Somatic hypermutation of immunoglobulin genes is linked to transcription

Current Topics in Microbiology and Immunology

Volumn 229, Issue , 1997, Pages 11-19

  Storb, U ^a   Peters, A ^a   Klotz, E ^a   Kim, N ^a   Shen, H M ^a   Kage, K ^a   Rogerson, B ^b   Martin, T E ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b TRUDEAU INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; DOUBLE STRANDED DNA; RNA POLYMERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; B LYMPHOCYTE; DNA REPAIR; DNA STRAND; GENE REARRANGEMENT; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SOMATIC MUTATION; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE;

ANIMALS; B-LYMPHOCYTES; GENES, IMMUNOGLOBULIN; MODELS, GENETIC; MUTATION; TRANSCRIPTION, GENETIC;

ANIMALIA; MUS MUSCULUS;

EID: 0031443534     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (7)

1. Azuma T, Motoyama N, Fields L, Loh D (1993) Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer. Int Immunol 5:121-130
2. Betz A, Milstein C, Gonzalez-Fernandez R, Pannell R, Larson T, Neuberger M (1994) Elements regulating somatic hypermutation of an immunoglobulin κ gene: critical role for the intron enhancer/matrix attachment region. Cell 77:239-248
3. Eisenbeis C, Singh H, Storb U (1995) Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev 9:1377-1387
4. French D, Laskov R, Scharff M (1989) The role of somatic hypermutation in the generation of antibody diversity. Science 244:1152-1157
5. Friedberg E, Walker G, Siede W (1995) DNA repair and mutagenesis. American Society for Microbiology, Washington DC
6. Giusti A, Manser T (1993) Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation. J Exp Med 177:797-809
7. Golding G, Gearhart P, Glockman B (1987) Patterns of somatic mutation in immunoglobulin variable genes. Genetics 115:169-176