Organic anion transporters involved in the excretion of bestatin in the kidney

Peptides

Volumn 33, Issue 2, 2012, Pages 265-271

  Zhu, Yanna ^a   Meng, Qiang ^a   Wang, Changyuan ^a   Liu, Qi ^a   Sun, Huijun ^a   Kaku, Taiichi ^b   Liu, Kexin ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b Japan Bioproducts Industry Co Ltd   (Japan)

Author keywords

Bestatin; Dipeptide; Drug interaction; Organic anion transporter; Pharmacokinetics; Renal excretion

Indexed keywords

4 AMINOHIPPURIC ACID; BESTATIN; JBP 485; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; PENICILLIN G; PROBENECID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG ACCUMULATION; DRUG EXCRETION; ENZYME SUBSTRATE; KIDNEY CLEARANCE; KIDNEY SLICE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; URINARY EXCRETION;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG INTERACTIONS; HEK293 CELLS; HUMANS; KIDNEY; LEUCINE; MALE; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; PEPTIDES, CYCLIC; PROBENECID; RATS; RATS, WISTAR; URICOSURIC AGENTS;

RATTUS;

EID: 84862822311     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2012.01.007     Document Type: Article

References (47)

1. F. Abe, G. Alvord, M. Koyama, A. Matsuda, and J.E. Talmadge Pharmacokinetics of bestatin and oral activity for treatment of experimental metastases Cancer Immunol Immunother 28 1989 29 33
2. P. Annaert, and K.R. Brouwer Assessment of drug interactions in hepatobiliary transport using rhodamine123 in sandwich-cultured rat hepatocytes Drug Metab Dispos 33 2005 388 394 (Pubitemid 40279939)
3. G. Burckhardt, and N.A. Wolff Structure of renal organic anion and cation transporters Am J Physiol 278 2000 F853 F866
4. R.S. Bourke, G. Chheda, A. Bremer, O. Watanabe, and D.B. Tower Inhibition of renal tubular transport of methotrexate by probenecid Cancer Res 35 1975 110 116
5. S.H. Cha, T. Sekine, J.I. Fukushima, Y. Kanai, Y. Kobayashi, and T. Goya Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney Mol Pharmacol 59 2001 1277 1286 (Pubitemid 32385197)
6. T. Deguchi, H. Kusuhara, A. Takadate, H. Endou, M. Otagiri, and Y. Sugiyama Characterization of uremic toxin transport by organic anion transporters in the kidney Kidney Int 65 2004 162 174 (Pubitemid 38037501)
7. M. Hasegawa, H. Kusuhara, D. Sugiyama, K. Ito, S. Ueda, and H. Endou Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions J Pharmacol Exp Ther 300 2002 746 753 (Pubitemid 34164975)
8. R. Hori, Y. Tomita, T. Katsura, M. Yasuhara, K. Inui, and M. Takano Transport of bestatin in rat renal brush-border membrane vesicles Biochem Pharmacol 45 1993 1763 1768 (Pubitemid 23150964)
9. K.I. Inui, S. Masuda, and H. Saito Cellular and molecular aspects of drug transport in the kidney Kidney Int 58 2000 944 958
10. + coupled active transport of bestatin via the dipeptide transport system in rabbit intestinal brush-border membranes J Pharmacol Exp Ther 260 1992 482 486
11. K. Ito, T. Iwatsubo, S. Kanamitsu, K. Ueda, H. Suzuki, and Y. Sugiyama Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver Pharmacol Rev 50 1998 387 412
12. H. Koepsell Polyspecific organic cation transporters: their functions and interactions with drugs Trends Pharmacol Sci 25 2004 375 381 (Pubitemid 38829491)
13. M. Koyama, M. Hashimoto, N. Asakawa, M. Ishibashi, and H. Miyazaki Simultaneous determination of bestatin and p-hydroxybestatin, a major metabolite, in human serum by gas chromatography mass spectrometry Biomed Mass Spectrom 7 1980 372 376
14. S. Khamdang, M. Teda, E. Babu, M. Marreli, and S.D. Shafran Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics Eur J Pharmacol 465 2003 1 7 (Pubitemid 36332269)
15. S. Khamdang, M. Takeda, M. Shimoda, R. Noshiro, S. Narikawa, and X.L. Huang Interactions 386 of human- and rat-organic anion transporters with pravastatin and cimetidine J Pharmacol Sci 94 2 2004 197 202 (Pubitemid 38405135)
16. W. Lee, and R.B. Kim Transporters and renal drug elimination Annu Rev Pharmacol Toxicol 44 2004 137 166 (Pubitemid 38263837)
17. G. Leyhausen, M. Gramzow, R.K. Zahn, R. Steffen, H. Umezawa, and W.E. Müller Immunochemical identification of the cell surface bound leucine aminopeptidase, the target enzyme for the immunostimulant bestatin J Antibiot 36 1983 728 734 (Pubitemid 13067635)
18. Z. Liu, C. Wang, Q. Liu, Q. Meng, J. Cang, and L. Mei Uptake, transport and regulation of JBP485 by PEPT1 in vitro and in vivo Peptides 32 2011 747 754
19. K.X. Liu, Y. Kato, T. Kaku, F. Santa, K. Imai, and A. Yagi Hydroxyprolylserine derivatives JBP923 and JBP485 exhibit the antihepatitis activities after gastrointestinal absorption in rats J Pharmacol Exp Ther 294 2000 510 515 (Pubitemid 30490823)
20. K. Liu, Y. Kato, T. Kaku, and Y. Sugiyama Human placental extract stimulates liver regeneration in rats Biol Pharm Bull 21 1 1998 44 49 (Pubitemid 28087816)
21. H. Miyazaki, T. Sekine, and H. Endou The multispecific organic anion transporter family: properties and pharmacological significance Trends Pharmacol Sci 25 2004 654 662 (Pubitemid 39458172)
22. H. Motohashi, Y. Sakurai, H. Saito, S. Masuda, Y. Urakami, and M. Goto Gene expression levels and immunolocalization of organic ion transporters in the human kidney J Am Soc Nephrol 13 2002 866 874 (Pubitemid 34274082)
23. G. Mathe Bestatin, an aminopeptidase inhibitor with a multipharmacological function Biomed Pharmacother 45 1991 49 54
24. Q. Miao, Q. Liu, C. Wang, Q. Meng, X. Guo, and J. Peng Inhibitory effect of zinc on the absorption of JBP485 via the gastrointestinal oligopeptide transporter (PEPT1) in rats Drug Metab Pharmacokinet 26 5 2011 494 502
25. S. Matsushima, K. Maeda, K. Inoue, K. Ohta, H. Yuasa, and T. Kondo The inhibition of human multidrug and toxin extrusion 1 (hMATE1) is involved in the drug-drug interaction caused by cimetidine Drug Metab Dispos 37 2009 555 559
26. Y. Nozaki, H. Kusuhara, H. Endou, and Y. Sugiyama Quantitative evaluation of the drug-drug interactions between methotrexate and nonsteroidal anti-inflammatory drugs in the renal uptake process based on the contribution of organic anion transporters and reduced folate carrier J Pharmacol Exp Ther 309 2004 226 234 (Pubitemid 38393134)
27. Y. Nozaki, H. Kusuhara, T. Kondo, M. Hasegawa, Y. Shiroyanagi, and H. Nakazawa Characterization of the uptake of organic anion transporter (OAT) 1 and OAT3 substrates by human kidney slices J Pharmacol Exp Ther 321 2007 362 369 (Pubitemid 46456974)
28. K. Ota Review of ubenimex (Bestatin): clinical research Biomed Pharmacother 45 1991 55 60
29. D. Overbosch, C. Van Gulpen, J. Hermans, and H. Mattie The effect of probenecid on the renal tubular excretion of benzylpenicillin Br J Clin Pharmacol 25 1988 51 58
30. I. Shirou, S. Mitsuru, K. Michiya, N. Sachiho, F. Michio, and M. Katsumi Major role of organic anion transporters in the uptake of phenolsulfonaphthalein in the kidney Eur J Pharmacol 475 2003 85 92
31. M. Sakuraya, J. Tamura, K. Itoh, K. Kubota, and T. Naruse Aminopeptidase inhibitor ubenimex inhibits the growth of leukaemic cell lines and myeloma cells through its cytotoxicity J Int Med Res 28 2000 214 221
32. H. Suda, T. Takita, T. Aoyagi, and H. Umezawa The structure of bestatin J Antibiot (Tokyo) 29 1976 100 101
33. D.H. Sweet, N.A. Wolff, and J.B. Pritchard Expression cloning and characterization of ROAT1 the basolateral organic anion transporter in rat kidney J Biol Chem 272 1997 30088 30095 (Pubitemid 27512205)
34. G.W. Schnabolk, G.L. Youngblood, and D.H. Sweet Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20) Am J Physiol Renal Physiol 291 2006 F314 F321
35. H. Tahara, H. Kusuhara, K. Maeda, H. Koepsell, E. Fuse, and Y. Sugiyama Inhibition of OAT3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid Drug Metab Dispos 34 2006 743 747
36. T. Takeuchi Antitumor antibiotics discovered and studied at the Institute of Microbial Chemistry J Cancer Res Clin Oncol 121 1995 505 510
37. +/dipeptide cotransport system J Pharmacol Exp Ther 252 1990 859 862 (Pubitemid 20101909)
38. 2 receptor antagonists by rat and human renal organic anion and cation transporters J Pharmacol Exp Ther 315 2005 337 345 (Pubitemid 41380529)
39. Y. Uwai, M. Okuda, K. Takami, Y. Hashimoto, and K. Inui Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney FEBS Lett 438 1998 321 324 (Pubitemid 28529298)
40. H. Umezawa, M. Ishizuka, T. Aoyagi, and T. Takeuchi Bestatin, an inhibitor of aminopeptidase B produced by actinomycetes J Antibiot 29 1976 97 99
41. A. Urabe, Y. Mutoh, H. Mizoguchi, F. Takaku, and N. Ogawa Ubenimex in the treatment of acute nonlymphocytic leukemia in adults Ann Hematol 67 1993 63 66 (Pubitemid 23246571)
42. S.H. Wright, and W.H. Dantzler Molecular and cellular physiology of renal organic cation and anion transport Physiol Rev 84 2004 987 1049 (Pubitemid 38823772)
43. J. Wu, C. Wang, Q. Liu, T. Yang, Q. Zhang, and J. Peng Protective effect of JBP485 on concanavalin A-induced hepatocyte toxicity in primary cultured rat hepatocytes Eur J Pharmacol 589 1-3 2008 299 305
44. W. Wang, Q. Liu, C. Wang, Q. Meng, T. Kaku, and K. Liu Effects of JBP485 on the expression and function of PEPT1 in indomethacin-induced intestinal injury in rats and damage in Caco-2 cells Peptides 32 2011 946 955
45. I. Yano, A. Takayama, M. Takano, M. Inatani, H. Tanihara, and Y. Ogura Pharmacokinetics and pharmacodynamics of acetazolamide in patients with transient intraocular pressure elevation Eur J Clin Pharmacol 54 1998 63 68 (Pubitemid 28189402)
46. T. Yang, J. Wu, C. Wang, Q. Liu, X. Ma, and J. Peng Protective effect of JBP485 on concanavalin A-induced liver injury in mice J Pharm Pharmacol 61 6 2009 767 774
47. J. Zhang, C. Wang, Q. Liu, Q. Meng, J. Cang, and H. Sun Pharmacokinetic interaction between JBP485 and cephalexin in rats Drug Metab Dispos 38 2010 930 938