Alteration in renal organic anion transporter 1 after ischemia/reperfusion in cadaveric renal allografts

Journal of Histochemistry and Cytochemistry

Volumn 55, Issue 6, 2007, Pages 575-584

  Kwon, Osun ^a,c   Hong, Seok Min ^a   Blouch, Kristina ^b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Confocal microscopy; Human organic anion transporter 1; Postischemic acute renal failure; Renal tubular secretion

Indexed keywords

4 AMINOHIPPURIC ACID; ORGANIC ANION TRANSPORTER 1;

ACUTE KIDNEY FAILURE; ADULT; ARTERY CLAMP; ARTICLE; BASOLATERAL MEMBRANE; BIOPSY; CELL AGGREGATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ISCHEMIA; KIDNEY ALLOGRAFT; KIDNEY DONOR; KIDNEY PROXIMAL TUBULE; KIDNEY TRANSPLANTATION; MALE; PRIORITY JOURNAL; RENAL ARTERY; REPERFUSION INJURY; THREE DIMENSIONAL IMAGING;

ADULT; CADAVER; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IOTHALAMIC ACID; ISCHEMIA; KIDNEY; KIDNEY TRANSPLANTATION; KIDNEY TUBULES, PROXIMAL; LIVING DONORS; MALE; METABOLIC CLEARANCE RATE; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; ORGANIC ANION TRANSPORT PROTEIN 1; P-AMINOHIPPURIC ACID; REPERFUSION; TISSUE DONORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 34248997530     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1369/jhc.6A7130.2007     Document Type: Article

References (65)

1. Alejandro V, Scandling JD, Sibley RK, Dafoe D, Alfrey E, Deen W, Myers BD (1995) Mechanism of filtration failure during postischemic injury of the human kidney. A study of the reperfused renal allograft. J Clin Invest 95:820-831
2. Anzai N, Jutabha P, Enomoto A, Yokoyama H, Nonoguchi H, Hirata T, Shiraya K, et al. (2005) Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules. J Pharmacol Exp Ther 315:534-544
3. Anzai N, Kanai Y, Endou H (2006) Organic anion transporter family: current knowledge. J Pharmacol Sci 100:411-426
4. Bahn A, Ebbinghaus C, Ebbinghaus D, Ponimaskin EG, Fuzesi L, Burckhardt G, Hagos Y (2004) Expression studies and functional characterization of renal human organic anion transporter 1 isoforms. Drug Metab Dispos 32:424-430
5. Bleasby K, Hall LA, Perry JL, Mohrenweiser HW, Pritchard JB (2005) Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). J Pharmacol Exp Ther 4:923-931
6. Buist SCN, Klaassen CD (2004) Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levels. Drug Metab Dispos 32:620-625
7. Burckhardt BC, Burckhardt G (2003) Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev Physiol Biochem Pharmacol 146:95-158
8. Cerrutti JA, Brandoni A, Quaglia NA, Torres AM (2002) Sex differences in p-aminohippuric acid transport in rat kidney: role of membrane fluidity and expression of OAT1. Mol Cell Biochem 233:175-179
9. Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H (2001) Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol 59:1277-1286
10. Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sungiyama Y, et al. (2000) Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem 275:4507-4512
11. Chertow GM, Christiansen CL, Cleary PD, Munro C, Lazarus M (1995) Prognostic stratification in critically ill patients with acute renal failure requiring dialysis. Arch Intern Med 155:1505-1511
12. Clermont G, Acker CG, Angus DC, Sirio CA, Pinsky MR, Johnson JP (2002) Renal failure in the ICU: comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomes. Kidney Int 62:986-996
13. Corrigan G, Ramaswamy D, Kwon O, Sommer FG, Alfrey EJ, Dafoe DC, Olshen RA, et al. (1999) PAH extraction and estimation of plasma flow in human postischemic acute renal failure: a study of the renal allograft. Am J Physiol 277:F312-318
14. Crljen V, Saboli I, Susac J, Appenroth D, Herak-Kramberger CM, Ljubojevi M, Anzai N, et al. (2005) Immunocytochemical characterization of the incubated rat renal cortical slices. Pflugers Arch 450:269-279
15. Deguchi T, Kusuhara H, Takadate A, Endou H, Otagiri M, Sugiyama Y (2004) Characterization of uremic toxin transport by organic anion transporters in the kidney. Kidney Int 65:162-174
16. Dou L, Bertrand E, Cerini C, Faure V, Sampol J, Vanholder R, Berland Y, et al. (2004) The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair. Kidney Int 65:442-451
17. Dzurik R, Spustova V, Krivosikova Z, Gazdikova K (2001) Hippurate participates in the correction of metabolic acidosis. Kidney Int 78:S278-281
18. Eraly SA, Vallon V, Vaughn DA, Gangoiti JA, Richter K, Nagle M, Monte JC, et al. (2006) Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice. J Biol Chem 281:5072-5083
19. Gulyassy PF, Jarrard E, Stanfel LA (1987) Contribution of hipppurate, indoxyl sulfate, and o-hydroxyhippurate to impaired ligand binding by plasma in azotemic humans. Biochem Pharmacol 36:4215-4220
20. Halloran PF, Hunsicker LG (2001) Delayed graft function: state of the art, November 10-11, 2000. Summit meeting, Scottsdale, Arizona, USA. Am J Transplant 1:115-120
21. Hladunewich MA, Corrigan G, Derby GC, Ramaswamy D, Kambham N, Scandling JD, Myers BD (2003) A randomized, placebo-controlled trial of IGF-1 for delayed graft function: a human model to study postischemic ARF. Kidney Int 64:593-602
22. Hosoyamada M, Sekine T, Kanai Y, Endou H (1999) Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am J Physiol 276:F122-128
23. Hostetter TH, Meyer TW (2004) The development of clearance methods for measurement of glomerular filtration and tubular reabsorption. Am J Physiol Renal Physiol 287:F868-870
24. Kawashima Y, Sanaka T, Sugino N, Takahashi M, Mizoguchi H (1987) Suppressive effect of quinolinic acid and hippuric acid on bone marrow erythroid growth and lymphocyte blast formation in uremia. Adv Exp Med Biol 223:69-72
25. Kelly KJ, Molitoris BA (2000) Acute renal failure in the new millennium: time to consider combination therapy. Semin Nephrol 20:4-19
26. Kojima R, Sekine T, Kawachi M, Cha SH, Suzuki Y, Endou H (2002) Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney. J Am Soc Nephrol 13:848-857
27. Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, et al. (1999) Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem 274:13675-13680
28. +-ATPase during postischemic injury to the renal allograft. Kidney Int 55:963-975
29. Kwon O, Nelson WJ, Sibley R, Huie P, Scandling JD, Alfrey E, Dafoe D, et al. (1998) Backleak, tight junctions and cell-cell adhesion in postischemic injury to the renal allograft. J Clin Invest 101:2054-2064
30. Lemley KV, Blouch K, Abdullah I, Boothroyd DB, Bennett PH, Myers BD, Nelson RG (2000) Glomerular permselectivity at the onset of nephropathy in type 2 diabetes mellitus. J Am Soc Nephrol 11:2095-2105
31. Liano F, Pascual J (1998) Outcomes in acute renal failure. Semin Nephrol 18:541-550
32. Ljubojevic M, Herak-Kramberger CM, Hagos Y, Bahn A, Endou H, Burckhardt G, Sabolic I (2004) Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition. Am J Physiol Renal Physiol 287:F124-138
33. Lopez-Nieto CE, You G, Bush KT, Barros EJG, Beier DR, Nigam SK (1997) Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J Biol Chem 272:6471-6478
34. Lu R, Chan BS, Schuster VL (1999) Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. Am J Physiol Renal Physiol 276:F295-303
35. Moller JV, Sheikh MI (1983) Renal organic anion transport system: pharmacological, physiological, and biochemical aspects. Pharmacol Rev 34:315-358
36. Monte JC, Nagle MA, Eraly SA, Nigam SK (2004) Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa. Biochem Biophys Res Commun 323:429-436
37. Motohashi H, Sakurai Y, Saito H, Masuda S, Urakami Y, Goto M, Fukatsu A, et al. (2002) Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J Am Soc Nephrol 13:866-874
38. Motojima M, Hosokawa A, Yamato H, Muraki T, Yoshioka T (2002) Uremic toxins induce proximal tubular injury via organic anion transporter-1 mediated uptake. Br J Pharmacol 135:555-563
39. Nelson WJ, Rodriguez-Boulan E (2004) Unravelling protein sorting. Nature Cell Biol 6:282-284
40. Niwa T (1996) Organic acids and the uremic syndrome: protein metabolite hypothesis in the progression of chronic renal failure. Semin Nephrol 16:167-182
41. Ohtsuki S, Asaba H, Takanaga H, Deguchi T, Hosoya K, Otagiri M, Terasaki T (2002) Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain. J Neurochem 83:57-66
42. Ringoir S (1997) An update on uremic toxins. Kidney Int Suppl 62:S2-4
43. Rubinger D, Wald H, Gimelreich D, Halaihel N, Rogers T, Levi M, Popovtzer MM (2005) Regulation of the renal sodium-dependent phosphate cotransporter NaPi2 (Npt2) in acute renal failure due to ischemia and reperfusion. Nephron Physiol 100:1-12
44. Russel FGM, Masereeuw R, van Aubel RAMH (2002) Molecular aspects of renal anion drug transport. Annu Rev Physiol 64:563-594
45. Satoh M, Hayashi H, Watanabe M, Ueda K, Yamato H, Yoshioka T, Motojima M (2003) Uremic toxins overload accelerates renal damage in a rat model of chronic renal failure. Nephron Exp Nephrol 95:e111-118
46. Schnabolk GW, Youngblood GL, Sweet DH (2006) Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20). Am J Physiol Renal Physiol 291:F314-321
47. Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H (1998) Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett 429:179-182
48. Sekine T, Miyazaki H, Endou H (2006) Molecular physiology of renal organic anion transporters. Am J Physiol Renal Physiol 290:F251-261
49. Sekine T, Watanabe N, Hosoyama M, Kanai Y, Endou H (1997) Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 272:18526-18529
50. Smeets PH, van Aubel RA, Wouterse AC, van den Heuvel JJ, Russel FG (2004) Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter. J Am Soc Nephrol 15:2828-2835
51. Spustova V, Cernay P, Golier I (1989) Inhibition of glucose utilization in uremia by hippurate: liquid chromatographic isolation and mass spectrometric and nuclear magnetic resonance spectroscopic identification. J Chromatogr 490:186-192
52. Sun W, Wu RR, Poelje PDV, Erion MD (2001) Isolation of a family of organic anion transporters from human liver and kidney. Biochem Biophys Res Commun 283:417-422
53. Sweet DH, Bush KT, Nigam SK (2001) The organic anion transporter family: from physiology to ontogeny and the clinic. Am J Physiol Renal Physiol 281:F197-205
54. Thadhani R, Pascual M, Bonventre JV (1996) Acute renal failure. N Engl J Med 334:1448-1460
55. Tojo A, Sekine T, Nakajima N, Hosoyamada M, Kanai Y, Kimura K, Endou H (1999) Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney. J Am Soc Nephrol 10:464-471
56. Tsutsumi Y, Deguchi T, Takano M, Takadate A, Lindup WE, Otagiri M (2002) Renal disposition of a furan dicarboxylic acid and other uremic toxins in the rat. J Pharmacol Exp Ther 303:880-887
57. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, et al. (2005) Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 294:813-818
58. Vanholder R, De Smet R (1999) Pathophysiologic effects of uremic retention solutes. J Am Soc Nephrol 10:1815-1823
59. Vanholder R, De Smet R, Glorieux G, Dhondt A (2003) Survival of hemodialysis patients and uremic toxin removal. Artif Organs 27:218-223
60. Vanholder R, De Smet R, Lameire N (2001) Protein-bound uremic solutes: the forgotten toxins. Kidney Int Suppl 78:S266-270
61. Vanholder R, De Smet R, Waterloos MA, Van Landschoot N, Vogeleere P, Hoste E, Ringoir S (1995) Mechanisms of uremic inhibition of phagocyte reactive species production: characterization of the role of p-cresol. Kidney Int 47:510-517
62. Wolff NA, Thies K, Kuhnke N, Reid G, Friedrich B, Lang F, Burckhardt G (2003) Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization. J Am Soc Nephrol 14:1959-1968
63. You G (2002) Structure, function, and regulationg of renal organic anion transporters. Med Res Rev 22:602-616
64. Youngblood GL, Sweet DH (2004) Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. Am J Physiol Renal Physiol 287:F236-244
65. Xue JL, Daniels F, Star RA, Kimmel PL, Eggers PW, Molitoris BA, Himmelfarb J, et al. (2006) Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001. J Am Soc Nephrol 17:1135-1142