Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various β-cell antigens

Diabetes

Volumn 46, Issue 5, 1997, Pages 758-764

  Elias, Dana ^a   Meilin, Aviram ^a   Ablamunits, Vitaly ^a   Birk, Ohad S ^a   Carmi, Pnina ^a   Könen Waisman, Stephanie ^a   Cohen, Irun R ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; HEAT SHOCK PROTEIN 60; INTERLEUKIN 10; INTERLEUKIN 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; DRUG RESPONSE; DRUG SCREENING; FEMALE; HELPER CELL; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SECRETION; T LYMPHOCYTE SUBPOPULATION;

EID: 0030960632     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.46.5.758     Document Type: Article

References (33)

1. Bach J-F: Insulin-dependent diabetes mellitus. Curr Opin Immunol 3:902-905, 1991
2. Miller BJ, Appel MC, O'Neill JJ, Wicker LS: Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. J Immunol 140:152-158, 1988
3. Christianson SW, Shultz LD, Leiter EH: Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice: relative contributions of CD4+ and CDS+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors. Diabetes 42:44-55, 1993
4. Mosmann TR, Coffman RL: TH1 and TH2 cells: different patterns of lymphokine secertion lead to different functional properties. Ann Rev Immunol 7:145-173, 1989
5. Banchereau J, Rybak ME: Interleukin 4. In The Cytokine Handbook. 2nd ed. Thompson A, Ed. New York, Academic, 1994, p. 99
6. Moore KV, O'Garra A, de Waal Malefyt R, Vieira P, Mosmann TR: Interleukin-10. Ann Rev Immunol 11:165-190, 1993
7. Katz JD, Benoist C, Mathis D: T helper cell subsets in insulin-dependent diabetes. Science 268:1185-1188, 1995
8. Healey D, Ozegbe P, Arden S, Chandler P, Hutton J, Cooke A: In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice. J Clin Invest 95:2979-2985, 1995
9. Liblau RS, Singer SM, McDevitt HO: Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today 16:34-38, 1995
10. Tisch R, McDevitt HO: Insulin-dependent diabetes mellitus. Cell 85:291-297, 1996
11. Kaufman DL, Clare-Salzler M, Tian J, Forsthuber T, Ting GS, Robinson P, Atkinson MA, Sercarz EE, Tobin AJ, Lehmann PV: Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes Nature 366:69-72, 1993
12. Tian J, Atkinson MA, Clare-Salzler M, Herschenfeld A, Forsthuber T, Lehmann PV, Kaufmann DL: Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes J Exp Med 183:1561-1567, 1996
13. Tisch R, Yand XD, Singer SM, Liblau RS, Fugger L, McDevitt HO: Immune response to glutamic acid decarboxylase correlates with insulitis in nonobese diabetic mice. Nature 366:72-75, 1993
14. Zhang ZJ, Davidson L, Eisenbarth GS, Weiner HL: Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc Natl Acad Sci USA 88:10252-10256, 1991
15. Elias D, Reshef T, Birk OS, van der Zee R, Walker MD, Cohen R: Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc Natl Acad Sci USA 88:3088-3091, 1991
16. Elias D, Cohen IR: Peptide therapy for diabetes in NOD mice. Lancet 343:704-706, 1994
17. Elias D, Cohen IR: Treatment of autoimmune diabetes in NOD mice. Diabetes 44:1132-1138, 1995
18. Elias D, Prigozin H, Polak N, Rapoport M, Lohse AW, Cohen IR: Autoimmune diabetes induced by the β-cell toxin STZ. Diabetes 43:992-998, 1994
19. Elias D, Cohen IR: The hsp60 peptide p277 arrests the autoimmune diabetes induced by the toxin streptozotocin. Diabetes 45:1168-1172, 1996
20. Elias D, Markovits D, Reshef T, van der Zee R, Cohen IR: Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. Proc Natl Acad Sci USA 87:1576-1580, 1990
21. Snapper CM, Mond JJ: Towards a comprehensive view of immunoglobulin class switching. Immunol Today 14:15-17, 1993
22. Snapper CM, Waegell W, Beernink H, Dasch JR: Transforming growth factor-beta 1 is required for secretion of IgG of all subclasses by LPS-activated murine B in cells in vitro. J Immunol 151:4625-4636, 1993
23. McIntyre TM, Klinman DR, Rothman P, Lugo M, Dascg JR, Mond JJ, Snapper CM: Transforming growth factor beta 1 selectivity stimulates immunoglobulin G2b secretion by lipopolysaccharide-activated murine B cells. J Exp Med 177:1031-1037, 1993
24. Pennline KJ, Roque-Gaffney E, Monahan M: Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse, Clin Immunol Immunopathol 71:169-175, 1994
25. Rapoport MJ, Jaramillo A, Zipris D, Lazarus AH, Serreze DV, Leiter EH, Cyopick P, Danska JS, Delovitch TL: Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J Exp Med 178:87-99, 1993
26. Rabinovitch A, Suarez-Pinzon WK, Sorensen O, Bleakley RC, Power RF, Rajotte RV: Combined therapy with interleukin-4 and interleukin-10 inhibits autoimmune diabetes recurrence in syngeneic islet-transplanted nonobese diabetic mice: analysis of cytokine mRNA expression in the graft. Transplantation 60:368-374, 1995
27. Wogensen L, Lee MS, Sarvetnick N: Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice. J Exp Med 179:1379-1384, 1994
28. Birk OS, Elias D, Weiss AS, Rosen A, van der Zee R, Walker MD, Cohen IR: NOD mouse diabetes: the ubiquitous mouse hsp60 is a beta-cell antigen of autoimmune T cells. J Autoimmunity 9:159-166, 1996
29. Elias D, Marcus H, Reshef T, Ablamunits V, Cohen IR: Induction of diabetes in standard mice by immunization to the p277 peptide of a 60KDa heat shock protein. Eur J Immunol 25:2851-2857, 1995
30. Weiner HL, Friedman A, Miller A, Khoury SJ, al-Sabbagh A, Santos L, Sayegh M, Nussenblatt RB, Trentham DE, Hafler DA: Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol 12:809-837, 1994
31. Birk OS, Douek DC, Elias D, Takacs K, Dewchand H, Gur, SL, Walker MD, van der Zee R, Cohen IR, Altmann DM: The role of hsp60 in autoimmune diabetes: analysis in a transgenic model. Proc Natl Acad Sci USA 93:1032-1037, 1996
32. Cohen IR: Treatment of autoimmune disease: to activate or to deactivate? Chem Immunol 60:150-160, 1995
33. Cohen IR: The cognitive paradigm and the immunological homunculus. Immunol Today 13:490-494, 1992