Retardation or acceleration of diabetes in NOD/Lt mice mediated by intrathymic administration of candidate β-cell antigens

Diabetes

Volumn 46, Issue 12, 1997, Pages 1975-1982

  Cetkovic Cvrlje, Marina ^a   Gerling, Ivan C ^a   Muir, Andrew ^b   Atkinson, Mark A ^b   Elliott, John F ^c   Leiter, Edward H ^a  

^a JACKSON LABORATORY   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ARTICLE; DIABETES MELLITUS; FEMALE; IMMUNOTHERAPY; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0030731920     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.12.1975     Document Type: Article

References (49)

1. Kikutani H, Makino S: The murine autoimmune diabetes model: NOD and related strains. In Advances in Immunology. Dixon FJ, Ed. San Diego, CA, Academic, 1992, p. 285-322
2. Bowman MA, Leiter EH, Atkinson MA: Prevention of diabetes in the NOD mouse: implications for therapeutic intervention in human disease. Immunol Today 15:115-120, 1994
3. Gerling IC, Serreze DV, Christianson SW, Leiter EH: Intrathymic islet cell transplantation reduces beta cell autoimmunity and prevents diabetes in NOD/Lt mice. Diabetes 41:1672-1676, 1992
4. Nomura Y, Stein E, Mullen Y: Prevention of overt diabetes and insulitis by intrathymic injection of syngeneic islets in newborn nonobese diabetic (NOD) mice. Transplantation 56:638-642, 1993
5. Gerling IC, Atkinson MA, Leiter EH: The thymus as a site for evaluating the potency of candidate β cell autoantigens in NOD mice. J Autoimmun 7:851-858, 1994
6. Song YH, Li YX, Maclaren NK: The nature of autoantigens targeted in autoimmune endocrine diseases. Immunol Today 17:232-238, 1996
7. Tisch R, Yang X-D, Singer S, Liblau R, Fugger L, McDevitt H: Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366:72-75, 1993
8. Kaufman DL, Clare-Salzler M, Tian J, Forsthuber T, Ting GSP, Robinson P, Atkinson MA, Sercarz EE, Tobin AJ, Lehmann PV: Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366:69-72, 1993
9. Petersen JS, Karlsen AE, Markholst H, Worsaae A, Dyrberg T, Michelsen B: Neonatal tolerization with glutamic acid decarboxylase but not with bovine serum albumin delays the onset of diabetes in NOD mice. Diabetes 43:1478-1484, 1994
10. Pleau JM, Fernandez Saravia F, Esling A, Homo Delarche F, Dardenne M: Prevention of autoimmune diabetes in nonobese diabetic female mice by treatment with recombinant glutamic acid decarboxylase (GAD 65). Clin Immunol Immunopathol 76:90-95, 1995
11. Tisch R, Yang XD, Liblau RS, McDevitt HO: Administering glutamic acid decarboxylase to NOD mice prevents diabetes. J Autoimmun 7:845-850, 1994
12. Elliott JF, Qin HY, Bhatti S, Smith DK, Singh RK, Dillon T, Lauzon J, Singh B: Immunization with the larger isoform of mouse glutamic acid decarboxylase (GAD[67]) prevents autoimmune diabetes in NOD mice. Diabetes 43:1494-1499, 1994
13. Muir A, Luchetta R, Song Y-H, Peck A, Krischer J, MacLaren N: Insulin immunization protects NOD mice from diabetes. Diabetes 42 (Suppl. 1):5A, 1993
14. Ramiya VK, Shang XZ, Pharis PG, Wasserfall CH, Stabler TV, Muir AB, Schatz DA, Maclaren NK: Antigen based therapies to prevent diabetes in NOD mice. J Autoimmun 9:349-356, 1996
15. Elias D, Markovits D, Reshef T, van der Zee R, Cohen IR: Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. Proc Natl Acad Sci USA 87:1576-1580,1990
16. Elias D, Cohen IR: Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock protein 60 peptide p277. Diabetes 44:1132-1138, 1995
17. Liblau RS, Singer SM, McDevitt HO: Th1 and Th2 CD4(+) T-cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today 16:34-38,1995
18. Rabinovitch A, Suarezpinzon WL, Sorensen O, Bleackley RC, Power RF: IFN-gamma gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. J Immunol 154:4874-4882, 1995
19. Trembleau S, Penna G, Bosi E, Mortara A, Gately MK, Adorini L: Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J Exp Med 181:817-821, 1995
20. Rothe H, Burkart V, Faust A, Kolb H: Interleukin-12 gene expression is associated with rapid development of diabetes mellitus in non-obese diabetic mice. Diabetologia 39:119-122, 1996
21. Debray-Sachs M, Camaud C, Boitard C, Cohen H, Gresser I, Bedossa P, Bach J-F: Prevention of diabetes in NOD mice treated with antibody to murine IFN-γ. J Autoimmun 4:237-248,1991
22. Rapoport M, Zipris D, Lazarus A, Jaramillo A, Serreze D, Leiter E, Cyopick P, Delovitch T: IL-4 reverses thymic T-cell anergy and prevents the onset of diabetes in NOD mice. J Exp Med 178:87-99, 1993
23. Hanson MS, Cetkovic-Cvrlje M, Ramiya VK, Atkinson MA, Maclaren NK, Singh B, Elliott JF, Serrezze DV, Leiter EH: Quantitative thresholds of MHC class II I-E expressed on hemopoietically derived antigen-presenting cells in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection. J Immunol 157:1279-1287, 1996
24. Rocken M, Racke M, Shevach EM: IL4-induced immune deviation as antigenspecific therapy for inflammatory autoimmune disease. Immunol Today 17:225-231, 1996
25. Pennline KJ, Roquegaffney E, Monahan M: Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin Immunol Immunopathol 71:169-175, 1994
26. Hancock WW, Polanski M, Zhang J, Blogg N, Weiner HL: Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-beta, and prostaglandin-E. Am J Pathol 147:1193-1199,1995
27. Tian J, Atkinson AM, Clare-Salzler M, Herschenfeld A, Forsthuber T, Lehmann PV, Kaufman DL: Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J Exp Med 183:1561-1567, 1996
28. Shultz LD, Schweitzer PA, Christianson SW, Gott B, Birdsall-Maller I, Tennent B, McKenna S, Mobraaten L, Rajan TV, Greiner DL, Leiter EH: Multiple defects in innate and adaptive immunological function in NOD/LtSZ-scid mice. J Immunol 154:180-191, 1995
29. Daniel D, Gill RG, Schloot N, Wegmann D: Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T-cell clones isolated from NOD mice. Eur J Immunol 25:1056-1062, 1995
30. Anderson J, Cornelius J, Jarpe A, Winter W. Peck A: Insulin-dependent diabetes in the NOD mouse model. II. β cell destruction in autoimmune diabetes is a Th2 and not a Th1 mediated event. Autoimmunity 15:113-122, 1993
31. Maeda T, Sumida T, Kurasawa K, Tomioka H, Itoh I, Yoshida S, Koike T: T-lymphocyte-receptor repertoire of infiltrating T lymphocytes into NOD mouse pancreas. Diabetes 40:1580-1585, 1991
32. Tisch R, McDevitt H: Insulin-dependent diabetes mellitus. Cell 85:291-297,1996
33. Muir A, Peck A, Claresalzler M, Song YH, Cornelius J, Luchetta R, Krischer J, Maclaren N: Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription. J Clin Invest 95:628-634, 1995
34. Many M-C, Drexhage HA, Denef J-F: High frequency of thymic ectopy in thyroids from autoimmune prone nonobese diabetic female mice. Lab Invest 69:364-367, 1993
35. Posselt A, Naji A, Roark J, Markmann J, Barker C: Intrathymic islet transplantation in the spontaneously diabetic BB rat. Ann Surg 214:363-371,1991
36. Pilstrom B, Bjork L, Bohme J: Demonstration of a t-h1 cytokine profile in the late phase of NOD insulitis. Cytokine 7:806-814, 1995
37. Kelso A: Th1 and Th2 subsets: paradigms lost? Immunol Today 16:374-379, 1995
38. Serreze DV, Hamaguchi K, Letter EH: Immunostimulation circumvents diabetes in NOD/Lt mice. J Autoimmun 2:759-776, 1990
39. Wogensen L, Lee MS, Sarvetnick N: Production of interleukin-10 by islet cells accelerates immune-mediated destruction of beta-cells in nonobese diabetic mice. J Exp Med 179:1379-1384, 1994
40. Moritani M, Yoshimoto K, Li S, Kondo M, Iwahana H, Yamaoka T, Sano T, Nakano N, Kikutani H, Itakura M: Prevention of adoptively transferred diabetes in NOD mice with IL-10-transduced islet-specific Th1 lymphocytes: a gene therapy model for autoimmune diabetes. J Clin Invest 98:1851-1859, 1996
41. Viner NJ, Nelson CA, Deck B, Unanue ER: Complexes generated by the binding of free peptides to class II MHC molecules are antigenically diverse compared with those generated by intracellular processing. J Immunol 156:2365-2368, 1996
42. Schloot NC, Daniel D, Norburyglaser M, Wegmann DR: Peripheral T-cell clones from NOD mice specific for GAD65 peptides: lack of islet responsiveness or diabetogenicity. J Autoimmun 9:357-363, 1996
43. Zekzer D, Wong S, Altieri M, Sherwin RS: Induction of diabetogenic T-cells in a young NOD mouse following immunization with purified GAD. Autoimmunity 24 (Suppl. 1):A006, 1996
44. McFarland HF: Complexities in the treatment of autoimmune disease. Science 274:2037-2038, 1996
45. Blanas E, Carbone FR, Allison J, Miller JFAP, Heath WR: Induction of autoimmune diabetes by oral administration of autoantigen. Science 274:1707-1709, 1996
46. Lohmann T, Leslie DRG, Hawa M, Geysen M, Rodda S, Londei M: Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulindependent diabetes mellitus. Lancet 343:1607-1608, 1994
47. Lohmann T, Leslie RDG, Londei M: T-cell clones to epitopes of glutamic acid decarboxylase 65 raised from normal subjects and patients with insulindependent diabetes. J Autoimmun 9:385-389, 1996
48. Atkinson MA, Bowman MA, Campbell L, Darrow BL, Kaufman DL, Maclaren NK: Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J Clin Invest 94:2125-2129, 1994
49. Tian J, Lehmann PV, Kaufman DL: T-cell cross-reactivity between Coxsackie and glutamate decarboxylase is associated with a murine diabetes susceptibility allele. J Exp Med 180:1979-1984, 1994