Analyses of 5′ regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3)

Journal of Human Genetics

Volumn 51, Issue 6, 2006, Pages 575-580

  Bhatnagar, Vibha ^a   Xu, Gang ^a   Hamilton, Bruce A ^a   Truong, David M ^a   Eraly, Satish A ^a   Wu, Wei ^a   Nigam, Sanjay K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Organic anion transporters; Promoters; Single nucleotide polymorphisms; SLC22A6, OAT1, NKT; SLC22A8, OAT3, ROCT

Indexed keywords

ANTIBIOTIC AGENT; ANTIHYPERTENSIVE AGENT; ANTIVIRUS AGENT; DIURETIC AGENT; DNA; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; TOXIN; ORGANIC ANION TRANSPORTER;

ARTICLE; CHROMOSOME 11; CONTROLLED STUDY; DNA POLYMORPHISM; DNA SEQUENCE; DRUG TRANSPORT; FEMALE; GENE; HAPLOTYPE; HUMAN; KIDNEY PROXIMAL TUBULE; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; PHYLOGENY; POLYMERASE CHAIN REACTION; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; SLC22A6 GENE; SLC22A8 GENE; TRANSCRIPTION REGULATION; URINARY EXCRETION; ANIMAL; COMPARATIVE STUDY; DNA FOOTPRINTING; ETHNIC GROUP; GENETIC TRANSCRIPTION; GENETICS; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; PAN TROGLODYTES; REGULATORY SEQUENCE;

AVENA;

ANIMALS; BASE SEQUENCE; DNA; DNA FOOTPRINTING; ETHNIC GROUPS; HAPLOTYPES; HUMANS; MICE; MULTIGENE FAMILY; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; PAN TROGLODYTES; PHYLOGENY; POLYMORPHISM, SINGLE NUCLEOTIDE; REGULATORY ELEMENTS, TRANSCRIPTIONAL; TRANSCRIPTION, GENETIC;

EID: 33745444581     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10038-006-0398-1     Document Type: Article

References (17)

1. Anzai N, Enomoto A, Endou H (2005) Renal urate handling: clinical relevance of recent advances. Curr Rheumatol Rep 7:227-234
2. Bleasby K, Hall LA, Perry JL, Mohrenweiser HW, Pritchard JB (2005) Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). J Pharmacol Exp Ther 314:923-931
3. Brady KP, Dushkin H, Fornzler D, Koike T, Magner F, Her H, Gullans S, Segre GV, Green RM, Beier DR (1999) A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse. Genomics 56:254-261
4. Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T, Matsuo H, Kikuchi Y, Oda T, Ichida K, Hosoya T, Shimokata K, Niwa T, Kanai Y, Endou H (2002) Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature 417:447-452
5. Eraly SA, Hamilton BA, Nigam SK (2003) Organic anion and cation transporters occur in pairs of similar and similarly expressed genes. Biochem Biophys Res Commun 300:333-342
6. Eraly SA, Bush KT, Sampogna RV, Bhatnagar V, Nigam SK (2004a) The molecular pharmacology of organic anion transporters: from DNA to FDA? Mol Pharmacol 65:479-487
7. Eraly SA, Monte JC, Nigam SK (2004b) Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Physiol Genomics 18:12-24
8. Eraly SA, Vallon V, Vaughn DA, Gangoiti JA, Richter K, Nagle M, Monte JC, Rieg T, Truong DM, Long JM, Barshop BA, Kaler G, Nigam SK (2005) Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knockout mice. J Biol Chem 281:5072-5083
9. Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Fujita K, Castro R, Chen C-W, Lin ET, Brett CM, Burchard EG, Ferrin TE, Huang CC, Leabman MK, Giacomini KM (2005) Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenet Genomics 15:201-209
10. Hediger MA, Johnson RJ, Miyazaki H, Endou H (2005) Molecular physiology of urate transport. Physiology 20:125-133
11. Kim JW, Zeller KI, Wang Y, Jegga AG, Aronow BJ, O'Donnell KA, Dang CV (2004) Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays. Mol Cell Biol 24:5923-5936
12. Lopez-Nieto CE, You G, Barros EJG, Beier DR, Nigam SK (1996) Molecular cloning and characterization of a novel transport protein with very high expression in the kidney (Abstract). J Am Soc Nephrol 7:1301
13. Lopez-Nieto CE, You G, Bush KT, Barros EJ, Beier DR, Nigam SK (1997) Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family almost exclusively expressed in the kidney. J Biol Chem 272:6471-6478
14. Prohaska SJ, Fried C, Flamm C, Wagner GP, Stadler PF (2004) Surveying phylogenetic footprints in large gene clusters: applications to Hox cluster duplications. Mol Phylogenet Evol 31:581-604
15. Sweet DH (2005) Organic anion transporter (Slc22a) family members as mediators of toxicity. Toxicol Appl Pharmacol 204:198-215
16. Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, Nigam SK (2002) Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 [Slc22a8]) knockout mice. J Biol Chem 277:26934-26943
17. Xu G, Bhatnagar V, Wen G, Hamilton BA, Eraly SA, Nigam SK (2005) Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]. Kidney Int 68:1491-1499