Kinome-side RNAi screen implicates at least 5 host hepatocyte kinases in Plasmodium sporozoite infection

PLoS Pathogens

Volumn 4, Issue 11, 2008, Pages

  Prudêncio, Miguel ^a,b   Rodrigues, Cristina D ^a,b   Hannus, Michael ^c   Martin, Cécilie ^c   Real, Eliana ^a   Gonçalves, Lígia A ^b   Carret, Céline ^a   Dorkin, Robert ^d   Röhl, Ingo ^e   Jahn Hoffmann, Kerstin ^e   Luty, Adrian J F ^f   Sauerwein, Robert ^f   Echeverri, Christophe J ^c   Mota, Maria M ^a,b  

^a UNIVERSITY OF LISBON   (Portugal)

^b INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^c Cenix BioScience GmbH   (Germany)

^d ALNYLAM PHARMACEUTICALS   (United States)

^e Roche Kulmbach GmbH   (Germany)

^f RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; LIPOSOME; LIVER ENZYME; PROTEIN KINASE C ZETA; SMALL INTERFERING RNA; PHOSPHOTRANSFERASE; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FUNCTIONAL GENOMICS; GENE SILENCING; GENETIC SCREENING; HEPATITIS; HEPATOMA CELL; HOST CELL; HUMAN; HUMAN CELL; LIVER CELL; MALE; MICROSCOPY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMODIUM; PLASMODIUM BERGHEI; PROTOZOAL INFECTION; REPRODUCIBILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL LINE; ENZYMOLOGY; GENETICS; HUMAN GENOME; MALARIA; PARASITOLOGY; PATHOGENICITY; SPOROZOITE;

ANOPHELES (GENUS); MUS; PLASMODIUM BERGHEI; VERTEBRATA;

ANIMALS; CELL LINE; GENE SILENCING; GENOME, HUMAN; HEPATOCYTES; HUMANS; MALARIA; MICE; MICE, INBRED C57BL; PHOSPHOTRANSFERASES; PLASMODIUM BERGHEI; PROTEIN KINASE C; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SPOROZOITES;

EID: 57149119672     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000201     Document Type: Article

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