Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance

Nature Medicine

Volumn 3, Issue 7, 1997, Pages 793-796

  Ma, S W ^a   Zhao, D L ^a   Yin, Z Q ^a   Mukherjee, R ^a   Singh, B ^a,b   Qin, H Y ^b   Stiller, C R ^a,b   Jevnikar, A M ^a,b,c  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN;

ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNITY; DIABETES MELLITUS; DIET SUPPLEMENTATION; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC PLANT;

ANIMALS; AUTOANTIBODIES; AUTOANTIGENS; CELLS, CULTURED; DIABETES MELLITUS, TYPE 1; DIET; FEMALE; GENETIC VECTORS; GLUTAMATE DECARBOXYLASE; IMMUNE TOLERANCE; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-4; MICE; MICE, INBRED NOD; PLANTS, GENETICALLY MODIFIED; PLANTS, TOXIC; RECOMBINANT FUSION PROTEINS; RHIZOBIUM RADIOBACTER; SOLANUM TUBEROSUM; SPLEEN; TOBACCO;

ANIMALIA; MAMMALIA;

EID: 0030791484     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0797-793     Document Type: Article

References (24)

1. Weiner, H.L. et al. Oral tolerance: Immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu. Rev. Immunol. 12, 809-837 (1994).
2. Sijmons, P.C. et al. Production of correctly processed human serum albumin in transgenic plants. BioTechnology 8, 217-221 (1990).
3. Tisch, R. et al. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366, 72-75 (1993).
4. Kaufman, D.L. et al. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366, 69-72 (1993).
5. De Aizpura, H.J., Wilson, Y.M. & Harrison, L.C. Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes. Proc. Natl. Acad. Sci. USA 89, 9841-9845 (1992).
6. Makino, S. et al. Breeding of non-obese diabetic strain of mice. Exp. Anim. 29, 1-13 (1980).
7. Elliott, J.F. et al. Immunization with the larger isoform of mouse glutamic acid decarboxylase (GAD67) prevents autoimmune diabetes in NOD mice. Diabetes 43, 1494-1499 (1994).
8. Tian, J. et al. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J. Exp. Med. 183, 1561-1567 (1996).
9. Tian, J. et al. Modulating autoimmune responses to GAD inhibits disease progression and prolongs graft survival in diabetes-prone mice. Nature Med. 2, 1348-1353 (1996).
10. Kaufman, D. L., McGinnis, J.F., Krieger, N.R. & Tobin, A.J. Brain glutamate decarboxylase cloned in lambda gt-11: Fusion protein produces gamma-aminobutyric acid Science 232, 1138-1140 (1986).
11. Katarova, Z., Szabo, G., Mugnaini, E. & Greenspan, R.J. Molecular characterization of the 62 kD form of glutamic acid decarboxylase from the mouse. Eur. J. Neurosci. 2, 190-202 (1990).
12. Karlsen, A.E. et al. Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10. Proc. Natl. Acad. Sci. USA 88, 8337-8341 (1991).
13. Friedman, A. & Weiner, H.L. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc. Natl. Acad. Sci. USA 91, 6688-6692 (1994).
14. Chen, Y. et al. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature 376, 177-180 (1995).
15. Zhang, Z.J., Davidson, L., Eisenbarth, G. & Weiner, H.L. Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc. Natl. Acad. Sci. USA 88, 10252-10256 (1991).
16. Qin, H.-Y. et al. GAD specific T cell tolerance and TH1 to TH2 switch in mouse GAD67 or adjuvant immunized NOD mice. Autoimmunity 21, 50 (1995).
17. Haq, T.A., Mason, H.S., Clements, J.D. & Arntzen, C.J. Oral immunization with a recombinant bacterial antigen produced in transgenic plants. Science 268, 714-716 (1995).
18. Genain, C.P. et al. Late complications of immune deviation therapy in a non-human primate. Science 274, 2054-2057 (1996).
19. Blanas, E., Carbone, F.R., Allison, J., Miller, J.F.A.P. & Heath, W.R. Induction of autoimmune diabetes by oral administration of autoantigen. Science 274, 1707-1709 (1996).
20. Carrington, J.C. & Freed, D.D. Cap-independent enhancement of translation by a plant potyvirus 5′ nontranslated region. J. Virol. 64, 1590-1597 (1990).
21. Ditta, G., Stanfield, S., Corbin, D. & Helinski, D.R. Broad host range DNA cloning system for gram-negative bacteria: construction of a gene bank of Rhizobium meliloti. Proc. Natl. Acad. Sci. USA 77, 7347-7351 (1980).
22. Horsch, R.B. et al. A simple and general method for transferring genes into plants. Science 227, 1229-1231 (1985).
23. De Block, M. Genotype-independent leaf disc transformation of potato (Solanum tuberosum) using Agrobacterium tumefaciens. Theor. Appl. Genet. 76, 767-774 (1998).
24. Laemmli, U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685 (1970).