's adjuvant depends on route of administration
    • Hutchings P, Cooke A. 1998. Protection from insulin dependent diabetes mellitus afforded by insulin antigens in incomplete Freund's adjuvant depends on route of administration. J Autoimmun 11: 127-130.
    • (1998) J Autoimmun , vol.11 , pp. 127-130
    • Hutchings, P.1    Cooke, A.2
  • 87
    • 34249825219 scopus 로고    scopus 로고
    • Therapy with the hsp60 peptide DiaPep277 in C-peptide positive type 1 diabetes patients
    • Huurman VA, Decochez K, Mathieu C, Cohen IR, Roep BO. 2007. Therapy with the hsp60 peptide DiaPep277 in C-peptide positive type 1 diabetes patients. Diabetes Metab Res Rev 23: 269-275.
    • (2007) Diabetes Metab Res Rev , vol.23 , pp. 269-275
    • Huurman, V.A.1    Decochez, K.2    Mathieu, C.3    Cohen, I.R.4    Roep, B.O.5
  • 89
    • 0038204841 scopus 로고    scopus 로고
    • Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase
    • Jaeckel E, Klein L, Martin-Orozco N, von Boehmer H. 2003. Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase. J Exp Med 197: 1635-1644.
    • (2003) J Exp Med , vol.197 , pp. 1635-1644
    • Jaeckel, E.1    Klein, L.2    Martin-Orozco, N.3    von Boehmer, H.4
  • 91
    • 0029009977 scopus 로고
    • The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
    • Jiang W, Swiggard WJ, Heufler C, Peng M, Mirza A, Steinman RM, NussenzweigMC. 1995. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 375: 151-155.
    • (1995) Nature , vol.375 , pp. 151-155
    • Jiang, W.1    Swiggard, W.J.2    Heufler, C.3    Peng, M.4    Mirza, A.5    Steinman, R.M.6    Nussenzweig, M.C.7
  • 92
    • 0033791462 scopus 로고    scopus 로고
    • Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The Altered Peptide Ligand in Relapsing MS Study Group
    • Kappos L, Comi G, Panitch H, Oger J, Antel J, Conlon P, Steinman L. 2000. Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The Altered Peptide Ligand in Relapsing MS Study Group. Nat Med 6: 1176-1182.
    • (2000) Nat Med , vol.6 , pp. 1176-1182
    • Kappos, L.1    Comi, G.2    Panitch, H.3    Oger, J.4    Antel, J.5    Conlon, P.6    Steinman, L.7
  • 93
    • 0036828917 scopus 로고    scopus 로고
    • Induction of autoimmune diabetes through insulin (but not GAD65) DNA vaccination in nonobese diabetic and in RIP-B7. 1 mice
    • Karges W, Pechhold K, Al Dahouk S, Riegger I, Rief M, Wissmann A, Schirmbeck R, Barth C, Boehm BO. 2002. Induction of autoimmune diabetes through insulin (but not GAD65) DNA vaccination in nonobese diabetic and in RIP-B7. 1 mice. Diabetes 51: 3237-3244.
    • (2002) Diabetes , vol.51 , pp. 3237-3244
    • Karges, W.1    Pechhold, K.2    Al Dahouk, S.3    Riegger, I.4    Rief, M.5    Wissmann, A.6    Schirmbeck, R.7    Barth, C.8    Boehm, B.O.9
  • 94
    • 0026661122 scopus 로고
    • Recombinant glutamic acid decarboxylase (representing the single isoform expressed in human islets) detects IDDM-associated 64, 000-M(r) autoantibodies
    • Karlsen AE, Hagopian WA, Petersen JS, Boel E, Dyrberg T, Grubin CE, MichelsenBK, Madsen OD, Lernmark A. 1992. Recombinant glutamic acid decarboxylase (representing the single isoform expressed in human islets) detects IDDM-associated 64, 000-M(r) autoantibodies. Diabetes 41: 1355-1359.
    • (1992) Diabetes , vol.41 , pp. 1355-1359
    • Karlsen, A.E.1    Hagopian, W.A.2    Petersen, J.S.3    Boel, E.4    Dyrberg, T.5    Grubin, C.E.6    Michelsen, B.K.7    Madsen, O.D.8    Lernmark, A.9
  • 96
    • 0023851039 scopus 로고
    • Evidence of IgG autoantibodies against human proinsulin in patients with IDDM before insulin treatment
    • Kuglin B, Gries FA, Kolb H. 1988. Evidence of IgG autoantibodies against human proinsulin in patients with IDDM before insulin treatment. Diabetes 37: 130-132.
    • (1988) Diabetes , vol.37 , pp. 130-132
    • Kuglin, B.1    Gries, F.A.2    Kolb, H.3
  • 98
    • 34249820806 scopus 로고    scopus 로고
    • Heat-shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: A randomised, double-blind phase II study
    • Lazar L, Ofan R, Weintrob N, Avron A, Tamir M, Elias D, Phillip M, Josefsberg Z. 2007. Heat-shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: A randomised, double-blind phase II study. Diabetes Metab Res Rev 23: 286-291.
    • (2007) Diabetes Metab Res Rev , vol.23 , pp. 286-291
    • Lazar, L.1    Ofan, R.2    Weintrob, N.3    Avron, A.4    Tamir, M.5    Elias, D.6    Phillip, M.7    Josefsberg, Z.8
  • 100
    • 70449711382 scopus 로고    scopus 로고
    • Suppression of ongoing T cell-mediated autoimmunity by peptide-MHC class II dimer vaccination
    • Li L, Yi Z, Wang B, Tisch R. 2009. Suppression of ongoing T cell-mediated autoimmunity by peptide-MHC class II dimer vaccination. J Immunol 183: 4809-4816.
    • (2009) J Immunol , vol.183 , pp. 4809-4816
    • Li, L.1    Yi, Z.2    Wang, B.3    Tisch, R.4
  • 101
    • 0242364727 scopus 로고    scopus 로고
    • A comprehensive guide to antibody and T-cell responses in type 1 diabetes
    • Lieberman SM, DiLorenzo TP. 2003. A comprehensive guide to antibody and T-cell responses in type 1 diabetes. Tissue Antigens 62: 359-377.
    • (2003) Tissue Antigens , vol.62 , pp. 359-377
    • Lieberman, S.M.1    DiLorenzo, T.P.2
  • 102
    • 77956112950 scopus 로고    scopus 로고
    • Reversal of type 1 diabetes by a new MHC II-peptide chimera: "Single-epitope-mediated suppression" to stabilize a polyclonal autoimmune T-cell process
    • Lin M, Stoica-Nazarov C, Surls J, Kehl M, Bona C, Olsen C, Brumeanu TD, Casares S. 2010. Reversal of type 1 diabetes by a new MHC II-peptide chimera: "Single-epitope-mediated suppression" to stabilize a polyclonal autoimmune T-cell process. Eur J Immunol 40: 2277-2288.
    • (2010) Eur J Immunol , vol.40 , pp. 2277-2288
    • Lin, M.1    Stoica-Nazarov, C.2    Surls, J.3    Kehl, M.4    Bona, C.5    Olsen, C.6    Brumeanu, T.D.7    Casares, S.8
  • 103
    • 0036790542 scopus 로고    scopus 로고
    • Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B: 9-23 and B: 13-23
    • Liu E, Moriyama H, Abiru N, Miao D, Yu L, Taylor RM, Finkelman FD, EisenbarthGS. 2002. Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B: 9-23 and B: 13-23. J Clin Invest 110: 1021-1027.
    • (2002) J Clin Invest , vol.110 , pp. 1021-1027
    • Liu, E.1    Moriyama, H.2    Abiru, N.3    Miao, D.4    Yu, L.5    Taylor, R.M.6    Finkelman, F.D.7    Eisenbarth, G.S.8
  • 105
    • 79953756466 scopus 로고    scopus 로고
    • Extended evaluation of the safety and efficacy of GAD treatment of children and adolescents with recent-onset type 1 diabetes: A randomised controlled trial
    • Ludvigsson J, Hjorth M, Cheramy M, Axelsson S, Pihl M, Forsander G, NilssonNO, Samuelsson BO, Wood T, Aman J, et al. 2011. Extended evaluation of the safety and efficacy of GAD treatment of children and adolescents with recent-onset type 1 diabetes: A randomised controlled trial. Diabetologia 54: 634-640.
    • (2011) Diabetologia , vol.54 , pp. 634-640
    • Ludvigsson, J.1    Hjorth, M.2    Cheramy, M.3    Axelsson, S.4    Pihl, M.5    Forsander, G.6    Nilsson, N.O.7    Samuelsson, B.O.8    Wood, T.9    Aman, J.10
  • 108
    • 1842732158 scopus 로고    scopus 로고
    • Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4
    • Ma S, Huang Y, Yin Z, Menassa R, Brandle JE, Jevnikar AM. 2004. Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4. Proc Natl Acad Sci 101: 5680-5685.
    • (2004) Proc Natl Acad Sci , vol.101 , pp. 5680-5685
    • Ma, S.1    Huang, Y.2    Yin, Z.3    Menassa, R.4    Brandle, J.E.5    Jevnikar, A.M.6
  • 109
    • 4644297765 scopus 로고    scopus 로고
    • Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells
    • Machen J, Harnaha J, Lakomy R, Styche A, Trucco M, Giannoukakis N. 2004. Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells. J Immunol 173: 4331-4341.
    • (2004) J Immunol , vol.173 , pp. 4331-4341
    • McHen, J.1    Harnaha, J.2    Lakomy, R.3    Styche, A.4    Trucco, M.5    Giannoukakis, N.6
  • 110
    • 0038792101 scopus 로고    scopus 로고
    • +regulatory T cells by targeting of antigens to immature dendritic cells
    • +regulatory T cells by targeting of antigens to immature dendritic cells. Blood 101: 4862-4869.
    • (2003) Blood , vol.101 , pp. 4862-4869
    • Mahnke, K.1    Qian, Y.2    Knop, J.3    Enk, A.H.4
  • 112
    • 0033055884 scopus 로고    scopus 로고
    • Regulatory Th2-type T cell lines against insulin and GAD peptides derived from orally-and nasally-treated NOD mice suppress diabetes
    • Maron R, Melican NS, Weiner HL. 1999. Regulatory Th2-type T cell lines against insulin and GAD peptides derived from orally-and nasally-treated NOD mice suppress diabetes. J Autoimmun 12: 251-258.
    • (1999) J Autoimmun , vol.12 , pp. 251-258
    • Maron, R.1    Melican, N.S.2    Weiner, H.L.3
  • 114
  • 115
    • 0024513169 scopus 로고
    • The role of major histocompatibility molecules in antigen-specific immune responses
    • McCluskey J, Blok R, Kjer-Nielsen L. 1989. The role of major histocompatibility molecules in antigen-specific immune responses. Transplant Proc 21: 591-594.
    • (1989) Transplant Proc , vol.21 , pp. 591-594
    • McCluskey, J.1    Blok, R.2    Kjer-Nielsen, L.3
  • 116
    • 33744947093 scopus 로고    scopus 로고
    • Current status of pancreatic islet transplantation
    • Merani S, Shapiro AM. 2006. Current status of pancreatic islet transplantation. Clin Sci (Lond) 110: 611-625.
    • (2006) Clin Sci (Lond) , vol.110 , pp. 611-625
    • Merani, S.1    Shapiro, A.M.2
  • 119
    • 0028861576 scopus 로고
    • Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-γ transcription
    • Muir A, Peck A, Clare-Salzler M, Song YH, Cornelius J, Luchetta R, Krischer J, Maclaren N. 1995. Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-γ transcription. J Clin Invest 95: 628-634.
    • (1995) J Clin Invest , vol.95 , pp. 628-634
    • Muir, A.1    Peck, A.2    Clare-Salzler, M.3    Song, Y.H.4    Cornelius, J.5    Luchetta, R.6    Krischer, J.7    McLaren, N.8
  • 122
    • 55749104546 scopus 로고    scopus 로고
    • Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: A double-blind, randomised controlled trial
    • Nanto-Salonen K, Kupila A, Simell S, Siljander H, Salonsaari T, Hekkala A, Korhonen S, Erkkola R, Sipila JI, Haavisto L, et al. 2008. Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: A double-blind, randomised controlled trial. Lancet 372: 1746-1755.
    • (2008) Lancet , vol.372 , pp. 1746-1755
    • Nanto-Salonen, K.1    Kupila, A.2    Simell, S.3    Siljander, H.4    Salonsaari, T.5    Hekkala, A.6    Korhonen, S.7    Erkkola, R.8    Sipila, J.I.9    Haavisto, L.10
  • 125
    • 79953172219 scopus 로고    scopus 로고
    • Prevention of "humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach
    • Niens M, Grier AE, Marron M, Kay TW, Greiner DL, Serreze DV. 2011. Prevention of "humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach. Diabetes 60: 1229-1236.
    • (2011) Diabetes , vol.60 , pp. 1229-1236
    • Niens, M.1    Grier, A.E.2    Marron, M.3    Kay, T.W.4    Greiner, D.L.5    Serreze, D.V.6
  • 126
    • 33748988721 scopus 로고    scopus 로고
    • Peptide p277 of HSP60 signals T cells: Inhibition of inflammatory chemotaxis
    • Nussbaum G, Zanin-Zhorov A, Quintana F, Lider O, Cohen IR. 2006. Peptide p277 of HSP60 signals T cells: Inhibition of inflammatory chemotaxis. Int Immunol 18: 1413-1419.
    • (2006) Int Immunol , vol.18 , pp. 1413-1419
    • Nussbaum, G.1    Zanin-Zhorov, A.2    Quintana, F.3    Lider, O.4    Cohen, I.R.5
  • 132
    • 0029146498 scopus 로고
    • Prevention of autoimmune diabetes in nonobese diabetic female mice by treatment with recombinant glutamic acid decarboxylase (GAD 65)
    • Pleau JM, Fernandez-Saravia F, Esling A, Homo-Delarche F, Dardenne M. 1995. Prevention of autoimmune diabetes in nonobese diabetic female mice by treatment with recombinant glutamic acid decarboxylase (GAD 65). Clin Immunol Immunopathol 76: 90-95.
    • (1995) Clin Immunol Immunopathol , vol.76 , pp. 90-95
    • Pleau, J.M.1    Fernandez-Saravia, F.2    Esling, A.3    Homo-Delarche, F.4    Dardenne, M.5
  • 133
    • 0031784202 scopus 로고    scopus 로고
    • Immunization of diabetes-prone or non-diabetes-prone mice with GAD65 does not induce diabetes or islet cell pathology
    • Plesner A, Worsaae A, Dyrberg T, Gotfredsen C, Michelsen BK, Petersen JS. 1998. Immunization of diabetes-prone or non-diabetes-prone mice with GAD65 does not induce diabetes or islet cell pathology. J Autoimmun 11: 335-341.
    • (1998) J Autoimmun , vol.11 , pp. 335-341
    • Plesner, A.1    Worsaae, A.2    Dyrberg, T.3    Gotfredsen, C.4    Michelsen, B.K.5    Petersen, J.S.6
  • 136
    • 26044438468 scopus 로고    scopus 로고
    • Soluble, dimeric HLA DR4-peptide chimeras: An approach for detection and immunoregulation of human type-1 diabetes
    • Preda I, McEvoy RC, Lin M, Bona CA, Rapaport R, Brumeanu TD, Casares S. 2005. Soluble, dimeric HLA DR4-peptide chimeras: An approach for detection and immunoregulation of human type-1 diabetes. Eur J Immunol 35: 2762-2775.
    • (2005) Eur J Immunol , vol.35 , pp. 2762-2775
    • Preda, I.1    McEvoy, R.C.2    Lin, M.3    Bona, C.A.4    Rapaport, R.5    Brumeanu, T.D.6    Casares, S.7
  • 137
    • 0036202406 scopus 로고    scopus 로고
    • Immunoinhibitory DNA vaccine protects against autoimmune diabetes through cDNA encoding a selective CTLA-4 (CD152) ligand
    • Prud'homme GJ, Chang Y, Li X. 2002. Immunoinhibitory DNA vaccine protects against autoimmune diabetes through cDNA encoding a selective CTLA-4 (CD152) ligand. Hum Gene Ther 13: 395-406.
    • (2002) Hum Gene Ther , vol.13 , pp. 395-406
    • Prud'homme, G.J.1    Chang, Y.2    Li, X.3
  • 138
    • 33947432878 scopus 로고    scopus 로고
    • Plasmid-based gene therapy of diabetes mellitus
    • Prud'homme GJ, Draghia-Akli R, Wang Q. 2007. Plasmid-based gene therapy of diabetes mellitus. Gene Ther 14: 553-564.
    • (2007) Gene Ther , vol.14 , pp. 553-564
    • Prud'homme, G.J.1    Draghia-Akli, R.2    Wang, Q.3
  • 139
    • 0034548005 scopus 로고    scopus 로고
    • Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in nonobese diabetic mice: Modulation of spontaneous 60-kDa heat shock protein autoimmunity
    • Quintana FJ, Rotem A, Carmi P, Cohen IR. 2000. Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in nonobese diabetic mice: Modulation of spontaneous 60-kDa heat shock protein autoimmunity. J Immunol 165: 6148-6155.
    • (2000) J Immunol , vol.165 , pp. 6148-6155
    • Quintana, F.J.1    Rotem, A.2    Carmi, P.3    Cohen, I.R.4
  • 140
    • 0031440003 scopus 로고    scopus 로고
    • Effect of oral and intravenous insulin and glutamic acid decarboxylase in NOD mice
    • Ramiya VK, Shang XZ, Wasserfall CH, Maclaren NK. 1997. Effect of oral and intravenous insulin and glutamic acid decarboxylase in NOD mice. Autoimmunity 26: 139-151.
    • (1997) Autoimmunity , vol.26 , pp. 139-151
    • Ramiya, V.K.1    Shang, X.Z.2    Wasserfall, C.H.3    McLaren, N.K.4
  • 141
    • 34247160441 scopus 로고    scopus 로고
    • Inhalation of glutamic acid decarboxylase 65-derived peptides can protect against recurrent autoimmune but not alloimmune responses in the non-obese diabetic mouse
    • Ravanan R, Wong SF, Morgan NG, Mathieson PW, Smith RM. 2007. Inhalation of glutamic acid decarboxylase 65-derived peptides can protect against recurrent autoimmune but not alloimmune responses in the non-obese diabetic mouse. Clin Exp Immunol 148: 368-372.
    • (2007) Clin Exp Immunol , vol.148 , pp. 368-372
    • Ravanan, R.1    Wong, S.F.2    Morgan, N.G.3    Mathieson, P.W.4    Smith, R.M.5
  • 142
    • 0035944844 scopus 로고    scopus 로고
    • β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial
    • Raz I, Elias D, Avron A, Tamir M, Metzger M, Cohen IR. 2001. β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial. Lancet 358: 1749-1753.
    • (2001) Lancet , vol.358 , pp. 1749-1753
    • Raz, I.1    Elias, D.2    Avron, A.3    Tamir, M.4    Metzger, M.5    Cohen, I.R.6
  • 143
    • 34249812097 scopus 로고    scopus 로고
    • Treatment of new-onset type 1 diabetes with peptide DiaPep277 is safe and associated with preserved beta-cell function: Extension of a randomized, double-blind, phase II trial
    • Raz I, Avron A, Tamir M, Metzger M, Symer L, Eldor R, Cohen IR, Elias D. 2007. Treatment of new-onset type 1 diabetes with peptide DiaPep277 is safe and associated with preserved beta-cell function: Extension of a randomized, double-blind, phase II trial. Diabetes Metab Res Rev 23: 292-298.
    • (2007) Diabetes Metab Res Rev , vol.23 , pp. 292-298
    • Raz, I.1    Avron, A.2    Tamir, M.3    Metzger, M.4    Symer, L.5    Eldor, R.6    Cohen, I.R.7    Elias, D.8
  • 144
    • 79955011427 scopus 로고    scopus 로고
    • Targeting of a T cell agonist peptide to lysosomes by DNA vaccination induces tolerance in the nonobese diabetic mouse
    • Rivas EI, Driver JP, Garabatos N, Presa M, Mora C, Rodriguez F, Serreze DV, Stratmann T. 2011. Targeting of a T cell agonist peptide to lysosomes by DNA vaccination induces tolerance in the nonobese diabetic mouse. J Immunol 186: 4078-4087.
    • (2011) J Immunol , vol.186 , pp. 4078-4087
    • Rivas, E.I.1    Driver, J.P.2    Garabatos, N.3    Presa, M.4    Mora, C.5    Rodriguez, F.6    Serreze, D.V.7    Stratmann, T.8
  • 145
    • 77953193333 scopus 로고    scopus 로고
    • Islet transplantation a decade later and strategies for filling a half-full glass
    • Robertson RP. 2010. Islet transplantation a decade later and strategies for filling a half-full glass. Diabetes 59: 1285-1291.
    • (2010) Diabetes , vol.59 , pp. 1285-1291
    • Robertson, R.P.1
  • 146
    • 0029360443 scopus 로고
    • Similar peptides from two β cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes
    • Rudy G, Stone N, Harrison LC, Colman PG, McNair P, Brusic V, French MB, Honeyman MC, Tait B, Lew AM. 1995. Similar peptides from two β cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes. Mol Med 1: 625-633.
    • (1995) Mol Med , vol.1 , pp. 625-633
    • Rudy, G.1    Stone, N.2    Harrison, L.C.3    Colman, P.G.4    McNair, P.5    Brusic, V.6    French, M.B.7    Honeyman, M.C.8    Tait, B.9    Lew, A.M.10
  • 147
    • 77955610171 scopus 로고    scopus 로고
    • Dendritic cells transduced to express interleukin 4 reduce diabetes onset in both normoglycemic and prediabetic nonobese diabetic mice
    • Ruffner MA, Robbins PD. 2010. Dendritic cells transduced to express interleukin 4 reduce diabetes onset in both normoglycemic and prediabetic nonobese diabetic mice. PLoS One 5: e11848.
    • (2010) PLoS One , vol.5
    • Ruffner, M.A.1    Robbins, P.D.2
  • 148
    • 0030474308 scopus 로고    scopus 로고
    • Prophylactic oral administration of metabolically active insulin entrapped in isobutylcyanoacrylate nanocapsules reduces the incidence of diabetes in nonobese diabetic mice
    • Sai P, Damage C, Rivereau AS, Hoeltzel A, Gouin E. 1996. Prophylactic oral administration of metabolically active insulin entrapped in isobutylcyanoacrylate nanocapsules reduces the incidence of diabetes in nonobese diabetic mice. J Autoimmun 9: 713-722.
    • (1996) J Autoimmun , vol.9 , pp. 713-722
    • Sai, P.1    Damage, C.2    Rivereau, A.S.3    Hoeltzel, A.4    Gouin, E.5
  • 149
    • 34249786263 scopus 로고    scopus 로고
    • Effect of heat shock protein peptide DiaPep277 on β-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: Two prospective, randomized, double-blind phase II trials
    • Schloot NC, Meierhoff G, Lengyel C, Vandorfi G, Takacs J, Panczel P, Barkai L, Madacsy L, Oroszlan T, Kovacs P, et al. 2007. Effect of heat shock protein peptide DiaPep277 on β-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: Two prospective, randomized, double-blind phase II trials. Diabetes Metab Res Rev 23: 276-285.
    • (2007) Diabetes Metab Res Rev , vol.23 , pp. 276-285
    • Schloot, N.C.1    Meierhoff, G.2    Lengyel, C.3    Vandorfi, G.4    Takacs, J.5    Panczel, P.6    Barkai, L.7    Madacsy, L.8    Oroszlan, T.9    Kovacs, P.10
  • 155
    • 0029933309 scopus 로고    scopus 로고
    • Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
    • Sloan-Lancaster J, Allen PM. 1996. Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology. Annu Rev Immunol 14: 1-27.
    • (1996) Annu Rev Immunol , vol.14 , pp. 1-27
    • Sloan-Lancaster, J.1    Allen, P.M.2
  • 156
    • 58849117178 scopus 로고    scopus 로고
    • Improved efficacy of a tolerizing DNA vaccine for reversal of hyperglycemia through enhancement of gene expression and localization to intracellular sites
    • Solvason N, Lou YP, Peters W, Evans E, Martinez J, Ramirez U, Ocampo A, YunR, Ahmad S, Liu E, et al. 2008. Improved efficacy of a tolerizing DNA vaccine for reversal of hyperglycemia through enhancement of gene expression and localization to intracellular sites. J Immunol 181: 8298-8307.
    • (2008) J Immunol , vol.181 , pp. 8298-8307
    • Solvason, N.1    Lou, Y.P.2    Peters, W.3    Evans, E.4    Martinez, J.5    Ramirez, U.6    Ocampo, A.7    Yun, R.8    Ahmad, S.9    Liu, E.10
  • 157
    • 77954304378 scopus 로고    scopus 로고
    • Patient-reported outcomes following islet cell or pancreas transplantation (alone or after kidney) in Type 1 diabetes: A systematic review
    • Speight J, Reaney MD, Woodcock AJ, Smith RM, Shaw JA. 2010. Patient-reported outcomes following islet cell or pancreas transplantation (alone or after kidney) in Type 1 diabetes: A systematic review. Diabet Med 27: 812-822.
    • (2010) Diabet Med , vol.27 , pp. 812-822
    • Speight, J.1    Reaney, M.D.2    Woodcock, A.J.3    Smith, R.M.4    Shaw, J.A.5
  • 158
    • 0041666293 scopus 로고    scopus 로고
    • β-cell function and the development of diabetes-related complications in the diabetes control and complications trial
    • Steffes MW, Sibley S, Jackson M, Thomas W. 2003. β-cell function and the development of diabetes-related complications in the diabetes control and complications trial. Diabetes Care 26: 832-836.
    • (2003) Diabetes Care , vol.26 , pp. 832-836
    • Steffes, M.W.1    Sibley, S.2    Jackson, M.3    Thomas, W.4
  • 163
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • The Diabetes Control and Complications Trial Research Group
    • The Diabetes Control and Complications Trial Research Group. 1993. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329: 977-986.
    • (1993) N Engl J Med , vol.329 , pp. 977-986
  • 164
    • 0034628425 scopus 로고    scopus 로고
    • Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy
    • The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
    • The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. 2000. Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. N Engl J Med 342: 381-389.
    • (2000) N Engl J Med , vol.342 , pp. 381-389
  • 165
    • 0026771385 scopus 로고
    • Glutamic acid decarboxylase (GAD) autoantibodies are additional predictive markers of type 1 (insulin-dependent) diabetes mellitus in high risk individuals
    • Thivolet CH, Tappaz M, Durand A, Petersen J, Stefanutti A, Chatelain P, Vialettes B, Scherbaum W, Orgiazzi J. 1992. Glutamic acid decarboxylase (GAD) autoantibodies are additional predictive markers of type 1 (insulin-dependent) diabetes mellitus in high risk individuals. Diabetologia 35: 570-576.
    • (1992) Diabetologia , vol.35 , pp. 570-576
    • Thivolet, C.H.1    Tappaz, M.2    Durand, A.3    Petersen, J.4    Stefanutti, A.5    Chatelain, P.6    Vialettes, B.7    Scherbaum, W.8    Orgiazzi, J.9
  • 166
    • 0029923430 scopus 로고    scopus 로고
    • Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes
    • Tian J, Atkinson MA, Clare-Salzler M, Herschenfeld A, Forsthuber T, LehmannPV, Kaufman DL. 1996. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J Exp Med 183: 1561-1567.
    • (1996) J Exp Med , vol.183 , pp. 1561-1567
    • Tian, J.1    Atkinson, M.A.2    Clare-Salzler, M.3    Herschenfeld, A.4    Forsthuber, T.5    Lehmann, P.V.6    Kaufman, D.L.7
  • 167
    • 73249137408 scopus 로고    scopus 로고
    • Transgenically induced GAD tolerance curtails the development of early β-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other β-cell antigens
    • Tian J, Dang H, von Boehmer H, Jaeckel E, Kaufman DL. 2009. Transgenically induced GAD tolerance curtails the development of early β-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other β-cell antigens. Diabetes 58: 2843-2850.
    • (2009) Diabetes , vol.58 , pp. 2843-2850
    • Tian, J.1    Dang, H.2    von Boehmer, H.3    Jaeckel, E.4    Kaufman, D.L.5
  • 168
    • 0027908753 scopus 로고
    • Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
    • Tisch R, Yang XD, Singer SM, Liblau RS, Fugger L, McDevitt HO. 1993. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366: 72-75.
    • (1993) Nature , vol.366 , pp. 72-75
    • Tisch, R.1    Yang, X.D.2    Singer, S.M.3    Liblau, R.S.4    Fugger, L.5    McDevitt, H.O.6
  • 169
    • 0033178763 scopus 로고    scopus 로고
    • Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent
    • Tisch R, Wang B, Serreze DV. 1999. Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent. J Immunol 163: 1178-1187.
    • (1999) J Immunol , vol.163 , pp. 1178-1187
    • Tisch, R.1    Wang, B.2    Serreze, D.V.3
  • 170
    • 0035253510 scopus 로고    scopus 로고
    • Antigen-specific mediated suppression of β cell autoimmunity by plasmid DNA vaccination
    • Tisch R, Wang B, Weaver DJ, Liu B, Bui T, Arthos J, Serreze DV. 2001. Antigen-specific mediated suppression of β cell autoimmunity by plasmid DNA vaccination. J Immunol 166: 2122-2132.
    • (2001) J Immunol , vol.166 , pp. 2122-2132
    • Tisch, R.1    Wang, B.2    Weaver, D.J.3    Liu, B.4    Bui, T.5    Arthos, J.6    Serreze, D.V.7
  • 174
    • 33846919872 scopus 로고    scopus 로고
    • Peripheral tolerance induction using ethylenecarbodiimide-fixed APCs uses both direct and indirect mechanisms of antigen presentation for prevention of experimental autoimmune encephalomyelitis
    • Turley DM, Miller SD. 2007. Peripheral tolerance induction using ethylenecarbodiimide-fixed APCs uses both direct and indirect mechanisms of antigen presentation for prevention of experimental autoimmune encephalomyelitis. J Immunol 178: 2212-2220.
    • (2007) J Immunol , vol.178 , pp. 2212-2220
    • Turley, D.M.1    Miller, S.D.2
  • 175
    • 57749203195 scopus 로고    scopus 로고
    • GAD65 autoimmunity-clinical studies
    • Uibo R, Lernmark A. 2008. GAD65 autoimmunity-clinical studies. Adv Immunol 100: 39-78.
    • (2008) Adv Immunol , vol.100 , pp. 39-78
    • Uibo, R.1    Lernmark, A.2
  • 176
    • 0034900849 scopus 로고    scopus 로고
    • Immunization with DNA encoding an immunodominant peptide of insulin prevents diabetes in NOD mice
    • Urbanek-Ruiz I, Ruiz PJ, Paragas V, Garren H, Steinman L, Fathman CG. 2001. Immunization with DNA encoding an immunodominant peptide of insulin prevents diabetes in NOD mice. Clin Immunol 100: 164-171.
    • (2001) Clin Immunol , vol.100 , pp. 164-171
    • Urbanek-Ruiz, I.1    Ruiz, P.J.2    Paragas, V.3    Garren, H.4    Steinman, L.5    Fathman, C.G.6
  • 178
    • 0029995958 scopus 로고    scopus 로고
    • Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies
    • Verge CF, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Jackson RA, Chase HP, Eisenbarth GS. 1996. Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 45: 926-933.
    • (1996) Diabetes , vol.45 , pp. 926-933
    • Verge, C.F.1    Gianani, R.2    Kawasaki, E.3    Yu, L.4    Pietropaolo, M.5    Jackson, R.A.6    Chase, H.P.7    Eisenbarth, G.S.8
  • 179
    • 70449412682 scopus 로고    scopus 로고
    • No effect of the altered peptide ligand NBI-6024 on β-cell residual function and insulin needs in new-onset type 1 diabetes
    • Walter M, Philotheou A, Bonnici F, Ziegler AG, Jimenez R. 2009. No effect of the altered peptide ligand NBI-6024 on β-cell residual function and insulin needs in new-onset type 1 diabetes. Diabetes Care 32: 2036-2040.
    • (2009) Diabetes Care , vol.32 , pp. 2036-2040
    • Walter, M.1    Philotheou, A.2    Bonnici, F.3    Ziegler, A.G.4    Jimenez, R.5
  • 181
    • 0028145676 scopus 로고
    • Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice
    • Wegmann DR, Norbury-Glaser M, Daniel D. 1994b. Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice. Eur J Immunol 24: 1853-1857.
    • (1994) Eur J Immunol , vol.24 , pp. 1853-1857
    • Wegmann, D.R.1    Norbury-Glaser, M.2    Daniel, D.3
  • 183
    • 0031753329 scopus 로고    scopus 로고
    • DNA vaccination with glutamic acid decarboxylase (GAD) generates a strong humoral immune response in BALB/c, C57BL/6, and in diabetes-prone NOD mice
    • Wiest-Ladenburger U, Fortnagel A, Richter W, Reimann J, Boehm BO. 1998. DNA vaccination with glutamic acid decarboxylase (GAD) generates a strong humoral immune response in BALB/c, C57BL/6, and in diabetes-prone NOD mice. Horm Metab Res 30: 605-609.
    • (1998) Horm Metab Res , vol.30 , pp. 605-609
    • Wiest-Ladenburger, U.1    Fortnagel, A.2    Richter, W.3    Reimann, J.4    Boehm, B.O.5
  • 185
    • 34547583229 scopus 로고    scopus 로고
    • Transfusion of apoptotic β-cells induces immune tolerance to β-cell antigens and prevents type 1 diabetes in NOD mice
    • Xia CQ, Peng R, Qiu Y, Annamalai M, Gordon D, Clare-Salzler MJ. 2007. Transfusion of apoptotic β-cells induces immune tolerance to β-cell antigens and prevents type 1 diabetes in NOD mice. Diabetes 56: 2116-2123.
    • (2007) Diabetes , vol.56 , pp. 2116-2123
    • Xia, C.Q.1    Peng, R.2    Qiu, Y.3    Annamalai, M.4    Gordon, D.5    Clare-Salzler, M.J.6
  • 187
    • 9144221452 scopus 로고    scopus 로고
    • Presence of diabetes-inhibiting, glutamic acid decarboxylase-specific, IL-10-dependent, regulatory T cells in naive nonobese diabetic mice
    • You S, Chen C, Lee WH, Brusko T, Atkinson M, Liu CP. 2004. Presence of diabetes-inhibiting, glutamic acid decarboxylase-specific, IL-10-dependent, regulatory T cells in naive nonobese diabetic mice. J Immunol 173: 6777-6785.
    • (2004) J Immunol , vol.173 , pp. 6777-6785
    • You, S.1    Chen, C.2    Lee, W.H.3    Brusko, T.4    Atkinson, M.5    Liu, C.P.6
  • 188
    • 0034652317 scopus 로고    scopus 로고
    • Early expression of antiinsulin autoantibodies of humans and the NOD mouse: Evidence for early determination of subsequent diabetes
    • Yu L, Robles DT, Abiru N, Kaur P, Rewers M, Kelemen K, Eisenbarth GS. 2000. Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. Proc Natl Acad Sci 97: 1701-1706.
    • (2000) Proc Natl Acad Sci , vol.97 , pp. 1701-1706
    • Yu, L.1    Robles, D.T.2    Abiru, N.3    Kaur, P.4    Rewers, M.5    Kelemen, K.6    Eisenbarth, G.S.7
  • 189
    • 0027398099 scopus 로고
    • Presentation of a viral T cell epitope expressed in the CDR3 region of a self immunoglobulin molecule
    • Zaghouani H, Steinman R, Nonacs R, Shah H, Gerhard W, Bona C. 1993. Presentation of a viral T cell epitope expressed in the CDR3 region of a self immunoglobulin molecule. Science 259: 224-227.
    • (1993) Science , vol.259 , pp. 224-227
    • Zaghouani, H.1    Steinman, R.2    Nonacs, R.3    Shah, H.4    Gerhard, W.5    Bona, C.6
  • 190
    • 21244489948 scopus 로고    scopus 로고
    • Heat shock protein 60 activates cytokine-associated negative regulator suppressor of cytokine signaling 3 in T cells: Effects on signaling, chemotaxis, and inflammation
    • Zanin-Zhorov A, Tal G, Shivtiel S, Cohen M, Lapidot T, Nussbaum G, MargalitR, Cohen IR, Lider O. 2005. Heat shock protein 60 activates cytokine-associated negative regulator suppressor of cytokine signaling 3 in T cells: Effects on signaling, chemotaxis, and inflammation. J Immunol 175: 276-285.
    • (2005) J Immunol , vol.175 , pp. 276-285
    • Zanin-Zhorov, A.1    Tal, G.2    Shivtiel, S.3    Cohen, M.4    Lapidot, T.5    Nussbaum, G.6    Margalit, R.7    Cohen, I.R.8    Lider, O.9
  • 193
    • 0025837184 scopus 로고
    • Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin
    • Zhang ZJ, Davidson L, Eisenbarth G, Weiner HL. 1991. Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc Natl Acad Sci 88: 10252-10256.
    • (1991) Proc Natl Acad Sci , vol.88 , pp. 10252-10256
    • Zhang, Z.J.1    Davidson, L.2    Eisenbarth, G.3    Weiner, H.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.