Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients

Journal of Clinical Investigation

Volumn 99, Issue 10, 1997, Pages 2405-2415

  Endl, Josef ^a   Otto, Heike ^b   Jung, Günther ^b   Dreisbusch, Barbara ^a   Donie, Frederic ^a   Stahl, Peter ^a   Elbracht, Rudi ^c   Schmilz, Gerd ^c   Meinl, Edgar ^d   Hummel, Michael ^e   Ziegler, Anette G ^e   Wank, Rudolf ^f   Schendel, Dolores J ^f  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF REGENSBURG   (Germany)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^e Klinikum Schwabing   (Germany)

^f UNIVERSITY OF MUNICH   (Germany)

Author keywords

autoimmunity; Coxsackie virus; glutamic acid decarboxylase; peptide autoantigens; T cell epitopes

Indexed keywords

EPITOPE; GENE PRODUCT; GLUTAMATE DECARBOXYLASE; HLA DR ANTIGEN; T LYMPHOCYTE ANTIGEN; VIRUS PROTEIN;

ADULT; ALLELE; ANTIGEN PRESENTATION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; COXSACKIE VIRUS; FEMALE; HAPLOTYPE; HELPER CELL; HIGH RISK POPULATION; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE PROLIFERATION; MALE; PRIORITY JOURNAL; RESTRICTION FRAGMENT; SEQUENCE HOMOLOGY; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 0007102288     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119423     Document Type: Article

References (36)

1. Bottazzo, G.G., A. Florin-Christensen, and D. Doniach. 1974. Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet. ii:1279-1282.
2. Todd, J.A., J.I. Bell, and H.O. McDevitt. 1987. HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature (Lond.). 329:599-604.
3. Thomson, G., W.P, Robinson, M.K. Kuhner, S. Joe, M.J. Macdonald, J.L. Gottschall, J. Barbosa, S.S. Rich, J. Bertrams, M.P. Baur, et al. 1988. Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus. Am. J. Hum. Genet. 43:799-816.
4. Sheehy, M.J., S.J. Scharf, J.R. Rowe, M.H.N. Degimenez, L.M. Meske, H.A. Erlich, and B.S. Nepom. 1989. A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and HLA-DQ alleles. J. Clin. Invest. 83:830-835.
5. Nepom, G.T., and H. Erlich. 1991. MHC class-II molecules and autoimmunity. Annu. Rev. Immunol. 9:493-525.
6. Atkinson, M.A., and N.K. Maclaren. 1994. The pathogenesis of insulin-dependent diabetes mellitus. N. Engl. J. Med. 331:1428-1436.
7. Baekkeskov, S., M. Landin, J.K. Kristensen, S. Srikanta, G.J. Bruining, T. Mandrup-Poulsen, C. De Beaufort , J.S. Soeldner, and G. Eisenbarth. 1987. Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes. J. Clin. Invest. 79:926-934.
8. Castano, L., and G.S. Eisenbarth. 1990. Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat. Annu. Rev. Immunol. 8:647-679.
9. Atkinson, M.A., D.L. Kaufmann, L. Campbell, K.A. Gibbs, S.C. Shah, D.-F. Bu, M.G. Erlander, A.J. Tobin, and N.K. Maclaren. 1992. Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet. 339: 458-459.
10. Honeyman, M.C., D.S. Cram, and L.C. Harrison. 1993. Glutamic acid decarboxylase 67-reactive T cells: a marker of insulin-dependent diabetes. J. Exp. Med. 177:535-540.
11. Harrison, L.C., M.C. Honeyman, H.J. Deaizpurua, R.S. Schmidli, P.G. Colman, B.D. Tait, and D.S. Cram. 1993. Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes. Lancet. 341:1365-1369.
12. Atkinson, M.A., M.A. Bowman, L. Campbell, B.L. Darrow, D.L. Kaufman, and N.K. Maclaren. 1994. Cellular immunity to a determinant common to glutamate decarboxylase and Coxsackie virus in insulin-dependent diabetes. J. Clin. Invest. 94:2125-2129.
13. Lohmann, T., R.D.G. Leslie, M. Hawa, M. Geysen, S. Rodda, and M. Londei. 1994. Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus. Lancet. 343:1607-1608.
14. Panina-Bordignon, P., R. Lang, P.M. van Endert, E. Benazzi, A.M. Felix, R.M. Pastore, G.A. Spinas, and F. Sinigaglia. 1995. Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes. J. Exp. Med. 181: 1923-1927.
15. Wu, J.Y., L. Denner, C.T. Lin, and G. Song. 1985. L-Glutamate decarboxylase from brain. Methods Enzymol. 113:3-10.
16. Pette, M., K. Fujita, D. Wilkinson, D.M. Altmann, J. Trowsdale, G. Giegerich, A. Hinkkanen, J.T. Epplen, L. Kappos, and H. Wekerle. 1990. Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors. Proc. Natl. Acad. Sci USA. 87:7968-7972.
17. Tsuji, K.-E., M.-E. Aizawa, and T.-E. Sasazuki. 1992. HLA 1991: Proceedings of the Eleventh Histocompatibility Workshop & Conference. Oxford University Press, Oxford, UK. 419-426.
18. Johnson, J.P., H. Nordwig, and R. Wank. 1987. Epitope analysis with monoclonal antibodies directed against class II molecules subdivides HLA-DR2, DR3 and DR4: correlations with cellularly defined Dw specificities. Tissue Antigens: 29:26-33.
19. Roll, U., M.R. Christie, M. Füchtenbusch, M.A. Payton, C.J. Hawkes, and A.G. Ziegler. 1996. Perinatal autoimmunity in offspring of diabetic parents: the German multicenter 'BABY-DIAB' study. Detection of humoral immune responses to islet antigens in early childhood. Diabetes. 45:967-973.
20. Ogata, K., K. Ohta, H. Kubo, A. Yamaguchi, and H. Watanabe. 1995. The glutamic acid decarboxylase (GAD) antibodies and their clinical significance. Rinsho Byori. 43(5):468-471.
21. Bu, D.F., M.G. Erlander, B.C. Hitz, N.J.K. Tillakaratne, D.L. Kaufmann, C.B. Wagner-McPherson, G.A. Evans, and A.J. Tobin. 1992. Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene. Proc. Natl. Acad. Sci. USA. 89:2115-2119.
22. Jenkins, O., J.D. Booth, P.D. Minor, and J.W. Almond. 1987. The complete nucleotide sequence of Coxsackie virus B4 and its comparison to other members of the picornaviridae. J. Gen. Virol. 68:1835-1848.
23. Kaufman, D.L., M.G. Erlander, M. Claresalzler, M.A. Atkinson, N.K. Maclaren, and A.J. Tobin. 1992. Autoimmunity to two forms of glutamate-decar-boxylase in insulin-dependent diabetes mellitus. J. Clin. Invest. 89:283-292.
24. Yoon, J.W., W.T. London, B.L. Curfman, R.L. Brown, and A.L. Notkins. 1986. Coxsackie virus-B4 produces transient diabetes in nonhuman-primates. Diabetes. 35:712-716.
25. Hou, J., C. Said, D. Franchi, P. Dockstader, and N.K. Chatterjce. 1994. Antibodies to glutamic acid decarboxylase and P2-C peptides in sera from Coxsackie virus B4-infected mice and IDDM patients. Diabetes. 43:1260-1266.
26. Hammer, J., E. Bono, F. Gallazzi, C. Belunis, Z. Nagy, and F. Sinigaglia. 1994. Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning. J. Exp. Med. 180:2353-2358.
27. Rammensee, H.G., T. Friede, and S. Stevanovic. 1995. MHC ligands and peptide motifs - first listing. Immunogenetics. 41:178-228.
28. Durinivic-Bello, I., M. Hummel, and A.-G. Ziegler. 1996. Cellular immune response to diverse islet cell antigens in IDDM. Diabetes. 45:795-800.
29. Somoza, N., F. Vargas, C. Roura-Mir, M. Vives-Pi, M.T. Fernandez-Figueras, A. Ariza, R. Gomis, R. Bragado, M. Marti, D. Jaraquemada, and R. Pujol-Borrell. 1994. Pancreas in recent onset insulin-dependent diabetes mellitus. J. Immunol. 153:1360-1377.
30. Gorsuch, A.N., K.M. Spencer, J. Lister, J.M. McNally, B.M. Dean, G.F. Bottazzo, and A.G. Cudworth. 1991. The natural history of type-1 insulin-dependent diabetes mellitus: evidence for a long prediabetic period. Lancet. ii: 1363-1366.
31. Nishimoto, H., H. Kikutani, K. Yamamura, and T. Kishimoto. 1986. Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice. Nature (Lond.). 328: 432-434.
32. Wicker, L.S., L. Chen, G.T. Nepom, J.F. Elliott, D.C. Freed, A. Bansal, S. Zheng, A. Herman, A. Lernmark, D.M. Zaller, et al. 1996. Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401. J. Clin. Invest. 98:2597-2603.
33. Wucherpfennig, K.W., and J.L. Strominger. 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell. 80:695-705.
34. Saventnick, N., D. Liggitt, S.L. Pitts, S.E. Hansen, and T.A. Stewart. 1988. Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and Interferon gamma. Cell. 52:773-782.
35. Campbell, I.L., A. Isarco, and L.C. Harrisson. 1988. IFNγ and tumor necrosis factor a cytotoxicity to murine islets of Langerhans. J. Immunol. 141: 2325-2329.
36. Kaufman, D.L., M. Claresalzler, J.D. Tian, T. Forsthuber, G.S.P. Ting, P. Robinson, M.A. Atkinson, E.E. Sercarz, A.J. Tobin, and P.V. Lehmann. 1993. Spontaneous loss of T-cell tolerance to glutamic-acid decarboxylase in murine insulin-dependent diabetes. Nature (Lond.). 366:69-72.