Dendritic cells transduced to express interleukin 4 reduce diabetes onset in both normoglycemic and prediabetic nonobese diabetic mice

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Ruffner, Melanie A ^a   Robbins, Paul D ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; INTERLEUKIN 4; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; BONE MARROW CELL; CELL BASED GENE THERAPY; CELL INFILTRATION; CONTROLLED STUDY; DENDRITIC CELL; DIABETES MELLITUS; DISEASE COURSE; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; IMPAIRED GLUCOSE TOLERANCE; INSULITIS; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; SPLEEN CELL; TH1 CELL; TH2 CELL; THERAPY DELAY; UPREGULATION; ADENOVIRUS; ANIMAL; CELL CULTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENETICS; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; METABOLISM; POLYMERASE CHAIN REACTION;

ANIMALIA; MURINAE; MUS;

ADENOVIRIDAE; ANIMALS; CELLS, CULTURED; DENDRITIC CELLS; DIABETES MELLITUS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; INTERLEUKIN-4; MICE; MICE, INBRED NOD; POLYMERASE CHAIN REACTION; PREDIABETIC STATE;

EID: 77955610171     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011848     Document Type: Article

References (34)

1. Anderson MS, Bluestone JA (2005) The NOD mouse: a model of immune dysregulation. Annu Rev Immunol 23: 447-485.
2. Rodacki M, Milech A, de Oliveira JE (2006) NK cells and type 1 diabetes. Clin Dev Immunol 13: 101-107.
3. Lo J, Clare-Salzler MJ (2006) Dendritic cell subsets and type I diabetes: focus upon DC-based therapy. Autoimmun Rev 5: 419-423.
4. Cameron MJ, Arreaza GA, Zucker P, Chensue SW, Strieter RM, et al. (1997) IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function. J Immunol 159: 4686-4692.
5. Rehman KK, Trucco M, Wang Z, Xiao X, Robbins PD (2008) AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice. Mol Ther 16: 1409-1416.
6. Creusot RJ, Yaghoubi SS, Kodama K, Dang DN, Dang VH, et al. (2008) Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice. Clin Immunol. pp 176-187.
7. Feili-Hariri M, Falkner DH, Gambotto A, Papworth GD, Watkins SC, et al.(2003) Dendritic cells transduced to express interleukin-4 prevent diabetes in nonobese diabetic mice with advanced insulitis. Hum Gene Ther. pp 13-23.
8. Angelini F, Del Duca E, Piccinini S, Pacciani V, Rossi P, et al. (2005) Altered phenotype and function of dendritic cells in children with type 1 diabetes. Clin Exp Immunol 142: 341-346.
9. Grohmann U, Fallarino F, Bianchi R, Orabona C, Vacca C, et al. (2003) A defect in tryptophan catabolism impairs tolerance in nonobese diabetic mice. J Exp Med 198: 153-160.
10. Mollah ZU, Pai S, Moore C, O'Sullivan BJ, Harrison MJ, et al. (2008) Abnormal NF-kappa B function characterizes human type 1 diabetes dendritic cells and monocytes. J Immunol 180: 3166-3175.
11. Weaver DJ, Jr., Poligone B, Bui T, Abdel-Motal UM, Baldwin AS, Jr., et al. (2001) Dendritic cells from nonobese diabetic mice exhibit a defect in NF-kappa B regulation due to a hyperactive I kappa B kinase. J Immunol 167: 1461-1468.
12. Allen JS, Pang K, Skowera A, Ellis R, Rackham C, et al. (2009) Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture. Diabetes 58: 138-145.
13. Calderon B, Suri A, Miller MJ, Unanue ER (2008) Dendritic cells in islets of Langerhans constitutively present beta cell-derived peptides bound to their class II MHC molecules. Proc Natl Acad Sci USA 105: 6121-6126.
14. Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, et al. (2006) Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol 7: 83-92.
15. Perone MJ, Bertera S, Tawadrous ZS, Shufesky WJ, Piganelli JD, et al. (2006) Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice. J Immunol 177: 5278-5289.
16. Machen J, Harnaha J, Lakomy R, Styche A, Trucco M, et al. (2004) Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells. J Immunol 173: 4331-4341.
17. Ma L, Qian S, Liang X, Wang L, Woodward JE, et al. (2003) Prevention of diabetes in NOD mice by administration of dendritic cells deficient in nuclear transcription factor-kappaB activity. Diabetes 52: 1976-1985.
18. Shoda LK, Young DL, Ramanujan S, Whiting CC, Atkinson MA, et al. (2005) A comprehensive review of interventions in the NOD mouse and implications for translation. Immunity 23: 115-126.
19. Zhong L, Granelli-Piperno A, Choi Y, Steinman RM (1999) Recombinant adenovirus is an efficient and non-perturbing genetic vector for human dendritic cells. Eur J Immunol 29: 964-972.
20. Kim SH, Bianco NR, Shufesky WJ, Morelli AE, Robbins PD (2007) Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL-4. J Immunol 179: 2242-2249.
21. King C, Mueller Hoenger R, Malo Cleary M, Murali-Krishna K, Ahmed R, et al. (2001) Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses. Nat Med 7: 206-214.
22. Rapoport MJ, Bistritzer T, Aharoni D, Weiss M, Ramot Y, et al. (2005) TH1/TH2 cytokine secretion of first degree relatives of T1DM patients. Cytokine 30: 219-227.
23. Hill NJ, Van Gunst K, Sarvetnick N (2003) Th1 and Th2 pancreatic inflammation differentially affects homing of islet-reactive CD4 cells in nonobese diabetic mice. J Immunol 170: 1649-1658.
24. Papaccio G, Pisanti FA, Montefiano RD, Graziano A, Latronico MV (2002) Th1 and Th2 cytokines exert regulatory effects upon islet microvascular areas in the NOD mouse. J Cell Biochem 86: 651-664.
25. Gagnerault MC, Luan JJ, Lotton C, Lepault F (2002) Pancreatic lymph nodes are required for priming of beta cell reactive T cells in NOD mice. J Exp Med 196: 369-377.
26. Roep BO, Atkinson M, von Herrath M (2004) Satisfaction (not) guaranteed: reevaluating the use of animal models of type 1 diabetes. Nat Rev Immunol 4: 989-997.
27. Klueh U, Liu Z, Cho B, Ouyang T, Feldman B, et al. (2006) Continuous glucose monitoring in normal mice and mice with prediabetes and diabetes. Diabetes Technol Ther 8: 402-412.
28. Tan PH, Beutelspacher SC, Xue SA, Wang YH, Mitchell P, et al. (2005) Modulation of human dendritic-cell function following transduction with viral vectors: implications for gene therapy. Blood 105: 3824-3832.
29. Morelli AE, Larregina AT, Ganster RW, Zahorchak AF, Plowey JM, et al. (2000) Recombinant adenovirus induces maturation of dendritic cells via an NFkappaB-dependent pathway. J Virol 74: 9617-9628.
30. Skapenko A, Kalden JR, Lipsky PE, Schulze-Koops H (2005) The IL-4 receptor alpha-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25+CD4+ regulatory T cells from CD252CD4+ precursors. J Immunol 175: 6107-6116.
31. Kim SH, Evans CH, Kim S, Oligino T, Ghivizzani SC, et al. (2000) Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4. Arthritis Res 2: 293-302.
32. Son YI, Egawa S, Tatsumi T, Redlinger RE, Jr., Kalinski P, et al. (2002) A novel bulk-culture method for generating mature dendritic cells from mouse bone marrow cells. J Immunol Methods 262: 145-157.
33. Bianco NR, Kim SH, Ruffner MA, Robbins PD (2009) Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collageninduced arthritis and delayed-type hypersensitivity disease models. Arthritis Rheum 60: 380-389.
34. Kim SH, Kim S, Oligino TJ, Robbins PD (2002) Effective treatment of established mouse collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express FasL. Mol Ther 6: 584-590.