MicroRNA regulation of human protease genes essential for influenza virus replication

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Meliopoulos, Victoria A ^a   Andersen, Lauren E ^a   Brooks, Paula ^a   Yan, Xiuzhen ^a   Bakre, Abhijeet ^a   Coleman, J Keegan ^a   Tompkins, S Mark ^a   Tripp, Ralph A ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICRORNA; PROTEINASE; ADAM PROTEIN; ADAMTS7 PROTEIN, HUMAN; CARBOXYPEPTIDASE H; DIPEPTIDYL PEPTIDASE; DPP3 PROTEIN, HUMAN; NEUROTRYPSIN; PEPTIDE HYDROLASE; PROTEIN SERINE THREONINE KINASE; SERINE PROTEINASE; SMALL INTERFERING RNA; STK4 PROTEIN, HUMAN;

ADAMTS7 GENE; APOPTOSIS; ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; CPE GENE; DPP3 GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC IDENTIFICATION; HUMAN; HUMAN CELL; INFLAMMATION; INFLUENZA VIRUS; MST1 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEASE GENE; PRSS12 GENE; RNA INTERFERENCE; VIRUS CELL INTERACTION; VIRUS GENE; VIRUS ISOLATION; VIRUS REPLICATION; CELL LINE; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; HOST PATHOGEN INTERACTION; INFLUENZA; INFLUENZA VIRUS A; PATHOGENICITY; PHYSIOLOGY; VIROLOGY;

INFLUENZA A VIRUS; ORTHOMYXOVIRIDAE;

ADAM PROTEINS; BASE SEQUENCE; CARBOXYPEPTIDASE H; CELL LINE; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; HOST-PATHOGEN INTERACTIONS; HUMANS; INFLUENZA A VIRUS; INFLUENZA, HUMAN; MICRORNAS; PEPTIDE HYDROLASES; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SERINE ENDOPEPTIDASES; VIRUS REPLICATION;

EID: 84861014569     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037169     Document Type: Article

References (85)

1. Kandel R, Hartshorn KL, (2001) Prophylaxis and treatment of influenza virus infection. BioDrugs 15: 303-323.
2. Thompson WW, Shay DK, Weintraub E, Brammer L, Cox N, et al. (2003) Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 289: 179-186.
3. Hale BG, Randall RE, Ortin J, Jackson D, (2008) The multifunctional NS1 protein of influenza A viruses. J Gen Virol 89: 2359-2376.
4. Basler CF, (2007) Influenza viruses: basic biology and potential drug targets. Infect Disord Drug Targets 7: 282-293.
5. Betakova T, (2007) M2 protein-a proton channel of influenza A virus. Curr Pharm Des 13: 3231-3235.
6. Hsieh HP, Hsu JT, (2007) Strategies of development of antiviral agents directed against influenza virus replication. Curr Pharm Des 13: 3531-3542.
7. Jefferson T, Demicheli V, Di Pietrantonj C, Rivetti D, (2006) Amantadine and rimantadine for influenza A in adults. Cochrane Database Syst Rev.
8. Lowen AC, Palese P, (2007) Influenza virus transmission: basic science and implications for the use of antiviral drugs during a pandemic. Infect Disord Drug Targets 7: 318-328.
9. Matheson NJ, Harnden AR, Perera R, Sheikh A, Symmonds-Abrahams M, (2007) Neuraminidase inhibitors for preventing and treating influenza in children. Cochrane Database Syst Rev.
10. Beigel J, Bray M, (2008) Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res 78: 91-102.
11. Conly J, Johnston B, (2006) Ode to oseltamivir and amantadine? Can J Infect Dis Med Microbiol 17: 11-14.
12. Lackenby A, Thompson CI, Democratis J, (2008) The potential impact of neuraminidase inhibitor resistant influenza. Curr Opin Infect Dis 21: 626-638.
13. Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, et al. (2008) RNA interference screen for human genes associated with West Nile virus infection. Nature 455: 242-245.
14. Hirsch AJ, (2010) The use of RNAi-based screens to identify host proteins involved in viral replication. Future Microbiol 5: 303-311.
15. Leung RK, Whittaker PA, (2005) RNA interference: from gene silencing to gene-specific therapeutics. Pharmacol Ther 107: 222-239.
16. Tripp RA, Tompkins SM, (2009) Therapeutic applications of RNAi for silencing virus replication. Methods Mol Biol 555: 43-61.
17. Haasnoot J, Westerhout EM, Berkhout B, (2007) RNA interference against viruses: strike and counterstrike. Nat Biotechnol 25: 1435-1443.
18. Kim DH, Rossi JJ, (2007) Strategies for silencing human disease using RNA interference. Nat Rev Genet 8: 173-184.
19. Wiznerowicz M, Szulc J, Trono D, (2006) Tuning silence: conditional systems for RNA interference. Nat Methods 3: 682-688.
20. Alvarez R, Elbashir S, Borland T, Toudjarska I, Hadwiger P, et al. (2009) RNA interference-mediated silencing of the respiratory syncytial virus nucleocapsid defines a potent antiviral strategy. Antimicrob Agents Chemother 53: 3952-3962.
21. Barik S, (2004) Control of nonsegmented negative-strand RNA virus replication by siRNA. Virus Res 102: 27-35.
22. Bitko V, Musiyenko A, Shulyayeva O, Barik S, (2005) Inhibition of respiratory viruses by nasally administered siRNA. Nat Med 11: 50-55.
23. DeVincenzo J, Cehelsky JE, Alvarez R, Elbashir S, Harborth J, et al. (2008) Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV). Antiviral Res 77: 225-231.
24. Zhang W, Tripp RA, (2008) RNA interference inhibits respiratory syncytial virus replication and disease pathogenesis without inhibiting priming of the memory immune response. J Virol 82: 12221-12231.
25. Zhang W, Yang H, Kong X, Mohapatra S, San Juan-Vergara H, et al. (2005) Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene. Nat Med 11: 56-62.
26. Barakat MR, Kaiser PK, (2009) VEGF inhibitors for the treatment of neovascular age-related macular degeneration. Expert Opin Investig Drugs 18: 637-646.
27. Konig R, Stertz S, Zhou Y, Inoue A, Hoffmann HH, et al. (2009) Human host factors required for influenza virus replication. Nature 463: 813-817.
28. Pan HY, Yamada H, Chida J, Wang S, Yano M, et al. (2011) Up-regulation of ectopic trypsins in the myocardium by influenza A virus infection triggers acute myocarditis. Cardiovascular research 89: 595-603.
29. Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, et al. (2009) The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell 139: 1243-1254.
30. Hao L, Sakurai A, Watanabe T, Sorensen E, Nidom CA, et al. (2008) Drosophila RNAi screen identifies host genes important for influenza virus replication. Nature 454: 890-893.
31. Karlas A, Machuy N, Shin Y, Pleissner KP, Artarini A, et al. (2010) Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication. Nature.
32. Shapira SD, Gat-Viks I, Shum BO, Dricot A, de Grace MM, et al. (2009) A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection. Cell 139: 1255-1267.
33. Sui B, Bamba D, Weng K, Ung H, Chang S, et al. (2009) The use of Random Homozygous Gene Perturbation to identify novel host-oriented targets for influenza. Virology 387: 473-481.
34. Bradel-Tretheway BG, Mattiacio JL, Krasnoselsky A, Stevenson C, Purdy D, et al. (2011) Comprehensive proteomic analysis of influenza virus polymerase complex reveals a novel association with mitochondrial proteins and RNA polymerase accessory factors. Journal of Virology 85: 8569-8581.
35. Meliopoulos VA, Andersen LE, Birrer KF, Simpson KJ, Lowenthal JW, et al. (2012) Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens. The FASEB journal official publication of the Federation of American Societies for Experimental Biology.
36. Bottcher E, Freuer C, Steinmetzer T, Klenk HD, Garten W, (2009) MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition. Vaccine 27: 6324-6329.
37. Bottcher E, Matrosovich T, Beyerle M, Klenk HD, Garten W, et al. (2006) Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium. J Virol 80: 9896-9898.
38. Bottcher-Friebertshauser E, Freuer C, Sielaff F, Schmidt S, Eickmann M, et al. (2010) Cleavage of Influenza Virus Hemagglutinin by Airway Proteases TMPRSS2 and HAT Differs in Subcellular Localization and Susceptibility to Protease Inhibitors. Journal of Virology 84: 5605-5614.
39. Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, et al. (2008) Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses. J Mol Genet Med 3: 167-175.
40. Maytal-Kivity V, Reis N, Hofmann K, Glickman MH, (2002) MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function. BMC Biochem 3: 28.
41. Bovee ML, Marissen WE, Zamora M, Lloyd RE, (1998) The predominant elF4G-specific cleavage activity in poliovirus-infected HeLa cells is distinct from 2A protease. Virology 245: 229-240.
42. Ueda M, Daidoji T, Du A, Yang CS, Ibrahim MS, et al. (2010) Highly pathogenic H5N1 avian influenza virus induces extracellular Ca2+ influx, leading to apoptosis in avian cells. J Virol 84: 3068-3078.
43. Wang S, Le Trong Q, Kurihara N, Chida J, Cisse Y, et al. (2010) Influenza Virus-Cytokine-Protease Cycle in the Pathogenesis of Vascular Hyperpermeability in Severe Influenza. The Journal of Infectious Diseases 202: 991-1001.
44. Carthew RW, Sontheimer EJ, (2009) Origins and Mechanisms of miRNAs and siRNAs. Cell 136: 642-655.
45. Pfeffer S, Zavolan M, Grasser FA, Chien M, Russo JJ, et al. (2004) Identification of virus-encoded microRNAs. Science 304: 734-736.
46. Grundhoff A, Sullivan CS, (2011) Virus-encoded microRNAs. Virology 411: 325-343.
47. Song L, Liu H, Gao S, Jiang W, Huang W, (2010) Cellular MicroRNAs Inhibit Replication of the H1N1 Influenza A Virus in Infected Cells. Journal of Virology 84: 8849-8860.
48. Latronico MV, Condorelli G, (2011) Therapeutic Use of MicroRNAs in Myocardial Diseases. Current heart failure reports.
49. Schonrock N, Humphreys DT, Preiss T, Gotz J, (2011) Target Gene Repression Mediated by miRNAs miR-181c and miR-9 Both of Which Are Down-regulated by Amyloid-beta. Journal of molecular neuroscience MN.
50. Buck AH, Perot J, Chisholm MA, Kumar DS, Tuddenham L, et al. (2010) Post-transcriptional regulation of miR-27 in murine cytomegalovirus infection. RNA 16: 307-315.
51. Li Y, Chan EY, Li J, Ni C, Peng X, et al. (2010) MicroRNA Expression and Virulence in Pandemic Influenza Virus-Infected Mice. Journal of Virology 84: 3023-3032.
52. Vermeulen A, Robertson B, Dalby AB, Marshall WS, Karpilow J, et al. (2007) Double-stranded regions are essential design components of potent inhibitors of RISC function. RNA 13: 723-730.
53. Ostano P, Bione S, Belgiovine C, Chiodi I, Ghimenti C, et al. (2012) Cross-analysis of gene and miRNA genome-wide expression profiles in human fibroblasts at different stages of transformation. Omics: a journal of integrative biology 16: 24-36.
54. Stakkestad O, Larsen AC, Kvissel AK, Eikvar S, Orstavik S, et al. (2011) Protein kinase A type I activates a CRE-element more efficiently than protein kinase A type II regardless of C subunit isoform. BMC biochemistry 12: 7.
55. Mallakin A, Kutcher LW, McDowell SA, Kong S, Schuster R, et al. (2006) Gene expression profiles of Mst1r-deficient mice during nickel-induced acute lung injury. Am J Respir Cell Mol Biol 34: 15-27.
56. Luan Y, Kong L, Howell DR, Ilalov K, Fajardo M, et al. (2008) Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. Osteoarthritis Cartilage 16: 1413-1420.
57. Johnston RA, Theman TA, Shore SA, (2006) Augmented responses to ozone in obese carboxypeptidase E-deficient mice. Am J Physiol Regul Integr Comp Physiol 290: R126-133.
58. Shukla AA, Jain M, Chauhan SS, (2010) Ets-1/Elk-1 is a critical mediator of dipeptidyl-peptidase III transcription in human glioblastoma cells. The FEBS journal 277: 1861-1875.
59. Kim JH, Yoon S, Won M, Sim SH, Ko JJ, et al. (2009) HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death. Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology 23: 43-52.
60. Wright CW, Rumble JM, Duckett CS, (2007) CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells. The Journal of biological chemistry 282: 10252-10262.
61. Fang L, Adkins B, Deyev V, Podack ER, (2008) Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation. The Journal of experimental medicine 205: 1037-1048.
62. Ekchariyawat P, Thitithanyanont A, Sirisinha S, Utaisincharoen P, (2011) Apoptosis induced by avian H5N1 virus in human monocyte-derived macrophages involves TRAIL-inducing caspase-10 activation. Innate immunity.
63. Kumar N, Xin ZT, Liang Y, Ly H, (2008) NF-kappaB signaling differentially regulates influenza virus RNA synthesis. Journal of Virology 82: 9880-9889.
64. Djuranovic S, Nahvi A, Green R, (2011) A parsimonious model for gene regulation by miRNAs. Science 331: 550-553.
65. Cai K, Wang Y, Bao X, (2011) MiR-106b promotes cell proliferation via targeting RB in laryngeal carcinoma. Journal of experimental & clinical cancer research: CR 30: 73.
66. Zheng ZM, Wang X, (2011) Regulation of cellular miRNA expression by human papillomaviruses. Biochimica et biophysica acta.
67. He T, Feng G, Chen H, Wang L, Wang Y, (2009) Identification of host encoded microRNAs interacting with novel swine-origin influenza A (H1N1) virus and swine influenza virus. Bioinformation 4: 112-118.
68. Someya A, Tanaka N, Okuyama A, (1990) Inhibition of influenza virus A/WSN replication by a trypsin inhibitor, 6-amidino-2-naphthyl p-guanidinobenzoate. Biochemical and biophysical research communications 169: 148-152.
69. Woolcock PR, (2008) Avian influenza virus isolation and propagation in chicken eggs. Methods Mol Biol 436: 35-46.
70. Reed LJM H, (1938) A simple method of estimating fifty percent endpoints The American Journal of Hygiene 27: 493-497.
71. Kumar N, Liang Y, Parslow TG, (2011) Receptor tyrosine kinase inhibitors block multiple steps of influenza a virus replication. Journal of Virology 85: 2818-2827.
72. Crouch SP, Kozlowski R, Slater KJ, Fletcher J, (1993) The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity. Journal of Immunological Methods 160: 81-88.
73. Olsson T, Gulliksson H, Palmeborn M, Bergstrom K, Thore A, (1983) Leakage of adenylate kinase from stored blood cells. Journal of applied biochemistry 5: 437-445.
74. Subbarao EK, Kawaoka Y, Ryan-Poirier K, Clements ML, Murphy BR, (1992) Comparison of different approaches to measuring influenza A virus-specific hemagglutination inhibition antibodies in the presence of serum inhibitors. J Clin Microbiol 30: 996-999.
75. Spackman E, Senne DA, Myers TJ, Bulaga LL, Garber LP, et al. (2002) Development of a real-time reverse transcriptase PCR assay for type A influenza virus and the avian H5 and H7 hemagglutinin subtypes. J Clin Microbiol 40: 3256-3260.
76. Schultz-Cherry S, Koci M, Thompson E, Tumpey TM, (2003) Examining the cellular pathways involved in influenza virus induced apoptosis. Avian diseases 47: 968-971.
77. Somerville RP, Longpre JM, Apel ED, Lewis RM, Wang LW, et al. (2004) ADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domain. J Biol Chem 279: 35159-35175.
78. Liu CJ, Kong W, Ilalov K, Yu S, Xu K, et al. (2006) ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein. FASEB J 20: 988-990.
79. Bevitt DJ, Mohamed J, Catterall JB, Li Z, Arris CE, et al. (2003) Expression of ADAMTS metalloproteinases in the retinal pigment epithelium derived cell line ARPE-19: transcriptional regulation by TNFalpha. Biochim Biophys Acta 1626: 83-91.
80. He P, Varticovski L, Bowman ED, Fukuoka J, Welsh JA, et al. (2004) Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray. Hum Pathol 35: 1196-1209.
81. Fan X, Olson SJ, Johnson MD, (2001) Immunohistochemical localization and comparison of carboxypeptidases D, E, and Z, alpha-MSH, ACTH, and MIB-1 between human anterior and corticotroph cell "basophil invasion" of the posterior pituitary. J Histochem Cytochem 49: 783-790.
82. Fan X, Olson SJ, Blevins LS, Allen GS, Johnson MD, (2002) Immunohistochemical localization of carboxypeptidases D, E, and Z in pituitary adenomas and normal human pituitary. J Histochem Cytochem 50: 1509-1516.
83. Shin MR, Cui XS, Jun JH, Jeong YJ, Kim NH, (2005) Identification of mouse blastocyst genes that are downregulated by double-stranded RNA-mediated knockdown of Oct-4 expression. Mol Reprod Dev 70: 390-396.
84. Navarathna DH, Hornby JM, Krishnan N, Parkhurst A, Duhamel GE, et al. (2007) Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans. Infect Immun 75: 1609-1618.
85. Liu Y, Kern JT, Walker JR, Johnson JA, Schultz PG, et al. (2007) A genomic screen for activators of the antioxidant response element. Proc Natl Acad Sci U S A 104: 5205-5210.