메뉴 건너뛰기




Volumn 15, Issue 1, 2013, Pages 53-69

Renal organic anion transporters (SLC22 Family): Expression, regulation, roles in toxicity, and impact on injury and disease

Author keywords

kidney; nephrotoxicity; proximal tubule; solute carrier

Indexed keywords

BESTATIN; BUMETANIDE; CAFFEIC ACID; DIAZEPAM; FERULIC ACID; GABOXADOL; GALLIC ACID; GEMCABENE; GEMFIBROZIL; GENTISIC ACID; INDOMETACIN; LITHOSPERMIC ACID; LUMIRACOXIB; MERCURY; MESNA; MIANSERIN; ORGANIC ANION TRANSPORTER; PARECOXIB; PHENOL DERIVATIVE; PRAVASTATIN; PROBENECID; PROTOCATECHUIC ACID; QUINAPRIL; RIFAMPICIN; ROSMARINIC ACID; SALAZOSULFAPYRIDINE; SALVIANOLIC ACID B; SINAPIC ACID; UNINDEXED DRUG; VANILLIC ACID;

EID: 84871983440     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-012-9413-y     Document Type: Review
Times cited : (124)

References (108)
  • 1
    • 65249139907 scopus 로고    scopus 로고
    • Analysis and update of the human solute carrier (SLC) gene superfamily
    • 19164095 1:CAS:528:DC%2BC3cXpt1yrsrg%3D 10.1186/1479-7364-3-2-195
    • He L, Vasiliou K, Nebert DW. Analysis and update of the human solute carrier (SLC) gene superfamily. Hum Genomics. 2009;3:195-206.
    • (2009) Hum Genomics , vol.3 , pp. 195-206
    • He, L.1    Vasiliou, K.2    Nebert, D.W.3
  • 2
    • 17444420647 scopus 로고    scopus 로고
    • Organic anion transporter (Slc22a) family members as mediators of toxicity
    • DOI 10.1016/j.taap.2004.10.016, Membrane Transporters in Toxicology
    • Sweet DH. Organic anion transporter (Slc22a) family members as mediators of toxicity. Toxicol Appl Pharmacol. 2005;204:198-215. (Pubitemid 40545228)
    • (2005) Toxicology and Applied Pharmacology , vol.204 , Issue.3 , pp. 198-215
    • Sweet, D.H.1
  • 3
    • 75349105185 scopus 로고    scopus 로고
    • Organic anion transporters: Discovery, pharmacology, regulation and roles in pathophysiology
    • 19953504 1:CAS:528:DC%2BD1MXhsF2jtrzM
    • VanWert AL, Gionfriddo MR, Sweet DH. Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology. Biopharm Drug Dispos. 2010;31:1-71.
    • (2010) Biopharm Drug Dispos , vol.31 , pp. 1-71
    • Vanwert, A.L.1    Gionfriddo, M.R.2    Sweet, D.H.3
  • 4
    • 85012839591 scopus 로고    scopus 로고
    • Renal organic cation and anion transport: From physiology to genes
    • C.A. McQueen (eds) Elsevier Oxford
    • Sweet DH. Renal organic cation and anion transport: from physiology to genes. In: McQueen CA, editor. Comprehensive toxicology, 2nd ed., vol. 7. Oxford: Elsevier; 2010. p. 23-53.
    • (2010) Comprehensive Toxicology, 2nd Ed., Vol. 7 , pp. 23-53
    • Sweet, D.H.1
  • 5
    • 77949922736 scopus 로고    scopus 로고
    • Identification of a novel organic anion transporter mediating carnitine transport in mouse liver and kidney
    • 20332632 1:CAS:528:DC%2BC3cXjslSktr8%3D 10.1159/000303060
    • Tsuchida H, Anzai N, Shin HJ, Wempe MF, Jutabha P, Enomoto A, et al. Identification of a novel organic anion transporter mediating carnitine transport in mouse liver and kidney. Cell Physiol Biochem. 2010;25:511-22.
    • (2010) Cell Physiol Biochem , vol.25 , pp. 511-522
    • Tsuchida, H.1    Anzai, N.2    Shin, H.J.3    Wempe, M.F.4    Jutabha, P.5    Enomoto, A.6
  • 7
    • 36348965458 scopus 로고    scopus 로고
    • Regulation of tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1 α/β and DNA methylation
    • DOI 10.1124/mol.107.039701
    • Kikuchi R, Kusuhara H, Hattori N, Kim I, Shiota K, Gonzalez FJ, et al. Regulation of tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1 alpha/beta and DNA methylation. Mol Pharmacol. 2007;72:1619-25. (Pubitemid 350146099)
    • (2007) Molecular Pharmacology , vol.72 , Issue.6 , pp. 1619-1625
    • Kikuchi, R.1    Kusuhara, H.2    Hattori, N.3    Kim, I.4    Shiota, K.5    Gonzalez, F.J.6    Sugiyama, Y.7
  • 9
    • 33747606242 scopus 로고    scopus 로고
    • Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1α/β and DNA methylation
    • DOI 10.1124/mol.106.025494
    • Kikuchi R, Kusuhara H, Hattori N, Shiota K, Kim I, Gonzalez FJ, et al. Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1alpha/beta and DNA methylation. Mol Pharmacol. 2006;70:887-96. (Pubitemid 44268446)
    • (2006) Molecular Pharmacology , vol.70 , Issue.3 , pp. 887-896
    • Kikuchi, R.1    Kusuhara, H.2    Hattori, N.3    Shiota, K.4    Kim, I.5    Gonzalez, F.J.6    Sugiyama, Y.7
  • 10
    • 84857247515 scopus 로고    scopus 로고
    • Regulation of tissue-specific expression of renal organic anion transporters by hepatocyte nuclear factor 1 alpha/beta and DNA methylation
    • 22160269 1:CAS:528:DC%2BC38XjtVSlu7c%3D 10.1124/jpet.111.187161
    • Jin L, Kikuchi R, Saji T, Kusuhara H, Sugiyama Y. Regulation of tissue-specific expression of renal organic anion transporters by hepatocyte nuclear factor 1 alpha/beta and DNA methylation. J Pharmacol Exp Ther. 2012;340:648-55.
    • (2012) J Pharmacol Exp Ther , vol.340 , pp. 648-655
    • Jin, L.1    Kikuchi, R.2    Saji, T.3    Kusuhara, H.4    Sugiyama, Y.5
  • 11
    • 78649949040 scopus 로고    scopus 로고
    • The human organic anion transporter genes OAT5 and OAT7 are transactivated by hepatocyte nuclear factor-1alpha (HNF-1alpha)
    • 20829431 1:CAS:528:DC%2BC3cXhsFGgu7nL 10.1124/mol.110.065201
    • Klein K, Jungst C, Mwinyi J, Stieger B, Krempler F, Patsch W, et al. The human organic anion transporter genes OAT5 and OAT7 are transactivated by hepatocyte nuclear factor-1alpha (HNF-1alpha). Mol Pharmacol. 2010;78:1079-87.
    • (2010) Mol Pharmacol , vol.78 , pp. 1079-1087
    • Klein, K.1    Jungst, C.2    Mwinyi, J.3    Stieger, B.4    Krempler, F.5    Patsch, W.6
  • 13
    • 17844385785 scopus 로고    scopus 로고
    • The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4α and suppressed by bile acids
    • DOI 10.1124/mol.104.010223
    • Popowski K, Eloranta JJ, Saborowski M, Fried M, Meier PJ, Kullak-Ublick GA. The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4 alpha and suppressed by bile acids. Mol Pharmacol. 2005;67:1629-38. (Pubitemid 40594162)
    • (2005) Molecular Pharmacology , vol.67 , Issue.5 , pp. 1629-1638
    • Popowski, K.1    Eloranta, J.J.2    Saborowski, M.3    Fried, M.4    Meier, P.J.5    Kullak-Ublick, G.A.6
  • 14
    • 84859970418 scopus 로고    scopus 로고
    • Male-dominant activation of rat renal organic anion transporter 1 (Oat1) and 3 (Oat3) expression by transcription factor BCL6
    • 22530049 1:CAS:528:DC%2BC38XmsVGhtrs%3D 10.1371/journal.pone.0035556
    • Wegner W, Burckhardt BC, Burckhardt G, Henjakovic M. Male-dominant activation of rat renal organic anion transporter 1 (Oat1) and 3 (Oat3) expression by transcription factor BCL6. PLoS One. 2012;7:e35556.
    • (2012) PLoS One , vol.7 , pp. 35556
    • Wegner, W.1    Burckhardt, B.C.2    Burckhardt, G.3    Henjakovic, M.4
  • 15
    • 73449110470 scopus 로고    scopus 로고
    • Angiotensin II inhibits activity of human organic anion transporter 3 through activation of protein kinase Calpha: Accelerating endocytosis of the transporter
    • 19878671 10.1016/j.ejphar.2009.10.048 1:CAS:528:DC%2BC3cXksVegsQ%3D%3D
    • Duan P, Li S, You G. Angiotensin II inhibits activity of human organic anion transporter 3 through activation of protein kinase Calpha: accelerating endocytosis of the transporter. Eur J Pharmacol. 2009;627:49-55.
    • (2009) Eur J Pharmacol , vol.627 , pp. 49-55
    • Duan, P.1    Li, S.2    You, G.3
  • 16
    • 77952374820 scopus 로고    scopus 로고
    • Regulation of human organic anion transporter 3 by peptide hormone bradykinin
    • 20299424 1:CAS:528:DC%2BC3cXmvFCltrs%3D 10.1124/jpet.110.165472
    • Li S, Duan P, You G. Regulation of human organic anion transporter 3 by peptide hormone bradykinin. J Pharmacol Exp Ther. 2010;333:970-5.
    • (2010) J Pharmacol Exp Ther , vol.333 , pp. 970-975
    • Li, S.1    Duan, P.2    You, G.3
  • 17
    • 59149087698 scopus 로고    scopus 로고
    • Activation of protein kinase Czeta increases OAT1 (SLC22A6)- and OAT3 (SLC22A8)-mediated transport
    • 19028678 1:CAS:528:DC%2BD1MXpsV2jtw%3D%3D 10.1074/jbc.M808078200
    • Barros SA, Srimaroeng C, Perry JL, Walden R, Dembla-Rajpal N, Sweet DH, et al. Activation of protein kinase Czeta increases OAT1 (SLC22A6)- and OAT3 (SLC22A8)-mediated transport. J Biol Chem. 2009;284:2672-9.
    • (2009) J Biol Chem , vol.284 , pp. 2672-2679
    • Barros, S.A.1    Srimaroeng, C.2    Perry, J.L.3    Walden, R.4    Dembla-Rajpal, N.5    Sweet, D.H.6
  • 18
    • 0037427506 scopus 로고    scopus 로고
    • Organic anion and cation transporters occur in pairs of similar and similarly expressed genes
    • DOI 10.1016/S0006-291X(02)02853-X, PII S0006291X0202853X
    • Eraly SA, Hamilton BA, Nigam SK. Organic anion and cation transporters occur in pairs of similar and similarly expressed genes. Biochem Biophys Res Commun. 2003;300:333-42. (Pubitemid 38379656)
    • (2003) Biochemical and Biophysical Research Communications , vol.300 , Issue.2 , pp. 333-342
    • Eraly, S.A.1    Hamilton, B.A.2    Nigam, S.K.3
  • 20
    • 0026558715 scopus 로고
    • LFB1 and LFB3 homeoproteins are sequentially expressed during kidney development
    • 1350532 1:CAS:528:DyaK38XitFWlurY%3D
    • Lazzaro D, De Simone V, De Magistris L, Lehtonen E, Cortese R. LFB1 and LFB3 homeoproteins are sequentially expressed during kidney development. Development. 1992;114:469-79.
    • (1992) Development , vol.114 , pp. 469-479
    • Lazzaro, D.1    De Simone, V.2    De Magistris, L.3    Lehtonen, E.4    Cortese, R.5
  • 21
    • 33745952758 scopus 로고    scopus 로고
    • Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1α
    • DOI 10.1016/j.bcp.2006.03.016, PII S0006295206001882
    • Maher JM, Slitt AL, Callaghan TN, Cheng X, Cheung C, Gonzalez FJ, et al. Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha. Biochem Pharmacol. 2006;72:512-22. (Pubitemid 44061742)
    • (2006) Biochemical Pharmacology , vol.72 , Issue.4 , pp. 512-522
    • Maher, J.M.1    Slitt, A.L.2    Callaghan, T.N.3    Cheng, X.4    Cheung, C.5    Gonzalez, F.J.6    Klaassen, C.D.7
  • 22
    • 0035991421 scopus 로고    scopus 로고
    • Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy
    • DOI 10.1046/j.1523-1755.2002.00464.x
    • Ji L, Masuda S, Saito H, Inui K. Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy. Kidney Int. 2002;62:514-24. (Pubitemid 34779762)
    • (2002) Kidney International , vol.62 , Issue.2 , pp. 514-524
    • Ji, L.1    Masuda, S.2    Saito, H.3    Inui, K.-I.4
  • 24
    • 79960615869 scopus 로고    scopus 로고
    • Effects of chronic renal failure on kidney drug transporters and cytochrome P450 in rats
    • 21525170 1:CAS:528:DC%2BC3MXps1yqt7o%3D 10.1124/dmd.111.039115
    • Naud J, Michaud J, Beauchemin S, Hebert MJ, Roger M, Lefrancois S, et al. Effects of chronic renal failure on kidney drug transporters and cytochrome P450 in rats. Drug Metab Dispos. 2011;39:1363-9.
    • (2011) Drug Metab Dispos , vol.39 , pp. 1363-1369
    • Naud, J.1    Michaud, J.2    Beauchemin, S.3    Hebert, M.J.4    Roger, M.5    Lefrancois, S.6
  • 25
    • 34248997530 scopus 로고    scopus 로고
    • Alteration in renal organic anion transporter 1 after ischemia/reperfusion in cadaveric renal allografts
    • DOI 10.1369/jhc.6A7130.2007
    • Kwon O, Hong SM, Blouch K. Alteration in renal organic anion transporter 1 after ischemia/reperfusion in cadaveric renal allografts. J Histochem Cytochem. 2007;55:575-84. (Pubitemid 46791940)
    • (2007) Journal of Histochemistry and Cytochemistry , vol.55 , Issue.6 , pp. 575-584
    • Kwon, O.1    Hong, S.-M.2    Blouch, K.3
  • 26
    • 57349102370 scopus 로고    scopus 로고
    • Renal organic anion transporter 1 is maldistributed and diminishes in proximal tubule cells but increases in vasculature after ischemia and reperfusion
    • 18922885 1:CAS:528:DC%2BD1cXhsFSnur3P 10.1152/ajprenal.90409.2008
    • Kwon O, Wang WW, Miller S. Renal organic anion transporter 1 is maldistributed and diminishes in proximal tubule cells but increases in vasculature after ischemia and reperfusion. Am J Physiol Renal Physiol. 2008;295:F1807-16.
    • (2008) Am J Physiol Renal Physiol , vol.295 , pp. 1807-1816
    • Kwon, O.1    Wang, W.W.2    Miller, S.3
  • 29
    • 58149095489 scopus 로고    scopus 로고
    • Oat5 and NaDC1 protein abundance in kidney and urine after renal ischemic reperfusion injury
    • 18796410 10.1369/jhc.2008.951582 1:CAS:528:DC%2BD1MXis1ahsQ%3D%3D
    • Di Giusto G, Anzai N, Endou H, Torres AM. Oat5 and NaDC1 protein abundance in kidney and urine after renal ischemic reperfusion injury. J Histochem Cytochem. 2009;57:17-27.
    • (2009) J Histochem Cytochem , vol.57 , pp. 17-27
    • Di Giusto, G.1    Anzai, N.2    Endou, H.3    Torres, A.M.4
  • 30
    • 84859353768 scopus 로고    scopus 로고
    • Urinary organic anion transporter protein profiles in AKI
    • 21945944 1:CAS:528:DC%2BC38XltFGktLs%3D 10.1093/ndt/gfr541
    • Kunin M, Holtzman EJ, Melnikov S, Dinour D. Urinary organic anion transporter protein profiles in AKI. Nephrol Dial Transplant. 2012;27:1387-95.
    • (2012) Nephrol Dial Transplant , vol.27 , pp. 1387-1395
    • Kunin, M.1    Holtzman, E.J.2    Melnikov, S.3    Dinour, D.4
  • 31
    • 79961135233 scopus 로고    scopus 로고
    • Differences in the substrate binding regions of renal organic anion transporters 1 (OAT1) and 3 (OAT3)
    • 21543413 1:CAS:528:DC%2BC3MXhtFSrtbjE 10.1152/ajprenal.00735.2010
    • Astorga B, Wunz TM, Morales M, Wright SH, Pelis RM. Differences in the substrate binding regions of renal organic anion transporters 1 (OAT1) and 3 (OAT3). Am J Physiol Renal Physiol. 2011;301:F378-86.
    • (2011) Am J Physiol Renal Physiol , vol.301 , pp. 378-386
    • Astorga, B.1    Wunz, T.M.2    Morales, M.3    Wright, S.H.4    Pelis, R.M.5
  • 32
    • 77649093398 scopus 로고    scopus 로고
    • Organic anion transporter 3 (OAT3) and renal transport of the metal chelator 2,3-dimercapto-1-propanesulfonic acid (DMPS)
    • 20237588 10.1139/Y09-123 1:CAS:528:DC%2BC3cXisFWisLc%3D
    • Rodiger M, Zhang X, Ugele B, Gersdorff N, Wright SH, Burckhardt G, et al. Organic anion transporter 3 (OAT3) and renal transport of the metal chelator 2,3-dimercapto-1-propanesulfonic acid (DMPS). Can J Physiol Pharmacol. 2010;88:141-6.
    • (2010) Can J Physiol Pharmacol , vol.88 , pp. 141-146
    • Rodiger, M.1    Zhang, X.2    Ugele, B.3    Gersdorff, N.4    Wright, S.H.5    Burckhardt, G.6
  • 33
    • 84864124149 scopus 로고    scopus 로고
    • 3-Monoglucuronyl-glycyrrhretinic acid is a substrate of organic anion transporters expressed in tubular epithelial cells and plays important roles in licorice-induced pseudoaldosteronism by inhibiting 11beta-hydroxysteroid dehydrogenase 2
    • 22543032 1:CAS:528:DC%2BC38XhtVOru7nN 10.1124/jpet.111.190009
    • Makino T, Okajima K, Uebayashi R, Ohtake N, Inoue K, Mizukami H. 3-Monoglucuronyl-glycyrrhretinic acid is a substrate of organic anion transporters expressed in tubular epithelial cells and plays important roles in licorice-induced pseudoaldosteronism by inhibiting 11beta-hydroxysteroid dehydrogenase 2. J Pharmacol Exp Ther. 2012;342:297-304.
    • (2012) J Pharmacol Exp Ther , vol.342 , pp. 297-304
    • Makino, T.1    Okajima, K.2    Uebayashi, R.3    Ohtake, N.4    Inoue, K.5    Mizukami, H.6
  • 34
    • 77952591501 scopus 로고    scopus 로고
    • Transport of aminopterin by human organic anion transporters hOAT1 and hOAT3: Comparison with methotrexate
    • 20460822 1:CAS:528:DC%2BC3cXovVWqtLc%3D 10.2133/dmpk.25.163
    • Uwai Y, Iwamoto K. Transport of aminopterin by human organic anion transporters hOAT1 and hOAT3: comparison with methotrexate. Drug Metab Pharmacokinet. 2010;25:163-9.
    • (2010) Drug Metab Pharmacokinet , vol.25 , pp. 163-169
    • Uwai, Y.1    Iwamoto, K.2
  • 35
    • 79957548529 scopus 로고    scopus 로고
    • Interactions of human organic anion transporter 1 (hOAT1) with substances associated with forensic toxicology
    • 1:CAS:528:DC%2BC3MXmvFChu78%3D 10.1016/j.legalmed.2011.04.001
    • Chiba S, Ikawa T, Takeshita H, Ichiba K, Sagi M, Mukai T, et al. Interactions of human organic anion transporter 1 (hOAT1) with substances associated with forensic toxicology. Leg Med (Tokyo). 2011;13:180-5.
    • (2011) Leg Med (Tokyo) , vol.13 , pp. 180-185
    • Chiba, S.1    Ikawa, T.2    Takeshita, H.3    Ichiba, K.4    Sagi, M.5    Mukai, T.6
  • 36
    • 80052406750 scopus 로고    scopus 로고
    • Linkage of organic anion transporter-1 to metabolic pathways through integrated "omics"-driven network and functional analysis
    • 21757732 1:CAS:528:DC%2BC3MXhtFaitbvN 10.1074/jbc.M111.272534
    • Ahn SY, Jamshidi N, Mo ML, Wu W, Eraly SA, Dnyanmote A, et al. Linkage of organic anion transporter-1 to metabolic pathways through integrated "omics"-driven network and functional analysis. J Biol Chem. 2011;286:31522-31.
    • (2011) J Biol Chem , vol.286 , pp. 31522-31531
    • Ahn, S.Y.1    Jamshidi, N.2    Mo, M.L.3    Wu, W.4    Eraly, S.A.5    Dnyanmote, A.6
  • 37
    • 69449105950 scopus 로고    scopus 로고
    • Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy
    • 19643159 1:CAS:528:DC%2BD1MXhtV2lt7zF 10.1016/j.tox.2009.07.014
    • Bakhiya N, Arlt VM, Bahn A, Burckhardt G, Phillips DH, Glatt H. Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy. Toxicology. 2009;264:74-9.
    • (2009) Toxicology , vol.264 , pp. 74-79
    • Bakhiya, N.1    Arlt, V.M.2    Bahn, A.3    Burckhardt, G.4    Phillips, D.H.5    Glatt, H.6
  • 38
    • 77953814077 scopus 로고    scopus 로고
    • Interactions of human organic anion transporters with aristolochic acids
    • 20508390 1:CAS:528:DC%2BC3cXos1Ojsr8%3D 10.1254/jphs.09339SC
    • Babu E, Takeda M, Nishida R, Noshiro-Kofuji R, Yoshida M, Ueda S, et al. Interactions of human organic anion transporters with aristolochic acids. J Pharmacol Sci. 2010;113:192-6.
    • (2010) J Pharmacol Sci , vol.113 , pp. 192-196
    • Babu, E.1    Takeda, M.2    Nishida, R.3    Noshiro-Kofuji, R.4    Yoshida, M.5    Ueda, S.6
  • 39
    • 82955169689 scopus 로고    scopus 로고
    • Critical role of organic anion transporters 1 and 3 in kidney accumulation and toxicity of aristolochic acid i
    • 21980933 1:CAS:528:DC%2BC3MXhtlertLvP 10.1021/mp100418u
    • Xue X, Gong LK, Maeda K, Luan Y, Qi XM, Sugiyama Y, et al. Critical role of organic anion transporters 1 and 3 in kidney accumulation and toxicity of aristolochic acid I. Mol Pharm. 2011;8:2183-92.
    • (2011) Mol Pharm , vol.8 , pp. 2183-2192
    • Xue, X.1    Gong, L.K.2    Maeda, K.3    Luan, Y.4    Qi, X.M.5    Sugiyama, Y.6
  • 40
    • 79960527351 scopus 로고    scopus 로고
    • Physiological and molecular characterization of aristolochic acid transport by the kidney
    • 21546538 1:CAS:528:DC%2BC3MXpvFelsr4%3D 10.1124/jpet.111.180984
    • Dickman KG, Sweet DH, Bonala R, Ray T, Wu A. Physiological and molecular characterization of aristolochic acid transport by the kidney. J Pharmacol Exp Ther. 2011;338:588-97.
    • (2011) J Pharmacol Exp Ther , vol.338 , pp. 588-597
    • Dickman, K.G.1    Sweet, D.H.2    Bonala, R.3    Ray, T.4    Wu, A.5
  • 41
    • 84865269067 scopus 로고    scopus 로고
    • Organic anion transporter 1 (OAT1) involved in renal cell transport of aristolochic acid i
    • Zeng Y, Zhang R, Wu J, Liu M, Peng W, Yu X, et al. Organic anion transporter 1 (OAT1) involved in renal cell transport of aristolochic acid I. Hum Exp Toxicol 2012; 31: 759-70.
    • (2012) Hum Exp Toxicol , vol.31 , pp. 759-770
    • Zeng, Y.1    Zhang, R.2    Wu, J.3    Liu, M.4    Peng, W.5    Yu, X.6
  • 42
    • 84862822311 scopus 로고    scopus 로고
    • Organic anion transporters involved in the excretion of bestatin in the kidney
    • 22273603 1:CAS:528:DC%2BC38XjtlOrsLk%3D 10.1016/j.peptides.2012.01.007
    • Zhu Y, Meng Q, Wang C, Liu Q, Sun H, Kaku T, et al. Organic anion transporters involved in the excretion of bestatin in the kidney. Peptides. 2012;33:265-71.
    • (2012) Peptides , vol.33 , pp. 265-271
    • Zhu, Y.1    Meng, Q.2    Wang, C.3    Liu, Q.4    Sun, H.5    Kaku, T.6
  • 43
    • 79956110490 scopus 로고    scopus 로고
    • Interaction of hydroxycinnamic acids and their conjugates with organic anion transporters and ATP-binding cassette transporters
    • 21538853 1:CAS:528:DC%2BC3MXotlKhs70%3D 10.1002/mnfr.201000652
    • Wong CC, Barron D, Orfila C, Dionisi F, Krajcsi P, Williamson G. Interaction of hydroxycinnamic acids and their conjugates with organic anion transporters and ATP-binding cassette transporters. Mol Nutr Food Res. 2011;55:979-88.
    • (2011) Mol Nutr Food Res , vol.55 , pp. 979-988
    • Wong, C.C.1    Barron, D.2    Orfila, C.3    Dionisi, F.4    Krajcsi, P.5    Williamson, G.6
  • 44
    • 80055099306 scopus 로고    scopus 로고
    • Inhibitory effect of caffeic acid on human organic anion transporters hOAT1 and hOAT3: A novel candidate for food-drug interaction
    • 21697612 1:CAS:528:DC%2BC3MXhs1Gqt7fE 10.2133/dmpk.DMPK-11-RG-020
    • Uwai Y, Ozeki Y, Isaka T, Honjo H, Iwamoto K. Inhibitory effect of caffeic acid on human organic anion transporters hOAT1 and hOAT3: a novel candidate for food-drug interaction. Drug Metab Pharmacokinet. 2011;26:486-93.
    • (2011) Drug Metab Pharmacokinet , vol.26 , pp. 486-493
    • Uwai, Y.1    Ozeki, Y.2    Isaka, T.3    Honjo, H.4    Iwamoto, K.5
  • 45
    • 77952297570 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between JBP485 and cephalexin in rats
    • 20219852 1:CAS:528:DC%2BC3cXmvVCjt7s%3D 10.1124/dmd.110.032060
    • Zhang J, Wang C, Liu Q, Meng Q, Cang J, Sun H, et al. Pharmacokinetic interaction between JBP485 and cephalexin in rats. Drug Metab Dispos. 2010;38:930-8.
    • (2010) Drug Metab Dispos , vol.38 , pp. 930-938
    • Zhang, J.1    Wang, C.2    Liu, Q.3    Meng, Q.4    Cang, J.5    Sun, H.6
  • 46
    • 79952575127 scopus 로고    scopus 로고
    • Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6)
    • 21244849 1:CAS:528:DC%2BC3MXjtFGkt7o%3D 10.1016/j.bcp.2011.01.004
    • Wong CC, Botting NP, Orfila C, Al-Maharik N, Williamson G. Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6). Biochem Pharmacol. 2011;81:942-9.
    • (2011) Biochem Pharmacol , vol.81 , pp. 942-949
    • Wong, C.C.1    Botting, N.P.2    Orfila, C.3    Al-Maharik, N.4    Williamson, G.5
  • 47
    • 84866080438 scopus 로고    scopus 로고
    • Potential for food-drug interactions by dietary phenolic acids on human organic anion transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11)
    • Wang L, Sweet DH. Potential for food-drug interactions by dietary phenolic acids on human organic anion transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11). Biochem Pharmacol. 2012;84:1088-95.
    • (2012) Biochem Pharmacol. , vol.84 , pp. 1088-1095
    • Wang, L.1    Sweet, D.H.2
  • 48
    • 73749084701 scopus 로고    scopus 로고
    • 5-Hydroxy-L-tryptophan alters gaboxadol pharmacokinetics in rats: Involvement of PAT1 and rOat1 in gaboxadol absorption and elimination
    • 19900542 1:CAS:528:DC%2BC3cXotVylsA%3D%3D 10.1016/j.ejps.2009.10.013
    • Larsen M, Holm R, Jensen KG, Sveigaard C, Brodin B, Nielsen CU. 5-Hydroxy-L-tryptophan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination. Eur J Pharm Sci. 2010;39:68-75.
    • (2010) Eur J Pharm Sci , vol.39 , pp. 68-75
    • Larsen, M.1    Holm, R.2    Jensen, K.G.3    Sveigaard, C.4    Brodin, B.5    Nielsen, C.U.6
  • 49
    • 79958226930 scopus 로고    scopus 로고
    • Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1)
    • 21476605 1:CAS:528:DC%2BC3MXltVyjtr0%3D 10.1021/pr200093w
    • Wikoff WR, Nagle MA, Kouznetsova VL, Tsigelny IF, Nigam SK. Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1). J Proteome Res. 2011;10:2842-51.
    • (2011) J Proteome Res , vol.10 , pp. 2842-2851
    • Wikoff, W.R.1    Nagle, M.A.2    Kouznetsova, V.L.3    Tsigelny, I.F.4    Nigam, S.K.5
  • 50
    • 84864910209 scopus 로고    scopus 로고
    • Active hydrophilic components of the medicinal herb salvia miltiorrhiza (Danshen) potently inhibit organic anion transporters 1 (Slc22a6) and 3 (Slc22a8)
    • Article ID: 872458
    • Wang L, Sweet DH. Active hydrophilic components of the medicinal herb salvia miltiorrhiza (Danshen) potently inhibit organic anion transporters 1 (Slc22a6) and 3 (Slc22a8). Evid Based Complement Alternat Med. 2012;2012:(Article ID: 872458).
    • (2012) Evid Based Complement Alternat Med. 2012
    • Wang, L.1    Sweet, D.H.2
  • 51
    • 78449257506 scopus 로고    scopus 로고
    • Inhibitory effect of selective cyclooxygenase-2 inhibitor lumiracoxib on human organic anion transporters hOAT1 and hOAT3
    • 20877132 1:CAS:528:DC%2BC3cXhs1artLzL 10.2133/dmpk.DMPK-10-RG-048
    • Uwai Y, Honjo H, Iwamoto K. Inhibitory effect of selective cyclooxygenase-2 inhibitor lumiracoxib on human organic anion transporters hOAT1 and hOAT3. Drug Metab Pharmacokinet. 2010;25:450-5.
    • (2010) Drug Metab Pharmacokinet , vol.25 , pp. 450-455
    • Uwai, Y.1    Honjo, H.2    Iwamoto, K.3
  • 52
    • 79953676852 scopus 로고    scopus 로고
    • Inhibitory effects of ketoconazole and rifampin on OAT1 and OATP1B1 transport activities: Considerations on drug-drug interactions
    • 21456052 1:CAS:528:DC%2BC3MXktVOju7k%3D 10.1002/bdd.749
    • Choi MK, Jin QR, Choi YL, Ahn SH, Bae MA, Song IS. Inhibitory effects of ketoconazole and rifampin on OAT1 and OATP1B1 transport activities: considerations on drug-drug interactions. Biopharm Drug Dispos. 2011;32:175-84.
    • (2011) Biopharm Drug Dispos , vol.32 , pp. 175-184
    • Choi, M.K.1    Jin, Q.R.2    Choi, Y.L.3    Ahn, S.H.4    Bae, M.A.5    Song, I.S.6
  • 53
    • 79955691418 scopus 로고    scopus 로고
    • In vitro risk assessment of AZD9056 perpetrating a transporter-mediated drug-drug interaction with methotrexate
    • 21440623 1:CAS:528:DC%2BC3MXlvVygur0%3D 10.1016/j.ejps.2011.03.006
    • Elsby R, Fox L, Stresser D, Layton M, Butters C, Sharma P, et al. In vitro risk assessment of AZD9056 perpetrating a transporter-mediated drug-drug interaction with methotrexate. Eur J Pharm Sci. 2011;43:41-9.
    • (2011) Eur J Pharm Sci , vol.43 , pp. 41-49
    • Elsby, R.1    Fox, L.2    Stresser, D.3    Layton, M.4    Butters, C.5    Sharma, P.6
  • 54
    • 79955998480 scopus 로고    scopus 로고
    • OAT2 catalyses efflux of glutamate and uptake of orotic acid
    • 21446918 1:CAS:528:DC%2BC3MXmtFGitr8%3D 10.1042/BJ20101904
    • Fork C, Bauer T, Golz S, Geerts A, Weiland J, Del Turco D, et al. OAT2 catalyses efflux of glutamate and uptake of orotic acid. Biochem J. 2011;436:305-12.
    • (2011) Biochem J , vol.436 , pp. 305-312
    • Fork, C.1    Bauer, T.2    Golz, S.3    Geerts, A.4    Weiland, J.5    Del Turco, D.6
  • 55
    • 77649212118 scopus 로고    scopus 로고
    • Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human
    • 20190416 1:CAS:528:DC%2BC3cXos1Ons7o%3D 10.1248/bpb.33.498
    • Sato M, Mamada H, Anzai N, Shirasaka Y, Nakanishi T, Tamai I. Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human. Biol Pharm Bull. 2010;33:498-503.
    • (2010) Biol Pharm Bull , vol.33 , pp. 498-503
    • Sato, M.1    Mamada, H.2    Anzai, N.3    Shirasaka, Y.4    Nakanishi, T.5    Tamai, I.6
  • 56
    • 77956235037 scopus 로고    scopus 로고
    • Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1)
    • 20519552 1:CAS:528:DC%2BC3cXhtFyksLzF 10.1124/jpet.110.170753
    • Lai Y, Sampson KE, Balogh LM, Brayman TG, Cox SR, Adams WJ, et al. Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1). J Pharmacol Exp Ther. 2010;334:936-44.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 936-944
    • Lai, Y.1    Sampson, K.E.2    Balogh, L.M.3    Brayman, T.G.4    Cox, S.R.5    Adams, W.J.6
  • 57
    • 77956237495 scopus 로고    scopus 로고
    • Organic anion transporter 6 (Slc22a20) specificity and Sertoli cell-specific expression provide new insight on potential endogenous roles
    • 20519554 1:CAS:528:DC%2BC3cXhtFyksLzE 10.1124/jpet.110.168765
    • Schnabolk GW, Gupta B, Mulgaonkar A, Kulkarni M, Sweet DH. Organic anion transporter 6 (Slc22a20) specificity and Sertoli cell-specific expression provide new insight on potential endogenous roles. J Pharmacol Exp Ther. 2010;334:927-35.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 927-935
    • Schnabolk, G.W.1    Gupta, B.2    Mulgaonkar, A.3    Kulkarni, M.4    Sweet, D.H.5
  • 58
    • 77953812855 scopus 로고    scopus 로고
    • Drug interaction between celecoxib and methotrexate in organic anion transporter 3-transfected renal cells and in rats in vivo
    • 20478302 1:CAS:528:DC%2BC3cXnvVOhtbk%3D 10.1016/j.ejphar.2010.04.051
    • Maeda A, Tsuruoka S, Ushijima K, Kanai Y, Endou H, Saito K, et al. Drug interaction between celecoxib and methotrexate in organic anion transporter 3-transfected renal cells and in rats in vivo. Eur J Pharmacol. 2010;640:168-71.
    • (2010) Eur J Pharmacol , vol.640 , pp. 168-171
    • Maeda, A.1    Tsuruoka, S.2    Ushijima, K.3    Kanai, Y.4    Endou, H.5    Saito, K.6
  • 59
    • 79954990740 scopus 로고    scopus 로고
    • Organic anion transporter 3 mediates the efflux transport of an amphipathic organic anion, dehydroepiandrosterone sulfate, across the blood-brain barrier in mice
    • 21325432 1:CAS:528:DC%2BC3MXls1Ojtbs%3D 10.1124/dmd.110.036863
    • Miyajima M, Kusuhara H, Fujishima M, Adachi Y, Sugiyama Y. Organic anion transporter 3 mediates the efflux transport of an amphipathic organic anion, dehydroepiandrosterone sulfate, across the blood-brain barrier in mice. Drug Metab Dispos. 2011;39:814-9.
    • (2011) Drug Metab Dispos , vol.39 , pp. 814-819
    • Miyajima, M.1    Kusuhara, H.2    Fujishima, M.3    Adachi, Y.4    Sugiyama, Y.5
  • 60
    • 77956921025 scopus 로고    scopus 로고
    • Characterization of cellular uptake of perfluorooctanoate via organic anion-transporting polypeptide 1A2, organic anion transporter 4, and urate transporter 1 for their potential roles in mediating human renal reabsorption of perfluorocarboxylates
    • 20639259 1:CAS:528:DC%2BC3cXhtFyltb3I 10.1093/toxsci/kfq219
    • Yang CH, Glover KP, Han X. Characterization of cellular uptake of perfluorooctanoate via organic anion-transporting polypeptide 1A2, organic anion transporter 4, and urate transporter 1 for their potential roles in mediating human renal reabsorption of perfluorocarboxylates. Toxicol Sci. 2010;117:294-302.
    • (2010) Toxicol Sci , vol.117 , pp. 294-302
    • Yang, C.H.1    Glover, K.P.2    Han, X.3
  • 61
    • 79551532461 scopus 로고    scopus 로고
    • Interactions of urate transporter URAT1 in human kidney with uricosuric drugs
    • 1:CAS:528:DC%2BC3MXjsFWrsbc%3D 10.1111/j.1440-1797.2010.01368.x
    • Shin HJ, Takeda M, Enomoto A, Fujimura M, Miyazaki H, Anzai N, et al. Interactions of urate transporter URAT1 in human kidney with uricosuric drugs. Nephrology (Carlton). 2011;16:156-62.
    • (2011) Nephrology (Carlton) , vol.16 , pp. 156-162
    • Shin, H.J.1    Takeda, M.2    Enomoto, A.3    Fujimura, M.4    Miyazaki, H.5    Anzai, N.6
  • 62
    • 75749156653 scopus 로고    scopus 로고
    • Effect of fenofibrate on uric acid metabolism and urate transporter 1
    • 20075570 1:CAS:528:DC%2BC38XhsVOmurfP 10.2169/internalmedicine.49.2597
    • Uetake D, Ohno I, Ichida K, Yamaguchi Y, Saikawa H, Endou H, et al. Effect of fenofibrate on uric acid metabolism and urate transporter 1. Intern Med. 2010;49:89-94.
    • (2010) Intern Med , vol.49 , pp. 89-94
    • Uetake, D.1    Ohno, I.2    Ichida, K.3    Yamaguchi, Y.4    Saikawa, H.5    Endou, H.6
  • 63
    • 77957949037 scopus 로고    scopus 로고
    • Concentration-dependent inhibitory effect of irbesartan on renal uric acid transporters
    • 20736511 1:CAS:528:DC%2BC3cXht1KjtbvJ 10.1254/jphs.10064SC
    • Nakamura M, Anzai N, Jutabha P, Sato H, Sakurai H, Ichida K. Concentration-dependent inhibitory effect of irbesartan on renal uric acid transporters. J Pharmacol Sci. 2010;114:115-8.
    • (2010) J Pharmacol Sci , vol.114 , pp. 115-118
    • Nakamura, M.1    Anzai, N.2    Jutabha, P.3    Sato, H.4    Sakurai, H.5    Ichida, K.6
  • 64
    • 79955893473 scopus 로고    scopus 로고
    • Human urate transporter 1 (hURAT1) mediates the transport of orotate
    • 21350910 1:CAS:528:DC%2BC3MXlsVWmtLw%3D 10.1007/s12576-011-0136-0
    • Miura D, Anzai N, Jutabha P, Chanluang S, He X, Fukutomi T, et al. Human urate transporter 1 (hURAT1) mediates the transport of orotate. J Physiol Sci. 2011;61:253-7.
    • (2011) J Physiol Sci , vol.61 , pp. 253-257
    • Miura, D.1    Anzai, N.2    Jutabha, P.3    Chanluang, S.4    He, X.5    Fukutomi, T.6
  • 65
    • 79955407045 scopus 로고    scopus 로고
    • Developing potent human uric acid transporter 1 (hURAT1) inhibitors
    • 21449597 1:CAS:528:DC%2BC3MXktVCnsb4%3D 10.1021/jm1015022
    • Wempe MF, Jutabha P, Quade B, Iwen TJ, Frick MM, Ross IR, et al. Developing potent human uric acid transporter 1 (hURAT1) inhibitors. J Med Chem. 2011;54:2701-13.
    • (2011) J Med Chem , vol.54 , pp. 2701-2713
    • Wempe, M.F.1    Jutabha, P.2    Quade, B.3    Iwen, T.J.4    Frick, M.M.5    Ross, I.R.6
  • 67
    • 0037333435 scopus 로고    scopus 로고
    • Human renal organic anion transporter 1-dependent uptake and toxicity of mercuric-thiol conjugates in madin-darby canine kidney cells
    • DOI 10.1124/mol.63.3.590
    • Aslamkhan AG, Han YH, Yang XP, Zalups RK, Pritchard JB. Human renal organic anion transporter 1-dependent uptake and toxicity of mercuric-thiol conjugates in Madin-Darby canine kidney cells. Mol Pharmacol. 2003;63:590-6. (Pubitemid 36297329)
    • (2003) Molecular Pharmacology , vol.63 , Issue.3 , pp. 590-596
    • Aslamkhan, A.G.1    Han, Y.-H.2    Yang, X.-P.3    Zalups, R.K.4    Pritchard, J.B.5
  • 68
    • 79960666822 scopus 로고    scopus 로고
    • Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury
    • 21652719 1:CAS:528:DC%2BC3MXpt1KktLs%3D 10.1074/jbc.M111.249292
    • Torres AM, Dnyanmote AV, Bush KT, Wu W, Nigam SK. Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury. J Biol Chem. 2011;286:26391-5.
    • (2011) J Biol Chem , vol.286 , pp. 26391-26395
    • Torres, A.M.1    Dnyanmote, A.V.2    Bush, K.T.3    Wu, W.4    Nigam, S.K.5
  • 69
    • 9644257189 scopus 로고    scopus 로고
    • Medicinal herbal extracts - Renal friend or foe? Part one: The toxicities of medicinal herbs
    • DOI 10.1111/j.1440-1797.2004.00310.x
    • Wojcikowski K, Johnson DW, Gobe G. Medicinal herbal extracts - renal friend or foe? Part one: the toxicities of medicinal herbs. Nephrology (Carlton). 2004;9:313-8. (Pubitemid 39576935)
    • (2004) Nephrology , vol.9 , Issue.5 , pp. 313-318
    • Wojcikowski, K.1    Johnson, D.W.2    Gobe, G.3
  • 70
    • 41549102309 scopus 로고    scopus 로고
    • Aristolochic acid nephropathy: A worldwide problem
    • DOI 10.1038/ki.2008.129, PII KI2008129
    • Debelle FD, Vanherweghem JL, Nortier JL. Aristolochic acid nephropathy: a worldwide problem. Kidney Int. 2008;74:158-69. (Pubitemid 351915079)
    • (2008) Kidney International , vol.74 , Issue.2 , pp. 158-169
    • Debelle, F.D.1    Vanherweghem, J.-L.2    Nortier, J.L.3
  • 75
    • 79651475358 scopus 로고    scopus 로고
    • Aristolochic acid-induced destruction of organic ion transporters and fatty acid metabolic disorder in the kidney of rats
    • 21167265 1:CAS:528:DC%2BC3MXhvFeksL4%3D 10.1016/j.toxlet.2010.12.007
    • Lou Y, Li J, Lu Y, Wang X, Jiao R, Wang S, et al. Aristolochic acid-induced destruction of organic ion transporters and fatty acid metabolic disorder in the kidney of rats. Toxicol Lett. 2011;201:72-9.
    • (2011) Toxicol Lett , vol.201 , pp. 72-79
    • Lou, Y.1    Li, J.2    Lu, Y.3    Wang, X.4    Jiao, R.5    Wang, S.6
  • 76
    • 80054883840 scopus 로고    scopus 로고
    • Plant secondary metabolites and gut health: The case for phenolic acids
    • 21781364 1:CAS:528:DC%2BC3MXps1egs74%3D 10.1017/S0029665111000152
    • Russell W, Duthie G. Plant secondary metabolites and gut health: the case for phenolic acids. Proc Nutr Soc. 2011;70:389-96.
    • (2011) Proc Nutr Soc , vol.70 , pp. 389-396
    • Russell, W.1    Duthie, G.2
  • 77
    • 32344444354 scopus 로고    scopus 로고
    • Stability and biotransformation of various dietary anthocyanins in vitro
    • DOI 10.1007/s00394-005-0557-8
    • Fleschhut J, Kratzer F, Rechkemmer G, Kulling SE. Stability and biotransformation of various dietary anthocyanins in vitro. Eur J Nutr. 2006;45:7-18. (Pubitemid 43221279)
    • (2006) European Journal of Nutrition , vol.45 , Issue.1 , pp. 7-18
    • Fleschhut, J.1    Kratzer, F.2    Rechkemmer, G.3    Kulling, S.E.4
  • 78
    • 79952802157 scopus 로고    scopus 로고
    • Antioxidant activities, total phenolics and HPLC analyses of the phenolic compounds of extracts from common Mediterranean plants
    • 21409721 1:CAS:528:DC%2BC3MXjt1Smt74%3D 10.1080/14786419.2010.488232
    • Rababah TM, Ereifej KI, Esoh RB, Al-u'datt MH, Alrababah MA, Yang W. Antioxidant activities, total phenolics and HPLC analyses of the phenolic compounds of extracts from common Mediterranean plants. Nat Prod Res. 2011;25:596-605.
    • (2011) Nat Prod Res , vol.25 , pp. 596-605
    • Rababah, T.M.1    Ereifej, K.I.2    Esoh, R.B.3    Al-U'Datt, M.H.4    Alrababah, M.A.5    Yang, W.6
  • 79
    • 22944481531 scopus 로고    scopus 로고
    • The dietary polyphenol ellagic acid is a potent inhibitor of hOAT1
    • DOI 10.1124/dmd.105.004275
    • Whitley AC, Sweet DH, Walle T. The dietary polyphenol ellagic acid is a potent inhibitor of hOAT1. Drug Metab Dispos. 2005;33:1097-100. (Pubitemid 41043750)
    • (2005) Drug Metabolism and Disposition , vol.33 , Issue.8 , pp. 1097-1100
    • Whitley, A.C.1    Sweet, D.H.2    Walle, T.3
  • 80
    • 72049089059 scopus 로고    scopus 로고
    • Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: Pharmacological and toxicological implications
    • 19837111 10.1016/j.pharmthera.2009.09.008 1:CAS:528:DC%2BD1MXhsFyiu7%2FI
    • Saito H. Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: pharmacological and toxicological implications. Pharmacol Ther. 2009;125:79-91.
    • (2009) Pharmacol Ther , vol.125 , pp. 79-91
    • Saito, H.1
  • 81
    • 28444444126 scopus 로고    scopus 로고
    • Effects of renal failure on drug transport and metabolism
    • DOI 10.1016/j.pharmthera.2005.05.010, PII S0163725805001543
    • Sun H, Frassetto L, Benet LZ. Effects of renal failure on drug transport and metabolism. Pharmacol Ther. 2006;109:1-11. (Pubitemid 41740811)
    • (2006) Pharmacology and Therapeutics , vol.109 , Issue.1-2 , pp. 1-11
    • Sun, H.1    Frassetto, L.2    Benet, L.Z.3
  • 82
    • 26244449838 scopus 로고    scopus 로고
    • Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease
    • DOI 10.1007/s10157-005-0368-5
    • Enomoto A, Endou H. Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease. Clin Exp Nephrol. 2005;9:195-205. (Pubitemid 41414118)
    • (2005) Clinical and Experimental Nephrology , vol.9 , Issue.3 , pp. 195-205
    • Enomoto, A.1    Endou, H.2
  • 83
    • 77951033351 scopus 로고    scopus 로고
    • Vascular calcification in animal models of CKD: A review
    • 20413965 10.1159/000299794
    • Shobeiri N, Adams MA, Holden RM. Vascular calcification in animal models of CKD: a review. Am J Nephrol. 2010;31:471-81.
    • (2010) Am J Nephrol , vol.31 , pp. 471-481
    • Shobeiri, N.1    Adams, M.A.2    Holden, R.M.3
  • 84
    • 0032856603 scopus 로고    scopus 로고
    • The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1
    • Cihlar T, Lin DC, Pritchard JB, Fuller MD, Mendel DB, Sweet DH. The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol Pharmacol. 1999;56:570-80. (Pubitemid 29406884)
    • (1999) Molecular Pharmacology , vol.56 , Issue.3 , pp. 570-580
    • Cihlar, T.1    Lin, D.C.2    Pritchard, J.B.3    Fuller, M.D.4    Mendel, D.B.5    Sweet, D.H.6
  • 86
    • 0032858230 scopus 로고    scopus 로고
    • PAH extraction and estimation of plasma flow in human postischemic acute renal failure
    • 10444587 1:CAS:528:DyaK1MXls1alsL8%3D
    • Corrigan G, Ramaswamy D, Kwon O, Sommer FG, Alfrey EJ, Dafoe DC, et al. PAH extraction and estimation of plasma flow in human postischemic acute renal failure. Am J Physiol. 1999;277:F312-8.
    • (1999) Am J Physiol , vol.277 , pp. 312-318
    • Corrigan, G.1    Ramaswamy, D.2    Kwon, O.3    Sommer, F.G.4    Alfrey, E.J.5    Dafoe, D.C.6
  • 87
    • 33645457811 scopus 로고    scopus 로고
    • Prostaglandin E2 inhibits its own renal transport by downregulation of organic anion transporters rOAT1 and rOAT3
    • 16338963 1:CAS:528:DC%2BD28XhtFyqurw%3D 10.1681/ASN.2005070727
    • Sauvant C, Holzinger H, Gekle M. Prostaglandin E2 inhibits its own renal transport by downregulation of organic anion transporters rOAT1 and rOAT3. J Am Soc Nephrol. 2006;17:46-53.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 46-53
    • Sauvant, C.1    Holzinger, H.2    Gekle, M.3
  • 88
    • 24944584034 scopus 로고    scopus 로고
    • 2 synthesis
    • DOI 10.1016/j.jvs.2005.05.032, PII S0741521405008943
    • Myers SI, Wang L, Liu F, Bartula LL. Suprarenal aortic clamping and reperfusion decreases medullary and cortical blood flow by decreased endogenous renal nitric oxide and PGE2 synthesis. J Vasc Surg. 2005;42:524-31. (Pubitemid 41323846)
    • (2005) Journal of Vascular Surgery , vol.42 , Issue.3 , pp. 524-531
    • Myers, S.I.1    Wang, L.2    Liu, F.3    Bartula, L.L.4
  • 89
    • 0036083528 scopus 로고    scopus 로고
    • Stenosis-dependent role of nitric oxide and prostaglandins in chronic renal ischemia
    • 11934696 1:CAS:528:DC%2BD38XjslWls7k%3D
    • Tokuyama H, Hayashi K, Matsuda H, Kubota E, Honda M, Okubo K, et al. Stenosis-dependent role of nitric oxide and prostaglandins in chronic renal ischemia. Am J Physiol Renal Physiol. 2002;282:F859-65.
    • (2002) Am J Physiol Renal Physiol , vol.282 , pp. 859-865
    • Tokuyama, H.1    Hayashi, K.2    Matsuda, H.3    Kubota, E.4    Honda, M.5    Okubo, K.6
  • 90
    • 71449084765 scopus 로고    scopus 로고
    • Low-dose indomethacin after ischemic acute kidney injury prevents downregulation of Oat1/3 and improves renal outcome
    • 19794109 1:CAS:528:DC%2BD1MXhsFOltbzF 10.1152/ajprenal.00268.2009
    • Schneider R, Meusel M, Renker S, Bauer C, Holzinger H, Roeder M, et al. Low-dose indomethacin after ischemic acute kidney injury prevents downregulation of Oat1/3 and improves renal outcome. Am J Physiol Renal Physiol. 2009;297:F1614-21.
    • (2009) Am J Physiol Renal Physiol , vol.297 , pp. 1614-1621
    • Schneider, R.1    Meusel, M.2    Renker, S.3    Bauer, C.4    Holzinger, H.5    Roeder, M.6
  • 91
    • 59149084250 scopus 로고    scopus 로고
    • COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the rat renal cortex
    • 18946499 10.1038/ki.2008.557 1:CAS:528:DC%2BD1MXhtF2rsrc%3D
    • Hocherl K, Schmidt C, Bucher M. COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the rat renal cortex. Kidney Int. 2009;75:373-80.
    • (2009) Kidney Int , vol.75 , pp. 373-380
    • Hocherl, K.1    Schmidt, C.2    Bucher, M.3
  • 92
    • 0018574181 scopus 로고
    • Probenecid: An unexplained effect on cephalosporin pharmacology
    • Welling PG, Dean S, Selen A, Kendall MJ, Wise R. Probenecid: an unexplained effect on cephalosporin pharmacology. Br J Clin Pharmacol. 1979;8:491-5. (Pubitemid 10194835)
    • (1979) British Journal of Clinical Pharmacology , vol.8 , Issue.5 , pp. 491-495
    • Welling, P.G.1    Dean, S.2    Selen, A.3
  • 93
    • 0016413786 scopus 로고
    • Inhibition of renal tubular transport of methotrexate by probenecid
    • 1109785 1:CAS:528:DyaE2MXkt1aiurs%3D
    • Bourke RS, Chheda G, Bremer A, Watanabe O, Tower DB. Inhibition of renal tubular transport of methotrexate by probenecid. Cancer Res. 1975;35:110-6.
    • (1975) Cancer Res , vol.35 , pp. 110-116
    • Bourke, R.S.1    Chheda, G.2    Bremer, A.3    Watanabe, O.4    Tower, D.B.5
  • 94
    • 0028822282 scopus 로고
    • Effect of probenecid on the distribution and elimination of ciprofloxacin in humans
    • 7586947 1:CAS:528:DyaK28XktlGltA%3D%3D 10.1016/0009-9236(95)90173-6
    • Jaehde U, Sorgel F, Reiter A, Sigl G, Naber KG, Schunack W. Effect of probenecid on the distribution and elimination of ciprofloxacin in humans. Clin Pharmacol Ther. 1995;58:532-41.
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 532-541
    • Jaehde, U.1    Sorgel, F.2    Reiter, A.3    Sigl, G.4    Naber, K.G.5    Schunack, W.6
  • 96
    • 84859981569 scopus 로고    scopus 로고
    • Fluoroquinolone disposition: Identification of the contribution of renal secretory and reabsorptive drug transporters
    • 22435536 1:CAS:528:DC%2BC38XlvV2qs70%3D 10.1517/17425255.2012.674512
    • Mulgaonkar A, Venitz J, Sweet DH. Fluoroquinolone disposition: identification of the contribution of renal secretory and reabsorptive drug transporters. Expert Opin Drug Metab Toxicol. 2012;8:553-69.
    • (2012) Expert Opin Drug Metab Toxicol , vol.8 , pp. 553-569
    • Mulgaonkar, A.1    Venitz, J.2    Sweet, D.H.3
  • 97
    • 84859039113 scopus 로고    scopus 로고
    • In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna
    • 21505084 1:CAS:528:DC%2BC38XmsFersLg%3D 10.1177/0091270011400414
    • Cutler MJ, Urquhart BL, Velenosi TJ, Meyer Zu Schwabedissen HE, Dresser GK, Leake BF, et al. In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna. J Clin Pharmacol. 2012;52:530-42.
    • (2012) J Clin Pharmacol , vol.52 , pp. 530-542
    • Cutler, M.J.1    Urquhart, B.L.2    Velenosi, T.J.3    Meyer Zu Schwabedissen, H.E.4    Dresser, G.K.5    Leake, B.F.6
  • 98
    • 0037534010 scopus 로고    scopus 로고
    • Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance
    • DOI 10.1016/S0009-9236(03)00052-3
    • Kyrklund C, Backman JT, Neuvonen M, Neuvonen PJ. Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance. Clin Pharmacol Ther. 2003;73:538-44. (Pubitemid 37249124)
    • (2003) Clinical Pharmacology and Therapeutics , vol.73 , Issue.6 , pp. 538-544
    • Kyrklund, C.1    Backman, J.T.2    Neuvonen, M.3    Neuvonen, P.J.4
  • 99
    • 34147133352 scopus 로고    scopus 로고
    • Inhibition of human organic anion transporter 3 mediated pravastatin transport by gemfibrozil and the metabolites in humans
    • DOI 10.1080/00498250601188808, PII 777020814
    • Nakagomi-Hagihara R, Nakai D, Tokui T. Inhibition of human organic anion transporter 3 mediated pravastatin transport by gemfibrozil and the metabolites in humans. Xenobiotica. 2007;37:416-26. (Pubitemid 46572887)
    • (2007) Xenobiotica , vol.37 , Issue.4 , pp. 416-426
    • Nakagomi-Hagihara, R.1    Nakai, D.2    Tokui, T.3
  • 100
    • 67649886935 scopus 로고    scopus 로고
    • Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril
    • 19349522 1:CAS:528:DC%2BD1MXosFeltbw%3D 10.1124/jpet.108.149476
    • Yuan H, Feng B, Yu Y, Chupka J, Zheng JY, Heath TG, et al. Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril. J Pharmacol Exp Ther. 2009;330:191-7.
    • (2009) J Pharmacol Exp Ther , vol.330 , pp. 191-197
    • Yuan, H.1    Feng, B.2    Yu, Y.3    Chupka, J.4    Zheng, J.Y.5    Heath, T.G.6
  • 101
    • 77649216536 scopus 로고    scopus 로고
    • Membrane transporters in drug development
    • 20190787 1:CAS:528:DC%2BC3cXisFelu74%3D 10.1038/nrd3028
    • Giacomini KM, Huang SM, Tweedie DJ. Membrane transporters in drug development. Nat Rev Drug Discov. 2010;9:215-36.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 215-236
    • Giacomini, K.M.1    Huang, S.M.2    Tweedie, D.J.3
  • 102
  • 103
    • 77957982189 scopus 로고    scopus 로고
    • Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates
    • 20668102 1:CAS:528:DC%2BC3cXhtlKlurrK 10.1152/ajprenal.00312.2010
    • Shima JE, Komori T, Taylor TR, Stryke D, Kawamoto M, Johns SJ, et al. Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates. Am J Physiol Renal Physiol. 2010;299:F767-75.
    • (2010) Am J Physiol Renal Physiol , vol.299 , pp. 767-775
    • Shima, J.E.1    Komori, T.2    Taylor, T.R.3    Stryke, D.4    Kawamoto, M.5    Johns, S.J.6
  • 104
    • 75649122519 scopus 로고    scopus 로고
    • Functional characterization of nonsynonymous single nucleotide polymorphisms in the human organic anion transporter 4 (hOAT4)
    • 20015291 10.1111/j.1476-5381.2009.00545.x 1:CAS:528:DC%2BC3cXhslGisr0%3D
    • Zhou F, Zhu L, Cui PH, Church WB, Murray M. Functional characterization of nonsynonymous single nucleotide polymorphisms in the human organic anion transporter 4 (hOAT4). Br J Pharmacol. 2010;159:419-27.
    • (2010) Br J Pharmacol , vol.159 , pp. 419-427
    • Zhou, F.1    Zhu, L.2    Cui, P.H.3    Church, W.B.4    Murray, M.5
  • 105
    • 33847139479 scopus 로고    scopus 로고
    • Organic anion transporters of the SLC22 family: Biopharmaceutical, physiological, and pathological roles
    • DOI 10.1007/s11095-006-9181-4
    • Rizwan AN, Burckhardt G. Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles. Pharm Res. 2007;24:450-70. (Pubitemid 46295167)
    • (2007) Pharmaceutical Research , vol.24 , Issue.3 , pp. 450-470
    • Rizwan, A.N.1    Burckhardt, G.2
  • 106
    • 79951675822 scopus 로고    scopus 로고
    • Association of intergenic polymorphism of organic anion transporter 1 and 3 genes with hypertension and blood pressure response to hydrochlorothiazide
    • 21164499 1:CAS:528:DC%2BC3MXhvVyrt7c%3D 10.1038/ajh.2010.191
    • Han YF, Fan XH, Wang XJ, Sun K, Xue H, Li WJ, et al. Association of intergenic polymorphism of organic anion transporter 1 and 3 genes with hypertension and blood pressure response to hydrochlorothiazide. Am J Hypertens. 2011;24:340-6.
    • (2011) Am J Hypertens , vol.24 , pp. 340-346
    • Han, Y.F.1    Fan, X.H.2    Wang, X.J.3    Sun, K.4    Xue, H.5    Li, W.J.6
  • 108
    • 33644499212 scopus 로고    scopus 로고
    • Organic anion and cation transporter expression and function during embryonic kidney development and in organ culture models
    • 16518343 1:CAS:528:DC%2BD28Xhs1KitrY%3D 10.1038/sj.ki.5000170
    • Sweet DH, Eraly SA, Vaughn DA, Bush KT, Nigam SK. Organic anion and cation transporter expression and function during embryonic kidney development and in organ culture models. Kidney Int. 2006;69:837-45.
    • (2006) Kidney Int , vol.69 , pp. 837-845
    • Sweet, D.H.1    Eraly, S.A.2    Vaughn, D.A.3    Bush, K.T.4    Nigam, S.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.