GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice

Journal of Clinical Investigation

Volumn 101, Issue 1, 1998, Pages 68-73

  Zekzer, Dan ^a   Wong, F Susan ^a   Ayalon, Oran ^a   Millet, Isabelle ^a   Altieri, Martha ^a   Shintani, Shigeki ^b   Solimena, Michele ^a   Sherwin, Robert S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KYOTO SECOND RED CROSS HOSPITAL   (Japan)

Author keywords

Animal model; Autoimmunity; Cytokine; Cytotoxicity; Immunology

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 65 ANTIGEN; INTERLEUKIN 4; LYMPHOTOXIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; DIABETOGENESIS; ENZYME PURIFICATION; FEMALE; HISTOPATHOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL;

EID: 0031985093     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119878     Document Type: Article

References (31)

1. Bendelac, A., C. Carnaud, C. Boitard, and J.F. Bach. 1987. Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells. J. Exp. Med. 166:823-832.
2. Miller, B.J., M.C. Appel, J.J. O'Neil, and L.S. Wicker. 1988. Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. J. Immunol. 140:52-58.
3. Reich., E.P., R.S. Sherwin, O. Kanagawa, and C.A. Janeway. 1989. An explanation for the protective effect of the MHC class II I-E molecule in murine diabetes. Nature. 341:326-328.
4. Rohane, P.W., A. Shimada, D.T. Kim, C.T. Edwards, B. Charlton, L.D. Shultz, and C.G. Fathman. 1995. Islet-infiltrating lymphocytes from prediabetic NOD mice rapidly transfer diabetes to NOD-scid/scid mice, Diabetes. 44:550-554.
5. Daniel, D., and D.R. Wegmann. 1996. Protection of nonobese diabetic mice from diabetic by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc. Natl. Acad. Sci. USA. 93:956-960.
6. Elias, D., T. Reshef, O.S. Birk, R. van der Zee, M.D. Walker, and I.R. Chen. 1991. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc. Natl. Acad. Sci. USA. 88:3088-3091.
7. Peterson, J.D., and K. Haskins. 1996. Transfer of diabetes in the NOD-scid mouse by CD4 T-cells clones. Diabetes. 45:328-336.
8. Wong, F.S., I. Visintin, L. Wen, R.A. Flavell, and C.A. Janeway, Jr. 1996. CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J. Exp. Med. 183:67-76.
9. Baekkeskov, S., H.-J. Aanstoot, S. Christgau, A. Reetz, M. Solimena, M. Cascalho, F. Folli, H. Richeter-Olesen, and P. De Camilli. 1990. Identification of the 64-kd autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature. 347:151-166.
10. Baekkeskov, S., J.H. Nielsen, B. Marner, T. Bilde, J. Ludvigsson, and A. Lernmark. 1982. Autoantibodies in newly diagnosed diabetic children immuno-precipitate specific human islet cell proteins. Nature. 298:167-169.
11. Harrison, L.C., M.C. Honeyman, and H.J. DeAizpurura. 1993. Inverse relationship between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes. Lancet. 341:1365-1369.
12. Kaufman, D.L., M. Clare-Salzler, J. Tian, T. Forsthuber, G.S.T. Ting, P. Robinson, M.A. Atkinson, E.E. Sercarz, A.J. Tobin, and P.V. Lehmann. 1993. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependant diabetes. Nature. 366:69-72.
13. Tisch, R., X.D Yang, S.M. Singer, R.S. Liblau, L. Fugger, and H.O. McDevitt. 1993. Immune response to glutamic acid decarboxylase correlates with insulitis in nonobese diabetic mice. Nature. 366:72-75.
14. Tian, J.M., A. Atkinson, M.C. Salzler, A. Herschenfeld, T. Forsthuber, P.V. Lehmann, and D.L. Kaufman. 1996. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J. Exp. Med. 183:1561-1567.
15. Butler, M.H., M. Solimena, R. Dirkx, Jr., A. Hayday, and P. De Camilli. 1993. Identification of a dominant epitope of glutamic acid decarboxylase (GAD)65 recognized by autoantibodies in stiff-man syndrome. J. Exp. Med. 178:2097-2106.
16. Dirkx, R., Jr., A. Thomas, L. Li, A. Lernmark, R.S. Sherwin, P. De Camilli, and M. Solimena. 1995. Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase. J. Biol. Chem. 270:2241-2246.
17. Matsuba, H., T. Jitsukawa, N. Yamagata, S. Uchida, and H. Watanabe. 1994. Establishment of rat glutamic acid decarboxylase (GAD)-reactive T-cell clones from NOD mice. Immunol. Lett. 42:101-103.
18. Solimena, M., D. Aggujaro, C. Muntzel, R. Dirkx, M. Butler, P. De Camilli, and A. Hayday. 1993. Association of GAD-65, but not of GAD-67. with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region. Proc. Natl. Acad. Sci. USA. 90:3073-3077.
19. Reiner, S.L., S. Zheng, D.B. Corry, and R.M. Locksley. 1993. Constructing polycompetitor cDNAs for quantitative PCR. J. Immunol. Methods. 165: 37-46 (published errata in J. Immunol. Methods. 1994. 173:133 and 1994. 175: 275).
20. Wang, X.M., P.I. Terasaki, G.W. Rankin, Jr., D. Chia, H.P. Zhong, and S. Hardy. 1993. A new microcellular cytotoxicity test based on calcein AM release. Hum. Immunol. 37:264-270.
21. Lichtenteld, R., W.E. Biddison, H. Schulz, A.B. Vogt, and R. Martin. 1994. CARE-LESS (calcein-release-assay), an improved fluorescence-based test system to measure cytotoxic T lymphocyte activity. J. Immunol. Methods. 172:227-239.
22. Braut-Boucher, F., J. Pichon, P. Rat, M. Adolphe, M. Aubery, and J. Font. 1995. A non-isotopic, highly sensitive, fluorimetric, cell-cell adhesion microplate assay using calcein AM-labeled lymphocytes. J. Immunol. Methods. 178:41-51.
23. De Camilli, P., R. Cameron, and P. Greengard. 1983. Synapsin I (protein I), a nerve terminal-specific phosphoprotein. I. Its general distribution in synapses of the central and peripheral nervous system demonstrated by immunofluorescence in frozen and plastic sections. J. Cell. Biol. 96:1337-1354.
24. Solimena, M., R. Dirkx, J.M. Hermel, S. Pleasic-Williams, J.A. Shapiro, L. Caron, and D.U. Rabin. 1996. ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules. EMBO (Eur. Mol. Biol. Organ.) J. 15:2102-2114.
25. Tian, J., M.C. Salzler, A. Herschenfeld, B. Middleton, D. Newman, R. Mueller, S. Arita, C. Evans, M. Atkinson, Y. Mullen, et al. 1996. Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice. Nat. Med. 2:1348-1353.
26. Blanas, E., J.F. Allison, A.P. Miller, and W.R. Heath. 1996. Induction of autoimmune diabetes by oral administration of autoantigen. Science. 274:1707-1709.
27. Signore, A., P. Pozzilli, E.A. Gale, D. Andreani, and P.C. Beverley. 1989. The natural history of lymphocyte subsets infiltrating the pancreas of NOD. Diabetologia. 32:282-289.
28. McInerney, M.F., S. Rath, and C.A. Janeway, Jr. 1991. Exclusive expression of MHC class II proteins on CD45+ cells in pancreatic islets of NOD mice. Diabetes. 40:648-651.
29. Kurrer, M.O., S.V. Pakala, H. Hanson, and J.D. Katz. 1997. Beta cell apoptosis in T-cell mediated autoimmune diabetes. Proc. Natl. Acad. Sci. USA. 94: 213-218.
30. Yamada, K., N. Takane-Gyotoku, X. Yuan, F. Ichikawa, C. Inada, and K. Nonaka. 1996. Mouse islet cell lysis mediated by interleukin-1-induced Fas. Diabetologia. 39:1306-1312.
31. Schloot, N.C., D. Daniel, M. Norbury-Glaser, and D.R. Wegmann. 1996. Peripheral T cell clones from NOD mice specific for GAD65 peptides: lack of islet responsiveness or diabetogenicity. J. Autoimmu. 9:357-363.