Progression of autoimmune diabetes driven by avidity maturation of a T- cell population

Nature

Volumn 406, Issue 6797, 2000, Pages 739-742

  Amranl, Abdelaziz ^a   Verdaguer, Joan ^a   Serra, Pau ^a   Tafuro, Sabrina ^b   Tan, Rusung ^c   Santamaria, Pere ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; CELL MATURATION; DIABETES MELLITUS; FLOW CYTOMETRY; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; AUTOIMMUNITY; CD8-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS I; ISLETS OF LANGERHANS; LEUKOPOIESIS; MICE; MICE, INBRED NOD; MICE, TRANSGENIC; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC;

ANIMALIA;

EID: 0034680105     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35021081     Document Type: Article

References (24)

1. Delovitch, T. & Singh, B. The nonobese diabetic mouse as a model of autoimmune diabetes: immune disregulation gets the NOD. Immunity 7, 727-738 (1997).
2. + T cell response against one peptide/MHC complex in autoimmune diabetes. Proc. Natl Acad. Sci. USA 96, 9311-9316 (1999).
3. Nagata, M., Santamaria, P., Kawamura, T., Utsugi, T. & Yoon, J.-W. Evidence for the role of CD8+ cytotoxic T cells in the destruction of pancreatic beta cells in NOD mice. J. Immunol. 152, 2042-2050 (1994).
4. Katz, I., Benoist, C. & Mathis, D. Major histocompatibility complex class I molecules are required for the generation of insulitis in non-obese diabetic mice. Eur. J. Immunol. 23, 3358-3360 (1993).
5. Wicker, L. et al. β2-microglobulin-deficient NOD mice do not develop insulitis or diabetes. Diabetes 43, 500-504 (1994).
6. bull mice are diabetes and insulitis resistant. Diabetes 43, 505-508 (1994).
7. Verdaguer, J. et al. Acceleration of spontaneous diabetes in TCRβ-transgenic nonobese diabetic mice by beta cell-cytotoxic CD8+ cells expressing identical endogenous TCRα chains. J. Immunol. 157, 4726-4735 (1996).
8. Verdaguer, J. et al. Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice. J. Exp. Med. 186, 1663-1676 (1997).
9. DiLorenzo, T. et al. Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use prevalent T cell receptor α chain gene rearrangement. Proc. Natl Acad. Sci. USA 95, 12538-12543 (1998).
10. Santamaria, P. et al. Beta cell cytotoxic CD8+ T cells from non-obese diabetic mice use highly homologous T cell receptor alpha chain CDR3 sequences. J. Immunol. 154, 2494-2503 (1995).
11. Rammensee, H. G., Friede, T. & Stevanoviic, S. MHC ligands and peptide motifs: first listing. Immunogenetics 41, 178-228 (1995).
12. Wong, S. et al. Identification of an MHC class I-restricted autoantigen in type I diabetes by screening an organ-specific cDNA library. Nature Med. 5, 1026-1031 (1999).
13. Savage, P. A., Boniface, J. I. & Davis, M. M. A kinetic basis for T cell receptor repertoire selection during an immune response. Immunity 10, 485-492 (1999).
14. Abiru, N. & Eisenbarth, G. Autoantibodies and autoantigens in type 1 diabetes: role in pathogenesis, prediction and prevention. Can. J. Diab. Care 23, 59-65 (1999).
15. Kaufman, D. et al. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366, 69-72 (1993).
16. Tisch, R. et al. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366, 72-75 (1993).
17. Wegmann, D. The immune response to islet in experimental diabetes and insulin-dependent diabetes mellitus. Curr. Opin. Immunol. 8, 860-864 (1996).
18. Alam, S. et al. T-cell receptor affinity and thymocyte positive selection. Nature 381, 616-620 (1996).
19. Kersh, G., Kersh, E., Fremont, D. 26amp; Allen, P. High and low potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling. Immunity 9, 817-826 (1998).
20. Lyons, D. et al. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity 5, 53-61 (1996).
21. k complexes:correlation of the dissociation rate with T-cell responsiveness. Proc. Natl Acad. Sci. USA 91, 12862-12866 (1994).
22. Monks, C., Freiberg, B., Kupfer, H., Sciaky, N. & Kupfer, A. Three dimensional segregation of supramolecular activation clusters in T-cells. Nature 395, 82-86 (1998).
23. Reich, Z. et al. Ligand-specific oligomerization of T-cell receptor molecules. Nature 387, 617-620 (1997).
24. Altman, J. et al. Direct visualization and phenotypic analysis of virus-specific T lymphocytes in HIV-infected individuals. Science 274, 94-96 (1996).