Selective delivery of β cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 17, 2008, Pages 6374-6379

  Mukhopadhaya, Arunika ^a   Hanafusa, Tadashi ^a   Jarchum, Irene ^a   Chen, Yi Guang ^b   Iwai, Yoshiko ^c,d   Serreze, David V ^b   Steinman, Ralph M ^c   Tarbell, Kristin V ^c,e   DiLorenzo, Teresa P ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b JACKSON LABORATORY   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^e NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Autoimmune disease; Type 1 diabetes

Indexed keywords

CELL ANTIGEN; CELL RECEPTOR; DEC 205; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; ANTIBODY; AUTOANTIGEN; CELL SURFACE RECEPTOR; DEC 205 RECEPTOR; DEC-205 RECEPTOR; EPITOPE; HLA ANTIGEN CLASS 1; LECTIN; LEUKOCYTE ANTIGEN; PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; ANTIGEN PRESENTATION; CYTOLOGY; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LYMPHOCYTE DEPLETION; NONOBESE DIABETIC MOUSE; PANCREAS ISLET BETA CELL;

MUS;

ANIMALS; ANTIBODIES; ANTIGEN PRESENTATION; ANTIGENS, CD; AUTOANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; DENDRITIC CELLS; EPITOPES; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS I; IMMUNE TOLERANCE; INSULIN-SECRETING CELLS; LECTINS, C-TYPE; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED NOD; PEPTIDES; RECEPTORS, CELL SURFACE;

EID: 44049086242     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0802644105     Document Type: Article

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