Active hydrophilic components of the medicinal herb salvia miltiorrhiza (Danshen) potently inhibit organic anion transporters 1 (Slc22a6) and 3 (Slc22a8)

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Wang, Li ^a   Sweet, Douglas H ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LITHOSPERMIC ACID; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; PLANT MEDICINAL PRODUCT; PROTOCATECHUIC ACID; ROSMARINIC ACID; SALVIA MILTIORRHIZA EXTRACT; SALVIANOLIC ACID A; TANSHINOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL PHENOMENA; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; HERB; HUMAN; IN VIVO STUDY; KINETICS; NONHUMAN; POLYPHARMACY; PRIORITY JOURNAL; PROTEIN FUNCTION; SALVIA MILTIORRHIZA;

EID: 84864910209     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/872458     Document Type: Article

References (33)

1. Zhou L., Zuo Z., Chow M. S. S., Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use Journal of Clinical Pharmacology 2005 45 12 1345 1359 (Pubitemid 41643896)
2. Cheng T. O., Cardiovascular effects of Danshen International Journal of Cardiology 2007 121 1 9 22 (Pubitemid 47287779)
3. Jiang R. W., Lau K. M., Hon P. M., Mak T. C. W., Woo K. S., Fung K. P., Chemistry and biological activities of caffeic acid derivatives from Salvia miltiorrhiza Current Medicinal Chemistry 2005 12 2 237 246 (Pubitemid 40089836)
4. Yuan D., Pan Y. N., Fu W. W., Makino T., Kano Y., Quantitative analysis of the marker compounds in Salvia miltiorrhiza root and its phytomedicinal preparations Chemical and Pharmaceutical Bulletin 2005 53 5 508 514 (Pubitemid 40740618)
5. Li X., Yu C., Cai Y., Liu G., Jia J., Wang Y., Simultaneous determination of six phenolic constituents of danshen in human serum using liquid chromatography/tandem mass spectrometry Journal of Chromatography B 2005 820 1 41 47 (Pubitemid 40615436)
6. Zhang J. L., Cui M., He Y., Yu H. L., Guo D. A., Chemical fingerprint and metabolic fingerprint analysis of Danshen injection by HPLC-UV and HPLC-MS methods Journal of Pharmaceutical and Biomedical Analysis 2005 36 5 1029 1035 (Pubitemid 40037823)
7. VanWert A. L., Gionfriddo M. R., Sweet D. H., Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology Biopharmaceutics and Drug Disposition 2010 31 1 1 71
8. Sweet D. H., Bush K. T., Nigam S. K., The organic anion transporter family: from physiology to ontogeny and the clinic American Journal of Physiology-Renal Physiology 2001 281 2 F197 F205
9. Sweet D. H., Organic anion transporter (Slc22a) family members as mediators of toxicity Toxicology and Applied Pharmacology 2005 204 3 198 215 (Pubitemid 40545228)
10. Dickman K. G., Sweet D. H., Bonala R., Ray T., Wu A., Physiological and molecular characterization of aristolochic acid transport by the kidney Journal of Pharmacology and Experimental Therapeutics 2011 338 2 588 597
11. Sweet D. H., Wolff N. A., Pritchard J. B., Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney Journal of Biological Chemistry 1997 272 48 30088 30095 (Pubitemid 27512205)
12. Sweet D. H., Chan L. M. S., Walden R., Yang X. P., Miller D. S., Pritchard J. B., Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient American Journal of Physiology-Renal Physiology 2003 284 4 F763 F769
13. VanWert A. L., Sweet D. H., Impaired clearance of methotrexate in organic anion transporter 3 (Slc22a8) knockout mice: a gender specific impact of reduced folates Pharmaceutical Research 2008 25 2 453 462 (Pubitemid 351257979)
14. VanWert A. L., Bailey R. M., Sweet D. H., Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G American Journal of Physiology-Renal Physiology 2007 293 4 F1332 F1341
15. VanWert A. L., Srimaroeng C., Sweet D. H., Organic anion transporter 3 (Oat3/Slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin Molecular Pharmacology 2008 74 1 122 131 (Pubitemid 351872164)
16. Eraly S. A., Vallon V., Vaughn D. A., Gangoiti J. A., Richter K., Nagle M., Monte J. C., Rieg T., Truong D. M., Long J. M., Barshop B. A., Kaler G., Nigam S. K., Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice Journal of Biological Chemistry 2006 281 8 5072 5083 (Pubitemid 43847773)
17. Schnabolk G. W., Gupta B., Mulgaonkar A., Kulkarni M., Sweet D. H., Organic anion transporter 6 (Slc22a20) specificity and sertoli cell-specific expression provide new insight on potential endogenous roles Journal of Pharmacology and Experimental Therapeutics 2010 334 3 927 935
18. Copeland R., Enzymes: A Practical Introduction to Structure, Mechanism, and Data Analysis, Chapter 8 2000 Cambridge, UK Wiley-VCH Press
19. Cheng Y., Prusoff W. H., Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction Biochemical Pharmacology 1973 22 23 3099 3108
20. Bent S., Herbal medicine in the United States: review of efficacy, safety, and regulation: grand rounds at University of California, San Francisco Medical Center Journal of General Internal Medicine 2008 23 6 854 859
21. Whitley A. C., Sweet D. H., Walle T., The dietary polyphenol ellagic acid is a potent inhibitor of hOAT1 Drug Metabolism and Disposition 2005 33 8 1097 1100 (Pubitemid 41043750)
22. Dickman K. G., Bonala R., Ray T., Aristolochic acid I is a substrate for mouse organic anion transporters: a basis for selective proximal tubule toxicity Journal of the American Society of Nephrology 2008 19 359A
23. Kaler G., Truong D. M., Khandelwal A., Nagle M., Eraly S. A., Swaan P. W., Nigam S. K., Structural variation governs substrate specificity for Organic Anion Transporter (OAT) homologs: potential remote sensing by OAT family members Journal of Biological Chemistry 2007 282 33 23841 23853 (Pubitemid 47328029)
24. Eraly S. A., Organic anion transporter 3 inhibitors as potential novel antihypertensives Pharmacological Research 2008 58 5-6 257 261
25. Lu T., Yang J., Gao X., Chen P., Du F., Sun Y., Wang F., Xu F., Shang H., Huang Y., Wang Y., Wan R., Liu C., Zhang B., Li C., Plasma and urinary tanshinol from Salvia miltiorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine Drug Metabolism and Disposition 2008 36 8 1578 1586
26. Chang B. B., Zhang L., Cao W. W., Cao Y., Yang W. L., Wang Y., Chen Y. C., Liu X. Q., Pharmacokinetic interactions induced by content variation of major water-soluble components of Danshen preparation in rats Acta Pharmacologica Sinica 2010 31 5 638 646
27. U. S. Department of Health and Human Services, Food and Drug Administration,. Guidance for Industry: Drug Interaction Studies-Study Design, Data Analysis, Implications for Dosing, and Labeling Recommendations, http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/ Guidances/UCM292362.pdf, 2012
28. Wong C. C., Barron D., Orfila C., Dionisi F., Krajcsi P., Williamson G., Interaction of hydroxycinnamic acids and their conjugates with organic anion transporters and ATP-binding cassette transporters Molecular Nutrition and Food Research 2011 55 7 979 988
29. Wong C. C., Botting N. P., Orfila C., Al-Maharik N., Williamson G., Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6) Biochemical Pharmacology 2011 81 7 942 949
30. Baba S., Osakabe N., Natsume M., Yasuda A., Muto Y., Hiyoshi K., Takano H., Yoshikawa T., Terao J., Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans European Journal of Nutrition 2005 44 1 1 9 (Pubitemid 40254228)
31. Nakazawa T., Ohsawa K., Metabolism of rosmarinic acid in rats Journal of Natural Products 1998 61 8 993 996 (Pubitemid 28417256)
32. Shen Y., Wang X., Xu L., Liu X., Chao R., Characterization of metabolites in rat plasma after intravenous administration of salvianolic acid A by liquid chromatography/time-of-flight mass spectrometry and liquid chromatography/ion trap mass spectrometry Rapid Communications in Mass Spectrometry 2009 23 12 1810 1816
33. Zhao D., Gao Z. D., Han D. E., Li N., Zhang Y. J., Lu Y., Li T. T., Chen X. J., Influence of rifampicin on the pharmacokinetics of salvianolic acid B may involve inhibition of organic anion transporting polypeptide (Oatp) mediated influx Phytotherapy Research 2012 26 1 118 121