Genome-wide RNAi screen in IFN-γ-treated human macrophages identifies genes mediating resistance to the intracellular pathogen Francisella tularensis

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Zhou, Hongwei ^a,e   DeLoid, Glen ^a   Browning, Erica ^a   Gregory, David J ^a   Tan, Fengxiao ^a   Bedugnis, Alice S ^a   Imrich, Amy ^a   Koziel, Henry ^b   Kramnik, Igor ^c   Lu, Quan ^a   Kobzik, Lester ^a,d  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD137 ANTIGEN; GAMMA INTERFERON; MESSENGER RNA; SHORT HAIRPIN RNA; MICRORNA;

ARTICLE; BACTERIAL GENE; CONTROLLED STUDY; DRUG MECHANISM; FRANCISELLA TULARENSIS; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE REPLICATION; GENETIC RESISTANCE; GENETIC SCREENING; GENOME ANALYSIS; HOST RESISTANCE; HUMAN; HUMAN CELL; INFECTION RESISTANCE; LISTERIOSIS; LUNG ALVEOLUS MACROPHAGE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGEN CLEARANCE; RNA INTERFERENCE; TNFRSF9 GENE; TULAREMIA; VALIDATION PROCESS; CELL CULTURE; DRUG EFFECT; GENETIC ASSOCIATION; GENETICS; HUMAN GENOME; IMMUNITY; IMMUNOLOGY; MACROPHAGE; MICROBIOLOGY;

ANTIGENS, CD137; CELLS, CULTURED; FRANCISELLA TULARENSIS; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; HUMANS; IMMUNITY; INTERFERON-GAMMA; MACROPHAGES; MICRORNAS; RNA INTERFERENCE;

EID: 84863116601     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031752     Document Type: Article

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