-
1
-
-
0029100015
-
Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness
-
Abastado JP, Lone YC, Casrouge A, Boulot G, Kourilsky P. 1995. Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness. J Exp Med 182: 439-447.
-
(1995)
J Exp Med
, vol.182
, pp. 439-447
-
-
Abastado, J.P.1
Lone, Y.C.2
Casrouge, A.3
Boulot, G.4
Kourilsky, P.5
-
2
-
-
0031913650
-
Islet T cells secreting IFN-γ in NOD mouse diabetes: Arrest by p277 peptide treatment
-
Ablamunits V, Elias D, Reshef T, Cohen IR. 1998. Islet T cells secreting IFN-γ in NOD mouse diabetes: Arrest by p277 peptide treatment. J Autoimmun 11: 73-81.
-
(1998)
J Autoimmun
, vol.11
, pp. 73-81
-
-
Ablamunits, V.1
Elias, D.2
Reshef, T.3
Cohen, I.R.4
-
3
-
-
0033106415
-
T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides
-
Abulafia-Lapid R, Elias D, Raz I, Keren-Zur Y, Atlan H, Cohen IR. 1999. T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides. J Autoimmun 12: 121-129.
-
(1999)
J Autoimmun
, vol.12
, pp. 121-129
-
-
Abulafia-Lapid, R.1
Elias, D.2
Raz, I.3
Keren-Zur, Y.4
Atlan, H.5
Cohen, I.R.6
-
4
-
-
0038617504
-
T cells and autoantibodies to human HSP70 in type 1 diabetes in children
-
Abulafia-Lapid R, Gillis D, Yosef O, Atlan H, Cohen IR. 2003. T cells and autoantibodies to human HSP70 in type 1 diabetes in children. J Autoimmun 20: 313-321.
-
(2003)
J Autoimmun
, vol.20
, pp. 313-321
-
-
Abulafia-Lapid, R.1
Gillis, D.2
Yosef, O.3
Atlan, H.4
Cohen, I.R.5
-
5
-
-
21344461521
-
Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes
-
Agardh CD, Cilio CM, Lethagen A, Lynch K, Leslie RD, Palmer M, Harris RA, Robertson JA, Lernmark A. 2005. Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes. J Diabetes Complications 19: 238-246.
-
(2005)
J Diabetes Complications
, vol.19
, pp. 238-246
-
-
Agardh, C.D.1
Cilio, C.M.2
Lethagen, A.3
Lynch, K.4
Leslie, R.D.5
Palmer, M.6
Harris, R.A.7
Robertson, J.A.8
Lernmark, A.9
-
6
-
-
0036300542
-
Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide
-
Alleva DG, Gaur A, Jin L, Wegmann D, Gottlieb PA, Pahuja A, Johnson EB, Motheral T, Putnam A, Crowe PD, et al. 2002. Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide. Diabetes 51: 2126-2134.
-
(2002)
Diabetes
, vol.51
, pp. 2126-2134
-
-
Alleva, D.G.1
Gaur, A.2
Jin, L.3
Wegmann, D.4
Gottlieb, P.A.5
Pahuja, A.6
Johnson, E.B.7
Motheral, T.8
Putnam, A.9
Crowe, P.D.10
-
7
-
-
33644856659
-
Immunomodulation in type 1 diabetes by NBI-6024, an altered peptide ligand of the insulin B epitope
-
Alleva DG, Maki RA, Putnam AL, Robinson JM, Kipnes MS, Dandona P, Marks JB, Simmons DL, Greenbaum CJ, Jimenez RG, et al. 2006. Immunomodulation in type 1 diabetes by NBI-6024, an altered peptide ligand of the insulin B epitope. Scand J Immunol 63: 59-69.
-
(2006)
Scand J Immunol
, vol.63
, pp. 59-69
-
-
Alleva, D.G.1
Maki, R.A.2
Putnam, A.L.3
Robinson, J.M.4
Kipnes, M.S.5
Dandona, P.6
Marks, J.B.7
Simmons, D.L.8
Greenbaum, C.J.9
Jimenez, R.G.10
-
8
-
-
0034680105
-
Progression of autoimmune diabetes driven by avidity maturation of a T-cell population
-
Amrani A, Verdaguer J, Serra P, Tafuro S, Tan R, Santamaria P. 2000. Progression of autoimmune diabetes driven by avidity maturation of a T-cell population. Nature 406: 739-742.
-
(2000)
Nature
, vol.406
, pp. 739-742
-
-
Amrani, A.1
Verdaguer, J.2
Serra, P.3
Tafuro, S.4
Tan, R.5
Santamaria, P.6
-
9
-
-
0032193195
-
Fine specificity of the myelin-reactive T cell repertoire: Implications for TCR antagonism in autoimmunity
-
Anderton SM, Manickasingham SP, Burkhart C, Luckcuck TA, Holland SJ, Lamont AG, Wraith DC. 1998. Fine specificity of the myelin-reactive T cell repertoire: Implications for TCR antagonism in autoimmunity. J Immunol 161: 3357-3364.
-
(1998)
J Immunol
, vol.161
, pp. 3357-3364
-
-
Anderton, S.M.1
Manickasingham, S.P.2
Burkhart, C.3
Luckcuck, T.A.4
Holland, S.J.5
Lamont, A.G.6
Wraith, D.C.7
-
10
-
-
0036408394
-
Nasal administration of CTB-insulin induces active tolerance against autoimmune diabetes in non-obese diabetic (NOD) mice
-
Aspord C, Thivolet C. 2002. Nasal administration of CTB-insulin induces active tolerance against autoimmune diabetes in non-obese diabetic (NOD) mice. Clin Exp Immunol 130: 204-211.
-
(2002)
Clin Exp Immunol
, vol.130
, pp. 204-211
-
-
Aspord, C.1
Thivolet, C.2
-
11
-
-
0025472820
-
Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy
-
Atkinson MA, Maclaren NK, Luchetta R. 1990. Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy. Diabetes 39: 933-937.
-
(1990)
Diabetes
, vol.39
, pp. 933-937
-
-
Atkinson, M.A.1
McLaren, N.K.2
Luchetta, R.3
-
12
-
-
0027529913
-
Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes
-
Atkinson MA, Kaufman DL, Newman D, Tobin AJ, Maclaren NK. 1993. Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes. J Clin Invest 91: 350-356.
-
(1993)
J Clin Invest
, vol.91
, pp. 350-356
-
-
Atkinson, M.A.1
Kaufman, D.L.2
Newman, D.3
Tobin, A.J.4
McLaren, N.K.5
-
13
-
-
78651376427
-
Early induction of GAD(65)-reactive Th2 response in type 1 diabetic children treated with alum-formulated GAD(65)
-
Axelsson S, Hjorth M, Akerman L, Ludvigsson J, Casas R. 2010. Early induction of GAD(65)-reactive Th2 response in type 1 diabetic children treated with alum-formulated GAD(65). Diabetes Metab Res Rev 26: 559-568.
-
(2010)
Diabetes Metab Res Rev
, vol.26
, pp. 559-568
-
-
Axelsson, S.1
Hjorth, M.2
Akerman, L.3
Ludvigsson, J.4
Casas, R.5
-
14
-
-
0023090843
-
Antibodies to a 64, 000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes
-
Baekkeskov S, Landin M, Kristensen JK, Srikanta S, Bruining GJ, Mandrup-Poulsen T, de Beaufort C, Soeldner JS, Eisenbarth G, Lindgren F, et al. 1987. Antibodies to a 64, 000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes. J Clin Invest 79: 926-934.
-
(1987)
J Clin Invest
, vol.79
, pp. 926-934
-
-
Baekkeskov, S.1
Landin, M.2
Kristensen, J.K.3
Srikanta, S.4
Bruining, G.J.5
Mandrup-Poulsen, T.6
de Beaufort, C.7
Soeldner, J.S.8
Eisenbarth, G.9
Lindgren, F.10
-
15
-
-
0019959221
-
Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins
-
Baekkeskov S, Nielsen JH, Marner B, Bilde T, Ludvigsson J, Lernmark A. 1982. Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins. Nature 298: 167-169.
-
(1982)
Nature
, vol.298
, pp. 167-169
-
-
Baekkeskov, S.1
Nielsen, J.H.2
Marner, B.3
Bilde, T.4
Ludvigsson, J.5
Lernmark, A.6
-
16
-
-
4243539805
-
A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes
-
Bergerot I, Ploix C, Petersen J, Moulin V, Rask C, Fabien N, Lindblad M, MayerA, Czerkinsky C, Holmgren J, et al. 1997. A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes. Proc Natl Acad Sci 94: 4610-4614.
-
(1997)
Proc Natl Acad Sci
, vol.94
, pp. 4610-4614
-
-
Bergerot, I.1
Ploix, C.2
Petersen, J.3
Moulin, V.4
Rask, C.5
Fabien, N.6
Lindblad, M.7
Mayer, A.8
Czerkinsky, C.9
Holmgren, J.10
-
17
-
-
0033786776
-
Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
-
Bielekova B, Goodwin B, Richert N, Cortese I, Kondo T, Afshar G, Gran B, EatonJ, Antel J, Frank JA, et al. 2000. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand. Nat Med 6: 1167-1175.
-
(2000)
Nat Med
, vol.6
, pp. 1167-1175
-
-
Bielekova, B.1
Goodwin, B.2
Richert, N.3
Cortese, I.4
Kondo, T.5
Afshar, G.6
Gran, B.7
Eaton, J.8
Antel, J.9
Frank, J.A.10
-
18
-
-
0030004757
-
NOD mouse diabetes: The ubiquitous mouse hsp60 is a β-cell target antigen of autoimmune T cells
-
Birk OS, Elias D, Weiss AS, Rosen A, van-der Zee R, Walker MD, Cohen IR. 1996. NOD mouse diabetes: The ubiquitous mouse hsp60 is a β-cell target antigen of autoimmune T cells. J Autoimmun 9: 159-166.
-
(1996)
J Autoimmun
, vol.9
, pp. 159-166
-
-
Birk, O.S.1
Elias, D.2
Weiss, A.S.3
Rosen, A.4
van-der Zee, R.5
Walker, M.D.6
Cohen, I.R.7
-
20
-
-
0035451681
-
Plasmid vaccination with insulin B chain prevents autoimmune diabetes in nonobese diabetic mice
-
Bot A, Smith D, Bot S, Hughes A, Wolfe T, Wang L, Woods C, von Herrath M. 2001. Plasmid vaccination with insulin B chain prevents autoimmune diabetes in nonobese diabetic mice. J Immunol 167: 2950-2955.
-
(2001)
J Immunol
, vol.167
, pp. 2950-2955
-
-
Bot, A.1
Smith, D.2
Bot, S.3
Hughes, A.4
Wolfe, T.5
Wang, L.6
Woods, C.7
von Herrath, M.8
-
21
-
-
33646392755
-
Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs
-
Bresson D, Togher L, Rodrigo E, Chen Y, Bluestone JA, Herold KC, von HerrathM. 2006. Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J Clin Invest 116: 1371-1381.
-
(2006)
J Clin Invest
, vol.116
, pp. 1371-1381
-
-
Bresson, D.1
Togher, L.2
Rodrigo, E.3
Chen, Y.4
Bluestone, J.A.5
Herold, K.C.6
von Herrath, M.7
-
22
-
-
76349093141
-
Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes
-
Bresson D, Fradkin M, Manenkova Y, Rottembourg D, von Herrath M. 2010. Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes. Mol Ther 18: 307-316.
-
(2010)
Mol Ther
, vol.18
, pp. 307-316
-
-
Bresson, D.1
Fradkin, M.2
Manenkova, Y.3
Rottembourg, D.4
von Herrath, M.5
-
23
-
-
0031738016
-
Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic β-cells
-
Bridgett M, Cetkovic-Cvrlje M, O'Rourke R, Shi Y, Narayanswami S, Lambert J, Ramiya V, Baekkeskov S, Leiter EH. 1998. Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic β-cells. Diabetes 47: 1848-1856.
-
(1998)
Diabetes
, vol.47
, pp. 1848-1856
-
-
Bridgett, M.1
Cetkovic-Cvrlje, M.2
O'Rourke, R.3
Shi, Y.4
Narayanswami, S.5
Lambert, J.6
Ramiya, V.7
Baekkeskov, S.8
Leiter, E.H.9
-
24
-
-
33644691658
-
On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetes
-
Bruder D, Westendorf AM, Hansen W, Prettin S, Gruber AD, Qian Y, von Boehmer H, Mahnke K, Buer J. 2005. On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetes. Diabetes 54: 3395-3401.
-
(2005)
Diabetes
, vol.54
, pp. 3395-3401
-
-
Bruder, D.1
Westendorf, A.M.2
Hansen, W.3
Prettin, S.4
Gruber, A.D.5
Qian, Y.6
von Boehmer, H.7
Mahnke, K.8
Buer, J.9
-
25
-
-
0027451440
-
Efficient loading of identical viral peptide onto class II molecules by antigenized immunoglobulin and influenza virus
-
Brumeanu TD, Swiggard WJ, Steinman RM, Bona CA, Zaghouani H. 1993. Efficient loading of identical viral peptide onto class II molecules by antigenized immunoglobulin and influenza virus. J Exp Med 178: 1795-1799.
-
(1993)
J Exp Med
, vol.178
, pp. 1795-1799
-
-
Brumeanu, T.D.1
Swiggard, W.J.2
Steinman, R.M.3
Bona, C.A.4
Zaghouani, H.5
-
26
-
-
0026577196
-
Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene
-
Bu DF, Erlander MG, Hitz BC, Tillakaratne NJ, Kaufman DL, Wagner-McPhersonCB, Evans GA, Tobin AJ. 1992. Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene. Proc Natl Acad Sci 89: 2115-2119.
-
(1992)
Proc Natl Acad Sci
, vol.89
, pp. 2115-2119
-
-
Bu, D.F.1
Erlander, M.G.2
Hitz, B.C.3
Tillakaratne, N.J.4
Kaufman, D.L.5
Wagner-McPherson, C.B.6
Evans, G.A.7
Tobin, A.J.8
-
27
-
-
29644440579
-
Bacterial and plant enterotoxin B subunit-autoantigen fusion proteins suppress diabetes insulitis
-
Carter JE 3rd., Yu J, Choi NW, Hough J, Henderson D, He D, Langridge WH. 2006. Bacterial and plant enterotoxin B subunit-autoantigen fusion proteins suppress diabetes insulitis. Mol Biotechnol 32: 1-15.
-
(2006)
Mol Biotechnol
, vol.32
, pp. 1-15
-
-
Carter III, J.E.1
Yu, J.2
Choi, N.W.3
Hough, J.4
Henderson, D.5
He, D.6
Langridge, W.H.7
-
29
-
-
0030731920
-
Retardation or acceleration of diabetes in NOD/Lt mice mediated by intrathymic administration of candidate β-cell antigens
-
Cetkovic-Cvrlje M, Gerling IC, Muir A, Atkinson MA, Elliott JF, Leiter EH. 1997. Retardation or acceleration of diabetes in NOD/Lt mice mediated by intrathymic administration of candidate β-cell antigens. Diabetes 46: 1975-1982.
-
(1997)
Diabetes
, vol.46
, pp. 1975-1982
-
-
Cetkovic-Cvrlje, M.1
Gerling, I.C.2
Muir, A.3
Atkinson, M.A.4
Elliott, J.F.5
Leiter, E.H.6
-
30
-
-
17444437590
-
Oral insulin administration and residual β-cell function in recent-onset type 1 diabetes: A multicentre randomised controlled trial. Diabete Insuline Orale group
-
Chaillous L, Lefevre H, Thivolet C, Boitard C, Lahlou N, Atlan-Gepner C, Bouhanick B, Mogenet A, Nicolino M, Carel JC, et al. 2000. Oral insulin administration and residual β-cell function in recent-onset type 1 diabetes: A multicentre randomised controlled trial. Diabete Insuline Orale group. Lancet 356: 545-549.
-
(2000)
Lancet
, vol.356
, pp. 545-549
-
-
Chaillous, L.1
Lefevre, H.2
Thivolet, C.3
Boitard, C.4
Lahlou, N.5
Atlan-Gepner, C.6
Bouhanick, B.7
Mogenet, A.8
Nicolino, M.9
Carel, J.C.10
-
31
-
-
27944486723
-
DNA vaccination with an insulin construct and a chimeric protein binding to both CTLA4 and CD40 ameliorates type 1 diabetes in NOD mice
-
Chang Y, Yap S, Ge X, Piganelli J, Bertera S, Giannokakis N, Mathews C, Prud'homme G, Trucco M. 2005. DNA vaccination with an insulin construct and a chimeric protein binding to both CTLA4 and CD40 ameliorates type 1 diabetes in NOD mice. Gene Ther 12: 1679-1685.
-
(2005)
Gene Ther
, vol.12
, pp. 1679-1685
-
-
Chang, Y.1
Yap, S.2
Ge, X.3
Piganelli, J.4
Bertera, S.5
Giannokakis, N.6
Mathews, C.7
Prud'homme, G.8
Trucco, M.9
-
32
-
-
0035500757
-
Evidence that a peptide spanning the B-C junction of proinsulin is an early autoantigen epitope in the pathogenesis of type 1 diabetes
-
Chen W, Bergerot I, Elliott JF, Harrison LC, Abiru N, Eisenbarth GS, DelovitchTL. 2001. Evidence that a peptide spanning the B-C junction of proinsulin is an early autoantigen epitope in the pathogenesis of type 1 diabetes. J Immunol 167: 4926-4935.
-
(2001)
J Immunol
, vol.167
, pp. 4926-4935
-
-
Chen, W.1
Bergerot, I.2
Elliott, J.F.3
Harrison, L.C.4
Abiru, N.5
Eisenbarth, G.S.6
Delovitch, T.L.7
-
34
-
-
0038783708
-
Induction of autoantigen-specific Th2 and Tr1 regulatory T cells and modulation of autoimmune diabetes
-
Chen C, Lee WH, Yun P, Snow P, Liu CP. 2003. Induction of autoantigen-specific Th2 and Tr1 regulatory T cells and modulation of autoimmune diabetes. J Immunol 171: 733-744.
-
(2003)
J Immunol
, vol.171
, pp. 733-744
-
-
Chen, C.1
Lee, W.H.2
Yun, P.3
Snow, P.4
Liu, C.P.5
-
35
-
-
77956614531
-
GAD-alum treatment in patients with type 1 diabetes and the subsequent effect on GADA IgG subclass distribution, GAD65 enzyme activity and humoral response
-
Cheramy M, Skoglund C, Johansson I, Ludvigsson J, Hampe CS, Casas R. 2010. GAD-alum treatment in patients with type 1 diabetes and the subsequent effect on GADA IgG subclass distribution, GAD65 enzyme activity and humoral response. Clin Immunol 137: 31-40.
-
(2010)
Clin Immunol
, vol.137
, pp. 31-40
-
-
Cheramy, M.1
Skoglund, C.2
Johansson, I.3
Ludvigsson, J.4
Hampe, C.S.5
Casas, R.6
-
36
-
-
0025718751
-
Pancreatic β cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble
-
Christgau S, Schierbeck H, Aanstoot HJ, Aagaard L, Begley K, Kofod H, HejnaesK, Baekkeskov S. 1991. Pancreatic β cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble. J Biol Chem 266: 23516.
-
(1991)
J Biol Chem
, vol.266
, pp. 23516
-
-
Christgau, S.1
Schierbeck, H.2
Aanstoot, H.J.3
Aagaard, L.4
Begley, K.5
Kofod, H.6
Hejnaes, K.7
Baekkeskov, S.8
-
37
-
-
0026684592
-
Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM. Studies with identical twins
-
Christie MR, Tun RY, Lo SS, Cassidy D, Brown TJ, Hollands J, Shattock M, Bottazzo GF, Leslie RD. 1992. Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM. Studies with identical twins. Diabetes 41: 782-787.
-
(1992)
Diabetes
, vol.41
, pp. 782-787
-
-
Christie, M.R.1
Tun, R.Y.2
Lo, S.S.3
Cassidy, D.4
Brown, T.J.5
Hollands, J.6
Shattock, M.7
Bottazzo, G.F.8
Leslie, R.D.9
-
38
-
-
0026700060
-
Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer
-
Clare-Salzler MJ, Brooks J, Chai A, Van Herle K, Anderson C. 1992. Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer. J Clin Invest 90: 741-748.
-
(1992)
J Clin Invest
, vol.90
, pp. 741-748
-
-
Clare-Salzler, M.J.1
Brooks, J.2
Chai, A.3
Van Herle, K.4
Anderson, C.5
-
39
-
-
80052479923
-
Peptide-MHC-based nanovaccines for the treatment of autoimmunity: A "one size fits all" approach?
-
Clemente-Casares X, Tsai S, Yang Y, Santamaria P. 2011. Peptide-MHC-based nanovaccines for the treatment of autoimmunity: A "one size fits all" approach? J Mol Med 89: 733-742.
-
(2011)
J Mol Med
, vol.89
, pp. 733-742
-
-
Clemente-Casares, X.1
Tsai, S.2
Yang, Y.3
Santamaria, P.4
-
41
-
-
41549150638
-
Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice
-
Creusot RJ, Yaghoubi SS, Kodama K, Dang DN, Dang VH, Breckpot K, Thielemans K, Gambhir SS, Fathman CG. 2008. Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice. Clin Immunol 127: 176-187.
-
(2008)
Clin Immunol
, vol.127
, pp. 176-187
-
-
Creusot, R.J.1
Yaghoubi, S.S.2
Kodama, K.3
Dang, D.N.4
Dang, V.H.5
Breckpot, K.6
Thielemans, K.7
Gambhir, S.S.8
Fathman, C.G.9
-
42
-
-
0029872093
-
Intranasal administration of insulin peptide B: 9-23 protects NOD mice from diabetes
-
Daniel D, Wegmann DR. 1996a. Intranasal administration of insulin peptide B: 9-23 protects NOD mice from diabetes. Ann NY Acad Sci 778: 371-372.
-
(1996)
Ann NY Acad Sci
, vol.778
, pp. 371-372
-
-
Daniel, D.1
Wegmann, D.R.2
-
43
-
-
0030069688
-
Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)
-
Daniel D, Wegmann DR. 1996b. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc Natl Acad Sci 93: 956-960.
-
(1996)
Proc Natl Acad Sci
, vol.93
, pp. 956-960
-
-
Daniel, D.1
Wegmann, D.R.2
-
44
-
-
0028385738
-
Pharmacological enhancement of in vivo foreign gene expression in muscle
-
Danko I, Fritz JD, Jiao S, Hogan K, Latendresse JS, Wolff JA. 1994. Pharmacological enhancement of in vivo foreign gene expression in muscle. Gene Ther 1: 114-121.
-
(1994)
Gene Ther
, vol.1
, pp. 114-121
-
-
Danko, I.1
Fritz, J.D.2
Jiao, S.3
Hogan, K.4
Latendresse, J.S.5
Wolff, J.A.6
-
45
-
-
0026667626
-
Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes
-
De Aizpurua HJ, Wilson YM, Harrison LC. 1992. Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes. Proc Natl Acad Sci 89: 9841-9845.
-
(1992)
Proc Natl Acad Sci
, vol.89
, pp. 9841-9845
-
-
De Aizpurua, H.J.1
Wilson, Y.M.2
Harrison, L.C.3
-
46
-
-
3242665039
-
Differential immune response to B: 9-23 insulin 1 and insulin 2 peptides in animal models of type 1 diabetes
-
Devendra D, Paronen J, Moriyama H, Miao D, Eisenbarth GS, Liu E. 2004. Differential immune response to B: 9-23 insulin 1 and insulin 2 peptides in animal models of type 1 diabetes. J Autoimmun 23: 17-26.
-
(2004)
J Autoimmun
, vol.23
, pp. 17-26
-
-
Devendra, D.1
Paronen, J.2
Moriyama, H.3
Miao, D.4
Eisenbarth, G.S.5
Liu, E.6
-
47
-
-
0037198427
-
Effects of insulin in relatives of patients with type 1 diabetes mellitus
-
Diabetes Prevention Trial-Type 1 Diabetes Study Group
-
Diabetes Prevention Trial-Type 1 Diabetes Study Group. 2002. Effects of insulin in relatives of patients with type 1 diabetes mellitus. N Engl J Med 346: 1685-1691.
-
(2002)
N Engl J Med
, vol.346
, pp. 1685-1691
-
-
-
48
-
-
0028215907
-
Peptide therapy for diabetes in NOD mice
-
Elias D, Cohen IR. 1994. Peptide therapy for diabetes in NOD mice. Lancet 343: 704-706.
-
(1994)
Lancet
, vol.343
, pp. 704-706
-
-
Elias, D.1
Cohen, I.R.2
-
49
-
-
0028787305
-
Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock protein 60 peptide 277
-
Elias D, Cohen IR. 1995. Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock protein 60 peptide 277. Diabetes 44: 1132-1138.
-
(1995)
Diabetes
, vol.44
, pp. 1132-1138
-
-
Elias, D.1
Cohen, I.R.2
-
50
-
-
0025058568
-
Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein
-
Elias D, Markovits D, Reshef T, van der Zee R, Cohen IR. 1990. Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. Proc Natl Acad Sci 87: 1576-1580.
-
(1990)
Proc Natl Acad Sci
, vol.87
, pp. 1576-1580
-
-
Elias, D.1
Markovits, D.2
Reshef, T.3
van der Zee, R.4
Cohen, I.R.5
-
51
-
-
0026322837
-
Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein
-
Elias D, Reshef T, Birk OS, van der Zee R, Walker MD, Cohen IR. 1991. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc Natl Acad Sci 88: 3088-3091.
-
(1991)
Proc Natl Acad Sci
, vol.88
, pp. 3088-3091
-
-
Elias, D.1
Reshef, T.2
Birk, O.S.3
van der Zee, R.4
Walker, M.D.5
Cohen, I.R.6
-
52
-
-
0028787628
-
Induction of diabetes in standard mice by immunization with the p277 peptide of a 60-kDa heat shock protein
-
Elias D, Marcus H, Reshef T, Ablamunits V, Cohen IR. 1995. Induction of diabetes in standard mice by immunization with the p277 peptide of a 60-kDa heat shock protein. Eur J Immunol 25: 2851-2857.
-
(1995)
Eur J Immunol
, vol.25
, pp. 2851-2857
-
-
Elias, D.1
Marcus, H.2
Reshef, T.3
Ablamunits, V.4
Cohen, I.R.5
-
53
-
-
0030960632
-
Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various β-cell antigens
-
Elias D, Meilin A, Ablamunits V, Birk OS, Carmi P, Konen-Waisman S, Cohen IR. 1997. Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various β-cell antigens. Diabetes 46: 758-764.
-
(1997)
Diabetes
, vol.46
, pp. 758-764
-
-
Elias, D.1
Meilin, A.2
Ablamunits, V.3
Birk, O.S.4
Carmi, P.5
Konen-Waisman, S.6
Cohen, I.R.7
-
54
-
-
0028586035
-
Immunization with the larger isoform of mouse glutamic acid decarboxylase (GAD67) prevents autoimmune diabetes in NOD mice
-
Elliott JF, Qin HY, Bhatti S, Smith DK, Singh RK, Dillon T, Lauzon J, Singh B. 1994. Immunization with the larger isoform of mouse glutamic acid decarboxylase (GAD67) prevents autoimmune diabetes in NOD mice. Diabetes 43: 1494-1499.
-
(1994)
Diabetes
, vol.43
, pp. 1494-1499
-
-
Elliott, J.F.1
Qin, H.Y.2
Bhatti, S.3
Smith, D.K.4
Singh, R.K.5
Dillon, T.6
Lauzon, J.7
Singh, B.8
-
55
-
-
0007102288
-
Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients
-
Endl J, Otto H, Jung G, Dreisbusch B, Donie F, Stahl P, Elbracht R, Schmitz G, Meinl E, Hummel M, et al. 1997. Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients. J Clin Invest 99: 2405-2415.
-
(1997)
J Clin Invest
, vol.99
, pp. 2405-2415
-
-
Endl, J.1
Otto, H.2
Jung, G.3
Dreisbusch, B.4
Donie, F.5
Stahl, P.6
Elbracht, R.7
Schmitz, G.8
Meinl, E.9
Hummel, M.10
-
56
-
-
0025738117
-
Two genes encode distinct glutamate decarboxylases
-
Erlander MG, Tillakaratne NJ, Feldblum S, Patel N, Tobin AJ. 1991. Two genes encode distinct glutamate decarboxylases. Neuron 7: 91-100.
-
(1991)
Neuron
, vol.7
, pp. 91-100
-
-
Erlander, M.G.1
Tillakaratne, N.J.2
Feldblum, S.3
Patel, N.4
Tobin, A.J.5
-
57
-
-
0026434554
-
Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand
-
Evavold BD, Allen PM. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252: 1308-1310.
-
(1991)
Science
, vol.252
, pp. 1308-1310
-
-
Evavold, B.D.1
Allen, P.M.2
-
58
-
-
0027333348
-
Tickling the TCR: Selective T-cell functions stimulated by altered peptide ligands
-
Evavold BD, Sloan-Lancaster J, Allen PM. 1993. Tickling the TCR: Selective T-cell functions stimulated by altered peptide ligands. Immunol Today 14: 602-609.
-
(1993)
Immunol Today
, vol.14
, pp. 602-609
-
-
Evavold, B.D.1
Sloan-Lancaster, J.2
Allen, P.M.3
-
60
-
-
0027134795
-
Localization and quantitation of expression of two glutamate decarboxylase genes in pancreatic β-cells and other peripheral tissues of mouse and rat
-
Faulkner-Jones BE, Cram DS, Kun J, Harrison LC. 1993. Localization and quantitation of expression of two glutamate decarboxylase genes in pancreatic β-cells and other peripheral tissues of mouse and rat. Endocrinology 133: 2962-2972.
-
(1993)
Endocrinology
, vol.133
, pp. 2962-2972
-
-
Faulkner-Jones, B.E.1
Cram, D.S.2
Kun, J.3
Harrison, L.C.4
-
61
-
-
0033513456
-
Immunotherapy of NOD mice with bone marrow-derived dendritic cells
-
Feili-Hariri M, Dong X, Alber SM, Watkins SC, Salter RD, Morel PA. 1999. Immunotherapy of NOD mice with bone marrow-derived dendritic cells. Diabetes 48: 2300-2308.
-
(1999)
Diabetes
, vol.48
, pp. 2300-2308
-
-
Feili-Hariri, M.1
Dong, X.2
Alber, S.M.3
Watkins, S.C.4
Salter, R.D.5
Morel, P.A.6
-
62
-
-
0037248946
-
Dendritic cells transduced to express interleukin-4 prevent diabetes in nonobese diabetic mice with advanced insulitis
-
Feili-Hariri M, Falkner DH, Gambotto A, Papworth GD, Watkins SC, RobbinsPD, Morel PA. 2003. Dendritic cells transduced to express interleukin-4 prevent diabetes in nonobese diabetic mice with advanced insulitis. Hum Gene Ther 14: 13-23.
-
(2003)
Hum Gene Ther
, vol.14
, pp. 13-23
-
-
Feili-Hariri, M.1
Falkner, D.H.2
Gambotto, A.3
Papworth, G.D.4
Watkins, S.C.5
Robbins, P.D.6
Morel, P.A.7
-
63
-
-
0036318881
-
Regulatory Th2 response induced following adoptive transfer of dendritic cells in prediabetic NOD mice
-
Feili-Hariri M, Falkner DH, Morel PA. 2002. Regulatory Th2 response induced following adoptive transfer of dendritic cells in prediabetic NOD mice. Eur J Immunol 32: 2021-2030.
-
(2002)
Eur J Immunol
, vol.32
, pp. 2021-2030
-
-
Feili-Hariri, M.1
Falkner, D.H.2
Morel, P.A.3
-
64
-
-
33751552197
-
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway
-
Fife BT, Guleria I, Gubbels Bupp M, Eagar TN, Tang Q, Bour-Jordan H, Yagita H, Azuma M, Sayegh MH, Bluestone JA. 2006. Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway. J Exp Med 203: 2737-2747.
-
(2006)
J Exp Med
, vol.203
, pp. 2737-2747
-
-
Fife, B.T.1
Guleria, I.2
Gubbels Bupp, M.3
Eagar, T.N.4
Tang, Q.5
Bour-Jordan, H.6
Yagita, H.7
Azuma, M.8
Sayegh, M.H.9
Bluestone, J.A.10
-
65
-
-
70350433514
-
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal
-
Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA. 2009. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nat Immunol 10: 1185-1192.
-
(2009)
Nat Immunol
, vol.10
, pp. 1185-1192
-
-
Fife, B.T.1
Pauken, K.E.2
Eagar, T.N.3
Obu, T.4
Wu, J.5
Tang, Q.6
Azuma, M.7
Krummel, M.F.8
Bluestone, J.A.9
-
66
-
-
0035573750
-
Effects of plasmid DNA injection on cyclophosphamide-accelerated diabetes in NOD mice
-
Filippova M, Liu J, Escher A. 2001. Effects of plasmid DNA injection on cyclophosphamide-accelerated diabetes in NOD mice. DNA Cell Biol 20: 175-181.
-
(2001)
DNA Cell Biol
, vol.20
, pp. 175-181
-
-
Filippova, M.1
Liu, J.2
Escher, A.3
-
67
-
-
76149134396
-
Immunomodulation with heat shock protein DiaPep277 to preserve β cell function in type 1 diabetes-an update
-
Fischer B, Elias D, Bretzel RG, Linn T. 2010. Immunomodulation with heat shock protein DiaPep277 to preserve β cell function in type 1 diabetes-an update. Expert Opin Biol Ther 10: 265-272.
-
(2010)
Expert Opin Biol Ther
, vol.10
, pp. 265-272
-
-
Fischer, B.1
Elias, D.2
Bretzel, R.G.3
Linn, T.4
-
68
-
-
79953220761
-
Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes
-
Fourlanos S, Perry C, Gellert SA, Martinuzzi E, Mallone R, Butler J, Colman PG, Harrison LC. 2011. Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes. Diabetes 60: 1237-1245.
-
(2011)
Diabetes
, vol.60
, pp. 1237-1245
-
-
Fourlanos, S.1
Perry, C.2
Gellert, S.A.3
Martinuzzi, E.4
Mallone, R.5
Butler, J.6
Colman, P.G.7
Harrison, L.C.8
-
69
-
-
77955549725
-
Subcutaneous insulin B: 9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNγ
-
Fousteri G, Dave A, Bot A, Juntti T, Omid S, von Herrath M. 2010. Subcutaneous insulin B: 9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNγ. Diabetologia 53: 1958-1970.
-
(2010)
Diabetologia
, vol.53
, pp. 1958-1970
-
-
Fousteri, G.1
Dave, A.2
Bot, A.3
Juntti, T.4
Omid, S.5
von Herrath, M.6
-
70
-
-
79954445262
-
Electroporation: A promising method for the nonviral delivery of DNA vaccines in humans?
-
Frelin L, Brass A, Ahlen G, Brenndorfer ED, Chen M, Sallberg M. 2010. Electroporation: A promising method for the nonviral delivery of DNA vaccines in humans? Drug News Perspect 23: 647-653.
-
(2010)
Drug News Perspect
, vol.23
, pp. 647-653
-
-
Frelin, L.1
Brass, A.2
Ahlen, G.3
Brenndorfer, E.D.4
Chen, M.5
Sallberg, M.6
-
71
-
-
3543046812
-
DNA vaccination encoding glutamic acid decarboxylase can enhance insulitis and diabetes in correlation with a specific Th2/3 CD4 T cell response in non-obese diabetic mice
-
Gauvrit A, Debailleul M, Vu AT, Sai P, Bach JM. 2004. DNA vaccination encoding glutamic acid decarboxylase can enhance insulitis and diabetes in correlation with a specific Th2/3 CD4 T cell response in non-obese diabetic mice. Clin Exp Immunol 137: 253-262.
-
(2004)
Clin Exp Immunol
, vol.137
, pp. 253-262
-
-
Gauvrit, A.1
Debailleul, M.2
Vu, A.T.3
Sai, P.4
Bach, J.M.5
-
72
-
-
0031754261
-
Altered peptide ligands of islet autoantigen Imogen 38 inhibit antigen specific T cell reactivity in human type-1 diabetes
-
Geluk A, van Meijgaarden KE, Roep BO, Ottenhoff TH. 1998. Altered peptide ligands of islet autoantigen Imogen 38 inhibit antigen specific T cell reactivity in human type-1 diabetes. J Autoimmun 11: 353-361.
-
(1998)
J Autoimmun
, vol.11
, pp. 353-361
-
-
Geluk, A.1
van Meijgaarden, K.E.2
Roep, B.O.3
Ottenhoff, T.H.4
-
73
-
-
0032543998
-
Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease
-
Geng L, Solimena M, Flavell RA, Sherwin RS, Hayday AC. 1998. Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease. Proc Natl Acad Sci 95: 10055-10060.
-
(1998)
Proc Natl Acad Sci
, vol.95
, pp. 10055-10060
-
-
Geng, L.1
Solimena, M.2
Flavell, R.A.3
Sherwin, R.S.4
Hayday, A.C.5
-
74
-
-
33748168720
-
Protective regulatory T cell generation in autoimmune diabetes by DNA covaccination with islet antigens and a selective CTLA-4 ligand
-
Glinka Y, Chang Y, Prud'homme GJ. 2006. Protective regulatory T cell generation in autoimmune diabetes by DNA covaccination with islet antigens and a selective CTLA-4 ligand. Mol Ther 14: 578-587.
-
(2006)
Mol Ther
, vol.14
, pp. 578-587
-
-
Glinka, Y.1
Chang, Y.2
Prud'homme, G.J.3
-
75
-
-
71949121184
-
Interim results of a phase I/II clinical trial of a DNA plasmid vaccine (BHT-3021) for type 1 diabetes
-
(Abstr)
-
Gottlieb P, Eisenbarth G, Kipnes M, Ratner R, Rockell J, Wagner R, Solvason N, Tersini K, Valone F, Woody K, et al. 2008. Interim results of a phase I/II clinical trial of a DNA plasmid vaccine (BHT-3021) for type 1 diabetes. Diabetologia 51 (Abstr): 574.
-
(2008)
Diabetologia
, vol.51
, pp. 574
-
-
Gottlieb, P.1
Eisenbarth, G.2
Kipnes, M.3
Ratner, R.4
Rockell, J.5
Wagner, R.6
Solvason, N.7
Tersini, K.8
Valone, F.9
Woody, K.10
-
76
-
-
51449104527
-
Gene gun-mediated DNA vaccination enhances antigen-specific immunotherapy at a late preclinical stage of type 1 diabetes in nonobese diabetic mice
-
Goudy KS, Wang B, Tisch R. 2008. Gene gun-mediated DNA vaccination enhances antigen-specific immunotherapy at a late preclinical stage of type 1 diabetes in nonobese diabetic mice. Clin Immunol 129: 49-57.
-
(2008)
Clin Immunol
, vol.129
, pp. 49-57
-
-
Goudy, K.S.1
Wang, B.2
Tisch, R.3
-
77
-
-
10344245538
-
A sudden decline in active membrane-bound TGF-β impairs both T regulatory cell function and protection against autoimmune diabetes
-
Gregg RK, Jain R, Schoenleber SJ, Divekar R, Bell JJ, Lee HH, Yu P, Zaghouani H. 2004. A sudden decline in active membrane-bound TGF-β impairs both T regulatory cell function and protection against autoimmune diabetes. J Immunol 173: 7308-7316.
-
(2004)
J Immunol
, vol.173
, pp. 7308-7316
-
-
Gregg, R.K.1
Jain, R.2
Schoenleber, S.J.3
Divekar, R.4
Bell, J.J.5
Lee, H.H.6
Yu, P.7
Zaghouani, H.8
-
78
-
-
20944441042
-
Prevention of diabetes by manipulation of anti-IGRP autoimmunity: High efficiency of a low-affinity peptide
-
Han B, Serra P, Amrani A, Yamanouchi J, Maree AF, Edelstein-Keshet L, Santamaria P. 2005. Prevention of diabetes by manipulation of anti-IGRP autoimmunity: High efficiency of a low-affinity peptide. Nat Med 11: 645-652.
-
(2005)
Nat Med
, vol.11
, pp. 645-652
-
-
Han, B.1
Serra, P.2
Amrani, A.3
Yamanouchi, J.4
Maree, A.F.5
Edelstein-Keshet, L.6
Santamaria, P.7
-
79
-
-
0030456670
-
Aerosol insulin induces regulatory CD8 γ δ T cells that prevent murine insulin-dependent diabetes
-
Harrison LC, Dempsey-Collier M, Kramer DR, Takahashi K. 1996. Aerosol insulin induces regulatory CD8 γ δ T cells that prevent murine insulin-dependent diabetes. J Exp Med 184: 2167-2174.
-
(1996)
J Exp Med
, vol.184
, pp. 2167-2174
-
-
Harrison, L.C.1
Dempsey-Collier, M.2
Kramer, D.R.3
Takahashi, K.4
-
80
-
-
4644230843
-
Pancreatic β-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes
-
Harrison LC, Honeyman MC, Steele CE, Stone NL, Sarugeri E, Bonifacio E, Couper JJ, Colman PG. 2004. Pancreatic β-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes. Diabetes Care 27: 2348-2355.
-
(2004)
Diabetes Care
, vol.27
, pp. 2348-2355
-
-
Harrison, L.C.1
Honeyman, M.C.2
Steele, C.E.3
Stone, N.L.4
Sarugeri, E.5
Bonifacio, E.6
Couper, J.J.7
Colman, P.G.8
-
81
-
-
36849017514
-
Programmed death-1 ligands-transfected dendritic cells loaded with glutamic acid decarboxylase 65 (GAD65) inhibit both the alloresponse and the GAD65-reactive lymphocyte response
-
He FR, Zhu HF, Huang H, Dai YD, Shen X, Wang M, Li L, Xing W, Shen GX. 2008. Programmed death-1 ligands-transfected dendritic cells loaded with glutamic acid decarboxylase 65 (GAD65) inhibit both the alloresponse and the GAD65-reactive lymphocyte response. Clin Exp Immunol 151: 86-93.
-
(2008)
Clin Exp Immunol
, vol.151
, pp. 86-93
-
-
He, F.R.1
Zhu, H.F.2
Huang, H.3
Dai, Y.D.4
Shen, X.5
Wang, M.6
Li, L.7
Xing, W.8
Shen, G.X.9
-
82
-
-
0022637719
-
The requirements for antigen multivalency in class I antigen recognition and triggering of primed precursor cytolytic T lymphocytes
-
Herrmann SH, Mescher MF. 1986. The requirements for antigen multivalency in class I antigen recognition and triggering of primed precursor cytolytic T lymphocytes. J Immunol 136: 2816-2825.
-
(1986)
J Immunol
, vol.136
, pp. 2816-2825
-
-
Herrmann, S.H.1
Mescher, M.F.2
-
84
-
-
0027534912
-
Glutamic acid decarboxylase 67-reactive T cells: A marker of insulin-dependent diabetes
-
Honeyman MC, Cram DS, Harrison LC. 1993. Glutamic acid decarboxylase 67-reactive T cells: A marker of insulin-dependent diabetes. J Exp Med 177: 535-540.
-
(1993)
J Exp Med
, vol.177
, pp. 535-540
-
-
Honeyman, M.C.1
Cram, D.S.2
Harrison, L.C.3
-
85
-
-
0029135158
-
Comparative study of the protective effect afforded by intravenous administration of bovine or ovine insulin to young NOD mice
-
Hutchings PR, Cooke A. 1995. Comparative study of the protective effect afforded by intravenous administration of bovine or ovine insulin to young NOD mice. Diabetes 44: 906-910.
-
(1995)
Diabetes
, vol.44
, pp. 906-910
-
-
Hutchings, P.R.1
Cooke, A.2
-
86
-
-
0031777665
-
Protection from insulin dependent diabetes mellitus afforded by insulin antigens in incomplete Freund's adjuvant depends on route of administration
-
Hutchings P, Cooke A. 1998. Protection from insulin dependent diabetes mellitus afforded by insulin antigens in incomplete Freund's adjuvant depends on route of administration. J Autoimmun 11: 127-130.
-
(1998)
J Autoimmun
, vol.11
, pp. 127-130
-
-
Hutchings, P.1
Cooke, A.2
-
87
-
-
34249825219
-
Therapy with the hsp60 peptide DiaPep277 in C-peptide positive type 1 diabetes patients
-
Huurman VA, Decochez K, Mathieu C, Cohen IR, Roep BO. 2007. Therapy with the hsp60 peptide DiaPep277 in C-peptide positive type 1 diabetes patients. Diabetes Metab Res Rev 23: 269-275.
-
(2007)
Diabetes Metab Res Rev
, vol.23
, pp. 269-275
-
-
Huurman, V.A.1
Decochez, K.2
Mathieu, C.3
Cohen, I.R.4
Roep, B.O.5
-
88
-
-
43349090939
-
Immunological efficacy of heat shock protein 60 peptide DiaPep277 therapy in clinical type I diabetes
-
Huurman VA, van der Meide PE, Duinkerken G, Willemen S, Cohen IR, Elias D, Roep BO. 2008. Immunological efficacy of heat shock protein 60 peptide DiaPep277 therapy in clinical type I diabetes. Clin Exp Immunol 152: 488-497.
-
(2008)
Clin Exp Immunol
, vol.152
, pp. 488-497
-
-
Huurman, V.A.1
van der Meide, P.E.2
Duinkerken, G.3
Willemen, S.4
Cohen, I.R.5
Elias, D.6
Roep, B.O.7
-
89
-
-
0038204841
-
Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase
-
Jaeckel E, Klein L, Martin-Orozco N, von Boehmer H. 2003. Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase. J Exp Med 197: 1635-1644.
-
(2003)
J Exp Med
, vol.197
, pp. 1635-1644
-
-
Jaeckel, E.1
Klein, L.2
Martin-Orozco, N.3
von Boehmer, H.4
-
90
-
-
38749111445
-
Innocuous IFNγ induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production
-
Jain R, Tartar DM, Gregg RK, Divekar RD, Bell JJ, Lee HH, Yu P, Ellis JS, HoemanCM, Franklin CL, et al. 2008. Innocuous IFNγ induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production. J Exp Med 205: 207-218.
-
(2008)
J Exp Med
, vol.205
, pp. 207-218
-
-
Jain, R.1
Tartar, D.M.2
Gregg, R.K.3
Divekar, R.D.4
Bell, J.J.5
Lee, H.H.6
Yu, P.7
Ellis, J.S.8
Hoeman, C.M.9
Franklin, C.L.10
-
91
-
-
0029009977
-
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
-
Jiang W, Swiggard WJ, Heufler C, Peng M, Mirza A, Steinman RM, NussenzweigMC. 1995. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 375: 151-155.
-
(1995)
Nature
, vol.375
, pp. 151-155
-
-
Jiang, W.1
Swiggard, W.J.2
Heufler, C.3
Peng, M.4
Mirza, A.5
Steinman, R.M.6
Nussenzweig, M.C.7
-
92
-
-
0033791462
-
Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The Altered Peptide Ligand in Relapsing MS Study Group
-
Kappos L, Comi G, Panitch H, Oger J, Antel J, Conlon P, Steinman L. 2000. Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The Altered Peptide Ligand in Relapsing MS Study Group. Nat Med 6: 1176-1182.
-
(2000)
Nat Med
, vol.6
, pp. 1176-1182
-
-
Kappos, L.1
Comi, G.2
Panitch, H.3
Oger, J.4
Antel, J.5
Conlon, P.6
Steinman, L.7
-
93
-
-
0036828917
-
Induction of autoimmune diabetes through insulin (but not GAD65) DNA vaccination in nonobese diabetic and in RIP-B7. 1 mice
-
Karges W, Pechhold K, Al Dahouk S, Riegger I, Rief M, Wissmann A, Schirmbeck R, Barth C, Boehm BO. 2002. Induction of autoimmune diabetes through insulin (but not GAD65) DNA vaccination in nonobese diabetic and in RIP-B7. 1 mice. Diabetes 51: 3237-3244.
-
(2002)
Diabetes
, vol.51
, pp. 3237-3244
-
-
Karges, W.1
Pechhold, K.2
Al Dahouk, S.3
Riegger, I.4
Rief, M.5
Wissmann, A.6
Schirmbeck, R.7
Barth, C.8
Boehm, B.O.9
-
94
-
-
0026661122
-
Recombinant glutamic acid decarboxylase (representing the single isoform expressed in human islets) detects IDDM-associated 64, 000-M(r) autoantibodies
-
Karlsen AE, Hagopian WA, Petersen JS, Boel E, Dyrberg T, Grubin CE, MichelsenBK, Madsen OD, Lernmark A. 1992. Recombinant glutamic acid decarboxylase (representing the single isoform expressed in human islets) detects IDDM-associated 64, 000-M(r) autoantibodies. Diabetes 41: 1355-1359.
-
(1992)
Diabetes
, vol.41
, pp. 1355-1359
-
-
Karlsen, A.E.1
Hagopian, W.A.2
Petersen, J.S.3
Boel, E.4
Dyrberg, T.5
Grubin, C.E.6
Michelsen, B.K.7
Madsen, O.D.8
Lernmark, A.9
-
95
-
-
0027368141
-
Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes
-
Kaufman DL, Clare-Salzler M, Tian J, Forsthuber T, Ting GS, Robinson P, Atkinson MA, Sercarz EE, Tobin AJ, Lehmann PV. 1993. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366: 69-72.
-
(1993)
Nature
, vol.366
, pp. 69-72
-
-
Kaufman, D.L.1
Clare-Salzler, M.2
Tian, J.3
Forsthuber, T.4
Ting, G.S.5
Robinson, P.6
Atkinson, M.A.7
Sercarz, E.E.8
Tobin, A.J.9
Lehmann, P.V.10
-
96
-
-
0023851039
-
Evidence of IgG autoantibodies against human proinsulin in patients with IDDM before insulin treatment
-
Kuglin B, Gries FA, Kolb H. 1988. Evidence of IgG autoantibodies against human proinsulin in patients with IDDM before insulin treatment. Diabetes 37: 130-132.
-
(1988)
Diabetes
, vol.37
, pp. 130-132
-
-
Kuglin, B.1
Gries, F.A.2
Kolb, H.3
-
98
-
-
34249820806
-
Heat-shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: A randomised, double-blind phase II study
-
Lazar L, Ofan R, Weintrob N, Avron A, Tamir M, Elias D, Phillip M, Josefsberg Z. 2007. Heat-shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: A randomised, double-blind phase II study. Diabetes Metab Res Rev 23: 286-291.
-
(2007)
Diabetes Metab Res Rev
, vol.23
, pp. 286-291
-
-
Lazar, L.1
Ofan, R.2
Weintrob, N.3
Avron, A.4
Tamir, M.5
Elias, D.6
Phillip, M.7
Josefsberg, Z.8
-
100
-
-
70449711382
-
Suppression of ongoing T cell-mediated autoimmunity by peptide-MHC class II dimer vaccination
-
Li L, Yi Z, Wang B, Tisch R. 2009. Suppression of ongoing T cell-mediated autoimmunity by peptide-MHC class II dimer vaccination. J Immunol 183: 4809-4816.
-
(2009)
J Immunol
, vol.183
, pp. 4809-4816
-
-
Li, L.1
Yi, Z.2
Wang, B.3
Tisch, R.4
-
101
-
-
0242364727
-
A comprehensive guide to antibody and T-cell responses in type 1 diabetes
-
Lieberman SM, DiLorenzo TP. 2003. A comprehensive guide to antibody and T-cell responses in type 1 diabetes. Tissue Antigens 62: 359-377.
-
(2003)
Tissue Antigens
, vol.62
, pp. 359-377
-
-
Lieberman, S.M.1
DiLorenzo, T.P.2
-
102
-
-
77956112950
-
Reversal of type 1 diabetes by a new MHC II-peptide chimera: "Single-epitope-mediated suppression" to stabilize a polyclonal autoimmune T-cell process
-
Lin M, Stoica-Nazarov C, Surls J, Kehl M, Bona C, Olsen C, Brumeanu TD, Casares S. 2010. Reversal of type 1 diabetes by a new MHC II-peptide chimera: "Single-epitope-mediated suppression" to stabilize a polyclonal autoimmune T-cell process. Eur J Immunol 40: 2277-2288.
-
(2010)
Eur J Immunol
, vol.40
, pp. 2277-2288
-
-
Lin, M.1
Stoica-Nazarov, C.2
Surls, J.3
Kehl, M.4
Bona, C.5
Olsen, C.6
Brumeanu, T.D.7
Casares, S.8
-
103
-
-
0036790542
-
Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B: 9-23 and B: 13-23
-
Liu E, Moriyama H, Abiru N, Miao D, Yu L, Taylor RM, Finkelman FD, EisenbarthGS. 2002. Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B: 9-23 and B: 13-23. J Clin Invest 110: 1021-1027.
-
(2002)
J Clin Invest
, vol.110
, pp. 1021-1027
-
-
Liu, E.1
Moriyama, H.2
Abiru, N.3
Miao, D.4
Yu, L.5
Taylor, R.M.6
Finkelman, F.D.7
Eisenbarth, G.S.8
-
104
-
-
55249110198
-
GAD treatment and insulin secretion in recent-onset type 1 diabetes
-
Ludvigsson J, Faresjo M, Hjorth M, Axelsson S, Cheramy M, Pihl M, Vaarala O, Forsander G, Ivarsson S, Johansson C, et al. 2008. GAD treatment and insulin secretion in recent-onset type 1 diabetes. N Engl J Med 359: 1909-1920.
-
(2008)
N Engl J Med
, vol.359
, pp. 1909-1920
-
-
Ludvigsson, J.1
Faresjo, M.2
Hjorth, M.3
Axelsson, S.4
Cheramy, M.5
Pihl, M.6
Vaarala, O.7
Forsander, G.8
Ivarsson, S.9
Johansson, C.10
-
105
-
-
79953756466
-
Extended evaluation of the safety and efficacy of GAD treatment of children and adolescents with recent-onset type 1 diabetes: A randomised controlled trial
-
Ludvigsson J, Hjorth M, Cheramy M, Axelsson S, Pihl M, Forsander G, NilssonNO, Samuelsson BO, Wood T, Aman J, et al. 2011. Extended evaluation of the safety and efficacy of GAD treatment of children and adolescents with recent-onset type 1 diabetes: A randomised controlled trial. Diabetologia 54: 634-640.
-
(2011)
Diabetologia
, vol.54
, pp. 634-640
-
-
Ludvigsson, J.1
Hjorth, M.2
Cheramy, M.3
Axelsson, S.4
Pihl, M.5
Forsander, G.6
Nilsson, N.O.7
Samuelsson, B.O.8
Wood, T.9
Aman, J.10
-
106
-
-
0030791484
-
Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance
-
Ma SW, Zhao DL, Yin ZQ, Mukherjee R, Singh B, Qin HY, Stiller CR, Jevnikar AM. 1997. Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance. Nat Med 3: 793-796.
-
(1997)
Nat Med
, vol.3
, pp. 793-796
-
-
Ma, S.W.1
Zhao, D.L.2
Yin, Z.Q.3
Mukherjee, R.4
Singh, B.5
Qin, H.Y.6
Stiller, C.R.7
Jevnikar, A.M.8
-
107
-
-
0042767606
-
Prevention of diabetes in NOD mice by administration of dendritic cells deficient in nuclear transcription factor-κB activity
-
Ma L, Qian S, Liang X, Wang L, Woodward JE, Giannoukakis N, Robbins PD, Bertera S, Trucco M, Fung JJ, et al. 2003. Prevention of diabetes in NOD mice by administration of dendritic cells deficient in nuclear transcription factor-κB activity. Diabetes 52: 1976-1985.
-
(2003)
Diabetes
, vol.52
, pp. 1976-1985
-
-
Ma, L.1
Qian, S.2
Liang, X.3
Wang, L.4
Woodward, J.E.5
Giannoukakis, N.6
Robbins, P.D.7
Bertera, S.8
Trucco, M.9
Fung, J.J.10
-
108
-
-
1842732158
-
Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4
-
Ma S, Huang Y, Yin Z, Menassa R, Brandle JE, Jevnikar AM. 2004. Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4. Proc Natl Acad Sci 101: 5680-5685.
-
(2004)
Proc Natl Acad Sci
, vol.101
, pp. 5680-5685
-
-
Ma, S.1
Huang, Y.2
Yin, Z.3
Menassa, R.4
Brandle, J.E.5
Jevnikar, A.M.6
-
109
-
-
4644297765
-
Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells
-
Machen J, Harnaha J, Lakomy R, Styche A, Trucco M, Giannoukakis N. 2004. Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells. J Immunol 173: 4331-4341.
-
(2004)
J Immunol
, vol.173
, pp. 4331-4341
-
-
McHen, J.1
Harnaha, J.2
Lakomy, R.3
Styche, A.4
Trucco, M.5
Giannoukakis, N.6
-
110
-
-
0038792101
-
+regulatory T cells by targeting of antigens to immature dendritic cells
-
+regulatory T cells by targeting of antigens to immature dendritic cells. Blood 101: 4862-4869.
-
(2003)
Blood
, vol.101
, pp. 4862-4869
-
-
Mahnke, K.1
Qian, Y.2
Knop, J.3
Enk, A.H.4
-
111
-
-
77950637110
-
Dendritic cells pulsed with antigen-specific apoptotic bodies prevent experimental type 1 diabetes
-
Marin-Gallen S, Clemente-Casares X, Planas R, Pujol-Autonell I, Carrascal J, Carrillo J, Ampudia R, Verdaguer J, Pujol-Borrell R, Borras FE, et al. 2010. Dendritic cells pulsed with antigen-specific apoptotic bodies prevent experimental type 1 diabetes. Clin Exp Immunol 160: 207-214.
-
(2010)
Clin Exp Immunol
, vol.160
, pp. 207-214
-
-
Marin-Gallen, S.1
Clemente-Casares, X.2
Planas, R.3
Pujol-Autonell, I.4
Carrascal, J.5
Carrillo, J.6
Ampudia, R.7
Verdaguer, J.8
Pujol-Borrell, R.9
Borras, F.E.10
-
112
-
-
0033055884
-
Regulatory Th2-type T cell lines against insulin and GAD peptides derived from orally-and nasally-treated NOD mice suppress diabetes
-
Maron R, Melican NS, Weiner HL. 1999. Regulatory Th2-type T cell lines against insulin and GAD peptides derived from orally-and nasally-treated NOD mice suppress diabetes. J Autoimmun 12: 251-258.
-
(1999)
J Autoimmun
, vol.12
, pp. 251-258
-
-
Maron, R.1
Melican, N.S.2
Weiner, H.L.3
-
113
-
-
0038814318
-
Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide
-
Martinez NR, Augstein P, Moustakas AK, Papadopoulos GK, Gregori S, AdoriniL, Jackson DC, Harrison LC. 2003. Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide. J Clin Invest 111: 1365-1371.
-
(2003)
J Clin Invest
, vol.111
, pp. 1365-1371
-
-
Martinez, N.R.1
Augstein, P.2
Moustakas, A.K.3
Papadopoulos, G.K.4
Gregori, S.5
Adorini, L.6
Jackson, D.C.7
Harrison, L.C.8
-
114
-
-
0242494202
-
Peptide-MHC class II dimers as therapeutics to modulate antigen-specific T cell responses in autoimmune diabetes
-
Masteller EL, Warner MR, Ferlin W, Judkowski V, Wilson D, Glaichenhaus N, Bluestone JA. 2003. Peptide-MHC class II dimers as therapeutics to modulate antigen-specific T cell responses in autoimmune diabetes. J Immunol 171: 5587-5595.
-
(2003)
J Immunol
, vol.171
, pp. 5587-5595
-
-
Masteller, E.L.1
Warner, M.R.2
Ferlin, W.3
Judkowski, V.4
Wilson, D.5
Glaichenhaus, N.6
Bluestone, J.A.7
-
115
-
-
0024513169
-
The role of major histocompatibility molecules in antigen-specific immune responses
-
McCluskey J, Blok R, Kjer-Nielsen L. 1989. The role of major histocompatibility molecules in antigen-specific immune responses. Transplant Proc 21: 591-594.
-
(1989)
Transplant Proc
, vol.21
, pp. 591-594
-
-
McCluskey, J.1
Blok, R.2
Kjer-Nielsen, L.3
-
116
-
-
33744947093
-
Current status of pancreatic islet transplantation
-
Merani S, Shapiro AM. 2006. Current status of pancreatic islet transplantation. Clin Sci (Lond) 110: 611-625.
-
(2006)
Clin Sci (Lond)
, vol.110
, pp. 611-625
-
-
Merani, S.1
Shapiro, A.M.2
-
117
-
-
43049130746
-
Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells
-
Monti P, Scirpoli M, Maffi P, Ghidoli N, De Taddeo F, Bertuzzi F, Piemonti L, Falcone M, Secchi A, Bonifacio E. 2008. Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells. J Clin Invest 118: 1806-1814.
-
(2008)
J Clin Invest
, vol.118
, pp. 1806-1814
-
-
Monti, P.1
Scirpoli, M.2
Maffi, P.3
Ghidoli, N.4
De Taddeo, F.5
Bertuzzi, F.6
Piemonti, L.7
Falcone, M.8
Secchi, A.9
Bonifacio, E.10
-
119
-
-
0028861576
-
Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-γ transcription
-
Muir A, Peck A, Clare-Salzler M, Song YH, Cornelius J, Luchetta R, Krischer J, Maclaren N. 1995. Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-γ transcription. J Clin Invest 95: 628-634.
-
(1995)
J Clin Invest
, vol.95
, pp. 628-634
-
-
Muir, A.1
Peck, A.2
Clare-Salzler, M.3
Song, Y.H.4
Cornelius, J.5
Luchetta, R.6
Krischer, J.7
McLaren, N.8
-
120
-
-
44049086242
-
+ T cells in NOD mice
-
+ T cells in NOD mice. Proc Natl Acad Sci 105: 6374-6379.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 6374-6379
-
-
Mukhopadhaya, A.1
Hanafusa, T.2
Jarchum, I.3
Chen, Y.G.4
Iwai, Y.5
Serreze, D.V.6
Steinman, R.M.7
Tarbell, K.V.8
DiLorenzo, T.P.9
-
121
-
-
18744366947
-
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
-
Nakayama M, Abiru N, Moriyama H, Babaya N, Liu E, Miao D, Yu L, WegmannDR, Hutton JC, Elliott JF, et al. 2005. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 435: 220-223.
-
(2005)
Nature
, vol.435
, pp. 220-223
-
-
Nakayama, M.1
Abiru, N.2
Moriyama, H.3
Babaya, N.4
Liu, E.5
Miao, D.6
Yu, L.7
Wegmann, D.R.8
Hutton, J.C.9
Elliott, J.F.10
-
122
-
-
55749104546
-
Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: A double-blind, randomised controlled trial
-
Nanto-Salonen K, Kupila A, Simell S, Siljander H, Salonsaari T, Hekkala A, Korhonen S, Erkkola R, Sipila JI, Haavisto L, et al. 2008. Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: A double-blind, randomised controlled trial. Lancet 372: 1746-1755.
-
(2008)
Lancet
, vol.372
, pp. 1746-1755
-
-
Nanto-Salonen, K.1
Kupila, A.2
Simell, S.3
Siljander, H.4
Salonsaari, T.5
Hekkala, A.6
Korhonen, S.7
Erkkola, R.8
Sipila, J.I.9
Haavisto, L.10
-
123
-
-
0037986208
-
Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus
-
Nathan DM, Lachin J, Cleary P, Orchard T, Brillon DJ, Backlund JY, O'Leary DH, Genuth S. 2003. Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus. N Engl J Med 348: 2294-2303.
-
(2003)
N Engl J Med
, vol.348
, pp. 2294-2303
-
-
Nathan, D.M.1
Lachin, J.2
Cleary, P.3
Orchard, T.4
Brillon, D.J.5
Backlund, J.Y.6
O'Leary, D.H.7
Genuth, S.8
-
124
-
-
29144453326
-
Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
-
Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, RaskinP, Zinman B. 2005. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 353: 2643-2653.
-
(2005)
N Engl J Med
, vol.353
, pp. 2643-2653
-
-
Nathan, D.M.1
Cleary, P.A.2
Backlund, J.Y.3
Genuth, S.M.4
Lachin, J.M.5
Orchard, T.J.6
Raskin, P.7
Zinman, B.8
-
125
-
-
79953172219
-
Prevention of "humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach
-
Niens M, Grier AE, Marron M, Kay TW, Greiner DL, Serreze DV. 2011. Prevention of "humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach. Diabetes 60: 1229-1236.
-
(2011)
Diabetes
, vol.60
, pp. 1229-1236
-
-
Niens, M.1
Grier, A.E.2
Marron, M.3
Kay, T.W.4
Greiner, D.L.5
Serreze, D.V.6
-
126
-
-
33748988721
-
Peptide p277 of HSP60 signals T cells: Inhibition of inflammatory chemotaxis
-
Nussbaum G, Zanin-Zhorov A, Quintana F, Lider O, Cohen IR. 2006. Peptide p277 of HSP60 signals T cells: Inhibition of inflammatory chemotaxis. Int Immunol 18: 1413-1419.
-
(2006)
Int Immunol
, vol.18
, pp. 1413-1419
-
-
Nussbaum, G.1
Zanin-Zhorov, A.2
Quintana, F.3
Lider, O.4
Cohen, I.R.5
-
127
-
-
77952243765
-
Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy
-
Orban T, Farkas K, Jalahej H, Kis J, Treszl A, Falk B, Reijonen H, Wolfsdorf J, Ricker A, Matthews JB, et al. 2010. Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy. J Autoimmun 34: 408-415.
-
(2010)
J Autoimmun
, vol.34
, pp. 408-415
-
-
Orban, T.1
Farkas, K.2
Jalahej, H.3
Kis, J.4
Treszl, A.5
Falk, B.6
Reijonen, H.7
Wolfsdorf, J.8
Ricker, A.9
Matthews, J.B.10
-
128
-
-
0021019885
-
Insulin antibodies in insulin-dependent diabetics before insulin treatment
-
Palmer JP, Asplin CM, Clemons P, Lyen K, Tatpati O, Raghu PK, Paquette TL. 1983. Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 222: 1337-1339.
-
(1983)
Science
, vol.222
, pp. 1337-1339
-
-
Palmer, J.P.1
Asplin, C.M.2
Clemons, P.3
Lyen, K.4
Tatpati, O.5
Raghu, P.K.6
Paquette, T.L.7
-
129
-
-
0028955372
-
Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes
-
Panina-Bordignon P, Lang R, van Endert PM, Benazzi E, Felix AM, Pastore RM, Spinas GA, Sinigaglia F. 1995. Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes. J Exp Med 181: 1923-1927.
-
(1995)
J Exp Med
, vol.181
, pp. 1923-1927
-
-
Panina-Bordignon, P.1
Lang, R.2
van Endert, P.M.3
Benazzi, E.4
Felix, A.M.5
Pastore, R.M.6
Spinas, G.A.7
Sinigaglia, F.8
-
130
-
-
33749530902
-
Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice
-
Perone MJ, Bertera S, Tawadrous ZS, Shufesky WJ, Piganelli JD, Baum LG, TruccoM, Morelli AE. 2006. Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice. J Immunol 177: 5278-5289.
-
(2006)
J Immunol
, vol.177
, pp. 5278-5289
-
-
Perone, M.J.1
Bertera, S.2
Tawadrous, Z.S.3
Shufesky, W.J.4
Piganelli, J.D.5
Baum, L.G.6
Trucco, M.7
Morelli, A.E.8
-
132
-
-
0029146498
-
Prevention of autoimmune diabetes in nonobese diabetic female mice by treatment with recombinant glutamic acid decarboxylase (GAD 65)
-
Pleau JM, Fernandez-Saravia F, Esling A, Homo-Delarche F, Dardenne M. 1995. Prevention of autoimmune diabetes in nonobese diabetic female mice by treatment with recombinant glutamic acid decarboxylase (GAD 65). Clin Immunol Immunopathol 76: 90-95.
-
(1995)
Clin Immunol Immunopathol
, vol.76
, pp. 90-95
-
-
Pleau, J.M.1
Fernandez-Saravia, F.2
Esling, A.3
Homo-Delarche, F.4
Dardenne, M.5
-
133
-
-
0031784202
-
Immunization of diabetes-prone or non-diabetes-prone mice with GAD65 does not induce diabetes or islet cell pathology
-
Plesner A, Worsaae A, Dyrberg T, Gotfredsen C, Michelsen BK, Petersen JS. 1998. Immunization of diabetes-prone or non-diabetes-prone mice with GAD65 does not induce diabetes or islet cell pathology. J Autoimmun 11: 335-341.
-
(1998)
J Autoimmun
, vol.11
, pp. 335-341
-
-
Plesner, A.1
Worsaae, A.2
Dyrberg, T.3
Gotfredsen, C.4
Michelsen, B.K.5
Petersen, J.S.6
-
135
-
-
0033846982
-
No effect of oral insulin on residual β-cell function in recent-onset type I diabetes (the IMDIAB VII). IMDIAB Group
-
Pozzilli P, Pitocco D, Visalli N, Cavallo MG, Buzzetti R, Crino A, Spera S, SuraciC, Multari G, Cervoni M, et al. 2000. No effect of oral insulin on residual β-cell function in recent-onset type I diabetes (the IMDIAB VII). IMDIAB Group. Diabetologia 43: 1000-1004.
-
(2000)
Diabetologia
, vol.43
, pp. 1000-1004
-
-
Pozzilli, P.1
Pitocco, D.2
Visalli, N.3
Cavallo, M.G.4
Buzzetti, R.5
Crino, A.6
Spera, S.7
Suraci, C.8
Multari, G.9
Cervoni, M.10
-
136
-
-
26044438468
-
Soluble, dimeric HLA DR4-peptide chimeras: An approach for detection and immunoregulation of human type-1 diabetes
-
Preda I, McEvoy RC, Lin M, Bona CA, Rapaport R, Brumeanu TD, Casares S. 2005. Soluble, dimeric HLA DR4-peptide chimeras: An approach for detection and immunoregulation of human type-1 diabetes. Eur J Immunol 35: 2762-2775.
-
(2005)
Eur J Immunol
, vol.35
, pp. 2762-2775
-
-
Preda, I.1
McEvoy, R.C.2
Lin, M.3
Bona, C.A.4
Rapaport, R.5
Brumeanu, T.D.6
Casares, S.7
-
137
-
-
0036202406
-
Immunoinhibitory DNA vaccine protects against autoimmune diabetes through cDNA encoding a selective CTLA-4 (CD152) ligand
-
Prud'homme GJ, Chang Y, Li X. 2002. Immunoinhibitory DNA vaccine protects against autoimmune diabetes through cDNA encoding a selective CTLA-4 (CD152) ligand. Hum Gene Ther 13: 395-406.
-
(2002)
Hum Gene Ther
, vol.13
, pp. 395-406
-
-
Prud'homme, G.J.1
Chang, Y.2
Li, X.3
-
138
-
-
33947432878
-
Plasmid-based gene therapy of diabetes mellitus
-
Prud'homme GJ, Draghia-Akli R, Wang Q. 2007. Plasmid-based gene therapy of diabetes mellitus. Gene Ther 14: 553-564.
-
(2007)
Gene Ther
, vol.14
, pp. 553-564
-
-
Prud'homme, G.J.1
Draghia-Akli, R.2
Wang, Q.3
-
139
-
-
0034548005
-
Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in nonobese diabetic mice: Modulation of spontaneous 60-kDa heat shock protein autoimmunity
-
Quintana FJ, Rotem A, Carmi P, Cohen IR. 2000. Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in nonobese diabetic mice: Modulation of spontaneous 60-kDa heat shock protein autoimmunity. J Immunol 165: 6148-6155.
-
(2000)
J Immunol
, vol.165
, pp. 6148-6155
-
-
Quintana, F.J.1
Rotem, A.2
Carmi, P.3
Cohen, I.R.4
-
140
-
-
0031440003
-
Effect of oral and intravenous insulin and glutamic acid decarboxylase in NOD mice
-
Ramiya VK, Shang XZ, Wasserfall CH, Maclaren NK. 1997. Effect of oral and intravenous insulin and glutamic acid decarboxylase in NOD mice. Autoimmunity 26: 139-151.
-
(1997)
Autoimmunity
, vol.26
, pp. 139-151
-
-
Ramiya, V.K.1
Shang, X.Z.2
Wasserfall, C.H.3
McLaren, N.K.4
-
141
-
-
34247160441
-
Inhalation of glutamic acid decarboxylase 65-derived peptides can protect against recurrent autoimmune but not alloimmune responses in the non-obese diabetic mouse
-
Ravanan R, Wong SF, Morgan NG, Mathieson PW, Smith RM. 2007. Inhalation of glutamic acid decarboxylase 65-derived peptides can protect against recurrent autoimmune but not alloimmune responses in the non-obese diabetic mouse. Clin Exp Immunol 148: 368-372.
-
(2007)
Clin Exp Immunol
, vol.148
, pp. 368-372
-
-
Ravanan, R.1
Wong, S.F.2
Morgan, N.G.3
Mathieson, P.W.4
Smith, R.M.5
-
142
-
-
0035944844
-
β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial
-
Raz I, Elias D, Avron A, Tamir M, Metzger M, Cohen IR. 2001. β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial. Lancet 358: 1749-1753.
-
(2001)
Lancet
, vol.358
, pp. 1749-1753
-
-
Raz, I.1
Elias, D.2
Avron, A.3
Tamir, M.4
Metzger, M.5
Cohen, I.R.6
-
143
-
-
34249812097
-
Treatment of new-onset type 1 diabetes with peptide DiaPep277 is safe and associated with preserved beta-cell function: Extension of a randomized, double-blind, phase II trial
-
Raz I, Avron A, Tamir M, Metzger M, Symer L, Eldor R, Cohen IR, Elias D. 2007. Treatment of new-onset type 1 diabetes with peptide DiaPep277 is safe and associated with preserved beta-cell function: Extension of a randomized, double-blind, phase II trial. Diabetes Metab Res Rev 23: 292-298.
-
(2007)
Diabetes Metab Res Rev
, vol.23
, pp. 292-298
-
-
Raz, I.1
Avron, A.2
Tamir, M.3
Metzger, M.4
Symer, L.5
Eldor, R.6
Cohen, I.R.7
Elias, D.8
-
144
-
-
79955011427
-
Targeting of a T cell agonist peptide to lysosomes by DNA vaccination induces tolerance in the nonobese diabetic mouse
-
Rivas EI, Driver JP, Garabatos N, Presa M, Mora C, Rodriguez F, Serreze DV, Stratmann T. 2011. Targeting of a T cell agonist peptide to lysosomes by DNA vaccination induces tolerance in the nonobese diabetic mouse. J Immunol 186: 4078-4087.
-
(2011)
J Immunol
, vol.186
, pp. 4078-4087
-
-
Rivas, E.I.1
Driver, J.P.2
Garabatos, N.3
Presa, M.4
Mora, C.5
Rodriguez, F.6
Serreze, D.V.7
Stratmann, T.8
-
145
-
-
77953193333
-
Islet transplantation a decade later and strategies for filling a half-full glass
-
Robertson RP. 2010. Islet transplantation a decade later and strategies for filling a half-full glass. Diabetes 59: 1285-1291.
-
(2010)
Diabetes
, vol.59
, pp. 1285-1291
-
-
Robertson, R.P.1
-
146
-
-
0029360443
-
Similar peptides from two β cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes
-
Rudy G, Stone N, Harrison LC, Colman PG, McNair P, Brusic V, French MB, Honeyman MC, Tait B, Lew AM. 1995. Similar peptides from two β cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes. Mol Med 1: 625-633.
-
(1995)
Mol Med
, vol.1
, pp. 625-633
-
-
Rudy, G.1
Stone, N.2
Harrison, L.C.3
Colman, P.G.4
McNair, P.5
Brusic, V.6
French, M.B.7
Honeyman, M.C.8
Tait, B.9
Lew, A.M.10
-
147
-
-
77955610171
-
Dendritic cells transduced to express interleukin 4 reduce diabetes onset in both normoglycemic and prediabetic nonobese diabetic mice
-
Ruffner MA, Robbins PD. 2010. Dendritic cells transduced to express interleukin 4 reduce diabetes onset in both normoglycemic and prediabetic nonobese diabetic mice. PLoS One 5: e11848.
-
(2010)
PLoS One
, vol.5
-
-
Ruffner, M.A.1
Robbins, P.D.2
-
148
-
-
0030474308
-
Prophylactic oral administration of metabolically active insulin entrapped in isobutylcyanoacrylate nanocapsules reduces the incidence of diabetes in nonobese diabetic mice
-
Sai P, Damage C, Rivereau AS, Hoeltzel A, Gouin E. 1996. Prophylactic oral administration of metabolically active insulin entrapped in isobutylcyanoacrylate nanocapsules reduces the incidence of diabetes in nonobese diabetic mice. J Autoimmun 9: 713-722.
-
(1996)
J Autoimmun
, vol.9
, pp. 713-722
-
-
Sai, P.1
Damage, C.2
Rivereau, A.S.3
Hoeltzel, A.4
Gouin, E.5
-
149
-
-
34249786263
-
Effect of heat shock protein peptide DiaPep277 on β-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: Two prospective, randomized, double-blind phase II trials
-
Schloot NC, Meierhoff G, Lengyel C, Vandorfi G, Takacs J, Panczel P, Barkai L, Madacsy L, Oroszlan T, Kovacs P, et al. 2007. Effect of heat shock protein peptide DiaPep277 on β-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: Two prospective, randomized, double-blind phase II trials. Diabetes Metab Res Rev 23: 276-285.
-
(2007)
Diabetes Metab Res Rev
, vol.23
, pp. 276-285
-
-
Schloot, N.C.1
Meierhoff, G.2
Lengyel, C.3
Vandorfi, G.4
Takacs, J.5
Panczel, P.6
Barkai, L.7
Madacsy, L.8
Oroszlan, T.9
Kovacs, P.10
-
150
-
-
0027234036
-
Prevalence of autoantibodies to the 65-and 67-kD isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitus
-
Seissler J, Amann J, Mauch L, Haubruck H, Wolfahrt S, Bieg S, Richter W, Holl R, Heinze E, Northemann W, et al. 1993. Prevalence of autoantibodies to the 65-and 67-kD isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J Clin Invest 92: 1394-1399.
-
(1993)
J Clin Invest
, vol.92
, pp. 1394-1399
-
-
Seissler, J.1
Amann, J.2
Mauch, L.3
Haubruck, H.4
Wolfahrt, S.5
Bieg, S.6
Richter, W.7
Holl, R.8
Heinze, E.9
Northemann, W.10
-
151
-
-
0034721255
-
Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
-
Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV. 2000. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343: 230-238.
-
(2000)
N Engl J Med
, vol.343
, pp. 230-238
-
-
Shapiro, A.M.1
Lakey, J.R.2
Ryan, E.A.3
Korbutt, G.S.4
Toth, E.5
Warnock, G.L.6
Kneteman, N.M.7
Rajotte, R.V.8
-
152
-
-
33749070784
-
International trial of the Edmonton protocol for islet transplantation
-
Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A, Brendel MD, Berney T, Brennan DC, et al. 2006. International trial of the Edmonton protocol for islet transplantation. N Engl J Med 355: 1318-1330.
-
(2006)
N Engl J Med
, vol.355
, pp. 1318-1330
-
-
Shapiro, A.M.1
Ricordi, C.2
Hering, B.J.3
Auchincloss, H.4
Lindblad, R.5
Robertson, R.P.6
Secchi, A.7
Brendel, M.D.8
Berney, T.9
Brennan, D.C.10
-
153
-
-
18144391496
-
Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial-Type 1
-
Skyler JS, Krischer JP, Wolfsdorf J, Cowie C, Palmer JP, Greenbaum C, Cuthbertson D, Rafkin-Mervis LE, Chase HP, Leschek E. 2005. Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial-Type 1. Diabetes Care 28: 1068-1076.
-
(2005)
Diabetes Care
, vol.28
, pp. 1068-1076
-
-
Skyler, J.S.1
Krischer, J.P.2
Wolfsdorf, J.3
Cowie, C.4
Palmer, J.P.5
Greenbaum, C.6
Cuthbertson, D.7
Rafkin-Mervis, L.E.8
Chase, H.P.9
Leschek, E.10
-
154
-
-
57749176852
-
Type 1 Diabetes TrialNet-an international collaborative clinical trials network
-
Skyler JS, Greenbaum CJ, Lachin JM, Leschek E, Rafkin-Mervis L, Savage P, Spain L. 2008. Type 1 Diabetes TrialNet-an international collaborative clinical trials network. Ann NY Acad Sci 1150: 14-24.
-
(2008)
Ann NY Acad Sci
, vol.1150
, pp. 14-24
-
-
Skyler, J.S.1
Greenbaum, C.J.2
Lachin, J.M.3
Leschek, E.4
Rafkin-Mervis, L.5
Savage, P.6
Spain, L.7
-
155
-
-
0029933309
-
Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
-
Sloan-Lancaster J, Allen PM. 1996. Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology. Annu Rev Immunol 14: 1-27.
-
(1996)
Annu Rev Immunol
, vol.14
, pp. 1-27
-
-
Sloan-Lancaster, J.1
Allen, P.M.2
-
156
-
-
58849117178
-
Improved efficacy of a tolerizing DNA vaccine for reversal of hyperglycemia through enhancement of gene expression and localization to intracellular sites
-
Solvason N, Lou YP, Peters W, Evans E, Martinez J, Ramirez U, Ocampo A, YunR, Ahmad S, Liu E, et al. 2008. Improved efficacy of a tolerizing DNA vaccine for reversal of hyperglycemia through enhancement of gene expression and localization to intracellular sites. J Immunol 181: 8298-8307.
-
(2008)
J Immunol
, vol.181
, pp. 8298-8307
-
-
Solvason, N.1
Lou, Y.P.2
Peters, W.3
Evans, E.4
Martinez, J.5
Ramirez, U.6
Ocampo, A.7
Yun, R.8
Ahmad, S.9
Liu, E.10
-
157
-
-
77954304378
-
Patient-reported outcomes following islet cell or pancreas transplantation (alone or after kidney) in Type 1 diabetes: A systematic review
-
Speight J, Reaney MD, Woodcock AJ, Smith RM, Shaw JA. 2010. Patient-reported outcomes following islet cell or pancreas transplantation (alone or after kidney) in Type 1 diabetes: A systematic review. Diabet Med 27: 812-822.
-
(2010)
Diabet Med
, vol.27
, pp. 812-822
-
-
Speight, J.1
Reaney, M.D.2
Woodcock, A.J.3
Smith, R.M.4
Shaw, J.A.5
-
158
-
-
0041666293
-
β-cell function and the development of diabetes-related complications in the diabetes control and complications trial
-
Steffes MW, Sibley S, Jackson M, Thomas W. 2003. β-cell function and the development of diabetes-related complications in the diabetes control and complications trial. Diabetes Care 26: 832-836.
-
(2003)
Diabetes Care
, vol.26
, pp. 832-836
-
-
Steffes, M.W.1
Sibley, S.2
Jackson, M.3
Thomas, W.4
-
160
-
-
79955968277
-
IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7. 1 mice
-
Tai N, Yasuda H, Xiang Y, Zhang L, Rodriguez-Pinto D, Yokono K, Sherwin R, Wong FS, Nagata M, Wen L. 2011. IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7. 1 mice. Clin Immunol 139: 336-349.
-
(2011)
Clin Immunol
, vol.139
, pp. 336-349
-
-
Tai, N.1
Yasuda, H.2
Xiang, Y.3
Zhang, L.4
Rodriguez-Pinto, D.5
Yokono, K.6
Sherwin, R.7
Wong, F.S.8
Nagata, M.9
Wen, L.10
-
161
-
-
2942642383
-
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
-
Tang Q, Henriksen KJ, Bi M, Finger EB, Szot G, Ye J, Masteller EL, McDevitt H, Bonyhadi M, Bluestone JA. 2004. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med 199: 1455-1465.
-
(2004)
J Exp Med
, vol.199
, pp. 1455-1465
-
-
Tang, Q.1
Henriksen, K.J.2
Bi, M.3
Finger, E.B.4
Szot, G.5
Ye, J.6
Masteller, E.L.7
McDevitt, H.8
Bonyhadi, M.9
Bluestone, J.A.10
-
162
-
-
77951643783
-
+ T helper intermediates display suppressive function against autoimmune diabetes
-
+ T helper intermediates display suppressive function against autoimmune diabetes. J Immunol 184: 3377-3385.
-
(2010)
J Immunol
, vol.184
, pp. 3377-3385
-
-
Tartar, D.M.1
VanMorlan, A.M.2
Wan, X.3
Guloglu, F.B.4
Jain, R.5
Haymaker, C.L.6
Ellis, J.S.7
Hoeman, C.M.8
Cascio, J.A.9
Dhakal, M.10
-
163
-
-
0027370108
-
The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
-
The Diabetes Control and Complications Trial Research Group
-
The Diabetes Control and Complications Trial Research Group. 1993. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329: 977-986.
-
(1993)
N Engl J Med
, vol.329
, pp. 977-986
-
-
-
164
-
-
0034628425
-
Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy
-
The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
-
The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. 2000. Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. N Engl J Med 342: 381-389.
-
(2000)
N Engl J Med
, vol.342
, pp. 381-389
-
-
-
165
-
-
0026771385
-
Glutamic acid decarboxylase (GAD) autoantibodies are additional predictive markers of type 1 (insulin-dependent) diabetes mellitus in high risk individuals
-
Thivolet CH, Tappaz M, Durand A, Petersen J, Stefanutti A, Chatelain P, Vialettes B, Scherbaum W, Orgiazzi J. 1992. Glutamic acid decarboxylase (GAD) autoantibodies are additional predictive markers of type 1 (insulin-dependent) diabetes mellitus in high risk individuals. Diabetologia 35: 570-576.
-
(1992)
Diabetologia
, vol.35
, pp. 570-576
-
-
Thivolet, C.H.1
Tappaz, M.2
Durand, A.3
Petersen, J.4
Stefanutti, A.5
Chatelain, P.6
Vialettes, B.7
Scherbaum, W.8
Orgiazzi, J.9
-
166
-
-
0029923430
-
Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes
-
Tian J, Atkinson MA, Clare-Salzler M, Herschenfeld A, Forsthuber T, LehmannPV, Kaufman DL. 1996. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J Exp Med 183: 1561-1567.
-
(1996)
J Exp Med
, vol.183
, pp. 1561-1567
-
-
Tian, J.1
Atkinson, M.A.2
Clare-Salzler, M.3
Herschenfeld, A.4
Forsthuber, T.5
Lehmann, P.V.6
Kaufman, D.L.7
-
167
-
-
73249137408
-
Transgenically induced GAD tolerance curtails the development of early β-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other β-cell antigens
-
Tian J, Dang H, von Boehmer H, Jaeckel E, Kaufman DL. 2009. Transgenically induced GAD tolerance curtails the development of early β-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other β-cell antigens. Diabetes 58: 2843-2850.
-
(2009)
Diabetes
, vol.58
, pp. 2843-2850
-
-
Tian, J.1
Dang, H.2
von Boehmer, H.3
Jaeckel, E.4
Kaufman, D.L.5
-
168
-
-
0027908753
-
Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
-
Tisch R, Yang XD, Singer SM, Liblau RS, Fugger L, McDevitt HO. 1993. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366: 72-75.
-
(1993)
Nature
, vol.366
, pp. 72-75
-
-
Tisch, R.1
Yang, X.D.2
Singer, S.M.3
Liblau, R.S.4
Fugger, L.5
McDevitt, H.O.6
-
169
-
-
0033178763
-
Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent
-
Tisch R, Wang B, Serreze DV. 1999. Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent. J Immunol 163: 1178-1187.
-
(1999)
J Immunol
, vol.163
, pp. 1178-1187
-
-
Tisch, R.1
Wang, B.2
Serreze, D.V.3
-
170
-
-
0035253510
-
Antigen-specific mediated suppression of β cell autoimmunity by plasmid DNA vaccination
-
Tisch R, Wang B, Weaver DJ, Liu B, Bui T, Arthos J, Serreze DV. 2001. Antigen-specific mediated suppression of β cell autoimmunity by plasmid DNA vaccination. J Immunol 166: 2122-2132.
-
(2001)
J Immunol
, vol.166
, pp. 2122-2132
-
-
Tisch, R.1
Wang, B.2
Weaver, D.J.3
Liu, B.4
Bui, T.5
Arthos, J.6
Serreze, D.V.7
-
172
-
-
77951882989
-
Reversal of autoimmunity by boosting memory-like autoregulatory T cells
-
Tsai S, Shameli A, Yamanouchi J, Clemente-Casares X, Wang J, Serra P, Yang Y, Medarova Z, Moore A, Santamaria P. 2010. Reversal of autoimmunity by boosting memory-like autoregulatory T cells. Immunity 32: 568-580.
-
(2010)
Immunity
, vol.32
, pp. 568-580
-
-
Tsai, S.1
Shameli, A.2
Yamanouchi, J.3
Clemente-Casares, X.4
Wang, J.5
Serra, P.6
Yang, Y.7
Medarova, Z.8
Moore, A.9
Santamaria, P.10
-
173
-
-
0028237147
-
Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease
-
Tuomilehto J, Zimmet P, Mackay IR, Koskela P, Vidgren G, Toivanen L, Tuomilehto-Wolf E, Kohtamaki K, Stengard J, Rowley MJ. 1994. Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease. Lancet 343: 1383-1385.
-
(1994)
Lancet
, vol.343
, pp. 1383-1385
-
-
Tuomilehto, J.1
Zimmet, P.2
McKay, I.R.3
Koskela, P.4
Vidgren, G.5
Toivanen, L.6
Tuomilehto-Wolf, E.7
Kohtamaki, K.8
Stengard, J.9
Rowley, M.J.10
-
174
-
-
33846919872
-
Peripheral tolerance induction using ethylenecarbodiimide-fixed APCs uses both direct and indirect mechanisms of antigen presentation for prevention of experimental autoimmune encephalomyelitis
-
Turley DM, Miller SD. 2007. Peripheral tolerance induction using ethylenecarbodiimide-fixed APCs uses both direct and indirect mechanisms of antigen presentation for prevention of experimental autoimmune encephalomyelitis. J Immunol 178: 2212-2220.
-
(2007)
J Immunol
, vol.178
, pp. 2212-2220
-
-
Turley, D.M.1
Miller, S.D.2
-
175
-
-
57749203195
-
GAD65 autoimmunity-clinical studies
-
Uibo R, Lernmark A. 2008. GAD65 autoimmunity-clinical studies. Adv Immunol 100: 39-78.
-
(2008)
Adv Immunol
, vol.100
, pp. 39-78
-
-
Uibo, R.1
Lernmark, A.2
-
176
-
-
0034900849
-
Immunization with DNA encoding an immunodominant peptide of insulin prevents diabetes in NOD mice
-
Urbanek-Ruiz I, Ruiz PJ, Paragas V, Garren H, Steinman L, Fathman CG. 2001. Immunization with DNA encoding an immunodominant peptide of insulin prevents diabetes in NOD mice. Clin Immunol 100: 164-171.
-
(2001)
Clin Immunol
, vol.100
, pp. 164-171
-
-
Urbanek-Ruiz, I.1
Ruiz, P.J.2
Paragas, V.3
Garren, H.4
Steinman, L.5
Fathman, C.G.6
-
177
-
-
59449093511
-
Accumulation of autoreactive effector T cells and allo-specific regulatory T cells in the pancreas allograft of a type 1 diabetic recipient
-
Velthuis JH, Unger WW, van der Slik AR, Duinkerken G, Engelse M, Schaapherder AF, Ringers J, van Kooten C, de Koning EJ, Roep BO. 2009. Accumulation of autoreactive effector T cells and allo-specific regulatory T cells in the pancreas allograft of a type 1 diabetic recipient. Diabetologia 52: 494-503.
-
(2009)
Diabetologia
, vol.52
, pp. 494-503
-
-
Velthuis, J.H.1
Unger, W.W.2
van der Slik, A.R.3
Duinkerken, G.4
Engelse, M.5
Schaapherder, A.F.6
Ringers, J.7
van Kooten, C.8
de Koning, E.J.9
Roep, B.O.10
-
178
-
-
0029995958
-
Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies
-
Verge CF, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Jackson RA, Chase HP, Eisenbarth GS. 1996. Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 45: 926-933.
-
(1996)
Diabetes
, vol.45
, pp. 926-933
-
-
Verge, C.F.1
Gianani, R.2
Kawasaki, E.3
Yu, L.4
Pietropaolo, M.5
Jackson, R.A.6
Chase, H.P.7
Eisenbarth, G.S.8
-
179
-
-
70449412682
-
No effect of the altered peptide ligand NBI-6024 on β-cell residual function and insulin needs in new-onset type 1 diabetes
-
Walter M, Philotheou A, Bonnici F, Ziegler AG, Jimenez R. 2009. No effect of the altered peptide ligand NBI-6024 on β-cell residual function and insulin needs in new-onset type 1 diabetes. Diabetes Care 32: 2036-2040.
-
(2009)
Diabetes Care
, vol.32
, pp. 2036-2040
-
-
Walter, M.1
Philotheou, A.2
Bonnici, F.3
Ziegler, A.G.4
Jimenez, R.5
-
180
-
-
0028020331
-
Analysis of the spontaneous T cell response to insulin in NOD mice
-
Wegmann DR, Gill RG, Norbury-Glaser M, Schloot N, Daniel D. 1994a. Analysis of the spontaneous T cell response to insulin in NOD mice. J Autoimmun 7: 833-843.
-
(1994)
J Autoimmun
, vol.7
, pp. 833-843
-
-
Wegmann, D.R.1
Gill, R.G.2
Norbury-Glaser, M.3
Schloot, N.4
Daniel, D.5
-
181
-
-
0028145676
-
Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice
-
Wegmann DR, Norbury-Glaser M, Daniel D. 1994b. Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice. Eur J Immunol 24: 1853-1857.
-
(1994)
Eur J Immunol
, vol.24
, pp. 1853-1857
-
-
Wegmann, D.R.1
Norbury-Glaser, M.2
Daniel, D.3
-
182
-
-
79960743608
-
Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: A randomised double-blind trial
-
Wherrett DK, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, GottliebPA, Greenbaum CJ, Herold KC, Marks JB, et al. 2011. Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: A randomised double-blind trial. Lancet 378: 319-327.
-
(2011)
Lancet
, vol.378
, pp. 319-327
-
-
Wherrett, D.K.1
Bundy, B.2
Becker, D.J.3
DiMeglio, L.A.4
Gitelman, S.E.5
Goland, R.6
Gottlieb, P.A.7
Greenbaum, C.J.8
Herold, K.C.9
Marks, J.B.10
-
183
-
-
0031753329
-
DNA vaccination with glutamic acid decarboxylase (GAD) generates a strong humoral immune response in BALB/c, C57BL/6, and in diabetes-prone NOD mice
-
Wiest-Ladenburger U, Fortnagel A, Richter W, Reimann J, Boehm BO. 1998. DNA vaccination with glutamic acid decarboxylase (GAD) generates a strong humoral immune response in BALB/c, C57BL/6, and in diabetes-prone NOD mice. Horm Metab Res 30: 605-609.
-
(1998)
Horm Metab Res
, vol.30
, pp. 605-609
-
-
Wiest-Ladenburger, U.1
Fortnagel, A.2
Richter, W.3
Reimann, J.4
Boehm, B.O.5
-
184
-
-
0025231388
-
Direct gene transfer into mouse muscle in vivo
-
Wolff JA, Malone RW, Williams P, Chong W, Acsadi G, Jani A, Felgner PL. 1990. Direct gene transfer into mouse muscle in vivo. Science 247: 1465-1468.
-
(1990)
Science
, vol.247
, pp. 1465-1468
-
-
Wolff, J.A.1
Malone, R.W.2
Williams, P.3
Chong, W.4
Acsadi, G.5
Jani, A.6
Felgner, P.L.7
-
185
-
-
34547583229
-
Transfusion of apoptotic β-cells induces immune tolerance to β-cell antigens and prevents type 1 diabetes in NOD mice
-
Xia CQ, Peng R, Qiu Y, Annamalai M, Gordon D, Clare-Salzler MJ. 2007. Transfusion of apoptotic β-cells induces immune tolerance to β-cell antigens and prevents type 1 diabetes in NOD mice. Diabetes 56: 2116-2123.
-
(2007)
Diabetes
, vol.56
, pp. 2116-2123
-
-
Xia, C.Q.1
Peng, R.2
Qiu, Y.3
Annamalai, M.4
Gordon, D.5
Clare-Salzler, M.J.6
-
186
-
-
0033553645
-
Control of autoimmune diabetes in NOD mice by GAD expression or suppression in β cells
-
Yoon JW, Yoon CS, Lim HW, Huang QQ, Kang Y, Pyun KH, Hirasawa K, SherwinRS, Jun HS. 1999. Control of autoimmune diabetes in NOD mice by GAD expression or suppression in β cells. Science 284: 1183-1187.
-
(1999)
Science
, vol.284
, pp. 1183-1187
-
-
Yoon, J.W.1
Yoon, C.S.2
Lim, H.W.3
Huang, Q.Q.4
Kang, Y.5
Pyun, K.H.6
Hirasawa, K.7
Sherwin, R.S.8
Jun, H.S.9
-
187
-
-
9144221452
-
Presence of diabetes-inhibiting, glutamic acid decarboxylase-specific, IL-10-dependent, regulatory T cells in naive nonobese diabetic mice
-
You S, Chen C, Lee WH, Brusko T, Atkinson M, Liu CP. 2004. Presence of diabetes-inhibiting, glutamic acid decarboxylase-specific, IL-10-dependent, regulatory T cells in naive nonobese diabetic mice. J Immunol 173: 6777-6785.
-
(2004)
J Immunol
, vol.173
, pp. 6777-6785
-
-
You, S.1
Chen, C.2
Lee, W.H.3
Brusko, T.4
Atkinson, M.5
Liu, C.P.6
-
188
-
-
0034652317
-
Early expression of antiinsulin autoantibodies of humans and the NOD mouse: Evidence for early determination of subsequent diabetes
-
Yu L, Robles DT, Abiru N, Kaur P, Rewers M, Kelemen K, Eisenbarth GS. 2000. Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. Proc Natl Acad Sci 97: 1701-1706.
-
(2000)
Proc Natl Acad Sci
, vol.97
, pp. 1701-1706
-
-
Yu, L.1
Robles, D.T.2
Abiru, N.3
Kaur, P.4
Rewers, M.5
Kelemen, K.6
Eisenbarth, G.S.7
-
189
-
-
0027398099
-
Presentation of a viral T cell epitope expressed in the CDR3 region of a self immunoglobulin molecule
-
Zaghouani H, Steinman R, Nonacs R, Shah H, Gerhard W, Bona C. 1993. Presentation of a viral T cell epitope expressed in the CDR3 region of a self immunoglobulin molecule. Science 259: 224-227.
-
(1993)
Science
, vol.259
, pp. 224-227
-
-
Zaghouani, H.1
Steinman, R.2
Nonacs, R.3
Shah, H.4
Gerhard, W.5
Bona, C.6
-
190
-
-
21244489948
-
Heat shock protein 60 activates cytokine-associated negative regulator suppressor of cytokine signaling 3 in T cells: Effects on signaling, chemotaxis, and inflammation
-
Zanin-Zhorov A, Tal G, Shivtiel S, Cohen M, Lapidot T, Nussbaum G, MargalitR, Cohen IR, Lider O. 2005. Heat shock protein 60 activates cytokine-associated negative regulator suppressor of cytokine signaling 3 in T cells: Effects on signaling, chemotaxis, and inflammation. J Immunol 175: 276-285.
-
(2005)
J Immunol
, vol.175
, pp. 276-285
-
-
Zanin-Zhorov, A.1
Tal, G.2
Shivtiel, S.3
Cohen, M.4
Lapidot, T.5
Nussbaum, G.6
Margalit, R.7
Cohen, I.R.8
Lider, O.9
-
192
-
-
0031985093
-
+ Th1 cells induce diabetes in NOD/SCID mice
-
+ Th1 cells induce diabetes in NOD/SCID mice. J Clin Invest 101: 68-73.
-
(1998)
J Clin Invest
, vol.101
, pp. 68-73
-
-
Zekzer, D.1
Wong, F.S.2
Ayalon, O.3
Millet, I.4
Altieri, M.5
Shintani, S.6
Solimena, M.7
Sherwin, R.S.8
-
193
-
-
0025837184
-
Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin
-
Zhang ZJ, Davidson L, Eisenbarth G, Weiner HL. 1991. Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc Natl Acad Sci 88: 10252-10256.
-
(1991)
Proc Natl Acad Sci
, vol.88
, pp. 10252-10256
-
-
Zhang, Z.J.1
Davidson, L.2
Eisenbarth, G.3
Weiner, H.L.4
|