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Volumn 107, Issue 8, 2010, Pages 3752-3757

Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression

Author keywords

Demethylase; HPV; LCR; Repression; Transcription

Indexed keywords

BRD4 PROTEIN; EP400 PROTEIN; GLYCOPROTEIN E2; SMALL INTERFERING RNA; SMCX PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

EID: 77649248469     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0914818107     Document Type: Article
Times cited : (128)

References (47)
  • 1
    • 34548182359 scopus 로고    scopus 로고
    • Papillomaviruses
    • eds Knipe DM, Howley PM Lippincott, Williams &Wilkins, Philadelphia, 5th Ed, pp
    • Howley PM, Lowy DR (2007) Papillomaviruses. Fields Virology, eds Knipe DM, Howley PM (Lippincott, Williams &Wilkins, Philadelphia), 5th Ed, pp 2299-2354.
    • (2007) Fields Virology , pp. 2299-2354
    • Howley, P.M.1    Lowy, D.R.2
  • 2
    • 59349121140 scopus 로고    scopus 로고
    • Papillomaviruses in the causation of human cancers - a brief historical account
    • zur Hausen H (2009) Papillomaviruses in the causation of human cancers - a brief historical account. Virology 384:260-265.
    • (2009) Virology , vol.384 , pp. 260-265
    • zur Hausen, H.1
  • 3
    • 0021845046 scopus 로고
    • Thephysical state of human papillomavirus type 16 DNA in benign and malignant genital tumours
    • Dürst M, Kleinheinz A, Hotz M, Gissmann L (1985)Thephysical state of human papillomavirus type 16 DNA in benign and malignant genital tumours. J Gen Virol 66:1515-1522.
    • (1985) J Gen Virol , vol.66 , pp. 1515-1522
    • Dürst, M.1    Kleinheinz, A.2    Hotz, M.3    Gissmann, L.4
  • 4
    • 0021986880 scopus 로고
    • Structure and transcription of human papillomavirus sequences in cervical carcinoma cells
    • Schwarz E, et al. (1985) Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature 314:111-114.
    • (1985) Nature , vol.314 , pp. 111-114
    • Schwarz, E.1
  • 5
    • 0022773680 scopus 로고
    • Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes
    • Schneider-Gädicke A, Schwarz E (1986) Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes. EMBO J 5:2285-2292.
    • (1986) EMBO J , vol.5 , pp. 2285-2292
    • Schneider-Gädicke, A.1    Schwarz, E.2
  • 6
    • 0023144684 scopus 로고
    • Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines
    • Baker CC, et al. (1987) Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines. J Virol 61:962-971.
    • (1987) J Virol , vol.61 , pp. 962-971
    • Baker, C.C.1
  • 7
    • 0023441712 scopus 로고
    • The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region
    • Thierry F, Yaniv M (1987) The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region. EMBO J 6:3391-3397.
    • (1987) EMBO J , vol.6 , pp. 3391-3397
    • Thierry, F.1    Yaniv, M.2
  • 8
    • 0024429348 scopus 로고
    • The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes
    • Bernard BA, et al. (1989) The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes. J Virol 63: 4317-4324.
    • (1989) J Virol , vol.63 , pp. 4317-4324
    • Bernard, B.A.1
  • 9
    • 0026061128 scopus 로고
    • Functional analysis of E2-mediated repression of the HPV18 P105 promoter
    • Thierry F, Howley PM (1991) Functional analysis of E2-mediated repression of the HPV18 P105 promoter. New Biol 3:90-100.
    • (1991) New Biol , vol.3 , pp. 90-100
    • Thierry, F.1    Howley, P.M.2
  • 10
    • 0027158747 scopus 로고
    • Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene
    • Hwang ES, et al. (1993) Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene. J Virol 67:3720-3729.
    • (1993) J Virol , vol.67 , pp. 3720-3729
    • Hwang, E.S.1
  • 11
    • 0028824891 scopus 로고
    • Suppression of cellular proliferation by the papillomavirus E2 protein
    • Dowhanick JJ, McBride AA, Howley PM (1995) Suppression of cellular proliferation by the papillomavirus E2 protein. J Virol 69:7791-7799.
    • (1995) J Virol , vol.69 , pp. 7791-7799
    • Dowhanick, J.J.1    McBride, A.A.2    Howley, P.M.3
  • 12
    • 0031025688 scopus 로고    scopus 로고
    • Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis
    • Desaintes C, Demeret C, Goyat S, Yaniv M, Thierry F (1997) Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis. EMBO J 16:504-514.
    • (1997) EMBO J , vol.16 , pp. 504-514
    • Desaintes, C.1    Demeret, C.2    Goyat, S.3    Yaniv, M.4    Thierry, F.5
  • 13
    • 0342948594 scopus 로고    scopus 로고
    • Repression of the integrated papillomavirus E6/E7 promoter is required for growth suppression of cervical cancer cells
    • Francis DA, Schmid SI, Howley PM (2000) Repression of the integrated papillomavirus E6/E7 promoter is required for growth suppression of cervical cancer cells. J Virol 74: 2679-2686.
    • (2000) J Virol , vol.74 , pp. 2679-2686
    • Francis, D.A.1    Schmid, S.I.2    Howley, P.M.3
  • 14
    • 0024076907 scopus 로고
    • Structural and mutational analysis of E2 trans-activating proteins of papillomaviruses reveals three distinct functional domains
    • Giri I, Yaniv M (1988) Structural and mutational analysis of E2 trans-activating proteins of papillomaviruses reveals three distinct functional domains. EMBO J 7:2823-2829.
    • (1988) EMBO J , vol.7 , pp. 2823-2829
    • Giri, I.1    Yaniv, M.2
  • 15
    • 0025953354 scopus 로고
    • The papillomavirus E2 regulatory proteins
    • McBride AA, Romanczuk H, Howley PM (1991) The papillomavirus E2 regulatory proteins. J Biol Chem 266:18411-18414.
    • (1991) J Biol Chem , vol.266 , pp. 18411-18414
    • McBride, A.A.1    Romanczuk, H.2    Howley, P.M.3
  • 16
    • 0028039853 scopus 로고
    • Human papillomavirus type 11 E2 proteins repress the homologous E6 promoter by interfering with the binding of host transcription factors to adjacent elements
    • Dong G, Broker TR, Chow LT (1994) Human papillomavirus type 11 E2 proteins repress the homologous E6 promoter by interfering with the binding of host transcription factors to adjacent elements. J Virol 68:1115-1127.
    • (1994) J Virol , vol.68 , pp. 1115-1127
    • Dong, G.1    Broker, T.R.2    Chow, L.T.3
  • 17
    • 0025950547 scopus 로고
    • The functional BPV-1 E2 trans-activating protein can act as a repressor by preventing formation of the initiation complex
    • Dostatni N, et al. (1991) The functional BPV-1 E2 trans-activating protein can act as a repressor by preventing formation of the initiation complex. Genes Dev 5:1657-1671.
    • (1991) Genes Dev , vol.5 , pp. 1657-1671
    • Dostatni, N.1
  • 18
    • 0031957756 scopus 로고    scopus 로고
    • Transactivationcompetent bovine papillomavirus E2 protein is specifically required for efficient repression of human papillomavirus oncogene expression and for acute growth inhibition of cervical carcinoma cell lines
    • Goodwin EC, Naeger LK, Breiding DE, Androphy EJ, DiMaio D (1998) Transactivationcompetent bovine papillomavirus E2 protein is specifically required for efficient repression of human papillomavirus oncogene expression and for acute growth inhibition of cervical carcinoma cell lines. J Virol 72:3925-3934.
    • (1998) J Virol , vol.72 , pp. 3925-3934
    • Goodwin, E.C.1    Naeger, L.K.2    Breiding, D.E.3    Androphy, E.J.4    DiMaio, D.5
  • 19
    • 0034026422 scopus 로고    scopus 로고
    • Mechanisms of human papillomavirus E2-mediated repression of viral oncogene expression and cervical cancer cell growth inhibition
    • Nishimura A, et al. (2000) Mechanisms of human papillomavirus E2-mediated repression of viral oncogene expression and cervical cancer cell growth inhibition. J Virol 74: 3752-3760.
    • (2000) J Virol , vol.74 , pp. 3752-3760
    • Nishimura, A.1
  • 20
    • 33748249631 scopus 로고    scopus 로고
    • Brd4 links chromatin targeting to HPV transcriptional silencing
    • Wu SY, et al. (2006) Brd4 links chromatin targeting to HPV transcriptional silencing. Genes Dev 20:2383-2396.
    • (2006) Genes Dev , vol.20 , pp. 2383-2396
    • Wu, S.Y.1
  • 21
    • 35348814352 scopus 로고    scopus 로고
    • Brd4-independent transcriptional repression function of the papillomavirus e2 proteins
    • Schweiger MR, Ottinger M, You J, Howley PM (2007) Brd4-independent transcriptional repression function of the papillomavirus e2 proteins. J Virol 81:9612-9622.
    • (2007) J Virol , vol.81 , pp. 9612-9622
    • Schweiger, M.R.1    Ottinger, M.2    You, J.3    Howley, P.M.4
  • 22
    • 33947302685 scopus 로고    scopus 로고
    • The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases
    • Iwase S, et al. (2007) The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell 128:1077-1088.
    • (2007) Cell , vol.128 , pp. 1077-1088
    • Iwase, S.1
  • 23
    • 34249900454 scopus 로고    scopus 로고
    • The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation
    • Tahiliani M, et al. (2007) The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature 447:601-605.
    • (2007) Nature , vol.447 , pp. 601-605
    • Tahiliani, M.1
  • 24
    • 1342346531 scopus 로고    scopus 로고
    • Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans
    • Doyon Y, Selleck W, Lane WS, Tan S, Côté J (2004) Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol 24:1884-1896.
    • (2004) Mol Cell Biol , vol.24 , pp. 1884-1896
    • Doyon, Y.1    Selleck, W.2    Lane, W.S.3    Tan, S.4    Côté, J.5
  • 25
    • 0035839104 scopus 로고    scopus 로고
    • The p400 complex is an essential E1A transformation target
    • Fuchs M, et al. (2001) The p400 complex is an essential E1A transformation target. Cell 106:297-307.
    • (2001) Cell , vol.106 , pp. 297-307
    • Fuchs, M.1
  • 26
    • 0021821058 scopus 로고
    • Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines
    • Yee C, Krishnan-Hewlett I, Baker CC, Schlegel R, Howley PM (1985) Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines. Am J Pathol 119:361-366.
    • (1985) Am J Pathol , vol.119 , pp. 361-366
    • Yee, C.1    Krishnan-Hewlett, I.2    Baker, C.C.3    Schlegel, R.4    Howley, P.M.5
  • 27
    • 2042468820 scopus 로고    scopus 로고
    • Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes
    • You J, Croyle JL, Nishimura A, Ozato K, Howley PM (2004) Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes. Cell 117:349-360.
    • (2004) Cell , vol.117 , pp. 349-360
    • You, J.1    Croyle, J.L.2    Nishimura, A.3    Ozato, K.4    Howley, P.M.5
  • 28
    • 70450223323 scopus 로고    scopus 로고
    • Cell-type specific transcriptional activities among different papillomavirus long control regions and their regulation by E2
    • Ottinger M, et al. (2009) Cell-type specific transcriptional activities among different papillomavirus long control regions and their regulation by E2. Virology 395:161-171.
    • (2009) Virology , vol.395 , pp. 161-171
    • Ottinger, M.1
  • 29
    • 39349097864 scopus 로고    scopus 로고
    • Identification of host proteins required for HIV infection through a functional genomic screen
    • Brass AL, et al. (2008) Identification of host proteins required for HIV infection through a functional genomic screen. Science 319:921-926.
    • (2008) Science , vol.319 , pp. 921-926
    • Brass, A.L.1
  • 30
    • 51049121572 scopus 로고    scopus 로고
    • Identification of genes that regulate epithelial cell migration using an siRNA screening approach
    • Simpson KJ, et al. (2008) Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Nat Cell Biol 10:1027-1038.
    • (2008) Nat Cell Biol , vol.10 , pp. 1027-1038
    • Simpson, K.J.1
  • 31
    • 0026586276 scopus 로고
    • Effects of Ad5 E1A mutant viruses on the cell cycle in relation to the binding of cellular proteins including the retinoblastoma protein and cyclin A
    • Howe JA, Bayley ST (1992) Effects of Ad5 E1A mutant viruses on the cell cycle in relation to the binding of cellular proteins including the retinoblastoma protein and cyclin A. Virology 186:15-24.
    • (1992) Virology , vol.186 , pp. 15-24
    • Howe, J.A.1    Bayley, S.T.2
  • 32
    • 0031060151 scopus 로고    scopus 로고
    • p300 Family members associate with the carboxyl terminus of simian virus 40 large tumor antigen
    • Lill NL, Tevethia MJ, Eckner R, Livingston DM, Modjtahedi N (1997) p300 Family members associate with the carboxyl terminus of simian virus 40 large tumor antigen. J Virol 71:129-137.
    • (1997) J Virol , vol.71 , pp. 129-137
    • Lill, N.L.1    Tevethia, M.J.2    Eckner, R.3    Livingston, D.M.4    Modjtahedi, N.5
  • 33
    • 37449019096 scopus 로고    scopus 로고
    • Repression of Smad3 activity by histone demethylase SMCX/JARID1C
    • Kim TD, Shin S, Janknecht R (2008) Repression of Smad3 activity by histone demethylase SMCX/JARID1C. Biochem Biophys Res Commun 366:563-567.
    • (2008) Biochem Biophys Res Commun , vol.366 , pp. 563-567
    • Kim, T.D.1    Shin, S.2    Janknecht, R.3
  • 34
    • 0037229178 scopus 로고    scopus 로고
    • Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cells
    • DeFilippis RA, Goodwin EC, Wu L, DiMaio D (2003) Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cells. J Virol 77:1551-1563.
    • (2003) J Virol , vol.77 , pp. 1551-1563
    • DeFilippis, R.A.1    Goodwin, E.C.2    Wu, L.3    DiMaio, D.4
  • 35
    • 2342478606 scopus 로고    scopus 로고
    • Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells
    • Psyrri A, et al. (2004) Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells. Cancer Res 64:3079-3086.
    • (2004) Cancer Res , vol.64 , pp. 3079-3086
    • Psyrri, A.1
  • 36
    • 33845626875 scopus 로고    scopus 로고
    • Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association
    • Abbate EA, Voitenleitner C, Botchan MR (2006) Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association. Mol Cell 24:877-889.
    • (2006) Mol Cell , vol.24 , pp. 877-889
    • Abbate, E.A.1    Voitenleitner, C.2    Botchan, M.R.3
  • 37
    • 0034682736 scopus 로고    scopus 로고
    • Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis
    • Ikura T, et al. (2000) Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell 102:463-473.
    • (2000) Cell , vol.102 , pp. 463-473
    • Ikura, T.1
  • 38
    • 0032467640 scopus 로고    scopus 로고
    • Tip60 acetylates six lysines of a specific class in core histones in vitro
    • Kimura A, Horikoshi M (1998) Tip60 acetylates six lysines of a specific class in core histones in vitro. Genes Cells 3:789-800.
    • (1998) Genes Cells , vol.3 , pp. 789-800
    • Kimura, A.1    Horikoshi, M.2
  • 39
    • 0041806599 scopus 로고    scopus 로고
    • The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis
    • Dey A, Chitsaz F, Abbasi A, Misteli T, Ozato K (2003) The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis. Proc Natl Acad Sci USA 100:8758-8763.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8758-8763
    • Dey, A.1    Chitsaz, F.2    Abbasi, A.3    Misteli, T.4    Ozato, K.5
  • 40
    • 33646140351 scopus 로고    scopus 로고
    • Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression
    • Tyteca S, Vandromme M, Legube G, Chevillard-Briet M, Trouche D (2006) Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression. EMBO J 25:1680-1689.
    • (2006) EMBO J , vol.25 , pp. 1680-1689
    • Tyteca, S.1    Vandromme, M.2    Legube, G.3    Chevillard-Briet, M.4    Trouche, D.5
  • 41
    • 34249705678 scopus 로고    scopus 로고
    • Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis
    • Ueda T, et al. (2007) Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis. Genes Cells 12:581-592.
    • (2007) Genes Cells , vol.12 , pp. 581-592
    • Ueda, T.1
  • 42
    • 63449140634 scopus 로고    scopus 로고
    • The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways
    • Mattera L, et al. (2009) The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways. Oncogene 28:1506-1517.
    • (2009) Oncogene , vol.28 , pp. 1506-1517
    • Mattera, L.1
  • 43
    • 35348962620 scopus 로고    scopus 로고
    • p400 function is required for the adenovirus E1A-mediated suppression of EGFR and tumour cell killing
    • Flinterman MB, et al. (2007) p400 function is required for the adenovirus E1A-mediated suppression of EGFR and tumour cell killing. Oncogene 26:6863-6874.
    • (2007) Oncogene , vol.26 , pp. 6863-6874
    • Flinterman, M.B.1
  • 44
    • 43149085045 scopus 로고    scopus 로고
    • Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc
    • Tworkowski KA, et al. (2008) Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc. Proc Natl Acad Sci USA 105:6103-6108.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 6103-6108
    • Tworkowski, K.A.1
  • 45
    • 0345390067 scopus 로고    scopus 로고
    • The chromatin structure of the long control region of human papillomavirus type 16 represses viral oncoprotein expression
    • Stünkel W, Bernard HU(1999) The chromatin structure of the long control region of human papillomavirus type 16 represses viral oncoprotein expression. J Virol 73:1918-1930.
    • (1999) J Virol , vol.73 , pp. 1918-1930
    • Stünkel, W.1    Bernard, H.U.2
  • 46
    • 33646205576 scopus 로고    scopus 로고
    • Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function
    • Schweiger MR, You J, Howley PM (2006) Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function. J Virol 80:4276-4285.
    • (2006) J Virol , vol.80 , pp. 4276-4285
    • Schweiger, M.R.1    You, J.2    Howley, P.M.3
  • 47
    • 72849149501 scopus 로고    scopus 로고
    • Yan J, Li Q, Lievens S, Tavernier J, You J (2010) Abrogation of the Brd4-P-TEFb positive transcription complex by the papillomavirus E2 protein contributes to the viral oncogene repression. J Virol 84:76-87.
    • Yan J, Li Q, Lievens S, Tavernier J, You J (2010) Abrogation of the Brd4-P-TEFb positive transcription complex by the papillomavirus E2 protein contributes to the viral oncogene repression. J Virol 84:76-87.


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