Spatial proximity of translocation-prone gene loci in human lymphomas

Nature Genetics

Volumn 34, Issue 3, 2003, Pages 287-291

  Roix, Jeffrey J ^a   McQueen, Philip G ^b   Munson, Peter J ^b   Parada, Luis A ^a   Misteli, Tom ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; B CELL LYMPHOMA; BCL GENE; CANCER CELL; CHROMOSOME BREAKAGE; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; GENE; GENE LOCATION; GENE LOCUS; GENE STRUCTURE; GENOME; GENOME ANALYSIS; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; LYMPHOMA; ONCOGENE MYC; PRIORITY JOURNAL; SPATIAL GENOME ORGANIZATION; SPATIAL PROXIMITY;

DNA-BINDING PROTEINS; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, MYC; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOMA, B-CELL; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-6; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 0038054340     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1177     Document Type: Article

References (29)

1. Rowley, J.D. The critical role of chromosome translocations in human leukemias. Annu. Rev. Genet. 32, 495-519 (1998).
2. Knudson, A.G. Two genetic hits (more or less) to cancer. Nat. Rev. Cancer 1, 157-162 (2001).
3. Elliott, B. & Jasin, M. Double-strand breaks and translocations in cancer. Cell Mol. Life Sci. 59, 373-385 (2002).
4. Mitelman, F. Recurrent chromosome aberrations in cancer. Mutat. Res. 462, 247-253 (2000).
5. Boxer, L.M. & Dang, C.V. Translocations involving c-myc and c-myc function. Oncogene 20, 5595-5610 (2001).
6. Harris, N.L. et al. New approaches to lymphoma diagnosis. Hematology 2001, 194-220 (2001).
7. Siebert, R., Rosenwald, A., Staudt, L.M. & Morris, S.W. Molecular features of B-cell lymphoma. Curr. Opin. Oncol. 13, 316-324 (2001).
8. Willis, T.G. & Dyer, M.J.S. The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies. Blood 96, 808-822 (2000).
9. Bartova, E. et al. The influence of the cell cycle, differentiation and irradiation on the nuclear location of the abl, bcr and c-mycgenes in human leukemic cells. Leuk. Res. 24, 233-241 (2000).
10. Bartova, E. et al. Nuclear topography of the c-myc gene in human leukemic cells. Gene 244, 1-11 (2000).
11. Kozubek, S. et al. 3D Structure of the human genome: order in randomness. Chromosoma 111, 321-331 (2002).
12. Neves, H., Ramos, C., da Silva, M.G., Parreira, A. & Parreira, L. The nuclear topography of ABL, BCR, PML, and RARα genes: evidence for gene proximity in specific phases of the cell cycle and stages of hematopoietic differentiation. Blood 93, 1197-1207 (1999).
13. Parreira, L. et al. The spatial distribution of human immunoglobulin genes within the nucleus: evidence for gene topography independent of cell type and transcriptional activity. Hum. Genet. 100, 588-594 (1997).
14. Lukasova, E. et al. Localisation and distance between ABL and BCR genes in interphase nuclei of bone marrow cells of control donors and patients with chronic myeloid leukaemia. Hum. Genet. 100, 525-535 (1997).
15. Sachs, R.K., Chen, A.M. & Brenner, D.J. Proximity effects in the production of chromosome aberrations by ionizing radiation. Int. J. Rad. Biol. 71, 1-19 (1997).
16. Parada, L., McQueen, P., Munson, P. & Misteli, T. Conservation of relative chromosome positioning in normal and cancer cells. Curr. Biol. 12, 1692-1697 (2002).
17. Parada, L. & Misteli, T. Chromosome positioning in the interphase nucleus. Trends Cell Biol. 12, 425-432 (2002).
18. Chubb, J.R., Boyle, S., Perry, P. & Bickmore, W.A. Chromatin motion is constrained by association with nuclear compartments in human cells. Curr. Biol. 12, 439-445 (2002).
19. Vazquez, J., Belmont, A.S. & Sedat, J.W. Multiple regimes of constrained chromosome motion are regulated in the interphase Drosophila nucleus. Curr. Biol. 11, 1227-1239 (2001).
20. Nikiforova, M.N. et al. Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells. Science 290, 138-141 (2000).
21. Haigis, K.M. & Dove, W.F. A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity. Nat. Genet. 33, 33-39 (2003).
22. Kosak, S.T. et al. Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science 296, 158-162 (2002).
23. Zhou, J., Ermakova, O.V., Riblet, R., Birshtein, B.K. & Schildkraut, C.L. Replication and subnuclear location dynamics of the immunoglobulin heavy-chain locus in B-lineage cells. Mol. Cell. Biol. 22, 4876-4889 (2002).
24. Stamatopoulos, K. et al. Molecular insights into the immunopathogenesis of follicular lymphoma. Immunol. Today 21, 298-305 (2000).
25. Skok, J.A. et al. Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes. Nat. Immunol. 2, 848-54 (2001).
26. Yoshida, S. et al. Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5′-RACE and LA-PCR analyses of biopsy samples. Oncogene 18, 7994-7999 (1999).
27. Chapter 14. Statistical description of data.in Numerical Recipes in C (eds. Press, W.H., Teuolskky, S.A., Vettering, W.T. and Flannery, B.P.) 609-655 (Cambridge University Press, Cambridge, 1992).
28. Stevens, M.A. Kolmogorov-Smernov Statistics. in Encyclopedia of Statistical Science vol. 4 (eds. Kotz, S. and Johnson, N.L.) 393-396 (Wiley and Sons, New York, 1982).
29. Fienberg, S.E. Contingency Tables. in Encyclopedia of Statistical Science vol. 2 (eds. Kotz, S. and Johnson, N.L.) 161-171 (Wiley and Sons, New York, 1982).