NOD mouse diabetes: The ubiquitous mouse hsp60 is a β-cell target antigen of autoimmune T cells

Journal of Autoimmunity

Volumn 9, Issue 2, 1996, Pages 159-166

  Birk, Ohad S ^a   Elias, Dana ^a   Weiss, Alona S ^a   Rosen, Ada ^a   Van Der Zee, Ruurd ^b   Walker, Michael D ^a   Cohen, Irun R ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Autoimmunity; Diabetes mellitus; hsp60

Indexed keywords

AUTOANTIGEN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 60; HYBRID PROTEIN; SYNTHETIC PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; ETIOLOGY; FEMALE; IMMUNIZATION; INSULIN DEPENDENT DIABETES MELLITUS; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE;

EID: 0030004757     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1996.0019     Document Type: Article

References (43)

1. Bendelac A., Carnaud C., Boitard C., Bach J.F. 1987. Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells. J. Exp. Med. 166: 823-832.
2. Castano L., Eisenbarth G.S. 1990. Type-1 diabetes: a chronic autoimmune disease of human, mouse, and rat. Annu. Rev. Immunol. 8: 647-679
3. Birk O.S., Cohen I.R. 1993. T-cell autoimmunity in type 1 diabetes mellitus. Curr. Opin. Immunol. 5: 903-909
4. Elias D., Markovits D., Reshef T., van-der-Zee R., Cohen I.R. 1990. Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. Proc. Natl. Acad. Sci. (USA). 87: 1576-1580
5. Elias D., Reshef T., Birk O.S., van-der-Zee R., Walker M.D., Cohen I.R. 1991. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc. Natl. Acad Sci. (USA). 88: 3088-3091
6. Elias D., Cohen I.R. 1994. Peptide therapy for diabetes in NOD mice. Lancet. 343: 704-706
7. Jones D.B., Coulsen A.F., Duff G.W. 1993. Sequence homologies between hsp60 and autoantigens. Immunol. Today. 14: 115-118
8. van Eden W., Thole J.E.R., van der Zee R., Noordzij A., van Embden J.D.A., Hensen E., Cohen I.R. 1988. Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis. Nature. 331: 171-173
9. Shinnick T.M. 1987. The 65-kilodalton antigen of mycobacterium tuberculosis. J. bacteriol. 169: 1080-1088
10. Snyder M. 1989. The SPA2 protein of yeast localizes to sites of cell growth. J. Cell. Biol. 108: 1419-1429
11. Towbin H., Staehelin T., Gordon J. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. (USA). 76: 4350-4354
12. Efrat S., Linde S., Kofod H., Spector D., Delannoy M, Grant S., Hanahan D., Baekkeskov S. 1988. Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene. Proc. Natl. Acad. Sci. (USA). 85: 9037-9041
13. Walker M.D., Park C.W., Rosen A., Aronheim A. 1990. A cDNA from a mouse pancreatic beta cell encoding a putative transcription factor of the insulin gene. Nucleic Acids Res. 18: 1159-1166
14. Sambrook J., Fritsch E.F., Maniatis T. Molecular Cloning: a Laboratory Manual. Cold Spring Harbour Laboratory. 1989.
15. Jindal S., Dudani A.K., Harley C.B., Singh B., Gupta R.S. 1989. Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen. Mol. Cell. Biol. 9: 2279-2283
16. Stanley K.K., Luzio J.P. 1984. Construction of a new family of high efficiency bacterial expression vectors: identification of cDNA clones coding for human liver proteins. EMBO J. 3: 1429-1434
17. Hamaguchi K., Gaskins H.R., Leiter E.H. 1991. NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse. Diabetes. 40: 842-849
18. Picketts D.J., Mayanil C.S., Gupta R.S. 1989. Molecular cloning of a Chinese hamster mitochondrial protein related to the 'chaperonin' family of bacterial and plant proteins. J. Biol. Chem. 264: 12001-12008
19. Venner T.J., Gupta R.S. 1990. Nucleotide sequence of mouse HSP60 (chaperonin, GroEL homolog) cDNA Biochem. Biophys. Acta (Netherlands). 1087: 336-338
20. Sette A., Alexander J., Ruppert J., Snoke K., Franco A., Ishioka G., Grey H.M. 1994. Antigen analogs/MHC complexes as specific T cell receptor antagonists. Annu. Rev. Immunol. 12: 413-431
21. Fisher H.P., Sharrock C.E.M., Panayi G.S. 1992. High frequency of cord blood lymphocytes against mycobacterial 65-kDa heat shock protein. Eur. J. Immunol. 22: 1667-1669
22. Munk E.M., Schoel B., Modrow S., Karr R.W., Young R.A., Kaufmann S.H.E. 1989. T lymphocytes from healthy individuals with specificity to self-epitopes shared by the mycobacterial and human 65-kilodalton heat shock protein. J. Immunol. 143: 2844-2849
23. Evalvold B.D., Sloan L.J., Allen P.M. 1993. Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands. Immunol. Today. 14: 602-609
24. Karin N., Mitchell D.J., Brocke S., Ling N., Steinman L. 1994. Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production. J. Exp. Med. 180: 2227-2237
25. Res P.C.M., Schaar C.G., Breedveld F.C., van Eden W., van Embden J.D.A., Cohen I.R. 1989. Synovial fluid T cell reactivity against 65 kD heat shock protein of mycobacteria in early chronic arthritis. Lancet 2: 478-480
26. Hogervorst E.J.M., Wagenaar J.P.A., Boog C.J., van der Zee R., van Embden J.D.A., van Eden W. 1992. Intern. Immunol. 4: 719
27. Selmaj K., Brosnan C.F., Raine C.S. 1991. Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis. Proc. Natl. Acad. Sci. (USA). 88: 6452-6456
28. Mor F., Cohen I.R. 1992. T cells in the lesion of experimental autoimmune encephalomyelitis. Enrichment for reactivities to myelin basic protein and to heat shock proteins. J. Clin. Invest. 90: 2447-2455
29. Jones D.B., Hunter N.R., Duff G.W. 1990. Heat-shock protein 65 as a beta cell antigen of insulin-dependent diabetes. Lancet 336: 583-585
30. Mackay I.R., Gershwin M.E. 1989. Molecular basis of mitochondrial autoreactivity in primary biliary cirrhosis. Immunol Today. 10: 315-318
31. Baekkeskov S., Aanstoot H.J., Christgau S., Reetz A., Solimena M., Cascalho M., Folli F., Richter-Olesen H., DeCamilli P. 1990. Identification of the 64 K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase Nature 347: 151-156
32. Kaufman D.L., Clare-Salzler M, Forsthuber T., Ting G.S.P., Robinson P., Atkinson M.A., Sercarz E.E., Tobin A.J., Lehmann P.V. 1993. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366: 69-72
33. Tisch R., Yang X.D., Singer S.M., Liblau R.S., Fugger L., McDevitt H.O. 1993. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366: 72-75
34. Erdo S.L., Wolff J.R. 1990. Gamma-Aminobutyric acid outside the mammalian brian. J. Neurochem. 54: 363-272
35. Brudzinski K., Martinez V., Gupta R.S. 1992. Secretory granule autoantigen in insulin-dependent diabetes mellitus is related to 62 kDa heat-shock protein (hsp60). J. Autoimmun. 5: 453-463
36. Venner T.J., Singh B., Gupta R.S. 1990. Nucleotide sequences and novel structural features of human and Chinese hamster hsp60 (chaperonin) gene families. DNA Cell Biol. 9: 545-552
37. Ross W.R., Bertrand W.S., Morrison A.R. 1992. Identification of a processed protein related to the human chaperonins (hsp60) protein in mammalian kidney. Biochem. Biophys. Res. Commun. (USA). 185: 683-687
38. Mandrup-Poulsen T., Helqvist S., Wogensen L.D., Molvig J., Pociot F., Johannesen J., Nerup J. 1990. Cytokine and free radicals as effector molecules in the destruction of pancreatic beta cells. Curr. Top. Microbiol. Immunol. 164: 169-193
39. Todd J.A. 1992. Genetic analysis of susceptibility to type 1 diabetes. Springer Semin. Immunopathol. (Germany) 14: 33-58
40. Bottazzo G.F. 1993. Banting Lecture. On the honey disease. A dialogue with Socrates. Diabetes 42: 778-800
41. Koga T., Wand-Wurttenberger A., de Bruyn J., Munk M.E., Schoel B., Kaufmann S.H.E. 1989. T cells against a bacterial heat shock protein recognize stressed macrophages. Science 246: 1112-1115
42. Steinhoff U., Schoel B., Kaufmann S.H.E. 1990. Lysis of interferon-gamma activated Schwann cell by cross-reactive CD8+ alpha/beta T cells with specificity for the mycobacterial 65 kd heat shock protein. Int. Immunol. 2: 279-284
43. Steinhoff U., Zugel U., Wand-Wurttenberger A., Hengel H., Rosch R., Munk M.E., Kaufmann S.H.E. 1994. Prevention of autoimmune lysis by T cells with specificity for a heat shock protein by antisense oligonucleotide treatment. Proc. Natl. Acad. Sci. (USA) 91: 5085-5088