No effect of oral insulin on residual beta-cell function in recent-onset Type I diabetes (the IMDIAB VII)

Diabetologia

Volumn 43, Issue 8, 2000, Pages 1000-1004

  Pozzilli, P ^a   Pitocco, D ^a   Visalli, N ^a   Cavallo, M G ^a   Buzzetti, R ^a   Crino A ^a   Spera, S ^a   Suraci, C ^a   Multari, G ^a   Cervoni, M ^a   Manca Bitti, M L ^a   Matteoli, M C ^a   Marietti, G ^a   Ferrazzoli, F ^a   Cassone Faldetta, M R ^a   Giordano, C ^b   Sbriglia, M ^b   Sarugeri, E ^c   Ghirlanda, G ^a  

^a University of Palermo ^*

^b UNIVERSITY OF PALERMO   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Insulin antibodies; Oral insulin; Prevention; Type I diabetes

Indexed keywords

C PEPTIDE; GLYCOSYLATED HEMOGLOBIN; INSULIN; INSULIN ANTIBODY; PLACEBO;

ADOLESCENT; ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGE OF ONSET; BLOOD GLUCOSE; C-PEPTIDE; CHILD; DIABETES MELLITUS, TYPE 1; DOUBLE-BLIND METHOD; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INJECTIONS, SUBCUTANEOUS; INSULIN; ISLETS OF LANGERHANS; ITALY; MALE;

EID: 0033846982     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051482     Document Type: Article

References (16)

1. The diabetes prevention trial-type 1 diabetes (DPT-1). Implementation of screening and staging of relatives. DPT-1 study group
2. Oral tolerance
3. The prevention of IDDM: Injecting insulin into the cytokine network
4. Suppression of diabetes in NOD mice by oral administration of porcine insulin
5. Suppression of insulitis in non obese diabetic (NOD) mice by oral insulin administration is associated with selective expression if interleukin -4 and -10, transforming growth factor-beta and prostaglandin E
6. Criteria for immune trials in Type I diabetes
7. Cow's milk and Type I diabetes: The gut immune system deserves attention
8. A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus
9. Double blind trial of nicotinamide in recent onset insulin dependent diabetes mellitus
10. A multi-centre randomised trial of two different doses of nicotinamide in patients with recent-onset Type I diabetes (The IMDI-AB VI)
11. A novel micro-assay for insulin-autoantibodies
12. Comparison of a novel micro-assay for insulin autoantibodies with the conventional radiobinding assay
13. Oral tolerance immune mechanisms and treatment of autoimmune disease
14. Lack of effect of one-year oral insulin therapy in recent onset Type I diabetes: Results of a multicenter randomised controlled trial
15. A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes
16. Oral administration of antigen can lead to the onset of autoimmune disease