Human renal organic anion transporter 1-dependent uptake and toxicity of mercuric-thiol conjugates in madin-darby canine kidney cells

Molecular Pharmacology

Volumn 63, Issue 3, 2003, Pages 590-596

  Aslamkhan, Amy G ^a   Han, Yong Hae ^a   Yang, Xiao Ping ^a   Zalups, Rudolfs K ^b   Pritchard, John B ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 AMINOHIPPURIC ACID; ACETYLCYSTEINE; ADIPIC ACID; CYSTEINE; DICARBOXYLIC ACID; GLUTARIC ACID; GLUTATHIONE; MERCURY 203; MERCURY DERIVATIVE; METHYLSUCCINATE; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 3; OXIDOREDUCTASE; PROBENECID; SUCCINIC ACID; THIOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN; CYTOPATHOGENIC EFFECT; ENZYME ASSAY; KIDNEY PROXIMAL TUBULE; NEPHROTOXICITY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; XENOBIOTIC METABOLISM; XENOPUS LAEVIS;

ANIMALS; BIOLOGICAL TRANSPORT; CELL SURVIVAL; CELLS, CULTURED; DOGS; HUMANS; KIDNEY; MERCURY; MERCURY ISOTOPES; ORGANIC ANION TRANSPORT PROTEIN 1;

EID: 0037333435     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.63.3.590     Document Type: Article

References (43)

1. Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, and Endou H (1999) Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol 55:847-854.
2. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
3. Brady KP, Dushkin H, Fornzler D, Koike D, Magner F, Her H, Gullans S, Segre GV, Green RM, and Beier DR (1999) A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse. Genomics 56:254-261.
4. Burckhardt G, Bahn A, and Wolff NA (2001) Molecular physiology of renal p-aminohippurate secretion. News Physiol Sci 16:114-118.
5. Cannon VT, Zalups RK, and Barfuss DW (2001) Amino acid transporters involved in luminal transport of mercuric conjugates of cysteine in rabbit proximal tubule. J Pharmacol Exp Ther 298:780-789.
6. Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, and Endou H (2001) Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol 59:1277-1286.
7. Chassaing C, Gonin J, Wilcox CS, and Wainer IW (1999) Determination of reduced and oxidized homocysteine and related thiols in plasma by thiol-specific precolumn derivatization and capillary electrophoresis with laser-induced fluorescence detection. J Chromatogr B Biomed Sci Appl 735:219-227.
8. Chatsudthipong V and Dantzler WH (1992) PAH/alpha-KG countertransport stimulates PAH uptake and net secretion in isolated rabbit renal tubules. Am J Physiol 263:F384-F391.
9. Cihlar T, Lin DC, Pritchard JB, Fuller MD, Mendel DB, and Sweet DH (1999) The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol Pharmacol 56:570-580.
10. Farrell RE, Germida JJ, and Huang PM (1990) Biotoxicity of mercury as influenced by mercury(II) speciation. Appl Environ Microbiol 56:3006-3016.
11. Hasegawa M, Kusuhara H, Sugiyama D, Ito K, Ueda S, Endou H, and Sugiyama Y (2002) Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. J Pharmacol Exp Ther 300:746-753.
12. Hosoyamada M, Sekine T, Kanai Y, and Endou H (1999) Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am J Physiol 276:F122-F128.
13. Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, and Endou H (1999) The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther 290:672-677.
14. Krick W, Wolff NA, and Burckhardt G (2000) Voltage-driven p-aminohippurate, chloride and urate transport in porcine renal brush-border membrane vesicles. Pflueg Arch Eur J Physiol 441:125-132.
15. Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, and Endou H (1999) Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem 274:13675-80.
16. Lau S and Sarkar B (1979) Inorganic mercury(II)-binding components in normal human blood serum. J Toxicol Environ Health 5:907-916.
17. Lu R, Chan BS, and Schuster VL (1999) Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. Am J Physiol 276:F295-F303.
18. Mansoor MA, Svardal AM, and Ueland PM (1992) Determination of the in vivo redox status of cysteine, cysteinylglycine, homocysteine and glutathione in human plasma. Anal Biochem 200:218-229.
19. Oram PD, Fang X, Fernando Q, Letkeman P, and Letkeman D (1996) The formation of constants of mercury(II)-glutathione complexes. Chem Res Toxicol 9:709-712.
20. Pombrio JM, Giangreco A, Li L, Wempe MF, Sweet DH, Pritchard JB, and Ballatori N (2001) Mercapturic acids (N-acetyl cysteine conjugates) as endogenous substrates for the renal organic anion transporter-1. Mol Pharmacol 60:1091-1099.
21. Pritchard JB (1995) Intracellular α-ketoglutarate controls the efficacy of renal organic anion transport. J Pharmacol Exp Ther 274:1278-1284.
22. Pritchard JB and Miller DS (1993) Mechanisms mediating renal secretion of organic anions and cations. Physiol Rev 73:765-796.
23. Rabenstein DL (1989) Metal complexes of glutathione and their biological significance, in Glutathione: Chemical, Biochemical, and Medical Aspects (Part A) (Dolphin D, Avramovic O, and Poulson R eds) pp 45-84, Wiley, New York.
24. Reid G, Wolff NA, Dautzenberg FM, and Burckhardt G (1998) Cloning of a human renal p-aminohippurate transporter, hROAT1. Kidney Blood Press Res 21:233-237.
25. Schiodt FV, Ott P, Christenson E, and Bondesen E (2002) The value of plasma acetaminophen half-life in antidote-treated acetaminophen overdosage. Clin Pharmacol Ther 71:221-225.
26. Sekine T, Watanabe N, Hosoyamada M, Kanai Y, and Endou H (1997) Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 272:18526-18529.
27. Stevens JL and Jones DP (1989) The mercaptic acid pathway: biosynthesis, intermediary metabolism and physiological disposition, in Glutathione, Part B (Dolphin D, Poulson R, and Avramovi'c eds) pp 45-84, Wiley, New York.
28. Sweet DH, Miller DS, and Pritchard JB (1999) Localization of an organic anion transporter-GFP fusion construct (rROAT1-GFP) in intact proximal tubules. Am J Physiol 276:F864-F873.
29. Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, and Nigam SK (2002) Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem 277:26934-26943.
30. Sweet DH, Wolff NA, and Pritchard JB (1997) Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney. J Biol Chem 272:30088-30095.
31. Tojo A, Sekine T, Nakajima N, Hosoyamada M, Kanai Y, Kimura K, and Endou H (1999) Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney. J Am Soc Nephrol 10:464-471.
32. Wolff NA, Werner A, Burkhardt S, and Burckhardt G (1997) Expression cloning and characterization of a renal organic anion transporter from winter flounder. FEBS Lett 417:287-291.
33. Zalups RK (1991a) Autometallographic localization of inorganic mercury in the kidneys of rats: effect of unilateral nephrectomy and compensatory renal growth. Exp Mol Pathol 54:10-21.
34. Zalups RK (1991b) Method for studying the in vivo accumulation of inorganic mercury in segments of the nephron in the kidneys of rats treated with mercuric chloride. J Pharmacol Methods 26:89-104.
35. Zalups RK (1998a) Basolateral uptake of inorganic mercury in the kidney. Toxicol Appl Pharmacol 151:192-199.
36. Zalups RK (1998b) Basolateral uptake of mercuric conjugates of N-acetylcysteine and cysteine in the kidney involves the organic anion transport system. J Toxicol Environ Health 55:13-29.
37. Zalups RK (2000) Molecular interactions with mercury in the kidney. Pharmacol Rev 52:113-143.
38. Zalups RK and Barfuss D (1990) Accumulation of inorganic mercury along the renal proximal tubule of the rabbit. Toxicol Appl Pharmacol 106:245-253.
39. Zalups RK and Barfuss DW (1996) Nephrotoxicity of inorganic mercury coadministrated with L-cysteine. Toxicology 109:15-29.
40. Zalups RK and Barfuss DW (1998a) Participation of mercuric conjugates of cysteine, homocysteine and N-acetylcysteine in mechanisms involved in the renal tubular uptake of inorganic mercury. J Am Soc Nephrol 9:551-561.
41. Zalups RK and Barfuss DW (2002) Renal organic anion transport system: a mechanism for the basolateral transport of mercury-thiol conjugates along the pars recta of the proximal tubule. Toxicol Appl Pharmacol 182:234-243.
42. Zalups RK and Barfuss DW (1998b) Small aliphatic dicarboxylic acids inhibit renal uptake of administered mercury. Toxicol Appl Pharmacol 148:183-193.
43. Zalups RK and Koropatnick J (2000) Molecular Biology and Toxicology of Metals. Taylor & Francis, London.