Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in nonobese diabetic mice: Modulation of spontaneous 60-kDa heat shock protein autoimmunity

Journal of Immunology

Volumn 165, Issue 11, 2000, Pages 6148-6155

  Quintana, F J ^a   Rotem, A ^a   Carmi, P ^a   Cohen, I R ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; GLUTAMATE DECARBOXYLASE; HEAT SHOCK PROTEIN; OLIGONUCLEOTIDE; PLASMID DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; AUTOIMMUNITY; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; HUMORAL IMMUNITY; IMMUNOREACTIVITY; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PLASMID; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RECEPTOR DOWN REGULATION; T LYMPHOCYTE ACTIVATION; VACCINATION;

EID: 0034548005     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.11.6148     Document Type: Article

References (33)

1. Insulin-dependent diabetes mellitus
2. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein
3. Inhibition of diabetes in NOD mice by idiotypic induction of SLE
4. Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock protein 60 peptide p277
5. Peptide therapy for diabetes in NOD mice
6. Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various β-cell antigens
7. Islet T cells secreting IFN-γ in NOD mouse diabetes: Arrest by p277 peptide treatment
8. Vaccination against tuberculosis by DNA injection
9. DNA vaccination against multiple myeloma
10. Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity
11. Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle
12. Immune responses following neonatal DNA vaccination are long-lived, abundant, and qualitatively similar to those induced by conventional immunization
13. Regulation of NOD mouse autoimmune diabetes by T cells that recognize a TCR CDR3 peptide
14. Bacterial DNA as immune cell activator
15. The role of CpG dinucleotides in DNA vaccines
16. CpG DNA: A novel immunomodulator
17. Non-coding plasmid DNA induces IFN-γ in vJvo and suppresses autoimmune encephalomyelitis
18. Transforming growth factor β1 selectivity stimulates immunoglobulin G2b secretion by lipopolysaccharide-activated murine B cells
19. Towards a comprehensive view of immunoglobulin class switching
20. The NOD mouse model of type 1 diabetes: As good as it gets?
21. TGF-β1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype
22. Treatment of NOD diabetes with a novel peptide of the bsp60 molecule induces Tb2-type antibodies
23. NOD mouse diabetes: The ubiquitous mouse hsp60 is a β-cell target antigen of autoimmune T cells
24. Contribution of CpG motifs to the immunogenicity of DNA vaccines
25. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon γ
26. Modulation of renal disease in autoimmune NZB/NZW mice by immunization with bacterial DNA
27. Reduction in insulitis following administration of IFN-γ and TNF-α in the NOD mouse
28. Paradoxical antidiabetogenic effect of γ-interferon in DP-BB rats
29. IL-18 inhibits diabetes development in nonobese diabetic mice by counterregulation of Th1-dependent destructive insulitis
30. Immunostimulation circumvents diabetes in NOD/Lt mice
31. Low dose poly I:C prevents diabetes in the diabetes prone BB rat
32. Effect of tumor necrosis factor α on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process