3-monoglucuronyl-glycyrrhretinic acid is a substrate of organic anion transporters expressed in tubular epithelial cells and plays important roles in licorice-induced pseudoaldosteronism by inhibiting 11β-hydroxysteroid dehydrogenase 2

Journal of Pharmacology and Experimental Therapeutics

Volumn 342, Issue 2, 2012, Pages 297-304

  Makino, Toshiaki ^a   Okajima, Kyoko ^a,c   Uebayashi, Rie ^a,d   Ohtake, Nobuhiro ^b   Inoue, Katsuhisa ^a   Mizukami, Hajime ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b Tsumura Co Ltd   (Japan)

^c FUJITA HEALTH UNIVERSITY HOSPITAL   (Japan)

^d MIE UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; 3 MONOGLUCURONYL GLYCYRRHRETINIC ACID; GLYCYRRHETINIC ACID; GLYCYRRHETINIC ACID DERIVATIVE; GLYCYRRHIZIC ACID; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; ORGANIC ANION TRANSPORTER 4; ORGANIC ANION TRANSPORTER 4C1; UNCLASSIFIED DRUG;

ADRENAL CORTEX DISEASE; ADVERSE OUTCOME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CELL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; EPITHELIUM CELL; GENETIC TRANSFORMATION; GLYCYRRHIZA; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MALE; MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PSEUDOALDOSTERONISM; TISSUE SLICE; URINE LEVEL;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ANIMALS; CELL LINE, TRANSFORMED; EPITHELIAL CELLS; GLYCYRRHETINIC ACID; GLYCYRRHIZA; GLYCYRRHIZIC ACID; HEK293 CELLS; HUMANS; KIDNEY; LIDDLE SYNDROME; LIVER; MALE; MICROSOMES; ORGANIC ANION TRANSPORTERS; PLANTS, MEDICINAL; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR;

EID: 84864124149     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.190009     Document Type: Article

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